Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Brysttæthed, hormonniveauer og anticancer-lægemiddelniveauer hos kvinder med invasiv brystkræft, der får exemestan eller anastrozol

22. januar 2019 opdateret af: Alliance for Clinical Trials in Oncology

Association of Breast Density Changes, Plasma Hormone Changes, and Breast Cancer Recurrence: A Companion Study to NCIC CTG MA.27

RATIONALE: Forståelse af sammenhængen mellem brysttæthed, niveauer af hormoner i blodet og niveauer af kræftlægemidler i blodet kan hjælpe med at forbedre evnen til at planlægge effektiv behandling for kvinder med invasiv brystkræft.

FORMÅL: Dette kliniske forsøg studerer forholdet mellem brystdensitet og blodniveauer af hormoner og kræftlægemidler hos kvinder med invasiv brystkræft, som får exemestan eller anastrozol.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

MÅL:

Primær

  • Vurder ændringen i procent brysttæthed og tæt område som reaktion på aromatasehæmmerbehandling fra forbehandling til 1 år, 1 år til 2 år og forbehandling til 2 år hos kvinder med invasiv brystkræft.
  • Bestem ændringerne i procent brysttæthed og tæt område som reaktion på aromatasehæmmerbehandling fra forbehandling til 1 år og korreler ændringerne med ændringer i plasmahormoner (f.eks. østron, østronsulfat, østradiol og kønshormonbindende globulin) og lægemiddelniveauer (anastrozol eller exemestan) i samme periode hos kvinder med invasiv brystkræft.
  • Bestem ændringen over tid i procent brysttæthed og tæt område (fra forbehandling til tidsperioden før lokalt tilbagefald) i det kontralaterale bryst i sammenhæng med lokalt tilbagefald af brystkræft.

Sekundær

  • Bestem ændringen over tid i procent brysttæthed og tæt område i det kontralaterale bryst i sammenhæng med udviklingen af ​​kontralateral brystkræft.
  • Bestem, om kvinder med høj præ-behandlingsprocenttæthed (øvre tertil) oplever større fald i procent brystdensitet efter 1 og 2 års aromatasehæmmerbehandling end kvinder med lav præbehandlingsprocentdensitet (lavere tertil).
  • Bestem, om kvinder med et højt tæt område før behandling (øvre tertil) oplever større fald i tæt område efter 1 og 2 års aromatasehæmmerbehandling end kvinder med et lavt tæt område før behandling (nedre tertil).
  • Korreler haplotypemærkede enkeltnukleotidpolymorfier i gener i aromatase-vejen (identificeret gennem Mayo Clinic og Indiana University Pharmacogenomics Research Network Projects) med ændringer i procent og areal af brystdensitet, plasmahormonniveauer og 1-årige lægemiddelniveauer.

OVERSIGT: Dette er et multicenter, ledsagende studie.

Patienterne udfylder et 10-minutters spørgeskema om faktorer, der kan påvirke ændringer i brysttæthed ved baseline og et andet spørgeskema 1 år og 2 år efter registrering. Blodprøver udtages ved baseline (før påbegyndelse af behandling) og 1 år efter registrering til hormon- og lægemiddelniveauanalyse. Mammogrammer taget før registrering (inden for 12 måneder før tilmelding) og ca. 1 og 2 år efter registrering til denne undersøgelse, hentes og digitaliseres til bestemmelse af procent brysttæthed og tæt område.

PROJEKTERET TILSLUTNING: I alt 550 patienter vil blive akkumuleret til denne undersøgelse.

