- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00093470
Tipifarnib til behandling af patienter med akut myeloid leukæmi i remission
En fase III randomiseret undersøgelse af Farnesyl Transferase-hæmmer R115777 hos patienter med akut myeloid leukæmi (AML) i anden eller efterfølgende remission eller i remission efter primær induktionssvigt eller patienter over 60 år i første remission
Studieoversigt
Status
Betingelser
- Akut myeloid leukæmi opstået fra tidligere myelodysplastisk syndrom
- Tilbagevendende akut myeloid leukæmi hos voksne
- Voksen akut myeloid leukæmi i remission
- Myelodysplastisk syndrom med overskydende blaster
- Akut monocytisk leukæmi hos voksne
- Voksen akut myeloid leukæmi med Inv(16)(p13.1q22); CBFB-MYH11
- Voksen akut myeloid leukæmi med modning
- Voksen akut myeloid leukæmi med minimal differentiering
- Voksen akut myeloid leukæmi med t(16;16)(p13.1;q22); CBFB-MYH11
- Voksen akut myeloid leukæmi med t(8;21); (q22; q22,1); RUNX1-RUNX1T1
- Voksen akut myeloid leukæmi med t(9;11)(p22.3;q23.3); MLLT3-KMT2A
- Voksen akut myeloid leukæmi uden modning
- Akut myelomonocytisk leukæmi hos voksne
- Alkyleringsmiddel-relateret akut myeloid leukæmi
- Akut megakaryoblastisk leukæmi hos voksne
- Voksen erythroleukæmi
- Voksen ren erythroid leukæmi
Intervention / Behandling
Detaljeret beskrivelse
PRIMÆRE MÅL:
I. At sammenligne R115777 (tipifarnib) vedligeholdelsesterapi med kun observation med hensyn til sygdomsfri overlevelse (DFS) hos patienter med AML i anden eller efterfølgende fuldstændig remission eller i komplet respons (CR) efter primær induktionssvigt.
SEKUNDÆRE MÅL:
I. At sammenligne den samlede overlevelse af patienter i begge arme. II. At evaluere den langsigtede sikkerhed og toksicitet af forlænget administration af R115777 hos AML-patienter i remission.
OVERSIGT: Patienterne randomiseres til 1 ud af 2 behandlingsarme.
ARM A: Patienterne får tipifarnib oralt (PO) to gange dagligt (BID) på dag 1-21. Kurser gentages hver 28. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.
ARM B: Patienter gennemgår kun observation.
Efter afsluttet studiebehandling følges patienterne op i 5 år.
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Fase 3
Kontakter og lokationer
Studiesteder
-
-
Alabama
-
Birmingham, Alabama, Forenede Stater, 35233
- University of Alabama at Birmingham Cancer Center
-
-
Alaska
-
Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
-
-
Arizona
-
Scottsdale, Arizona, Forenede Stater, 85259
- Mayo Clinic in Arizona
-
-
California
-
San Diego, California, Forenede Stater, 92108
- Kaiser Permanente-San Diego Mission
-
-
Colorado
-
Aurora, Colorado, Forenede Stater, 80012
- The Medical Center of Aurora
-
Boulder, Colorado, Forenede Stater, 80301
- Boulder Community Hospital
-
Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
-
Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
-
Denver, Colorado, Forenede Stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
-
Denver, Colorado, Forenede Stater, 80218
- SCL Health Saint Joseph Hospital
-
Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
-
Denver, Colorado, Forenede Stater, 80222
- Colorado Cancer Research Program NCORP
-
Englewood, Colorado, Forenede Stater, 80113
- Swedish Medical Center
-
Fort Collins, Colorado, Forenede Stater, 80524
- Poudre Valley Hospital
-
Grand Junction, Colorado, Forenede Stater, 81501
- Saint Mary's Hospital and Regional Medical Center
-
Greeley, Colorado, Forenede Stater, 80631
- North Colorado Medical Center
-
Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
-
Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
-
Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
-
Loveland, Colorado, Forenede Stater, 80539
- McKee Medical Center
-
Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
-
Thornton, Colorado, Forenede Stater, 80229
- North Suburban Medical Center
-
Wheat Ridge, Colorado, Forenede Stater, 80033
- SCL Health Lutheran Medical Center
-
-
Connecticut
-
Torrington, Connecticut, Forenede Stater, 06790
- Smilow Cancer Hospital-Torrington Care Center
-
-
Delaware
-
Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
-
Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
-
Wilmington, Delaware, Forenede Stater, 19805
- Saint Francis Hospital - Wilmington
-
-
District of Columbia
