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Cetuximab og/eller Bevacizumab kombineret med kombinationskemoterapi til behandling af patienter med metastatisk kolorektal cancer

28. april 2020 opdateret af: Alliance for Clinical Trials in Oncology

Et fase III forsøg med Irinotecan / 5-FU / Leucovorin eller Oxaliplatin / 5-FU / Leucovorin med Bevacizumab eller Cetuximab (C225) eller med kombinationen af Bevacizumab og Cetuximab til patienter med ubehandlet metastatisk adenocarcinom i tyktarmen

FORMÅL: Dette randomiserede fase III-studie studerer cetuximab og/eller bevacizumab, når det gives sammen med kombinationskemoterapi, for at sammenligne, hvor godt de virker ved behandling af patienter med metastatisk kolorektal cancer.

RATIONALE: Monoklonale antistoffer, såsom cetuximab og bevacizumab, kan blokere tumorvækst på forskellige måder. Nogle blokerer tumorcellernes evne til at vokse og sprede sig. Andre finder tumorceller og hjælper med at dræbe dem eller bære tumor-dræbende stoffer til dem. Cetuximab kan også stoppe væksten af tumorceller ved at blokere nogle af de enzymer, der er nødvendige for cellevækst. Bevacizumab kan også stoppe væksten af tumorceller ved at blokere blodtilførslen til tumoren. Lægemidler, der bruges i kemoterapi, såsom fluorouracil, leucovorin, oxaliplatin og irinotecan, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne eller ved at forhindre dem i at dele sig. At give monoklonale antistoffer sammen med kombinationskemoterapi kan dræbe flere tumorceller. Det vides endnu ikke, om kombinationskemoterapi er mere effektiv med cetuximab og/eller bevacizumab til behandling af patienter med kolorektal cancer.

Studieoversigt

Status

Afsluttet

Betingelser

Kolorektal cancer

Intervention / Behandling

Detaljeret beskrivelse

OVERSIGT: Dette er et randomiseret, åbent, multicenter-studie. Patienterne er stratificeret efter lægevalgt kemoterapi (FOLFOX eller FOLFIRI), tidligere adjuverende kemoterapi (ja vs nej) og tidligere bækkenstrålebehandling (ja vs nej). Patienterne blev randomiseret til 1 ud af 3 behandlingsarme.

Primært mål:

For at bestemme, om tilføjelsen af cetuximab til FOLFIRI eller FOLFOX kemoterapi forlænger overlevelsen sammenlignet med FOLFIRI eller FOLFOX med bevacizumab hos patienter med ubehandlet, fremskreden eller metastatisk kolorektal cancer, som har K-ras vildtype tumorer.

Sekundære mål:

For at evaluere respons, progressionsfri overlevelse (PFS), tid til behandlingssvigt (TTF) og varighed af respons (DR) blandt patienter med ikke-operabel fremskreden metastatisk tyktarmskræft behandlet med bevacizumab eller cetuximab ud over kemoterapi med FOLFIRI eller FOLFOX
At evaluere toksicitet og især 60-dages dødelighed blandt patienter med ikke-operabel fremskreden metastatisk tyktarmskræft behandlet med bevacizumab eller cetuximab ud over kemoterapi med FOLFIRI eller FOLFOX
At beskrive patienter med ikke-operabel lokalt fremskreden eller metastatisk kolorektal cancer, der er gjort "operable" med kemoterapi

Der er retningslinjer for præmedicinering, der blev etableret for patienter, der er udpeget til at modtage cetuximab. Alle patienter skal præmedicineres med diphenhydraminhydrochlorid 50 mg (eller et lignende middel) IV før den første dosis cetuximab i et forsøg på at forhindre en infusion eller overfølsomhedsreaktion. Præmedicinering anbefales også forud for efterfølgende doser, men efter investigatorens skøn kan dosis af diphenhydramin (eller et lignende middel) reduceres. Forbehandling med acetaminophen kan også anvendes.

Der er instruktioner til administration af bevacizumab til patienter, for hvem operation overvejes eller er påkrævet. For patienter, for hvem elektiv kirurgi er påtænkt, skal bevacizumab seponeres i mindst 8 uger før operationen. Bevacizumab kan genoptages efter mindst 4 uger efter operationen. Patienter, som gennemgår fuldstændig resektion af metastatisk sygdom, vil afbryde protokolbehandling og kan modtage yderligere behandling efter den behandlende læges skøn. For patienter, for hvem ikke-elektiv kirurgi er påkrævet, skal bevacizumab holdes så længe som muligt før operationen og i mindst 6 uger efter operationen.

Patienterne modtog minimum to behandlingscyklusser. Patienterne fik lov til at modtage supplerende terapi pr. protokol. Behandlingen fortsatte indtil sygdomsprogression, uacceptabel toksicitet eller operation med helbredende hensigt som planlagt. Efter afsluttet undersøgelsesbehandling følges patienterne op til 5 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