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

554

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Canada
    • British Columbia
      • Vancouver, British Columbia, Canada, V5Z 4E6
        • British Columbia Cancer Agency - Vancouver Cancer Centre
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3E 0V9
        • CancerCare Manitoba
    • New Brunswick
      • Moncton, New Brunswick, Canada, E1C 6Z8
        • Moncton Hospital
      • Saint John, New Brunswick, Canada, E2L 4L2
        • Saint John Regional Hospital
    • Ontario
      • Cambridge, Ontario, Canada, N1R 3G2
        • Cambridge Memorial Hospital
      • Sault Ste. Marie, Ontario, Canada, P6A 2C4
        • Algoma District Cancer Program at Sault Area Hospital
      • Thunder Bay, Ontario, Canada, P7B 6V4
        • Cancer Care Program at Thunder Bay Regional Health Sciences
      • Toronto, Ontario, Canada, M5B 1W8
        • St. Michael's Hospital - Toronto
      • Toronto, Ontario, Canada, M5G 2M9
        • Princess Margaret Hospital
      • Toronto, Ontario, Canada, M4N 3M5
        • Edmond Odette Cancer Centre at Sunnybrook
    • Quebec
      • Greenfield Park, Quebec, Canada, J4V 2H1
        • Hopital Charles LeMoyne
      • Quebec City, Quebec, Canada, G1S 4L8
        • Hopital du Saint-Sacrement - Quebec
    • Saskatchewan
      • Regina, Saskatchewan, Canada, S4T 7T1
        • Allan Blair Cancer Centre at Pasqua Hospital
  • Forenede Stater
    • Alaska
      • Fairbanks, Alaska, Forenede Stater, 99701
        • Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
    • Arizona
      • Scottsdale, Arizona, Forenede Stater, 85259-5499
        • Mayo Clinic Scottsdale
    • Arkansas
      • Fort Smith, Arkansas, Forenede Stater, 72903
        • Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
      • Little Rock, Arkansas, Forenede Stater, 72205
        • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
    • California
      • Berkeley, California, Forenede Stater, 94704
        • Alta Bates Summit Comprehensive Cancer Center
      • Burbank, California, Forenede Stater, 91505
        • Providence Saint Joseph Medical Center - Burbank
      • Burlingame, California, Forenede Stater, 94010
        • Peninsula Medical Center
      • Fairfield, California, Forenede Stater, 94533
        • North Bay Cancer Center
      • Fremont, California, Forenede Stater, 94538
        • Kaiser Permanente - Fremont
      • Glendale, California, Forenede Stater, 91204
        • Glendale Memorial Hospital Comprehensive Cancer Center
      • Greenbrae, California, Forenede Stater, 94904
        • Marin Cancer Institute at Marin General Hospital
      • Greenbrae, California, Forenede Stater, 94904
        • Sutter Health - Western Division Cancer Research Group
      • Greenbrae, California, Forenede Stater, 94904
        • California Cancer Care, Incorporated - Greenbrae
      • Hayward, California, Forenede Stater, 94545
        • Kaiser Permanente Medical Center - Hayward
      • Los Angeles, California, Forenede Stater, 90089-9181
        • USC/Norris Comprehensive Cancer Center and Hospital
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente Medical Center - Oakland
      • Palm Springs, California, Forenede Stater, 92262
        • Desert Regional Medical Center Comprehensive Cancer Center
      • Redwood City, California, Forenede Stater, 94063
        • Kaiser Permanente Medical Center - Redwood City
      • Richmond, California, Forenede Stater, 94801
        • Kaiser Permanente Medical Center - Richmond
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente Medical Center - Roseville
      • Sacramento, California, Forenede Stater, 95823
        • South Sacramento Kaiser-Permanente Medical Center
      • Sacramento, California, Forenede Stater, 95825
        • Kaiser Permanente Medical Center - Sacramento
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente Medical Center - San Francisco Geary Campus
      • San Francisco, California, Forenede Stater, 94118
        • California Pacific Medical Center - California Campus
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente Medical Center - Santa Teresa