-
Washington, District of Columbia, Forenede Stater, 20010
- Medstar Washington Hospital Center
-
Washington, District of Columbia, Forenede Stater, 20007
- MedStar Georgetown University Hospital
-
-
Florida
-
Boca Raton, Florida, Forenede Stater, 33486
- Boca Raton Regional Hospital
-
Fort Lauderdale, Florida, Forenede Stater, 33316
- Broward Health Medical Center
-
Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
-
Gainesville, Florida, Forenede Stater, 32610
- University of Florida Health Science Center - Gainesville
-
Hollywood, Florida, Forenede Stater, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
-
Jacksonville, Florida, Forenede Stater, 32207
- Baptist MD Anderson Cancer Center
-
Jupiter, Florida, Forenede Stater, 33458
- Jupiter Medical Center
-
Miami, Florida, Forenede Stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
-
Miami Beach, Florida, Forenede Stater, 33140
- Mount Sinai Medical Center
-
-
Georgia
-
Albany, Georgia, Forenede Stater, 31701
- Phoebe Putney Memorial Hospital
-
Athens, Georgia, Forenede Stater, 30607
- University Cancer and Blood Center LLC
-
Augusta, Georgia, Forenede Stater, 30912
- Augusta University Medical Center
-
Savannah, Georgia, Forenede Stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Savannah, Georgia, Forenede Stater, 31404
- Memorial University Medical Center
-
-
Idaho
-
Idaho Falls, Idaho, Forenede Stater, 83404
- Hematology Oncology Associates of Eastern Idaho
-
-
Illinois
-
Aurora, Illinois, Forenede Stater, 60504
- Rush - Copley Medical Center
-
Bloomington, Illinois, Forenede Stater, 61701
- Saint Joseph Medical Center
-
Canton, Illinois, Forenede Stater, 61520
- Graham Hospital Association
-
Carthage, Illinois, Forenede Stater, 62321
- Memorial Hospital
-
Chicago, Illinois, Forenede Stater, 60611
- Northwestern University
-
Chicago, Illinois, Forenede Stater, 60612
- Rush University Medical Center
-
Chicago, Illinois, Forenede Stater, 60637
- University of Chicago Comprehensive Cancer Center
-
Chicago, Illinois, Forenede Stater, 60625
- Swedish Covenant Hospital
-
Chicago, Illinois, Forenede Stater, 60611
- Hematology and Oncology Associates
-
Chicago, Illinois, Forenede Stater, 60612
- Jesse Brown Veterans Affairs Medical Center
-
Chicago, Illinois, Forenede Stater, 60616
- Mercy Hospital and Medical Center
-
Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Forenede Stater, 62526
- Heartland Cancer Research NCORP
-
Eureka, Illinois, Forenede Stater, 61530
- Eureka Hospital
-
Evanston, Illinois, Forenede Stater, 60201
- NorthShore University HealthSystem-Evanston Hospital
-
Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
-
Galesburg, Illinois, Forenede Stater, 61401
- Galesburg Cottage Hospital
-
Havana, Illinois, Forenede Stater, 62644
- Mason District Hospital
-
Hinsdale, Illinois, Forenede Stater, 60521
- Hinsdale Hematology Oncology Associates Incorporated
-
Hopedale, Illinois, Forenede Stater, 61747
- Hopedale Medical Complex - Hospital
-
Joliet, Illinois, Forenede Stater, 60435
- Joliet Oncology-Hematology Associates Limited
-
Joliet, Illinois, Forenede Stater, 60432
- Midwest Center for Hematology Oncology
-
Kewanee, Illinois, Forenede Stater, 61443
- Kewanee Hospital
-
Lake Forest, Illinois, Forenede Stater, 60045
- Deerpath Medical Associates
-
Libertyville, Illinois, Forenede Stater, 60048
- NorthShore Hematology Oncology-Libertyville
-
Macomb, Illinois, Forenede Stater, 61455
- Mcdonough District Hospital
-
Maywood, Illinois, Forenede Stater, 60153
- Loyola University Medical Center
-
Niles, Illinois, Forenede Stater, 60714
- Illinois Cancer Specialists-Niles
-
Normal, Illinois, Forenede Stater, 61761
- Community Cancer Center Foundation
-
Normal, Illinois, Forenede Stater, 61761
- Bromenn Regional Medical Center
-
Olympia Fields, Illinois, Forenede Stater, 60461
- Franciscan St. James Health-Olympia Fields Campus
-
Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa, Illinois, Forenede Stater, 61350
- Ottawa Regional Hospital and Healthcare Center
-
Pekin, Illinois, Forenede Stater, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
-
Pekin, Illinois, Forenede Stater, 61554
- Pekin Hospital
-
Peoria, Illinois, Forenede Stater, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Forenede Stater, 61614
- Proctor Hospital