2334

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 5L3
    - British Columbia Cancer Agency - Centre for the Southern Interior
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - British Columbia Cancer Agency - Vancouver Cancer Centre
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- New Brunswick
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Saint John Regional Hospital
- Ontario
  - Hamilton, Ontario, Canada, L8V 5C2
    - Margaret and Charles Juravinski Cancer Centre
  - Kingston, Ontario, Canada, K7L 5P9
    - Cancer Centre of Southeastern Ontario At Kingston General Hospital
  - Kitchener, Ontario, Canada, N2G 1G3
    - Grand River Regional Cancer Centre at Grand River Hospital
  - London, Ontario, Canada, N6A 4L6
    - London Regional Cancer Program at London Health Sciences Centre
  - Newmarket, Ontario, Canada, L3Y 2P9
    - Southlake Regional Health Centre
  - Oshawa, Ontario, Canada, L1G 2B9
    - R. S. McLaughlin Durham Regional Cancer Centre at Lakeridge Health Oshawa
  - Ottawa, Ontario, Canada, K1H 1C4
    - Ottawa Hospital Regional Cancer Centre - General Campus
  - Saint Catharines, Ontario, Canada, L2R 2Z7
    - St. Catharines General Hospital at Niagara Health System
  - Thunder Bay, Ontario, Canada, P7B 6V4
    - Cancer Care Program at Thunder Bay Regional Health Sciences
  - Toronto, Ontario, Canada, M4C 3E7
    - Toronto East General Hospital
  - Toronto, Ontario, Canada, M5B 1W8
    - St. Michael's Hospital - Toronto
  - Toronto, Ontario, Canada, M5G 2M9
    - Princess Margaret Hospital
  - Toronto, Ontario, Canada, M9C 1A5
    - Trillium Health Centre - Mississauga Site
  - Toronto, Ontario, Canada, M4N 3M5
    - Odette Cancer Centre at Sunnybrook
  - Windsor, Ontario, Canada, N8W 2X3
    - Windsor Regional Cancer Centre at Windsor Regional Hospital
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre at Pasqua Hospital
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre at the University of Saskatchewan
Forenede Stater
- Alabama
  - Mobile, Alabama, Forenede Stater, 36608
    - Providence Cancer Center at Providence Hospital
- Alaska
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Cancer Center
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Regional Hospital Cancer Center
- Arkansas
  - Fort Smith, Arkansas, Forenede Stater, 72903
    - Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - NEA Medical Center - Stadium Boulevard
- California
  - Burbank, California, Forenede Stater, 91505
    - Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center
  - Castro Valley, California, Forenede Stater, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Forenede Stater, 94546
    - Valley Medical Oncology Consultants - Castro Valley
  - Fairfield, California, Forenede Stater, 94533
    - North Bay Cancer Center
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente - Fremont
  - Fremont, California, Forenede Stater, 94538
    - Valley Medical Oncology
  - Glendale, California, Forenede Stater, 91204
    - Glendale Memorial Hospital Comprehensive Cancer Center
  - Greenbrae, California, Forenede Stater, 94904
    - California Cancer Care, Incorporated - Greenbrae
  - Hayward, California, Forenede Stater, 94545
    - Kaiser Permanente Medical Center - Hayward
  - Loma Linda, California, Forenede Stater, 92357
    - Veterans Affairs Medical Center - Loma Linda (Pettis)
  - Los Angeles, California, Forenede Stater, 90089-9181
    - USC/Norris Comprehensive Cancer Center and Hospital
  - Martinez, California, Forenede Stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Marysville, California, Forenede Stater, 95901
    - Tibotec Therapeutics - Division of Ortho Biotech Products, LP
  - Mountain View, California, Forenede Stater, 94040
    - El Camino Hospital Cancer Center
  - Mountain View, California, Forenede Stater, 94040
    - Camino Medical Group - Treatment Center
  - Oakland, California, Forenede Stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forenede Stater, 94609
    - Larry G Strieff MD Medical Corporation
  - Oakland, California, Forenede Stater, 94609
    - CCOP - Bay Area Tumor Institute
  - Oakland, California, Forenede Stater, 94609
    - Bay Area Breast Surgeons, Incorporated
  - Oakland, California, Forenede Stater, 94609
    - Tom K Lee, Incorporated
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente Medical Center - Oakland
  - Orange, California, Forenede Stater, 92868
    - St. Joseph Hospital Regional Cancer Center - Orange
  - Palm Springs, California, Forenede Stater, 92262
    - Desert Regional Medical Center Comprehensive Cancer Center
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Medical Oncology Consultants - Pleasanton
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente Medical Center - Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente Medical Center - Richmond
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente Medical Center - Roseville
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Cancer Center
  - Sacramento, California, Forenede Stater, 95823
    - South Sacramento Kaiser-Permanente Medical Center
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente Medical Center - Sacramento
  - Saint Helena, California, Forenede Stater, 94574
    - Saint Helena Hospital
  - San Diego, California, Forenede Stater, 92134
    - Naval Medical Center - San Diego
  - San Diego, California, Forenede Stater, 92108
    - Kaiser Permanente Medical Office -Vandever Medical Office
  - San Francisco, California, Forenede Stater, 94115
    - UCSF Helen Diller Family Comprehensive Cancer Center
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente Medical Center - San Francisco Geary Campus
  - San Francisco, California, Forenede Stater, 94110
    - San Francisco General Hospital Medical Center
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente Medical Center - Santa Teresa
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Foundation Hospital - San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara Kiely Campus
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente Medical Center - Santa Rosa
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente Medical Center - South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente Medical Facility - Stockton
  - Truckee, California, Forenede Stater, 96161
    - Tahoe Forest Cancer Center
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente Medical Center - Vallejo
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente Medical Center - Walnut Creek
- Colorado
  - Alamosa, Colorado, Forenede Stater, 81101
    - San Luis Valley Regional Medical Center
  - Aurora, Colorado, Forenede Stater, 80045
    - University of Colorado Cancer Center at UC Health Sciences Center
  - Aurora, Colorado, Forenede Stater, 80012
    - Aurora Presbyterian Hospital
  - Boulder, Colorado, Forenede Stater, 80301-9019
    - Boulder Community Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80933
    - Penrose Cancer Center at Penrose Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - Memorial Hospital Cancer Center - Colorado Springs
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Veterans Affairs Medical Center - Denver
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80204
    - Denver Health Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - St. Luke's Medical Center
  - Denver, Colorado, Forenede Stater, 80204
    - St. Anthony Central Hospital
  - Denver, Colorado, Forenede Stater, 80218
    - St. Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80224-2522
    - CCOP - Colorado Cancer Research Program
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente - Denver
  - Edwards, Colorado, Forenede Stater, 81632
    - Shaw Regional Cancer Center
  - Englewood, Colorado, Forenede Stater, 80110
    - Swedish Medical Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, Forenede Stater, 80528
    - Front Range Cancer Specialists
  - Glenwood Springs, Colorado, Forenede Stater, 81601
    - Valley View Hospital Cancer Center
  - Grand Junction, Colorado, Forenede Stater, 81502
    - St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente - Lafayette
  - Littleton, Colorado, Forenede Stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forenede Stater, 80501
    - Hope Cancer Care Center at Longmont United Hospital
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Montrose, Colorado, Forenede Stater, 81401
    - Montrose Memorial Hospital Cancer Center
  - Parker, Colorado, Forenede Stater, 80138
    - Parker Adventist Hospital
  - Pueblo, Colorado, Forenede Stater, 81004
    - St. Mary - Corwin Regional Medical Center
  - Thornton, Colorado, Forenede Stater, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - Exempla Lutheran Medical Center
- Connecticut
  - Greenwich, Connecticut, Forenede Stater, 06830
    - Bendheim Cancer Center at Greenwich Hospital
  - Hartford, Connecticut, Forenede Stater, 06105
    - Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
  - Hartford, Connecticut, Forenede Stater, 06102-5037
    - Helen and Harry Gray Cancer Center at Hartford Hospital
  - Middletown, Connecticut, Forenede Stater, 06457
    - Middlesex Hospital Cancer Center
  - New Britain, Connecticut, Forenede Stater, 06050
    - George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
  - Norwich, Connecticut, Forenede Stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
- Delaware
  - Dover, Delaware, Forenede Stater, 19901
    - Kent General Hospital
  - Lewes, Delaware, Forenede Stater, 19958
    - Tunnell Cancer Center at Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - CCOP - Christiana Care Health Services
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
  - Washington, District of Columbia, Forenede Stater, 20010
    - Washington Cancer Institute at Washington Hospital Center
- Florida
  - Boca Raton, Florida, Forenede Stater, 33486
    - Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Cancer Institute at Memorial Regional Hospital
  - Lakeland, Florida, Forenede Stater, 33805
    - Lakeland Regional Cancer Center at Lakeland Regional Medical Center
  - Orlando, Florida, Forenede Stater, 32803-1273
    - Florida Hospital Cancer Institute at Florida Hospital Orlando
  - Pensacola, Florida, Forenede Stater, 32504
    - Sacred Heart Cancer Center at Sacred Heart Hospital
  - Pensacola, Florida, Forenede Stater, 32514
    - Sacred Heart Medical Oncology
- Georgia
  - Albany, Georgia, Forenede Stater, 31701
    - Phoebe Cancer Center at Phoebe Putney Memorial Hospital
  - Athens, Georgia, Forenede Stater, 30607
    - Northeast Georgia Cancer Care, LLC - Medical Oncology
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forenede Stater, 30342-1611
    - Northside Hospital Cancer Center
  - Atlanta, Georgia, Forenede Stater, 30342-1701
    - Saint Joseph's Hospital of Atlanta
  - Atlanta, Georgia, Forenede Stater, 30342
    - CCOP - Atlanta Regional
  - Augusta, Georgia, Forenede Stater, 30912
    - MBCCOP - Medical College of Georgia Cancer Center
  - Austell, Georgia, Forenede Stater, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, Forenede Stater, 31904
    - John B. Amos Cancer Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Charles B. Eberhart Cancer Center at DeKalb Medical Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Veterans Affairs Medical Center - Atlanta (Decatur)
  - Dublin, Georgia, Forenede Stater, 31021
    - Dublin Hematology and Oncology Care
  - Fayetteville, Georgia, Forenede Stater, 30214
    - Piedmont Fayette Hospital
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center
  - Lawrenceville, Georgia, Forenede Stater, 30045
    - Gwinnett Medical Center
  - Macon, Georgia, Forenede Stater, 31208
    - Medical Center of Central Georgia
  - Marietta, Georgia, Forenede Stater, 30060
    - Kennestone Cancer Center at Wellstar Kennestone Hospital
  - Riverdale, Georgia, Forenede Stater, 30274-2600
    - Southern Regional Medical Center
  - Rome, Georgia, Forenede Stater, 30165
    - Harbin Clinic Cancer Center - Medical Oncology
  - Savannah, Georgia, Forenede Stater, 31403-3089
    - Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
  - Savannah, Georgia, Forenede Stater, 31405
    - Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
  - Valdosta, Georgia, Forenede Stater, 31602
    - Pearlman Comprehensive Cancer Center at South Georgia Medical Center
- Hawaii
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Kapiolani Medical Center at Pali Momi
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Cancer Research Center of Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96813
    - OnCare Hawaii, Incorporated - Lusitana
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Cancer Institute at Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital, Incorporated
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Medical Center - East
  - Honolulu, Hawaii, Forenede Stater, 96817
    - OnCare Hawaii, Incorporated - Kuakini
  - Honolulu, Hawaii, Forenede Stater, 96859
    - Tripler Army Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente - Moanalua Medical Center and Clinic
  - Lihue, Hawaii, Forenede Stater, 96766
    - Kauai Medical Clinic