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser Foundation Hospital - San Rafael
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara Kiely Campus
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente Medical Center - Santa Rosa
      • Santa Rosa, California, Forenede Stater, 95405
        • CCOP - Santa Rosa Memorial Hospital
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente Medical Center - South San Francisco
      • Stockton, California, Forenede Stater, 95210
        • Kaiser Permanente Medical Facility - Stockton
      • Vallejo, California, Forenede Stater, 94589
        • Sutter Solano Medical Center
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente Medical Center - Vallejo
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente Medical Center - Walnut Creek
    • Colorado
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Poudre Valley Hospital
      • Fort Collins, Colorado, Forenede Stater, 80528
        • Front Range Cancer Specialists
    • District of Columbia
      • Washington, District of Columbia, Forenede Stater, 20016
        • Sibley Memorial Hospital
    • Florida
      • Jacksonville, Florida, Forenede Stater, 32224
        • Mayo Clinic - Jacksonville
      • Pensacola, Florida, Forenede Stater, 32514
        • West Florida Cancer Institute at West Florida Hospital - Pensacola
    • Georgia
      • Augusta, Georgia, Forenede Stater, 30901
        • Augusta Oncology Associates - Walton Way
      • Gainesville, Georgia, Forenede Stater, 30501
        • Northeast Georgia Medical Center
    • Idaho
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Kootenai Cancer Center - Coeur d'Alene
      • Idaho Falls, Idaho, Forenede Stater, 83404
        • Snake River Oncology of Eastern Idaho PLLC
    • Illinois
      • Aurora, Illinois, Forenede Stater, 60504
        • Rush-Copley Cancer Care Center
      • Bloomington, Illinois, Forenede Stater, 61701
        • St. Joseph Medical Center
      • Canton, Illinois, Forenede Stater, 61520
        • Graham Hospital
      • Carthage, Illinois, Forenede Stater, 62321
        • Memorial Hospital
      • Chicago, Illinois, Forenede Stater, 60612
        • Rush University Medical Center
      • Chicago, Illinois, Forenede Stater, 60631
        • Resurrection Medical Center
      • Eureka, Illinois, Forenede Stater, 61530
        • Eureka Community Hospital
      • Evanston, Illinois, Forenede Stater, 60201-1781
        • Evanston Northwestern Healthcare - Evanston Hospital
      • Galesburg, Illinois, Forenede Stater, 61401
        • Galesburg Cottage Hospital
      • Galesburg, Illinois, Forenede Stater, 61401
        • Galesburg Clinic, PC
      • Geneva, Illinois, Forenede Stater, 60134
        • Delnor Community Hospital - Geneva
      • Havana, Illinois, Forenede Stater, 62644
        • Mason District Hospital
      • Hopedale, Illinois, Forenede Stater, 61747
        • Hopedale Medical Complex
      • Joliet, Illinois, Forenede Stater, 60435
        • Joliet Oncology-Hematology Associates, Limited - West
      • Kankakee, Illinois, Forenede Stater, 60901
        • Provena St. Mary's Regional Cancer Center - Kankakee
      • Kewanee, Illinois, Forenede Stater, 61443
        • Kewanee Hospital
      • Macomb, Illinois, Forenede Stater, 61455
        • Mcdonough District Hospital
      • Normal, Illinois, Forenede Stater, 61761
        • Bromenn Regional Medical Center
      • Normal, Illinois, Forenede Stater, 61761
        • Community Cancer Center
      • Oak Lawn, Illinois, Forenede Stater, 60453-2699
        • Advocate Christ Medical Center
      • Ottawa, Illinois, Forenede Stater, 61350
        • Community Hospital of Ottawa
      • Ottawa, Illinois, Forenede Stater, 61350
        • Oncology Hematology Associates of Central Illinois, PC - Ottawa
      • Pekin, Illinois, Forenede Stater, 61554
        • Cancer Treatment Center at Pekin Hospital
      • Peoria, Illinois, Forenede Stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forenede Stater, 61614
        • Proctor Hospital
      • Peoria, Illinois, Forenede Stater, 61637