-
Peoria, Illinois, Forenede Stater, 61603
- Methodist Medical Center of Illinois
-
Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
-
Peru, Illinois, Forenede Stater, 61354
- Illinois Valley Hospital
-
Princeton, Illinois, Forenede Stater, 61356
- Perry Memorial Hospital
-
Rushville, Illinois, Forenede Stater, 62681
- Sarah Culbertson Memorial Hospital
-
Skokie, Illinois, Forenede Stater, 60076
- Hematology Oncology Associates of Illinois - Skokie
-
Skokie, Illinois, Forenede Stater, 60076
- Edward H Kaplan MD and Associates
-
Skokie, Illinois, Forenede Stater, 60077
- Midwest Cancer Research Group Incorporated
-
Spring Valley, Illinois, Forenede Stater, 61362
- Saint Margaret's Hospital
-
Springfield, Illinois, Forenede Stater, 62781
- Memorial Medical Center
-
Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
-
-
Indiana
-
Beech Grove, Indiana, Forenede Stater, 46107
- Franciscan Saint Francis Health-Beech Grove
-
Elkhart, Indiana, Forenede Stater, 46515
- Elkhart General Hospital
-
Fort Wayne, Indiana, Forenede Stater, 46845
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
-
Kokomo, Indiana, Forenede Stater, 46904
- Community Howard Regional Health
-
La Porte, Indiana, Forenede Stater, 46350
- IU Health La Porte Hospital
-
Michigan City, Indiana, Forenede Stater, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Mishawaka, Indiana, Forenede Stater, 46545
- Saint Joseph Regional Medical Center-Mishawaka
-
Munster, Indiana, Forenede Stater, 46321
- The Community Hospital
-
South Bend, Indiana, Forenede Stater, 46601
- Memorial Hospital of South Bend
-
South Bend, Indiana, Forenede Stater, 46628
- Northern Indiana Cancer Research Consortium
-
-
Iowa
-
Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic PC-William R Bliss Cancer Center
-
Bettendorf, Iowa, Forenede Stater, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Clive, Iowa, Forenede Stater, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Heartland Oncology and Hematology LLP
-
Davenport, Iowa, Forenede Stater, 52803
- Genesis Medical Center - East Campus
-
Davenport, Iowa, Forenede Stater, 52804
- Genesis Medical Center - West Campus
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, Forenede Stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa-Wide Oncology Research Coalition NCORP
-
Des Moines, Iowa, Forenede Stater, 50314
- Medical Oncology and Hematology Associates-Laurel
-
Des Moines, Iowa, Forenede Stater, 50307
- Mercy Capitol
-
Sioux City, Iowa, Forenede Stater, 51101
- Siouxland Regional Cancer Center
-
Sioux City, Iowa, Forenede Stater, 51104
- Saint Luke's Regional Medical Center
-
Sioux City, Iowa, Forenede Stater, 51104
- Mercy Medical Center-Sioux City
-
-
Kansas
-
Anthony, Kansas, Forenede Stater, 67003
- Hospital District Sixth of Harper County
-
Arkansas City, Kansas, Forenede Stater, 67005
- Memorial Hospital of Arkansas City
-
Chanute, Kansas, Forenede Stater, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forenede Stater, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Forenede Stater, 66701
- Cancer Center of Kansas - Fort Scott
-
Independence, Kansas, Forenede Stater, 67301
- Cancer Center of Kansas-Independence
-
Kingman, Kansas, Forenede Stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Forenede Stater, 67901
- Southwest Medical Center
-
Newton, Kansas, Forenede Stater, 67114
- Cancer Center of Kansas - Newton
-
Ottawa, Kansas, Forenede Stater, 66067
- Cancer Center of Kansas - Ottawa
-
Overland Park, Kansas, Forenede Stater, 66209
- Menorah Medical Center
-
Overland Park, Kansas, Forenede Stater, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, Forenede Stater, 67357
- Cancer Center of Kansas - Parsons
-
Prairie Village, Kansas, Forenede Stater, 66208
- Kansas City NCI Community Oncology Research Program
-
Pratt, Kansas, Forenede Stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forenede Stater, 67401
- Cancer Center of Kansas - Salina
-
Shawnee Mission, Kansas, Forenede Stater, 66204
- Shawnee Mission Medical Center-KCCC
-
Topeka, Kansas, Forenede Stater, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Topeka, Kansas, Forenede Stater, 66606
- Saint Francis Hospital and Medical Center - Topeka
-
Wellington, Kansas, Forenede Stater, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Forenede Stater, 67208