  - Wailuku, Hawaii, Forenede Stater, 96793
    - Maui Memorial Medical Center
  - Wailuku, Hawaii, Forenede Stater, 96793
    - Pacific Cancer Institute - Maui
- Idaho
  - Boise, Idaho, Forenede Stater, 83712
    - Mountain States Tumor Institute at St. Luke's Regional Medical Center
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush-Copley Cancer Care Center
  - Chicago, Illinois, Forenede Stater, 60637-1470
    - University of Chicago Cancer Research Center
  - Chicago, Illinois, Forenede Stater, 60611-3013
    - Robert H. Lurie Comprehensive Cancer Center at Northwestern University
  - Chicago, Illinois, Forenede Stater, 60611
    - Hematology and Oncology Associates
  - Chicago, Illinois, Forenede Stater, 60657
    - Saint Joseph Hospital
  - Chicago, Illinois, Forenede Stater, 60657
    - Creticos Cancer Center at Advocate Illinois Masonic Medical Center
  - Chicago, Illinois, Forenede Stater, 60612-3785
    - John H. Stroger, Jr. Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60631
    - Resurrection Medical Center
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital Cancer Care Institute
  - Elgin, Illinois, Forenede Stater, 60123
    - Sherman Hospital
  - Elk Grove Village, Illinois, Forenede Stater, 60007
    - Alexian Brothers Radiation Oncology
  - Elmhurst, Illinois, Forenede Stater, 60126
    - Elmhurst Memorial Hospital
  - Evanston, Illinois, Forenede Stater, 60202
    - St. Francis Hospital
  - Evanston, Illinois, Forenede Stater, 60201-1781
    - Evanston Hospital
  - Freeport, Illinois, Forenede Stater, 61032
    - Leonard C. Ferguson Cancer Center
  - Hines, Illinois, Forenede Stater, 60141
    - Veterans Affairs Medical Center - Hines
  - Joliet, Illinois, Forenede Stater, 60435
    - Joliet Oncology-Hematology Associates, Limited - West
  - Kankakee, Illinois, Forenede Stater, 60901
    - Provena St. Mary's Regional Cancer Center - Kankakee
  - La Grange, Illinois, Forenede Stater, 60525
    - La Grange Memorial Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - North Shore Oncology and Hematology Associates, Limited - Libertyville
  - Moline, Illinois, Forenede Stater, 61265
    - Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
  - Naperville, Illinois, Forenede Stater, 60540
    - Edward Hospital Cancer Center
  - Naperville, Illinois, Forenede Stater, 60540
    - Hematology Oncology Consultants - Naperville
  - Niles, Illinois, Forenede Stater, 60714
    - Cancer Care and Hematology Specialists of Chicagoland - Niles
  - River Forest, Illinois, Forenede Stater, 60305
    - West Suburban Center for Cancer Care
  - Rockford, Illinois, Forenede Stater, 61104-2315
    - Swedish-American Regional Cancer Center
  - Rockford, Illinois, Forenede Stater, 61108
    - Center for Cancer Care at OSF Saint Anthony Medical Center
  - Skokie, Illinois, Forenede Stater, 60076
    - Hematology Oncology Associates - Skokie
  - Springfield, Illinois, Forenede Stater, 62781-0001
    - Regional Cancer Center at Memorial Medical Center
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center at Carle Foundation Hospital
  - Urbana, Illinois, Forenede Stater, 61801
    - CCOP - Carle Cancer Center
- Indiana
  - Beech Grove, Indiana, Forenede Stater, 46107
    - St. Francis Hospital and Health Centers - Beech Grove Campus
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forenede Stater, 46514-2098
    - Elkhart Clinic, LLC
  - Elkhart, Indiana, Forenede Stater, 46514
    - Michiana Hematology-Oncology, PC - Elkhart
  - Fort Wayne, Indiana, Forenede Stater, 46845
    - Fort Wayne Medical Oncology and Hematology
  - Indianapolis, Indiana, Forenede Stater, 46260
    - St. Vincent Indianapolis Hospital
  - Kokomo, Indiana, Forenede Stater, 46904
    - Howard Community Hospital
  - La Porte, Indiana, Forenede Stater, 46350
    - Center for Cancer Therapy at LaPorte Hospital and Health Services
  - Lafayette, Indiana, Forenede Stater, 47904
    - Clarian Arnett Cancer Care
  - Merrillville, Indiana, Forenede Stater, 46410
    - Suniti Medical Corporation
  - Michigan City, Indiana, Forenede Stater, 46360
    - Saint Anthony Memorial Health Centers
  - Mishawaka, Indiana, Forenede Stater, 46545-1470
    - Michiana Hematology-Oncology, PC - South Bend
  - Mishawaka, Indiana, Forenede Stater, 46545-1470
    - Saint Joseph Regional Medical Center
  - Munster, Indiana, Forenede Stater, 46321
    - Community Hospital
  - Plymouth, Indiana, Forenede Stater, 46563
    - Michiana Hematology Oncology PC - Plymouth
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Hospital & Health Care Services
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - CCOP - Northern Indiana CR Consortium
  - Westville, Indiana, Forenede Stater, 46391
    - Michiana Hematology Oncology PC - La Porte
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic, PC
  - Bettendorf, Iowa, Forenede Stater, 52722
    - Hematology Oncology Associates of the Quad Cities
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Cedar Rapids Oncology Associates
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Regional Cancer Center at Mercy Medical Center
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Heartland Oncology and Hematology
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - CCOP - Iowa Oncology Research Association
  - Des Moines, Iowa, Forenede Stater, 50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates at John Stoddard Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates at Mercy Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Cancer Center at Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50316
    - John Stoddard Cancer Center at Iowa Lutheran Hospital
  - Iowa City, Iowa, Forenede Stater, 52242-1002
    - Holden Comprehensive Cancer Center at University of Iowa
  - Iowa City, Iowa, Forenede Stater, 52246
    - Veterans Affairs Medical Center - Iowa City
  - Mason City, Iowa, Forenede Stater, 50401
    - Mercy Cancer Center at Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, Forenede Stater, 52501
    - McCreery Cancer Center at Ottumwa Regional
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Hematology-Oncology Associates, LLP
  - Sioux City, Iowa, Forenede Stater, 51102
    - Mercy Medical Center - Sioux City
  - Sioux City, Iowa, Forenede Stater, 51104
    - St. Luke's Regional Medical Center
  - Waterloo, Iowa, Forenede Stater, 50702
    - Covenant Cancer Treatment Center
- Kansas
  - Hays, Kansas, Forenede Stater, 67601
    - Hays Medical Center
  - Hutchinson, Kansas, Forenede Stater, 67502
    - Hutchinson Hospital Corporation
  - Kansas City, Kansas, Forenede Stater, 66160-7357
    - Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's Hospital - South
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Mount Carmel Regional Cancer Center
  - Prairie Village, Kansas, Forenede Stater, 66208
    - CCOP - Kansas City
  - Salina, Kansas, Forenede Stater, 67401
    - Tammy Walker Cancer Center at Salina Regional Health Center
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton-O'Neil Cancer Center
  - Topeka, Kansas, Forenede Stater, 66606
    - St. Francis Comprehensive Cancer Center
- Kentucky
  - Lexington, Kentucky, Forenede Stater, 40536-0093
    - Lucille P. Markey Cancer Center at University of Kentucky
  - Louisville, Kentucky, Forenede Stater, 40202
    - James Graham Brown Cancer Center at University of Louisville
- Louisiana
  - Alexandria, Louisiana, Forenede Stater, 71315-3198
    - Tulane Cancer Center Office of Clinical Research
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center - Bluebonnet
  - Covington, Louisiana, Forenede Stater, 70433
    - Ochsner Health Center - Covington
  - New Orleans, Louisiana, Forenede Stater, 70121
    - CCOP - Ochsner
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Cancer Institute at Ochsner Clinic Foundation
- Maine
  - York, Maine, Forenede Stater, 03909
    - York Hospital's Oncology Treatment Center
- Maryland
  - Annapolis, Maryland, Forenede Stater, 21401
    - DeCesaris Cancer Institute at Anne Arundel Medical Center
  - Baltimore, Maryland, Forenede Stater, 21201
    - Veterans Affairs Medical Center - Baltimore
  - Baltimore, Maryland, Forenede Stater, 21201
    - Greenebaum Cancer Center at University of Maryland Medical Center
  - Bethesda, Maryland, Forenede Stater, 20889-5600
    - National Naval Medical Center
  - Easton, Maryland, Forenede Stater, 21601
    - Shore Regional Cancer Center at Memorial Hospital - Easton
  - Elkton, Maryland, Forenede Stater, 21921
    - Union Hospital of Cecil County
  - Frederick, Maryland, Forenede Stater, 21701
    - Frederick Memorial Hospital Regional Cancer Therapy Center
  - Hagerstown, Maryland, Forenede Stater, 21740
    - John R. Marsh Cancer Center at Washington County Hospital
  - Salisbury, Maryland, Forenede Stater, 21801
    - Peninsula Regional Medical Center
  - Silver Spring, Maryland, Forenede Stater, 20910
    - Holy Cross Hospital
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02114
    - Massachusetts General Hospital
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston University Cancer Research Center
  - Boston, Massachusetts, Forenede Stater, 02115
    - Dana-Farber/Brigham and Women's Cancer Center
  - Boston, Massachusetts, Forenede Stater, 02115
    - Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
  - Brighton, Massachusetts, Forenede Stater, 02135-2997
    - Caritas St. Elizabeth's Medical Center
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Clinic Medical Center - Burlington
  - Lowell, Massachusetts, Forenede Stater, 01854
    - Lowell General Hospital
  - Milford, Massachusetts, Forenede Stater, 01757
    - Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center
  - Newton, Massachusetts, Forenede Stater, 02462
    - Newton-Wellesley Hospital
  - Norwood, Massachusetts, Forenede Stater, 02062
    - Caritas Norwood Hospital
  - Peabody, Massachusetts, Forenede Stater, 01960
    - NSMC Cancer Center - Peabody
  - Pittsfield, Massachusetts, Forenede Stater, 01201
    - Berkshire Hematology Oncology, PC
  - Quincy, Massachusetts, Forenede Stater, 02169
    - Commonwealth Hematology-Oncology, PC - Quincy
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Regional Cancer Program at D'Amour Center for Cancer Care
  - Worcester, Massachusetts, Forenede Stater, 01655
    - UMASS Memorial Cancer Center - University Campus
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center at Bixby Medical Center
  - Ann Arbor, Michigan, Forenede Stater, 48106-0995
    - Saint Joseph Mercy Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - CCOP - Michigan Cancer Research Consortium
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Battle Creek Health System Cancer Care Center
  - Big Rapids, Michigan, Forenede Stater, 49307
    - Mecosta County Medical Center
  - Dearborn, Michigan, Forenede Stater, 48123-2500
    - Oakwood Cancer Center at Oakwood Hospital and Medical Center
  - Detroit, Michigan, Forenede Stater, 48201-1379
    - Barbara Ann Karmanos Cancer Institute
  - Escanaba, Michigan, Forenede Stater, 49431
    - Green Bay Oncology, Limited - Escanaba
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Butterworth Hospital at Spectrum Health
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - CCOP - Grand Rapids
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Lacks Cancer Center at Saint Mary's Health Care
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Van Elslander Cancer Center at St. John Hospital and Medical Center
  - Iron Mountain, Michigan, Forenede Stater, 49801
    - Dickinson County Healthcare System
  - Jackson, Michigan, Forenede Stater, 49201
    - Foote Memorial Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49001
    - Borgess Medical Center
  - Kalamazoo, Michigan, Forenede Stater, 49007-3731
    - West Michigan Cancer Center
  - Lansing, Michigan, Forenede Stater, 48912-1811
    - Sparrow Regional Cancer Center
  - Livonia, Michigan, Forenede Stater, 48154
    - St. Mary Mercy Hospital
  - Monroe, Michigan, Forenede Stater, 48162
    - Community Cancer Center of Monroe
  - Monroe, Michigan, Forenede Stater, 48162
    - Mercy Memorial Hospital - Monroe
  - Mount Clemens, Michigan, Forenede Stater, 48043
    - Clemens Regional Medical Center
  - Muskegon, Michigan, Forenede Stater, 49443
    - Mercy General Health Partners
  - Niles, Michigan, Forenede Stater, 49120
    - Michiana Hematology Oncology PC - Niles
  - Petoskey, Michigan, Forenede Stater, 49770
    - Northern Michigan Hospital
  - Pontiac, Michigan, Forenede Stater, 48341-2985
    - St. Joseph Mercy Oakland
  - Port Huron, Michigan, Forenede Stater, 48060
    - Mercy Regional Cancer Center at Mercy Hospital
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital - Royal Oak Campus
  - Saginaw, Michigan, Forenede Stater, 48601
    - Seton Cancer Institute at Saint Mary's - Saginaw
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeside Cancer Specialists, PLLC
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Regional Cancer Care Center - St. Joseph
  - Southfield, Michigan, Forenede Stater, 48075
    - Providence Cancer Institute at Providence Hospital - Southfield Campus
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forenede Stater, 48093