        • OSF St. Francis Medical Center
      • Peoria, Illinois, Forenede Stater, 61615
        • CCOP - Illinois Oncology Research Association
      • Peoria, Illinois, Forenede Stater, 61615
        • Oncology Hematology Associates of Central Illinois, PC - Peoria
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois Valley Community Hospital
      • Princeton, Illinois, Forenede Stater, 61356
        • Perry Memorial Hospital
      • Rockford, Illinois, Forenede Stater, 61104-2315
        • Swedish-American Regional Cancer Center
      • Spring Valley, Illinois, Forenede Stater, 61362
        • St. Margaret's Hospital
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center at Carle Foundation Hospital
      • Urbana, Illinois, Forenede Stater, 61801
        • CCOP - Carle Cancer Center
    • Indiana
      • Beech Grove, Indiana, Forenede Stater, 46107
        • St. Francis Hospital and Health Centers - Beech Grove Campus
      • Bloomington, Indiana, Forenede Stater, 47403
        • Bloomington Hospital Regional Cancer Institute
      • Elkhart, Indiana, Forenede Stater, 46515
        • Elkhart General Hospital
      • Kokomo, Indiana, Forenede Stater, 46904
        • Howard Community Hospital
      • La Porte, Indiana, Forenede Stater, 46350
        • Center for Cancer Therapy at LaPorte Hospital and Health Services
      • Michigan City, Indiana, Forenede Stater, 46360
        • Saint Anthony Memorial Health Centers
      • Munster, Indiana, Forenede Stater, 46321
        • Community Hospital
      • Richmond, Indiana, Forenede Stater, 47374
        • Reid Hospital & Health Care Services
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, Forenede Stater, 46601
        • CCOP - Northern Indiana CR Consortium
      • South Bend, Indiana, Forenede Stater, 46617
        • Saint Joseph Regional Medical Center
    • Iowa
      • Bettendorf, Iowa, Forenede Stater, 52722
        • Hematology Oncology Associates of the Quad Cities
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Cedar Rapids Oncology Associates
      • Council Bluffs, Iowa, Forenede Stater, 51503
        • Heartland Oncology and Hematology
      • Davenport, Iowa, Forenede Stater, 52804
        • Genesis Medical Center - West Campus
      • Davenport, Iowa, Forenede Stater, 52803
        • Genesis Regional Cancer Center at Genesis Medical Center
      • Mason City, Iowa, Forenede Stater, 50401
        • Mercy Cancer Center at Mercy Medical Center - North Iowa
      • Ottumwa, Iowa, Forenede Stater, 52501
        • McCreery Cancer Center at Ottumwa Regional
      • Sioux City, Iowa, Forenede Stater, 51101
        • Siouxland Hematology-Oncology Associates, LLP
      • Sioux City, Iowa, Forenede Stater, 51104
        • St. Luke's Regional Medical Center
      • Sioux City, Iowa, Forenede Stater, 51104
        • Mercy Medical Center - Sioux City
      • Waterloo, Iowa, Forenede Stater, 50702
        • Covenant Cancer Treatment Center
      • Waterloo, Iowa, Forenede Stater, 50702
        • Cedar Valley Medical Specialists, PC - West Ridgeway Avenue
    • Kansas
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas, PA - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas, PA - Dodge City
      • El Dorado, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas, PA - El Dorado
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas, PA - Kingman
      • Liberal, Kansas, Forenede Stater, 67901
        • Southwest Medical Center
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas, PA - Newton
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas, PA - Parsons
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas, PA - Pratt
      • Salina, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas, PA - Salina
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas, PA - Wellington
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas, PA - Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas, PA - Wichita
      • Wichita, Kansas, Forenede Stater, 67214
        • CCOP - Wichita
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Cancer Center at Via Christi Regional Medical Center