- Associates In Womens Health
-
Wichita, Kansas, Forenede Stater, 67214
- Wichita NCI Community Oncology Research Program
-
Wichita, Kansas, Forenede Stater, 67214
- Via Christi Regional Medical Center
-
Winfield, Kansas, Forenede Stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Louisiana
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, Forenede Stater, 70806
- Baton Rouge General Medical Center
-
Houma, Louisiana, Forenede Stater, 70360
- Mary Bird Perkins Cancer Center/Terrebonne General Medical Center
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Forenede Stater, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, Forenede Stater, 70112
- Louisiana State University Health Science Center
-
Shreveport, Louisiana, Forenede Stater, 71103
- Louisiana State University Health Sciences Center Shreveport
-
Shreveport, Louisiana, Forenede Stater, 71101
- Overton Brooks Veteran's Administration Medical Center
-
-
Maine
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
Waterville, Maine, Forenede Stater, 04901
- Maine General Medical Center-Thayer
-
-
Maryland
-
Baltimore, Maryland, Forenede Stater, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Elkton, Maryland, Forenede Stater, 21921
- Union Hospital of Cecil County
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02111
- Tufts Medical Center
-
Boston, Massachusetts, Forenede Stater, 02118
- Boston Medical Center
-
Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Hospital and Medical Center
-
Greenfield, Massachusetts, Forenede Stater, 01301
- Franklin Medical Center
-
Springfield, Massachusetts, Forenede Stater, 01199
- Baystate Medical Center
-
-
Michigan
-
Detroit, Michigan, Forenede Stater, 48202
- Henry Ford Hospital
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forenede Stater, 49001
- Borgess Medical Center
-
Kalamazoo, Michigan, Forenede Stater, 49008
- Kalamazoo Center for Medical Studies
-
Royal Oak, Michigan, Forenede Stater, 48073
- William Beaumont Hospital-Royal Oak
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Lakeland Hospital
-
Southfield, Michigan, Forenede Stater, 48075
- Providence Hospital-Southfield Cancer Center
-
-
Minnesota
-
Alexandria, Minnesota, Forenede Stater, 56308
- Medini, Eitan MD (UIA Investigator)
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview-Southdale Hospital
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Etzell, Paul S MD (UIA Investigator)
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Swenson, Wade II, MD (UIA Investigator)
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic
-
Saint Cloud, Minnesota, Forenede Stater, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Cloud, Minnesota, Forenede Stater, 56303
- Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Hattiesburg, Mississippi, Forenede Stater, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, Forenede Stater, 39402
- Hematology and Oncology Clinic
-
-
Missouri
-
Independence, Missouri, Forenede Stater, 64057
- Centerpoint Medical Center LLC
-
Kansas City, Missouri, Forenede Stater, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, Forenede Stater, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Forenede Stater, 64132
- Research Medical Center
-
Kansas City, Missouri, Forenede Stater, 64108
- Truman Medical Center
-
Kansas City, Missouri, Forenede Stater, 64114
- Saint Joseph Health Center
-
Lee's Summit, Missouri, Forenede Stater, 64086
- Saint Luke's East - Lee's Summit
-
Liberty, Missouri, Forenede Stater, 64068
- Liberty Radiation Oncology Center
-
Saint Joseph, Missouri, Forenede Stater, 64507
- Heartland Regional Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63110
- Washington University School of Medicine
-
-
Montana
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Forenede Stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forenede Stater, 59102
- Montana Cancer Consortium NCORP
-
Billings, Montana, Forenede Stater, 59101
- Northern Rockies Radiation Oncology Center
-
Billings, Montana, Forenede Stater, 59102
- Saint Vincent Frontier Cancer Center
-
Billings, Montana, Forenede Stater, 59107
- Deaconess Medical Center
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Deaconess Hospital
-
Bozeman, Montana, Forenede Stater, 59715