    - St. John Macomb Hospital
  - Wyoming, Michigan, Forenede Stater, 49519
    - Metro Health Hospital
- Minnesota
  - Alexandria, Minnesota, Forenede Stater, 56308
  - Bemidji, Minnesota, Forenede Stater, 56601
    - MeritCare Bemidji
  - Brainerd, Minnesota, Forenede Stater, 56401
    - St. Joseph's Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy and Unity Cancer Center at Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55805
    - CCOP - Duluth
  - Duluth, Minnesota, Forenede Stater, 55805-1983
    - Duluth Clinic Cancer Center - Duluth
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller - Dwan Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - St. Luke's Hospital Cancer Care Center
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, Forenede Stater, 55432
    - Mercy and Unity Cancer Center at Unity Hospital
  - Hutchinson, Minnesota, Forenede Stater, 55350
    - Hutchinson Area Health Care
  - Mankato, Minnesota, Forenede Stater, 56002
    - Immanuel St. Joseph's
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology, PA - Maplewood
  - Maplewood, Minnesota, Forenede Stater, 55109
    - HealthEast Cancer Care at St. John's Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55417
    - Veterans Affairs Medical Center - Minneapolis
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center - Minneapolis
  - Robbinsdale, Minnesota, Forenede Stater, 55422-2900
    - Humphrey Cancer Center at North Memorial Outpatient Center
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - CentraCare Clinic - River Campus
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - CCOP - Metro-Minnesota
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Cancer Center
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital Cancer Care Center
  - Shakopee, Minnesota, Forenede Stater, 55379
    - St. Francis Cancer Center at St. Francis Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Willmar Cancer Center at Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology, PA - Woodbury
- Mississippi
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Cancer Clinic
  - Keesler Air Force Base, Mississippi, Forenede Stater, 39534
    - Keesler Air Force Base Medical Center
  - Pascagoula, Mississippi, Forenede Stater, 39581
    - Regional Cancer Center at Singing River Hospital
- Missouri
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center at Carrie J. Babb Cancer Center
  - Branson, Missouri, Forenede Stater, 65616
    - Skaggs Cancer Center at Skaggs Regional Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Columbia, Missouri, Forenede Stater, 65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Jefferson City, Missouri, Forenede Stater, 65109
    - Goldschmidt Cancer Center
  - Kansas City, Missouri, Forenede Stater, 64128
    - Veterans Affairs Medical Center - Kansas City
  - Kansas City, Missouri, Forenede Stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Center - Hospital Hill
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Cancer Institute at Saint Luke's Hospital
  - Kansas City, Missouri, Forenede Stater, 64114
    - St. Joseph Medical Center
  - Kansas City, Missouri, Forenede Stater, 64116
    - Parvin Radiation Oncology
  - Kansas City, Missouri, Forenede Stater, 64118
    - Heartland Hematology Oncology Associates, Incorporated
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Joseph, Missouri, Forenede Stater, 64507
    - Saint Joseph Oncology, Incorporated
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Cancer Center
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Saint Louis University Cancer Center
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Comprehensive Cancer Care, PC
  - Springfield, Missouri, Forenede Stater, 65802
    - CCOP - Cancer Research for the Ozarks
  - Springfield, Missouri, Forenede Stater, 65804
    - St. John's Regional Health Center
  - Springfield, Missouri, Forenede Stater, 65807
    - Hulston Cancer Center at Cox Medical Center South
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - CCOP - Montana Cancer Consortium
  - Billings, Montana, Forenede Stater, 59101
    - St. Vincent Healthcare Cancer Care Services
  - Billings, Montana, Forenede Stater, 59107-7000
    - Billings Clinic - Downtown
  - Billings, Montana, Forenede Stater, 59102
    - Hematology-Oncology Centers of the Northern Rockies - Billings
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Cancer Center
  - Butte, Montana, Forenede Stater, 59701
    - St. James Healthcare Cancer Care
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic - Main Facility
  - Great Falls, Montana, Forenede Stater, 59405-5309
    - Big Sky Oncology
  - Great Falls, Montana, Forenede Stater, 59405
    - Sletten Cancer Institute at Benefis Healthcare
  - Havre, Montana, Forenede Stater, 59501
    - Northern Montana Hospital
  - Helena, Montana, Forenede Stater, 59601
    - St. Peter's Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Kalispell, Montana, Forenede Stater, 59901
    - Glacier Oncology, PLLC
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Medical Oncology at KRMC
  - Missoula, Montana, Forenede Stater, 59807-7877
    - Montana Cancer Specialists at Montana Cancer Center
  - Missoula, Montana, Forenede Stater, 59807
    - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
  - Kearney, Nebraska, Forenede Stater, 68848-1990
    - Good Samaritan Cancer Center at Good Samaritan Hospital
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Cancer Resource Center - Lincoln
  - North Platte, Nebraska, Forenede Stater, 69103
    - Callahan Cancer Center at Great Plains Regional Medical Center
  - Omaha, Nebraska, Forenede Stater, 68198-6805
    - UNMC Eppley Cancer Center at the University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68106
    - CCOP - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, Forenede Stater, 68122
    - Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegant Health Cancer Center at Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68131-2197
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Methodist Estabrook Cancer Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Lakeside Hospital
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89135
    - Nevada Cancer Institute
  - Las Vegas, Nevada, Forenede Stater, 89106
    - CCOP - Nevada Cancer Research Foundation
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
  - Exeter, New Hampshire, Forenede Stater, 03833
    - Center for Cancer Care at Exeter Hospital
  - Hooksett, New Hampshire, Forenede Stater, 03106
    - New Hampshire Oncology - Hematology, PA - Hooksett
  - Laconia, New Hampshire, Forenede Stater, 03246
    - Lakes Region General Hospital
  - Lebanon, New Hampshire, Forenede Stater, 03756-0002
    - Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Elliot Regional Cancer Center at Elliot Hospital
  - Manchester, New Hampshire, Forenede Stater, 03102
    - Norris Cotton Cancer Center at Catholic Medical Center
  - Nashua, New Hampshire, Forenede Stater, 03060
    - Oncology Center at St. Joseph Hospital
- New Jersey
  - East Orange, New Jersey, Forenede Stater, 07018-1095
    - Veterans Affairs Medical Center - East Orange
  - Englewood, New Jersey, Forenede Stater, 07631
    - Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center
  - Flemington, New Jersey, Forenede Stater, 08822
    - Hunterdon Regional Cancer Center at Hunterdon Medical Center
  - Freehold, New Jersey, Forenede Stater, 07728
    - CentraState Medical Center
  - Marlton, New Jersey, Forenede Stater, 08053
    - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
  - Morristown, New Jersey, Forenede Stater, 07962
    - Carol G. Simon Cancer Center at Morristown Memorial Hospital
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Newark, New Jersey, Forenede Stater, 07103
    - UMDNJ University Hospital
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Valley Hospital - Ridgewood
  - Somerville, New Jersey, Forenede Stater, 08876
    - Somerset Medical Center
  - Sparta, New Jersey, Forenede Stater, 07871
    - Frederick R. and Betty M. Smith Cancer Treatment Center
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Cancer Institute of New Jersey at Cooper - Voorhees
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Fox Chase Virtua Health Cancer Program at Virtua West Jersey
- New York
  - Buffalo, New York, Forenede Stater, 14215
    - Veterans Affairs Medical Center - Buffalo
  - East Syracuse, New York, Forenede Stater, 13057
    - CCOP - Hematology-Oncology Associates of Central New York
  - Elmira, New York, Forenede Stater, 14905
    - Falck Cancer Center at Arnot Ogden Medical Center
  - Jamaica, New York, Forenede Stater, 11432
    - Queens Cancer Center of Queens Hospital
  - Manhasset, New York, Forenede Stater, 11030
    - CCOP - North Shore University Hospital
  - Manhasset, New York, Forenede Stater, 11030
    - Don Monti Comprehensive Cancer Center at North Shore University Hospital
  - Middletown, New York, Forenede Stater, 10940-4199
    - Tucker Center for Cancer Care at Orange Regional Medical Center
  - Mineola, New York, Forenede Stater, 11501
    - Winthrop University Hospital
  - Mount Kisco, New York, Forenede Stater, 10549-3417
    - Mount Kisco Medical Group, PC
  - New Hyde Park, New York, Forenede Stater, 11040
    - Long Island Jewish Medical Center
  - Rochester, New York, Forenede Stater, 14642
    - James P. Wilmot Cancer Center at University of Rochester Medical Center
  - Rochester, New York, Forenede Stater, 14623
    - Interlakes Oncology/Hematology PC
  - Staten Island, New York, Forenede Stater, 10305
    - Nalitt Cancer Institute at Staten Island University Hospital
  - Syracuse, New York, Forenede Stater, 13210
    - Veterans Affairs Medical Center - Syracuse
  - Syracuse, New York, Forenede Stater, 13210
    - SUNY Upstate Medical University Hospital
  - Utica, New York, Forenede Stater, 13502
    - Faxton Regional Cancer Center
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203-5400
    - Randolph Hospital
  - Asheville, North Carolina, Forenede Stater, 28801
    - Mission Hospitals - Memorial Campus
  - Burlington, North Carolina, Forenede Stater, 27216
    - Alamance Cancer Center at Alamance Regional Medical Center
  - Cary, North Carolina, Forenede Stater, 27518
    - Waverly Hematology Oncology
  - Chapel Hill, North Carolina, Forenede Stater, 27599-7295
    - Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
  - Charlotte, North Carolina, Forenede Stater, 28232-2861
    - Blumenthal Cancer Center at Carolinas Medical Center
  - Charlotte, North Carolina, Forenede Stater, 28233-3549
    - Presbyterian Cancer Center at Presbyterian Hospital
  - Concord, North Carolina, Forenede Stater, 28025
    - Batte Cancer Center at Northeast Medical Center
  - Gastonia, North Carolina, Forenede Stater, 28053
    - CaroMont Cancer Center at Gaston Memorial Hospital
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital, Incorporated
  - Greensboro, North Carolina, Forenede Stater, 27403-1198
    - Moses Cone Regional Cancer Center at Wesley Long Community Hospital
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Pardee Memorial Hospital
  - Kinston, North Carolina, Forenede Stater, 28501
    - Kinston Medical Specialists
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
  - Raleigh, North Carolina, Forenede Stater, 27607
    - Rex Cancer Center at Rex Hospital
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Cancer Center
  - Rocky Mount, North Carolina, Forenede Stater, 27804
    - Nash Hospitals, Incorporated
  - Rutherfordton, North Carolina, Forenede Stater, 28139
    - Rutherford Hospital
  - Statesville, North Carolina, Forenede Stater, 28677
    - Iredell Memorial Hospital
  - Washington, North Carolina, Forenede Stater, 27889
    - Marion L. Shepard Cancer Center at Beaufort County Hospital
  - Wilmington, North Carolina, Forenede Stater, 28401
    - Zimmer Cancer Center at New Hanover Regional Medical Center
  - Winston-Salem, North Carolina, Forenede Stater, 27157-1096
    - Wake Forest University Comprehensive Cancer Center
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Bismarck Cancer Center
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Medcenter One Hospital Cancer Care Center
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Mid Dakota Clinic, PC
  - Bismarck, North Dakota, Forenede Stater, 58502
    - St. Alexius Medical Center Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - CCOP - MeritCare Hospital
  - Fargo, North Dakota, Forenede Stater, 58102
    - MeritCare Broadway
  - Fargo, North Dakota, Forenede Stater, 58122
    - Roger Maris Cancer Center at MeritCare Hospital
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Altru Cancer Center at Altru Hospital
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Cancercare Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44307
    - McDowell Cancer Center at Akron General Medical Center
  - Bowling Green, Ohio, Forenede Stater, 43402
    - Wood County Oncology Center
  - Canton, Ohio, Forenede Stater, 44708
    - Mercy Cancer Center at Mercy Medical Center
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Taussig Cancer Center