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates in Womens Health, PA - North Review
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas, PA - Winfield
    • Kentucky
      • Lexington, Kentucky, Forenede Stater, 40503-9985
        • Central Baptist Hospital
      • Louisville, Kentucky, Forenede Stater, 40202
        • James Graham Brown Cancer Center at University of Louisville
    • Maine
      • Lewiston, Maine, Forenede Stater, 04240
        • Central Maine Comprehensive Cancer Center at Central Maine Medical Center
      • Portland, Maine, Forenede Stater, 04101
        • Mercy Hospital
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21215
        • Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
      • Baltimore, Maryland, Forenede Stater, 21201
        • Greenebaum Cancer Center at University of Maryland Medical Center
    • Massachusetts
      • Boston, Massachusetts, Forenede Stater, 02215
        • Beth Israel Deaconess Medical Center
      • Boston, Massachusetts, Forenede Stater, 02114
        • Massachusetts General Hospital
      • Boston, Massachusetts, Forenede Stater, 02115
        • Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
      • Boston, Massachusetts, Forenede Stater, 02111
        • Tufts-NEMC Cancer Center
      • Gloucester, Massachusetts, Forenede Stater, 01930
        • Addison Gilbert Hospital
      • Peabody, Massachusetts, Forenede Stater, 01960
        • NSMC Cancer Center - Peabody
    • Michigan
      • Adrian, Michigan, Forenede Stater, 49221
        • Hickman Cancer Center at Bixby Medical Center
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Battle Creek Health System Cancer Care Center
      • Big Rapids, Michigan, Forenede Stater, 49307
        • Mecosta County Medical Center
      • Escanaba, Michigan, Forenede Stater, 49431
        • Green Bay Oncology, Limited - Escanaba
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Butterworth Hospital at Spectrum Health
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • CCOP - Grand Rapids
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Lacks Cancer Center at Saint Mary's Health Care
      • Grand Rapids, Michigan, Forenede Stater, 49506
        • Metro Health Hospital
      • Holland, Michigan, Forenede Stater, 49423
        • Holland Community Hospital
      • Iron Mountain, Michigan, Forenede Stater, 49801
        • Dickinson County Healthcare System
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49001
        • Borgess Medical Center
      • Kalamazoo, Michigan, Forenede Stater, 49007-3731
        • West Michigan Cancer Center
      • Lambertville, Michigan, Forenede Stater, 48144
        • Haematology-Oncology Associates of Ohio and Michigan, PC
      • Monroe, Michigan, Forenede Stater, 48162
        • Community Cancer Center of Monroe
      • Monroe, Michigan, Forenede Stater, 48162
        • Mercy Memorial Hospital - Monroe
      • Muskegon, Michigan, Forenede Stater, 49442
        • Hackley Hospital
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital - Royal Oak Campus
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Lakeland Regional Cancer Care Center - St. Joseph
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Oncology Care Associates, PLLC
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
    • Minnesota
      • Alexandria, Minnesota, Forenede Stater, 56308
      • Bemidji, Minnesota, Forenede Stater, 56601
        • MeritCare Bemidji
      • Duluth, Minnesota, Forenede Stater, 55805
        • CCOP - Duluth
      • Duluth, Minnesota, Forenede Stater, 55805-1983
        • Duluth Clinic Cancer Center - Duluth
      • Duluth, Minnesota, Forenede Stater, 55805
        • Miller - Dwan Medical Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • St. Luke's Hospital Cancer Care Center
      • Fergus Falls, Minnesota, Forenede Stater, 56537
      • Rochester, Minnesota, Forenede Stater, 55905
        • Mayo Clinic Cancer Center
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • CentraCare Clinic - River Campus
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • Coborn Cancer Center
    • Missouri
      • Kansas City, Missouri, Forenede Stater, 64131