- Internal Medicine of Bozeman
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Great Falls, Montana, Forenede Stater, 59405
- Berdeaux, Donald MD (UIA Investigator)
-
Helena, Montana, Forenede Stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Regional Medical Center
-
Kalispell, Montana, Forenede Stater, 59901
- Glacier Oncology PLLC
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Medical Oncology
-
Miles City, Montana, Forenede Stater, 59301
- Eastern Montana Cancer Center
-
Missoula, Montana, Forenede Stater, 59804
- Community Medical Hospital
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forenede Stater, 59804
- Guardian Oncology and Center for Wellness
-
Missoula, Montana, Forenede Stater, 59802
- Montana Cancer Specialists
-
-
Nevada
-
Las Vegas, Nevada, Forenede Stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- Nevada Cancer Research Foundation CCOP
-
-
New Jersey
-
Camden, New Jersey, Forenede Stater, 08103
- Cooper Hospital University Medical Center
-
New Brunswick, New Jersey, Forenede Stater, 08903
- Rutgers Cancer Institute of New Jersey
-
-
New York
-
Bronx, New York, Forenede Stater, 10467
- Montefiore Medical Center - Moses Campus
-
Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Weiler Hospital
-
Bronx, New York, Forenede Stater, 10466
- Montefiore Medical Center-Wakefield Campus
-
Buffalo, New York, Forenede Stater, 14263
- Roswell Park Cancer Institute
-
East Syracuse, New York, Forenede Stater, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Middletown, New York, Forenede Stater, 10940
- Orange Regional Medical Center
-
New York, New York, Forenede Stater, 10065
- Weill Medical College of Cornell University
-
New York, New York, Forenede Stater, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Stony Brook, New York, Forenede Stater, 11794
- Stony Brook University Medical Center
-
-
North Carolina
-
Charlotte, North Carolina, Forenede Stater, 28203
- Carolinas Medical Center/Levine Cancer Institute
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Wayne Memorial Hospital
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Wayne Radiation Oncology
-
Kinston, North Carolina, Forenede Stater, 28501
- Kinston Medical Specialists PA
-
Rutherfordton, North Carolina, Forenede Stater, 28139
- Rutherford Hospital
-
Wilson, North Carolina, Forenede Stater, 27893
- Wilson Medical Center
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44304
- Summa Akron City Hospital/Cooper Cancer Center
-
Akron, Ohio, Forenede Stater, 44307
- Akron General Medical Center
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Health Foundation
-
Cincinnati, Ohio, Forenede Stater, 45236
- The Jewish Hospital
-
Cleveland, Ohio, Forenede Stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forenede Stater, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Foundation
-
Columbus, Ohio, Forenede Stater, 43210
- Ohio State University Comprehensive Cancer Center
-
Dayton, Ohio, Forenede Stater, 45415
- Samaritan North Health Center
-
Independence, Ohio, Forenede Stater, 44131
- Cleveland Clinic Cancer Center Independence
-
Lima, Ohio, Forenede Stater, 45801
- Saint Rita's Medical Center
-
Wooster, Ohio, Forenede Stater, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Cancer Care Associates
-
Tulsa, Oklahoma, Forenede Stater, 74136
- Natalie Warren Bryant Cancer Center at Saint Francis
-
-
Pennsylvania
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Medical Center
-
Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lewistown, Pennsylvania, Forenede Stater, 17044
- Lewistown Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Pennsylvania Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18510
- Scranton Hematology Oncology
-
Scranton, Pennsylvania, Forenede Stater, 18501
- Mercy Hospital
-
State College, Pennsylvania, Forenede Stater, 16801
- Geisinger Medical Group
-
State College, Pennsylvania, Forenede Stater, 16803
- Mount Nittany Medical Center
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
York, Pennsylvania, Forenede Stater, 17403
- WellSpan Health-York Hospital
-
-
South Carolina
-
Anderson, South Carolina, Forenede Stater, 29621
- AnMed Health Hospital
-
Florence, South Carolina, Forenede Stater, 29506
- McLeod Regional Medical Center