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Cancer Care Center at MetroHealth Medical Center
  - Columbus, Ohio, Forenede Stater, 43214-3998
    - Riverside Methodist Hospital Cancer Care
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health - West Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - CCOP - Columbus
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center Cancer Care
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital at Ohio Health
  - Columbus, Ohio, Forenede Stater, 43210-1240
    - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43219
    - Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43213
    - Mount Carmel Hospital East
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital
  - Dayton, Ohio, Forenede Stater, 45409
    - David L. Rike Cancer Center at Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Samaritan North Cancer Care Center
  - Dayton, Ohio, Forenede Stater, 45420
    - CCOP - Dayton
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forenede Stater, 44035
    - Community Cancer Center
  - Elyria, Ohio, Forenede Stater, 44035
    - Hematology Oncology Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Medical Associates
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Middletown Regional Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Kettering, Ohio, Forenede Stater, 45429
    - Charles F. Kettering Memorial Hospital
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45804
    - Lima Memorial Hospital
  - Lima, Ohio, Forenede Stater, 45801
    - St. Rita's Medical Center
  - Mansfield, Ohio, Forenede Stater, 44903
    - MedCentral - Mansfield Hospital
  - Marietta, Ohio, Forenede Stater, 45750
    - Strecker Cancer Center at Marietta Memorial Hospital
  - Maumee, Ohio, Forenede Stater, 43537-1839
    - Northwest Ohio Oncology Center
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Cancer Center at Hillcrest Hospital
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Cancer Care Program at Licking Memorial Hospital
  - Norwalk, Ohio, Forenede Stater, 44857
    - Fisher-Titus Medical Center
  - Oregon, Ohio, Forenede Stater, 43616
    - St. Charles Mercy Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - Toledo Clinic - Oregon
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center Cancer Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care, Incorporated
  - Springfield, Ohio, Forenede Stater, 45505
    - Community Hospital of Springfield and Clark County
  - Sylvania, Ohio, Forenede Stater, 43560
    - Flower Hospital Cancer Center
  - Tiffin, Ohio, Forenede Stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forenede Stater, 43608
    - St. Vincent Mercy Medical Center
  - Toledo, Ohio, Forenede Stater, 43606
    - Toledo Hospital
  - Toledo, Ohio, Forenede Stater, 43614
    - Medical University of Ohio Cancer Center
  - Toledo, Ohio, Forenede Stater, 43617
    - CCOP - Toledo Community Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic, Incorporated - Main Clinic
  - Toledo, Ohio, Forenede Stater, 43623
    - St. Anne Mercy Hospital
  - Troy, Ohio, Forenede Stater, 45373-1300
    - UVMC Cancer Care Center at Upper Valley Medical Center
  - Wauseon, Ohio, Forenede Stater, 43567
    - Fulton County Health Center
  - Westerville, Ohio, Forenede Stater, 43081
    - Mount Carmel St. Ann's Cancer Center
  - Wooster, Ohio, Forenede Stater, 44691
    - Cleveland Clinic - Wooster
  - Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
    - United States Air Force Medical Center - Wright-Patterson
  - Xenia, Ohio, Forenede Stater, 45385
    - Ruth G. McMillan Cancer Center at Greene Memorial Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis - Good Samaritan Hospital
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma, LLC - Lawton
  - Norman, Oklahoma, Forenede Stater, 73071
    - Cancer Care Associates - Norman
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - Oklahoma University Cancer Institute
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Cancer Care Associates - Mercy Campus
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Cancer Care Associates at Troy and Dollie Smith Cancer Center
- Oregon
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forenede Stater, 97045
    - Willamette Falls Hospital
  - Portland, Oregon, Forenede Stater, 97239-3098
    - Knight Cancer Institute At Oregon Health and Science University
  - Portland, Oregon, Forenede Stater, 97213-2967
    - Providence Cancer Center at Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, Forenede Stater, 97225
    - Providence St. Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Health Care - Portland
  - The Dalles, Oregon, Forenede Stater, 97058
    - Celilo Cancer Center at Mid-Columbia Medical Center
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Rosenfeld Cancer Center at Abington Memorial Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18105
    - Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - St. Luke's Cancer Network at St. Luke's Hospital
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Danville, Pennsylvania, Forenede Stater, 17822-0001
    - Geisinger Cancer Institute at Geisinger Health
  - Darby, Pennsylvania, Forenede Stater, 19023
    - Mercy Fitzgerald Hospital
  - Doylestown, Pennsylvania, Forenede Stater, 18901
    - Doylestown Hospital Cancer Center
  - Drexel Hill, Pennsylvania, Forenede Stater, 19026
    - Delaware County Regional Cancer Center at Delaware County Memorial Hospital
  - East Stroudsburg, Pennsylvania, Forenede Stater, 18301
    - Dale and Frances Hughes Cancer Center at Pocono Medical Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center at Ephrata Community Hospital
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Hazleton Cancer Center
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital Cancer Center
  - Paoli, Pennsylvania, Forenede Stater, 19301-1792
    - Cancer Center of Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104-4283
    - Abramson Cancer Center of the University of Pennsylvania
  - Philadelphia, Pennsylvania, Forenede Stater, 19107-5541
    - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224-1791
    - Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
  - Pottstown, Pennsylvania, Forenede Stater, 19464
    - Pottstown Memorial Regional Cancer Center
  - Reading, Pennsylvania, Forenede Stater, 19605
    - St. Joseph Medical Center
  - Reading, Pennsylvania, Forenede Stater, 19612-6052
    - McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Cancer Center at Guthrie Clinic Sayre
  - Scranton, Pennsylvania, Forenede Stater, 18508
    - Hematology and Oncology Associates of Northeastern Pennsylvania
  - Sellersville, Pennsylvania, Forenede Stater, 18960
    - Grand View Hospital
  - State College, Pennsylvania, Forenede Stater, 16803
    - Mount Nittany Medical Center
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group - Scenery Park
  - Upland, Pennsylvania, Forenede Stater, 19013
    - Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
  - West Grove, Pennsylvania, Forenede Stater, 19390-9499
    - Jennersville Regional Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Cancer Center at Lankenau Hospital
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - CCOP - Main Line Health
  - York, Pennsylvania, Forenede Stater, 17405
    - York Cancer Center at Apple Hill Medical Center
- Rhode Island
  - Pawtucket, Rhode Island, Forenede Stater, 02860
    - Memorial Hospital of Rhode Island
  - Warwick, Rhode Island, Forenede Stater, 02886
    - Kent County Memorial Hospital
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Cancer Center
  - Beaufort, South Carolina, Forenede Stater, 29902
    - Keyserling Cancer Center at Beaufort Memorial Hospital
  - Florence, South Carolina, Forenede Stater, 29501
    - McLeod Regional Medical Center
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - CCOP - Upstate Carolina
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
- South Dakota
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Medical X-Ray Center, PC
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5039
    - Sanford Cancer Center at Sanford USD Medical Center
- Tennessee
  - Kingsport, Tennessee, Forenede Stater, 37662
    - Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
  - Knoxville, Tennessee, Forenede Stater, 37916
    - Thompson Cancer Survival Center
  - Memphis, Tennessee, Forenede Stater, 38104
    - University of Tennessee Cancer Institute - Memphis
  - Nashville, Tennessee, Forenede Stater, 37208-3599
    - MBCCOP - Meharry Medical College - Nashville
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - Harrington Cancer Center
  - Austin, Texas, Forenede Stater, 78701
    - Seton Shivers Cancer Program at Brackenridge Hospital
  - Fort Sam Houston, Texas, Forenede Stater, 78234-6200
    - Brooke Army Medical Center
  - Houston, Texas, Forenede Stater, 77030
    - Ben Taub General Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Veterans Affairs Medical Center - Houston
  - Houston, Texas, Forenede Stater, 77030
    - Baylor University Medical Center - Houston
  - Houston, Texas, Forenede Stater, 77030
    - St. Luke's Texas Cancer Institute at St. Luke's Episcopal Hospital
  - Lackland Air Force Base, Texas, Forenede Stater, 78236
    - Wilford Hall Medical Center
  - Lubbock, Texas, Forenede Stater, 79415-3364
    - UMC Southwest Cancer and Research Center
  - San Antonio, Texas, Forenede Stater, 78229
    - Cancer Therapy and Research Center
  - San Antonio, Texas, Forenede Stater, 78209
    - Veterans Affairs Medical Center - San Antonio (Murphy)
  - San Antonio, Texas, Forenede Stater, 78229-3900
    - University of Texas Health Science Center at San Antonio
  - Temple, Texas, Forenede Stater, 76508
    - CCOP - Scott and White Hospital
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital
  - Cedar City, Utah, Forenede Stater, 84720
    - Sandra L. Maxwell Cancer Center
  - Logan, Utah, Forenede Stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forenede Stater, 84157
    - Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center - Provo
  - Saint George, Utah, Forenede Stater, 84770
    - Dixie Regional Medical Center - East Campus
  - Salt Lake City, Utah, Forenede Stater, 84143
    - LDS Hospital
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists at UCS Cancer Center
- Vermont
  - Berlin, Vermont, Forenede Stater, 05602
    - Mountainview Medical
  - Burlington, Vermont, Forenede Stater, 05401
    - Fletcher Allen Health Care - University Health Center Campus
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Danville, Virginia, Forenede Stater, 24541
    - Danville Regional Medical Center
  - Fredericksburg, Virginia, Forenede Stater, 22401
    - Fredericksburg Oncology, Incorporated
  - Hampton, Virginia, Forenede Stater, 23666
    - Virginia Oncology Associates - Hampton
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Lynchburg Hematology-Oncology Clinic
  - Norton, Virginia, Forenede Stater, 24273
    - Southwest Virginia Regional Cancer Center at Wellmonth Health
  - Richmond, Virginia, Forenede Stater, 23298-0037
    - Virginia Commonwealth University Massey Cancer Center
  - Richmond, Virginia, Forenede Stater, 23230
    - Virginia Cancer Institute - West End
- Washington
  - Anacortes, Washington, Forenede Stater, 98221
    - Island Hospital Cancer Care Center at Island Hospital
  - Bellingham, Washington, Forenede Stater, 98225
    - St. Joseph Cancer Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Olympic Hematology and Oncology
  - Burien, Washington, Forenede Stater, 98166
    - Highline Medical Center Cancer Center
  - Centralia, Washington, Forenede Stater, 98531-9027
    - Providence Centralia Hospital
  - Federal Way, Washington, Forenede Stater, 98003
    - St. Francis Hospital
  - Kennewick, Washington, Forenede Stater, 99336
    - Columbia Basin Hematology
  - Mount Vernon, Washington, Forenede Stater, 98274
    - Skagit Valley Hospital Cancer Care Center
  - Olympia, Washington, Forenede Stater, 98506-5166
    - Providence St. Peter Hospital Regional Cancer Center
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison Poulsbo Hematology and Onocology
  - Puyallup, Washington, Forenede Stater, 98372
    - Good Samaritan Cancer Center
  - Seattle, Washington, Forenede Stater, 98104
    - Minor and James Medical, PLLC
  - Seattle, Washington, Forenede Stater, 98112
    - Group Health Central Hospital
  - Seattle, Washington, Forenede Stater, 98122-4307
    - Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
  - Seattle, Washington, Forenede Stater, 98195
    - University Cancer Center at University of Washington Medical Center
  - Sedro-Woolley, Washington, Forenede Stater, 98284
    - North Puget Oncology at United General Hospital
  - Spokane, Washington, Forenede Stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forenede Stater, 99218
    - Evergreen Hematology and Oncology, PS
  - Spokane, Washington, Forenede Stater, 99204-2967
    - Rockwood Clinic Cancer Treatment Center
  - Tacoma, Washington, Forenede Stater, 98405-3004
    - Franciscan Cancer Center at St. Joseph Medical Center
  - Tacoma, Washington, Forenede Stater, 98405