        • CCOP - Kansas City
      • Saint Louis, Missouri, Forenede Stater, 63110
        • Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
      • Springfield, Missouri, Forenede Stater, 65802
        • CCOP - Cancer Research for the Ozarks
      • Springfield, Missouri, Forenede Stater, 65804
        • St. John's Regional Health Center
      • Springfield, Missouri, Forenede Stater, 65807
        • Hulston Cancer Center at Cox Medical Center South
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • CCOP - Montana Cancer Consortium
      • Billings, Montana, Forenede Stater, 59101
        • Hematology-Oncology Centers of the Northern Rockies - Billings
      • Billings, Montana, Forenede Stater, 59101
        • Northern Rockies Radiation Oncology Center
      • Billings, Montana, Forenede Stater, 59101
        • St. Vincent Healthcare Cancer Care Services
      • Billings, Montana, Forenede Stater, 59107-7000
        • Billings Clinic - Downtown
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Cancer Center
      • Butte, Montana, Forenede Stater, 59701
        • St. James Healthcare Cancer Care
      • Great Falls, Montana, Forenede Stater, 59405
        • Great Falls Clinic - Main Facility
      • Helena, Montana, Forenede Stater, 59601
        • St. Peter's Hospital
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Regional Medical Center
      • Kalispell, Montana, Forenede Stater, 59901
        • Glacier Oncology, PLLC
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Medical Oncology at KRMC
      • Missoula, Montana, Forenede Stater, 59801
        • Community Medical Center
      • Missoula, Montana, Forenede Stater, 59807-7877
        • Montana Cancer Specialists at Montana Cancer Center
      • Missoula, Montana, Forenede Stater, 59807
        • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
    • Nebraska
      • Kearney, Nebraska, Forenede Stater, 68848-1990
        • Good Samaritan Cancer Center at Good Samaritan Hospital
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Cancer Resource Center - Lincoln
      • Omaha, Nebraska, Forenede Stater, 68106
        • CCOP - Missouri Valley Cancer Consortium
      • Omaha, Nebraska, Forenede Stater, 68122
        • Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegant Health Cancer Center at Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68131-2197
        • Creighton University Medical Center
      • Omaha, Nebraska, Forenede Stater, 68114
        • Methodist Estabrook Cancer Center
    • New Hampshire
      • Concord, New Hampshire, Forenede Stater, 03301
        • New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
      • Exeter, New Hampshire, Forenede Stater, 03833
        • Center for Cancer Care at Exeter Hospital
      • Hooksett, New Hampshire, Forenede Stater, 03106
        • New Hampshire Oncology - Hematology, PA - Hooksett
      • Keene, New Hampshire, Forenede Stater, 03431
        • Kingsbury Center for Cancer Care at Cheshire Medical Center
      • Laconia, New Hampshire, Forenede Stater, 03246
        • Lakes Region General Hospital
      • Manchester, New Hampshire, Forenede Stater, 03103
        • Elliot Regional Cancer Center at Elliot Hospital
    • New Jersey
      • Flemington, New Jersey, Forenede Stater, 08822
        • Hunterdon Regional Cancer Center at Hunterdon Medical Center
      • Hackensack, New Jersey, Forenede Stater, 07601
        • CCOP - Northern New Jersey
      • Livingston, New Jersey, Forenede Stater, 07039
        • St. Barnabas Medical Center Cancer Center
      • Marlton, New Jersey, Forenede Stater, 08053
        • Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
      • Morristown, New Jersey, Forenede Stater, 07962
        • Carol G. Simon Cancer Center at Morristown Memorial Hospital
      • Phillipsburg, New Jersey, Forenede Stater, 08865
        • Warren Hospital
      • Summit, New Jersey, Forenede Stater, 07902
        • Overlook Hospital
      • Voorhees, New Jersey, Forenede Stater, 08043
        • Fox Chase Virtua Health Cancer Program at Virtua West Jersey
    • New York
      • Bronx, New York, Forenede Stater, 10461