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Spartanburg Medical Center
-
-
South Dakota
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center Oncology Clinic
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Medical X-Ray Center
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera McKennan Hospital and University Health Center
-
-
Tennessee
-
Knoxville, Tennessee, Forenede Stater, 37920
- University of Tennessee - Knoxville
-
-
Texas
-
Fort Sam Houston, Texas, Forenede Stater, 78234
- Brooke Army Medical Center
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Michael E DeBakey VA Medical Center
-
Houston, Texas, Forenede Stater, 77030
- The Methodist Hospital System
-
Houston, Texas, Forenede Stater, 77030
- Ben Taub General Hospital
-
Houston, Texas, Forenede Stater, 77030
- Baylor Saint Luke's Medical Center
-
Lackland Air Force Base, Texas, Forenede Stater, 78236
- Wilford Hall Medical Center
-
-
Utah
-
Cedar City, Utah, Forenede Stater, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Forenede Stater, 84321
- Logan Regional Hospital
-
Murray, Utah, Forenede Stater, 84107
- Intermountain Medical Center
-
Murray, Utah, Forenede Stater, 84107
- Cottonwood Hospital Medical Center
-
Ogden, Utah, Forenede Stater, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Forenede Stater, 84604
- Utah Valley Regional Medical Center
-
Saint George, Utah, Forenede Stater, 84770
- Dixie Medical Center Regional Cancer Center
-
Salt Lake City, Utah, Forenede Stater, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Forenede Stater, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Forenede Stater, 84143
- LDS Hospital
-
Salt Lake City, Utah, Forenede Stater, 84103
- Intermountain Health Care
-
-
Vermont
-
Berlin, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont College of Medicine
-
-
Washington
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Kennewick, Washington, Forenede Stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Mount Vernon, Washington, Forenede Stater, 98274
- Skagit Valley Hospital
-
Seattle, Washington, Forenede Stater, 98109
- Fred Hutchinson Cancer Research Center
-
Seattle, Washington, Forenede Stater, 98195
- University of Washington Medical Center
-
Seattle, Washington, Forenede Stater, 98104
- Harborview Medical Center
-
Seattle, Washington, Forenede Stater, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Forenede Stater, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, Forenede Stater, 98122-4307
- Swedish Medical Center-First Hill
-
Sedro-Woolley, Washington, Forenede Stater, 98284
- PeaceHealth United General Medical Center
-
Spokane, Washington, Forenede Stater, 99202
- Cancer Care Northwest - Spokane South
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Wenatchee, Washington, Forenede Stater, 98801
- Wenatchee Valley Hospital and Clinics
-
Wenatchee, Washington, Forenede Stater, 98801
- Central Washington Hospital
-
-
West Virginia
-
Morgantown, West Virginia, Forenede Stater, 26506
- West Virginia University Healthcare
-
-
Wisconsin
-
Chippewa Falls, Wisconsin, Forenede Stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Sacred Heart Hospital
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran Medical Center
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Clinic
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53226
- Froedtert and the Medical College of Wisconsin
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Clinic-Minocqua Center
-
Oconomowoc, Wisconsin, Forenede Stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Ascension Saint Mary's Hospital
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Clinic-Rice Lake Center
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Saint Michael's Hospital
-
Waukesha, Wisconsin, Forenede Stater, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Forenede Stater, 54401
- Marshfield Clinic-Wausau Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Diagnostic and Treatment Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Clinic - Weston Center
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
-
-
-
Haifa, Israel, 31096
- Rambam Medical Center
-
-
-
-
-
Lima, Peru, Lima 34
- Instituto Nacional de Enfermedades Neoplasicas
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Beskrivelse
Inklusionskriterier:
Patienter, der er kvalificerede til at deltage i denne undersøgelse, skal falde ind under en af disse kategorier:
- Patienter i første remission efter primær induktionssvigt
- Patienter skal have modtaget mindst to kemoterapi-induktionsregimer
- Patienter i anden eller efterfølgende remission
- Patienter > 60 år i første remission
Patienter skal være i fuldstændig remission (CR) eller morfologisk remission (MR) ved blodtællinger og knoglemarvsundersøgelser for at deltage i undersøgelsen
- Bekræftende knoglemarv skal udføres =< 2 uger før randomisering
Patienter skal have morfologisk bevis (fra knoglemarvsaspirat, udstrygninger eller berøringsforberedelser af marvbiopsi), at de havde AML af en af følgende typer før opnåelse af CR/MR
- Akut myeloblastisk leukæmi, minimal differentiering (fransk-amerikansk-britisk [FAB] M0)
- Akut myeloblastisk leukæmi uden differentiering (FAB M1)
- Akut myeloblastisk leukæmi med modning (FAB M2)
- Akut myelomonocytisk leukæmi (FAB M4)
- Akut monocytisk leukæmi (FAB M5)
- Akut erythroleukæmi (FAB M6)
- Akut megakaryocytisk leukæmi (FAB M7)
- Refraktær anæmi med overskydende blaster i transformation (RAEB-T)
- AML efter Verdenssundhedsorganisationens (WHO) kriterier
- Akut myeloid leukæmi med multilineage dysplasi
- Patienter med akut promyelocytisk leukæmi (FAB M3) er ikke kvalificerede
Patienter skal registreres inden for 60 dage efter afslutning af behandlingen for den aktuelle remission; patienter er kvalificerede, hvis de opfylder et af nedenstående kriterier:
- Inden for 60 dage efter remission (CR eller MR) ved perifere blodtællinger efter induktionsbehandling eller
- Inden for 60 dage efter udskrivelse fra hospitalet efter induktionsbehandling eller
- Inden for 60 dage efter udskrivelse fra hospitalet efter behandling efter remission eller
- Inden for 60 dage efter genopretning af blodtal efter sidste dosis kemoterapi
Alle nedenstående patienter er berettigede til studieoptagelse:
- Patienter, der har modtaget konsolideringsterapi
- Patienter, der ikke har modtaget konsoliderings- eller postremissionsbehandling
- Patienter, der har fået en autolog stamcelletransplantation
- Patienter, der har modtaget en allogen transplantation (knoglemarvstransplantation [BMT] eller perifer stamcelletransplantation [PSCT]) i deres nuværende remission, er ikke berettigede; patienter, der har fået en allogen transplantation i en tidligere remission og i øjeblikket er i remission efter efterfølgende tilbagefald, er berettigede
- Patienter med en anamnese med ekstramedullær sygdom er berettigede, hvis de er i fuldstændig remission på tidspunktet for studiestart og ikke længere har behov for behandling for deres ekstramedullære sygdom
- Patienter må ikke være gravide eller ammende; alle kvinder i den fødedygtige alder skal have en blodprøve eller urinundersøgelse < 2 uger før randomisering for at udelukke graviditet
- Kvinder i den fødedygtige alder og seksuelt aktive mænd anbefales kraftigt at bruge en accepteret og effektiv præventionsmetode
- Patienter må ikke være kendt for at have en allergi over for imidazolmedicin, såsom clotrimazol ketoconazol, miconazol, econazol eller terconazol; dette inkluderer ikke fluconazol, voriconazol eller itraconazol
- Eastern Cooperative Oncology Group (ECOG) præstationsstatus på 0 - 2
- Patienter må ikke have aktiv hjerte- eller lungesygdom; men patienten vil være berettiget, hvis sygdommen er medicinsk kontrolleret
- Patienter må ikke have aktiv nyresygdom; kreatinin skal være =< 1,5 x øvre normalgrænse
- Patienter må ikke have aktiv leversygdom; total eller direkte bilirubin skal være < 2 mg/dl
- Serumglutamin-oxaloeddikesyretransaminase (SGOT) (aspartataminotransferase [AST]) og serumglutamatpyruvattransaminase (SGPT) (alaninaminotransferase [ALT]) skal være =< 2,5 gange den øvre grænse for normalen
- Absolut neutrofiltal (ANC) >= 1000/mm^3
- Blodpladetal >= 50.000/mm^3
- Patienter må ikke tage et leverenzyminducerende antikonvulsivt middel; en patient vil ikke være berettiget til undersøgelsen, hvis patienten i øjeblikket tager et af disse midler og ikke kan skiftes til et ikke-hepatisk enzym-inducerende antikonvulsivt middel
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Eksperimentel: Arm A (tipifarnib)
Patienterne modtager tipifarnib PO BID på dag 1-21.