    - Allenmore Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - CCOP - Northwest
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Regional Cancer Center at Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98499
    - St. Clare Hospital
  - Vancouver, Washington, Forenede Stater, 98664
    - Southwest Washington Medical Center Cancer Center
  - Wenatchee, Washington, Forenede Stater, 98801-2028
    - Wenatchee Valley Medical Center
- West Virginia
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Health Sciences Center - Charleston
  - Huntington, West Virginia, Forenede Stater, 25701
    - Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
  - Parkersburg, West Virginia, Forenede Stater, 26102
    - Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital
  - Princeton, West Virginia, Forenede Stater, 24740
    - Princeton Community Hospital
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Memorial Hospital
  - Appleton, Wisconsin, Forenede Stater, 54911-3496
    - Fox Valley Hematology and Oncology - East Grant Street
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic - Chippewa Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Care at Regional Cancer Center
  - Green Bay, Wisconsin, Forenede Stater, 54307-3508
    - St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology, Limited at St. Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - St. Mary's Hospital Medical Center - Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
  - Janesville, Wisconsin, Forenede Stater, 53547
    - Mercy Regional Cancer Center
  - Johnson Creek, Wisconsin, Forenede Stater, 53038
    - UW Cancer Center Johnson Creek
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Center for Cancer and Blood
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Franciscan Skemp Healthcare - La Crosse Campus
  - Madison, Wisconsin, Forenede Stater, 53792-6164
    - University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
  - Madison, Wisconsin, Forenede Stater, 53717
    - Dean Medical Center - Madison
  - Manitowoc, Wisconsin, Forenede Stater, 54221-1450
    - Holy Family Memorial Medical Center Cancer Care Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Bay Area Cancer Care Center at Bay Area Medical Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Vince Lombardi Cancer Clinic - Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Saint Joseph's Hospital
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic - Marshfield Center
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic - Lakeland Center
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - D.N. Greenwald Center
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - Regional Cancer Center at Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Green Bay Oncology, Limited - Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53405
    - All Saints Cancer Center at Wheaton Franciscan Healthcare
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Ministry Medical Group at Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Clinic - Indianhead Center
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - St. Nicholas Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Saint Michael's Hospital Cancer Center
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235
    - Green Bay Oncology, Limited - Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic - Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - Waukesha Memorial Hospital Regional Cancer Center
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic - Wausau Center
  - Wausau, Wisconsin, Forenede Stater, 54401
    - University of Wisconcin Cancer Center at Aspirus Wausau Hospital
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Oncology Alliance, SC - Milwaukee - West
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic - Weston Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Riverview UW Cancer Center at Riverview Hospital
- Wyoming
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center at Sheridan Memorial Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (VOKSEN, OLDER_ADULT)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Lokalt avanceret eller metastatisk kolorektal cancer
1. Berettigede patienter skal have histologisk eller cytologisk dokumenteret adenokarcinom i colon eller rektum. Patienter skal have enten lokalt fremskreden (ikke-operabel) eller metastatisk sygdom. Patienter med resekerede primære tumorer, som har dokumenteret metastaser, er kvalificerede. Dokumentation af resterende sygdom ved CT-scanning eller kirurgens notater er påkrævet for alle patienter, og histologisk bekræftelse af metastaser opfordres kraftigt til.
2. Patienter med en historie med kolorektal cancerbehandling ved kirurgisk resektion, som udvikler radiologiske eller kliniske tegn på metastatisk cancer, behøver ikke separat histologisk eller cytologisk bekræftelse af metastatisk sygdom, medmindre:
  - Enten er der gået et interval på mere end fem år mellem den primære operation og udviklingen af metastatisk sygdom eller
  - Den primære cancer var stadium I. Klinikere bør overveje biopsi af læsioner for at fastslå diagnosen metastatisk kolorektal cancer i hvert enkelt tilfælde, hvis der er væsentlig klinisk uklarhed med hensyn til arten eller kilden til tilsyneladende metastaser.
3. På randomiseringstidspunktet skal hensigten med denne behandling være indiceret palliativ eller neoadjuverende kemoterapi med potentiale for resektion af alle steder med metastatisk sygdom.
Kun patienter med et vildtype K-ras-gen som bestemt af laboratoriet på SWOG Solid Tumor Repository eller af et lokalt CLIA-certificeret laboratorium er kvalificerede. Patienter med en mutation i K-ras-genet er ikke kvalificerede. Alle patienter skal have til rådighed for analyse af K-ras status mindst ét H- og E-objektglas og én paraffinblok af den tidligere resekerede primære kolorektale tumor og/eller en tumoraflejring. For patienter, der er registreret og randomiseret baseret på lokale CLIA-certificerede laboratorieresultater, vil SWOG-analyse kun være bekræftende.
Forudgående behandling
1. Ingen forudgående systemisk behandling af fremskreden eller metastatisk kolorektal cancer er tilladt. Forudgående regional kemoterapi (f.eks. hepatisk arteriel infusion) er heller ikke tilladt.
  - Patienter kan have modtaget tidligere adjuverende kemoterapi, der inkluderede fluorouracil alene eller i kombination med fluorouracil og oxaliplatin eller irinotecan (ikke mere end 6 måneder); eller stråling med radiosensibiliserende kemoterapi.
  - Det sidste forløb med adjuverende kemoterapi skal være afsluttet > 12 måneder før recidiv af kolorektal cancer.
  - Patienter kan have modtaget neoadjuverende kemostråling med capecitabin eller 5-fluorouracil.
  - Patienter har muligvis ikke fået itraconazol eller ketoconazol mindre end 4 uger før randomisering.
  - Ingen forudgående eksponering for nogen tyrosinkinasehæmmere eller andre midler (herunder proteinprodukter, monoklonale antistoffer, antisense osv.), som er målrettet mod VEGF- eller EGF-receptorer, er tilladt.
  - Ingen tidligere behandling med bevacizumab eller cetuximab.
2. Patienter har muligvis ikke tidligere haft strålebehandling til mere end 25 % af knoglemarven.
  (Standard adjuverende rektalcancer kemoradiation vil ikke udelukke patienten fra protokoladgang.) Strålingen skal være afsluttet ≥ 4 uger før randomisering.
3. Patienter skal have gennemført enhver større operation ≥ 4 uger efter randomisering. Patienter skal have gennemført enhver mindre operation ≥ 2 uger før randomisering. Patienterne skal være kommet sig helt efter proceduren. (Indsættelse af en vaskulær adgangsenhed betragtes ikke som større eller mindre operationer.)
Ingen tidligere eller samtidig malignitet er tilladt bortset fra tilstrækkeligt behandlet basalcelle- eller pladecellehudkræft, in situ livmoderhalskræft eller anden cancer, som patienten har været sygdomsfri for i fem år.
Til patienter, der skal modtage FOLFIRI: Ingen tegn på Gilberts syndrom eller homozygositet for UGT1A1*28-allelen.
1. Patienter med Gilberts syndrom kan have en større risiko for irinotecan-toksicitet på grund af den unormale glukuronidering af SN-38. Bevis for Gilberts syndrom ville omfatte et tidligere fund af en isoleret forhøjelse af indirekte bilirubin.
2. UGT1A1-genotypning er ikke påkrævet i denne undersøgelse. Patienter, der vides at være homozygote for UGT1A1*28-allelen, skal dog ikke modtage FOLFIRI til denne undersøgelse. Patienter med Gilberts syndrom, eller som viser sig at være homozygote for UGT1A1-allelen, som vil modtage FOLFOX, er kvalificerede.
Ingen sensorisk perifer neuropati på ≥ grad 2 ved baseline for patienter, der skal modtage FOLFOX.
Ingen kendte metastaser i centralnervesystemet eller carcinomatøs meningitis.
Ingen interstitiel lungebetændelse eller omfattende og symptomatisk interstitiel fibrose i lungen.
Ingen pleural effusion eller ascites, der forårsager ≥ grad 2 dyspnø.
Ingen disponerende tyktarms- eller tyndtarmsforstyrrelser, hvor symptomerne er ukontrollerede som angivet ved baseline-mønster på > 3 vandig eller blød afføring dagligt hos patienter uden kolostomi eller ileostomi. Patienter med en kolostomi eller ileostomi kan gå ind efter investigatorens skøn.
Patienter må ikke have en ukontrolleret anfaldsforstyrrelse eller aktiv neurologisk sygdom.
Ingen aktuel kongestiv hjertesvigt (New York Heart Association klasse II, III eller IV)
Patienter med hypertension i anamnesen skal være godt kontrolleret (< 160/90) på et regime med antihypertensiv behandling.
Patienter i fuld dosis antikoagulering (f.eks. warfarin) er kvalificerede, forudsat at begge følgende kriterier er opfyldt:
1. Patienten har en INR inden for området (normalt mellem 2 og 3) på en stabil dosis af oralt antikoagulant eller være på en stabil dosis af lavmolekylært heparin.
2. Patienten har ingen aktiv blødning eller patologisk tilstand, der medfører en høj risiko for blødning (f.eks. tumor, der involverer større kar eller kendte varicer).
Patienter, der modtager trombocythæmmende midler, er kvalificerede. Derudover er patienter, der er på daglig profylaktisk aspirin eller antikoagulering for atrieflimren, egnede.
Ingen signifikant historie med blødningshændelser eller GI-perforation:
1. Patienter med en anamnese med betydelige blødningsepisoder (f.eks. hæmoptyse, øvre eller nedre GI-blødning) inden for 6 måneder efter randomisering er ikke kvalificerede, medmindre blødningskilden er blevet resekeret.
2. Patienter med en historie med GI-perforation inden for 12 måneder efter randomisering er ikke kvalificerede.
Ingen arterielle trombotiske hændelser inden for 6 måneder før randomisering, inklusive forbigående iskæmisk anfald (TIA), cerebrovaskulær ulykke (CVA), ustabil angina eller angina, der kræver kirurgisk eller medicinsk intervention inden for de seneste 6 måneder, eller myokardieinfarkt (MI). Patienter med klinisk signifikant perifer arteriesygdom (f.eks. claudicatio på mindre end én blok) eller enhver anden arteriel trombotisk hændelse er også udelukket.
Ingen alvorlige eller ikke-helende sår, mavesår eller knoglebrud
Patienter med kendt overfølsomhed over for kinesisk hamster-ovariecelleprodukter eller over for rekombinante humane eller murine antistoffer er ikke kvalificerede.
Ikke-gravid og ikke ammende:
1. Kvinder i den fødedygtige alder skal have en negativ serum- eller uringraviditetstest (minimumsfølsomhed 25 IE/L eller tilsvarende enheder HCG) inden for 72 timer før randomisering.
2. DNA-alkyleringsmidler er kendt for at være teratogene, og virkningerne af irinotecan, oxaliplatin, 5-FU, bevacizumab og cetuximab på et foster under udvikling ved de anbefalede terapeutiske doser er ukendt.
3. Kvinder i den fødedygtige alder omfatter enhver kvinde, der har oplevet menarche, og som ikke har gennemgået kirurgisk sterilisering (hysterektomi, bilateral tubal ligering eller bilateral ooforektomi) eller ikke er postmenopausal.
4. Postmenopausal er defineret som amenoré ≥ 12 på hinanden følgende måneder eller kvinder i hormonsubstitutionsterapi (HRT) med dokumenteret serum follikelstimulerende hormon (FSH) niveau > 35 mIU/ml.
5. Kvinder i den fødedygtige alder omfatter også kvinder, der bruger orale, implanterede eller injicerbare svangerskabsforebyggende hormoner eller mekaniske produkter såsom en intrauterin enhed eller barrieremetoder (membran, kondomer, sæddræbende midler) for at forhindre graviditet eller praktisere afholdenhed, eller hvor partneren er steril (f.eks. , vasektomi), bør anses for at være i den fødedygtige alder.
ECOG Performance Status på 0-1
Alder ≥ 18 år
Påkrævede indledende laboratorieværdier:
1. Granulocytter ≥ 1500 µL
2. Hæmoglobin ≥ 9,0 gram/dL (patienten kan blive transfunderet for at opfylde dette kriterium)
3. Blodpladeantal ≥ 100.000/µL
4. Kreatinin ≤ 1,5 x Øvre normalgrænser
5. Bilirubin ≤ 1,5 mg/dL
6. Albumin ≥ 2,5 g/dL
7. Urinalyse ≤ 1 + protein*
  - *Patienter, der opdages at have ≥ 2+ proteinuri ved baseline, skal gennemgå en 24-timers urinopsamling, der skal demonstrere < 1 g protein/24 timer eller have en UPC < 1,0 for at tillade deltagelse i undersøgelsen.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: BEHANDLING
Tildeling: TILFÆLDIGT
Interventionel model: PARALLEL
Maskning: INGEN

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
ACTIVE_COMPARATOR: Arm A: FOLFOX eller FOLFIRI + bevacizumab Patienterne får bevacizumab 5 mg/kg IV hver anden uge og modtager derefter enten FOLFOX eller FOLFIRI hver anden uge som beskrevet i interventionsafsnittet. Én cyklus er defineret som 8 ugers behandling. Behandlingen fortsætter indtil sygdomsprogression, uacceptabel toksicitet eller operation med helbredende hensigt som planlagt.	Biologisk: bevacizumab Givet IV Medicin: FOLFOX eller Patienterne får oxaliplatin 85 mg/m^2 IV infunderet over to timer efterfulgt af leucovorin 400 mg/m^2 IV over 2 timer efterfulgt af 5-FU 400 mg/m^2 IV bolus, derefter 2400 mg/m^2 kontinuerlig IV. infusion over 46-48 timer Andre navne: Eloxatin (oxaliplatin), leucovorin (folinsyre) og 5-Fluorouracil (5-FU) Medicin: FOLFIRI Patienterne får irinotecan 180 mg/m^2 IV infunderet over 90 minutter efterfulgt af leucovorin 400 mg/m^2 IV over 2 timer efterfulgt af 5-FU 400 mg/m^2 IV bolus efter leucovorin derefter 2400 mg/m^2 kontinuerligt IV infusion over 46-48 timer. Andre navne: CPT-11 (irinotecan), leucovorin (folinsyre) og 5-fluorouracil (5-FU)
EKSPERIMENTEL: Arm B: FOLFOX eller FOLFIRI + cetuximab Patienterne får cetuximab 400 mg/m^2 IV over 2 timer på den første behandlingsdag, derefter 250 mg/m^2 IV over 1 time ugentligt. Patienterne får også enten FOLFOX eller FOLFIRI hver anden uge som beskrevet i interventionsafsnittet. Én cyklus er defineret som 8 ugers behandling. Behandlingen fortsætter indtil sygdomsprogression, uacceptabel toksicitet eller operation med helbredende hensigt som planlagt.	Biologisk: cetuximab Givet IV Medicin: FOLFOX eller Patienterne får oxaliplatin 85 mg/m^2 IV infunderet over to timer efterfulgt af leucovorin 400 mg/m^2 IV over 2 timer efterfulgt af 5-FU 400 mg/m^2 IV bolus, derefter 2400 mg/m^2 kontinuerlig IV. infusion over 46-48 timer Andre navne: Eloxatin (oxaliplatin), leucovorin (folinsyre) og 5-Fluorouracil (5-FU) Medicin: FOLFIRI Patienterne får irinotecan 180 mg/m^2 IV infunderet over 90 minutter efterfulgt af leucovorin 400 mg/m^2 IV over 2 timer efterfulgt af 5-FU 400 mg/m^2 IV bolus efter leucovorin derefter 2400 mg/m^2 kontinuerligt IV infusion over 46-48 timer. Andre navne: CPT-11 (irinotecan), leucovorin (folinsyre) og 5-fluorouracil (5-FU)
EKSPERIMENTEL: Arm C: FOLFOX eller FOLFIRI + cetuximab + bevacizumab Patienterne får cetuximab 400 mg/m^2 IV over 2 timer på den første behandlingsdag, derefter 250 mg/m^2 IV over 1 time ugentligt. Patienterne får også bevacizumab 5 mg/kg IV hver anden uge og modtager derefter enten FOLFOX eller FOLFIRI hver anden uge som beskrevet i interventionsafsnittet. Én cyklus er defineret som 8 ugers behandling. Behandlingen fortsætter indtil sygdomsprogression, uacceptabel toksicitet eller operation med helbredende hensigt som planlagt.	Biologisk: bevacizumab Givet IV Biologisk: cetuximab Givet IV Medicin: FOLFOX eller Patienterne får oxaliplatin 85 mg/m^2 IV infunderet over to timer efterfulgt af leucovorin 400 mg/m^2 IV over 2 timer efterfulgt af 5-FU 400 mg/m^2 IV bolus, derefter 2400 mg/m^2 kontinuerlig IV. infusion over 46-48 timer Andre navne: Eloxatin (oxaliplatin), leucovorin (folinsyre) og 5-Fluorouracil (5-FU) Medicin: FOLFIRI Patienterne får irinotecan 180 mg/m^2 IV infunderet over 90 minutter efterfulgt af leucovorin 400 mg/m^2 IV over 2 timer efterfulgt af 5-FU 400 mg/m^2 IV bolus efter leucovorin derefter 2400 mg/m^2 kontinuerligt IV infusion over 46-48 timer. Andre navne: CPT-11 (irinotecan), leucovorin (folinsyre) og 5-fluorouracil (5-FU)