Kurser gentages hver 28. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.
|
Givet PO
Andre navne:
|
Andet: Arm B (klinisk observation)
Patienter gennemgår kun observation.
|
Gennemgå observation
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Sygdomsfri overlevelse
Tidsramme: Vurderet månedligt i de første 6 måneder og derefter hver 3. måned eller som klinisk indiceret, op til 5 år.
|
Sygdomsfri overlevelse (DFS) er defineret som tiden fra randomisering til tilbagefald eller død uden tilbagefald.
|
Vurderet månedligt i de første 6 måneder og derefter hver 3. måned eller som klinisk indiceret, op til 5 år.
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Samlet overlevelse
Tidsramme: Vurderet månedligt i de første 6 måneder og derefter hver 3. måned eller som klinisk indiceret, op til 5 år.
|
Samlet overlevelse (OS) er defineret som tiden fra randomisering til død uanset årsag.
|
Vurderet månedligt i de første 6 måneder og derefter hver 3. måned eller som klinisk indiceret, op til 5 år.
|
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Ledende efterforsker: Selina Luger, ECOG-ACRIN Cancer Research Group
Publikationer og nyttige links
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Anslået)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Patologiske processer
- Neoplasmer efter histologisk type
- Neoplasmer
- Sygdom
- Knoglemarvssygdomme
- Hæmatologiske sygdomme
- Myeloproliferative lidelser
- Anæmi
- Forstadier til kræft
- Anæmi, ildfast
- Syndrom
- Myelodysplastiske syndromer
- Leukæmi
- Leukæmi, myeloid
- Leukæmi, Myeloid, Akut
- Præleukæmi
- Leukæmi, myelomonocytisk, akut
- Leukæmi, monocytisk, akut
- Leukæmi, Megakaryoblastisk, Akut
- Leukæmi, erytroblastisk, akut
- Anæmi, ildfast, med overskud af eksplosioner
- Antineoplastiske midler
- Tipifarnib
Andre undersøgelses-id-numre
- NCI-2009-00535 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180820 (U.S. NIH-bevilling/kontrakt)
- U10CA021115 (U.S. NIH-bevilling/kontrakt)
- E2902 (Anden identifikator: CTEP)
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Tipifarnib
-
Samsung Medical CenterAktiv, ikke rekrutterendeUrothelialt karcinomKorea, Republikken
-
National Cancer Institute (NCI)AfsluttetLymfom | Myelodysplastiske syndromer | Leukæmi | Kroniske myeloproliferative lidelser | Myelom og plasmacelle-neoplasmaForenede Stater
-
NYU Langone HealthNational Cancer Institute (NCI)Afsluttet
-
University of Maryland, BaltimoreNational Cancer Institute (NCI)Afsluttet
-
National Cancer Institute (NCI)AfsluttetTilbagevendende medulloblastom i barndommen | Cerebral astrocytom i høj grad i barndommen | Tilbagevendende Childhood Brain Stam Gliom | Tilbagevendende cerebellar astrocytom i barndommen | Tilbagevendende Cerebral Astrocytom i barndommen | Tilbagevendende supratentorial primitiv neuroektodermal... og andre forholdForenede Stater
-
Johnson & Johnson Pharmaceutical Research & Development...Afsluttet
-
Sidney Kimmel Comprehensive Cancer Center at Johns...National Cancer Institute (NCI)AfsluttetTumorer i hjernen og centralnervesystemetForenede Stater
-
National Institutes of Health Clinical Center (CC)National Cancer Institute (NCI); Children's Oncology GroupAfsluttetLeukæmiForenede Stater, Canada, Australien
-
Mayo ClinicNational Cancer Institute (NCI)AfsluttetLungekræftForenede Stater
-
City of Hope Medical CenterNational Cancer Institute (NCI)AfsluttetUspecificeret fast tumor hos voksne, protokolspecifikForenede Stater