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Samlet overlevelse Tidsramme: Op til 5 år efter behandling	Overlevelsestid vil blive defineret som tiden fra registrering til død. Tid til hændelse distributioner vil blive estimeret ved hjælp af Kaplan-Meier metoden. Samlet overlevelse (OS) vil blive sammenlignet mellem arm A og arm B.	Op til 5 år efter behandling

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Progressionsfri overlevelse (PFS) Tidsramme: Op til 5 år efter behandling	PFS vil blive målt fra studiestart indtil første dokumenterede progression eller død af enhver årsag. Tid til hændelse distributioner vil blive estimeret ved hjælp af Kaplan-Meier metoden. PFS vil blive sammenlignet mellem arm A og arm B.	Op til 5 år efter behandling
Tid til behandlingsfejl Tidsramme: Op til 5 år efter behandling		Op til 5 år efter behandling
Varighed af tumorrespons Tidsramme: Op til 5 år efter behandling		Op til 5 år efter behandling

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbejdspartnere

Bristol-Myers Squibb

National Cancer Institute (NCI)

Southwest Oncology Group

Aptuit

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. november 2005

Primær færdiggørelse (FAKTISKE)

1. februar 2015

Studieafslutning (FAKTISKE)

1. januar 2018

Datoer for studieregistrering

Først indsendt

14. december 2005

Først indsendt, der opfyldte QC-kriterier

14. december 2005

Først opslået (SKØN)

15. december 2005

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (FAKTISKE)

7. maj 2020

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

28. april 2020

Sidst verificeret

1. april 2020

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

CALGB 80405
U10CA037447 (U.S. NIH-bevilling/kontrakt)
CDR0000455161 (ANDET: Physician Data Query)
NCI-2009-00434 (REGISTRERING: NCI Clinical Trial Reporting Program Office)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Kolorektal cancer

University of Arkansas

Aktiv, ikke rekrutterende

Virkningen af det forbedrede restitution efter kirurgi-system til kolorektal kirurgi

Colorectal cancer og inflammatorisk tarmsygdom

Forenede Stater
University Health Network, Toronto
AstraZeneca

Aktiv, ikke rekrutterende

Kurvkombinationsundersøgelse af hæmmere af DNA-skaderespons, angiogenese og programmeret dødsligand 1 hos patienter med avancerede solide tumorer (DAPPER)

Adenocarcinom i bugspytkirtlen | Leiomyosarkom | Mismatch Reparation Proficient Colorectal Cancer

Canada
Tianjin Medical University Cancer Institute and...

Rekruttering

PD-1-hæmmer kombineret med Bevacizumab og FOLFIRI-regimen i andenlinjebehandlingen af avanceret kolorektal cancer

MSI-H Advanced Colorectal Cancer

Kina
Bristol-Myers Squibb

Aktiv, ikke rekrutterende

En undersøgelse af Nivolumab alene eller Nivolumab kombinationsterapi ved tyktarmskræft, der er vendt tilbage eller har spredt sig (CheckMate142)

Mikrosatellit stabil kolorektal cancer | Mismatch Reparation Proficient Colorectal Cancer | Mikrosatellit ustabil kolorektal cancer | Mismatch Reparation Manglende tyktarmskræft

Forenede Stater, Australien, Belgien, Canada, Irland, Italien, Spanien, Frankrig
Syndax Pharmaceuticals
Merck Sharp & Dohme LLC

Afsluttet

Ph1b/2 dosis-eskaleringsundersøgelse af entinostat med Pembrolizumab i NSCLC med ekspansionskohorter i NSCLC, melanom og kolorektal cancer

Melanom | Ikke-småcellet lungekræft | Mismatch Reparation-Proficient Colorectal Cancer

Forenede Stater

Kliniske forsøg med bevacizumab

National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

TORC1/2-hæmmer MLN0128 og Bevacizumab til behandling af patienter med tilbagevendende glioblastom eller avancerede solide tumorer

Tilbagevendende æggelederkarcinom | Tilbagevendende ovariekarcinom | Tilbagevendende primært peritonealt karcinom | Klarcellet ovariecystadenocarcinom | Ovarial Endometrioid Adenocarcinom | Serøst cystadenocarcinom i æggestokkene | Endometrie clear cell adenocarcinoma | Endometrial serøst adenokarcinom | Tilbagevendende livmoderkræft og andre forhold

Forenede Stater
M.D. Anderson Cancer Center

Rekruttering

Atezolizumab og Bevacizumab før operation til behandling af resektabel leverkræft

Stadie IB hepatocellulært karcinom AJCC v8 | Fase II hepatocellulært karcinom AJCC v8 | Resektabelt hepatocellulært karcinom | Stadie I hepatocellulært karcinom AJCC v8 | Stadie IA hepatocellulært karcinom AJCC v8

Forenede Stater
National Cancer Institute (NCI)
NRG Oncology

Afsluttet

Bevacizumab med eller uden trebananib til behandling af patienter med tilbagevendende hjernetumorer

Glioblastom | Gliosarkom | Tilbagevendende glioblastom | Oligodendrogliom | Kæmpecelleglioblastom | Tilbagevendende hjerneneoplasma

Forenede Stater, Canada
National Cancer Institute (NCI)

Afsluttet

Atezolizumab og Bevacizumab til behandling af patienter med tilbagevendende, vedvarende eller metastatisk livmoderhalskræft

Cervikal Adenocarcinom | Cervikal Adenosquamous Carcinom | Cervikal planocellulært karcinom, ikke andet specificeret | Stadie IVA Livmoderhalskræft AJCC v6 og v7 | Tilbagevendende cervikal karcinom | Stadie IV Livmoderhalskræft AJCC v6 og v7 | Stadie IVB Livmoderhalskræft AJCC v6 og v7

Forenede Stater
Mayo Clinic
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Nab-Paclitaxel og Bevacizumab til behandling af patienter med uoperabelt stadium IV melanom eller gynækologisk kræft

Ondartet fast neoplasma | Ovarial Endometrioid Adenocarcinom | Ovarialt udifferentieret karcinom | Cervikal Adenocarcinom | Cervikal Adenosquamous Carcinom | Ondartet peritoneal neoplasma | Endometrie clear cell adenocarcinoma | Endometrie Endometrioid Adenocarcinom | Endometrie blandet cellet adenokarcinom og andre forhold

Forenede Stater
Roswell Park Cancer Institute
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; Celldex Therapeutics

Rekruttering

Pembrolizumab kombineret med Bevacizumab med eller uden agonist Anti-CD40 CDX-1140 til behandling af patienter med tilbagevendende ovariecancer

Tilbagevendende æggelederkarcinom | Tilbagevendende ovariekarcinom | Tilbagevendende primært peritonealt karcinom | Tilbagevendende endometrie serøs adenokarcinom | Ovarial klarcellet adenokarcinom | Tilbagevendende platinresistent ovariekarcinom | Platinfølsomt ovariekarcinom | Tilbagevendende æggelederendometrioid... og andre forhold

Forenede Stater
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Ipilimumab med eller uden bevacizumab til behandling af patienter med trin III-IV melanom, der ikke kan fjernes ved kirurgi

Fase IV kutan melanom AJCC v6 og v7 | Fase IIIC kutan melanom AJCC v7 | Uoperabelt melanom

Forenede Stater
Roswell Park Cancer Institute
National Cancer Institute (NCI)

Rekruttering

APL-2 og Pembrolizumab versus APL-2, Pembrolizumab og Bevacizumab versus Bevacizumab alene til behandling af tilbagevendende ovarie-, æggeleder- eller primær peritoneal cancer og malign effusion

Tilbagevendende æggelederkarcinom | Tilbagevendende ovariekarcinom | Tilbagevendende primært peritonealt karcinom | Ovarial Endometrioid Adenocarcinom | Ovarial klarcellet adenokarcinom | Klarcellet adenokarcinom i æggelederen | Æggeleder endometrioid adenokarcinom | Serøst adenokarcinom i æggelederen | Serøst adenokarcinom i æggestokkene og andre forhold

Forenede Stater
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Bevacizumab og Anetumab Ravtansin eller Paclitaxel til behandling af patienter med refraktær ovarie-, æggeleder- eller primær peritonealcancer

Ovarial Endometrioid Adenocarcinom | Primært peritonealt højgradigt serøst adenokarcinom | Æggeleder endometrioid adenokarcinom | Platin-resistent æggelederkarcinom | Platin-resistent primært peritonealt karcinom | Ovarial højgradigt serøst adenokarcinom | Platin-resistent ovariekarcinom | Æggeleder...

Forenede Stater, Canada
City of Hope Medical Center
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Brigatinib og Bevacizumab til behandling af ALK-omlejret lokalt avanceret, metastatisk eller recidiverende NSCLC

Metastatisk lunge ikke-småcellet karcinom | Stadie IVA lungekræft AJCC v8 | Stadie IVB lungekræft AJCC v8 | Stadie III lungekræft AJCC v8 | Stadie IV lungekræft AJCC v8 | Stadie IIIA Lungekræft AJCC v8 | Stadie IIIB Lungekræft AJCC v8 | Stadie IIIC lungekræft AJCC v8 | Lokalt avanceret lunge ikke-småcellet... og andre forhold

Forenede Stater

Cetuximab og/eller Bevacizumab kombineret med kombinationskemoterapi til behandling af patienter med metastatisk kolorektal cancer

Et fase III forsøg med Irinotecan / 5-FU / Leucovorin eller Oxaliplatin / 5-FU / Leucovorin med Bevacizumab eller Cetuximab (C225) eller med kombinationen af ​​Bevacizumab og Cetuximab til patienter med ubehandlet metastatisk adenocarcinom i tyktarmen

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Publikationer og nyttige links

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Studer store datoer

Studiestart

Primær færdiggørelse (FAKTISKE)

Studieafslutning (FAKTISKE)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (SKØN)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (FAKTISKE)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Kolorektal cancer

Kliniske forsøg med bevacizumab

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Jordan

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Et fase III forsøg med Irinotecan / 5-FU / Leucovorin eller Oxaliplatin / 5-FU / Leucovorin med Bevacizumab eller Cetuximab (C225) eller med kombinationen af Bevacizumab og Cetuximab til patienter med ubehandlet metastatisk adenocarcinom i tyktarmen