        • Albert Einstein Cancer Center at Albert Einstein College of Medicine
      • Brooklyn, New York, Forenede Stater, 11212
        • Brookdale University Hospital and Medical Center
      • Clifton Springs, New York, Forenede Stater, 14432
        • Finger Lakes Hematology and Oncology
      • Glens Falls, New York, Forenede Stater, 12801
        • Adirondack Cancer Care - Glens Falls
    • North Carolina
      • Charlotte, North Carolina, Forenede Stater, 28233-3549
        • Presbyterian Cancer Center at Presbyterian Hospital
      • Hendersonville, North Carolina, Forenede Stater, 28791
        • Pardee Memorial Hospital
      • Kinston, North Carolina, Forenede Stater, 28501
        • Kinston Medical Specialists
      • Pinehurst, North Carolina, Forenede Stater, 28374
        • FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
      • Rutherfordton, North Carolina, Forenede Stater, 28139
        • Rutherford Hospital
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Bismarck Cancer Center
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Medcenter One Hospital Cancer Care Center
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Mid Dakota Clinic, PC
      • Bismarck, North Dakota, Forenede Stater, 58502
        • St. Alexius Medical Center Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • CCOP - MeritCare Hospital
      • Fargo, North Dakota, Forenede Stater, 58122
        • MeritCare Broadway
      • Grand Forks, North Dakota, Forenede Stater, 58201
        • Altru Cancer Center at Altru Hospital
    • Ohio
      • Akron, Ohio, Forenede Stater, 44309-2090
        • Summa Center for Cancer Care at Akron City Hospital
      • Bellefontaine, Ohio, Forenede Stater, 43311
        • Mary Rutan Hospital
      • Bowling Green, Ohio, Forenede Stater, 43402
        • Wood County Oncology Center
      • Canton, Ohio, Forenede Stater, 44710-1799
        • Aultman Cancer Center at Aultman Hospital
      • Canton, Ohio, Forenede Stater, 44708
        • Mercy Cancer Center at Mercy Medical Center
      • Chillicothe, Ohio, Forenede Stater, 45601
        • Adena Regional Medical Center
      • Cleveland, Ohio, Forenede Stater, 44106-5065
        • Case Comprehensive Cancer Center
      • Columbus, Ohio, Forenede Stater, 43214-3998
        • Riverside Methodist Hospital Cancer Care
      • Columbus, Ohio, Forenede Stater, 43222
        • Mount Carmel Health - West Hospital
      • Columbus, Ohio, Forenede Stater, 43215
        • CCOP - Columbus
      • Columbus, Ohio, Forenede Stater, 43215
        • Grant Medical Center Cancer Care
      • Columbus, Ohio, Forenede Stater, 43228
        • Doctors Hospital at Ohio Health
      • Dayton, Ohio, Forenede Stater, 45428
        • Veterans Affairs Medical Center - Dayton
      • Dayton, Ohio, Forenede Stater, 45405
        • Grandview Hospital
      • Dayton, Ohio, Forenede Stater, 45406
        • Good Samaritan Hospital
      • Dayton, Ohio, Forenede Stater, 45409
        • David L. Rike Cancer Center at Miami Valley Hospital
      • Dayton, Ohio, Forenede Stater, 45415
        • Samaritan North Cancer Care Center
      • Dayton, Ohio, Forenede Stater, 45429
        • CCOP - Dayton
      • Delaware, Ohio, Forenede Stater, 43015
        • Grady Memorial Hospital
      • Findlay, Ohio, Forenede Stater, 45840
        • Blanchard Valley Medical Associates
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Middletown Regional Hospital
      • Kettering, Ohio, Forenede Stater, 45429
        • Charles F. Kettering Memorial Hospital
      • Lancaster, Ohio, Forenede Stater, 43130
        • Fairfield Medical Center
      • Lima, Ohio, Forenede Stater, 45804
        • Lima Memorial Hospital
      • Marietta, Ohio, Forenede Stater, 45750
        • Strecker Cancer Center at Marietta Memorial Hospital
      • Maumee, Ohio, Forenede Stater, 43537
        • Northwest Ohio Oncology Center
      • Maumee, Ohio, Forenede Stater, 43537
        • St. Luke's Hospital
      • Newark, Ohio, Forenede Stater, 43055
        • Licking Memorial Cancer Care Program at Licking Memorial Hospital
      • Oregon, Ohio, Forenede Stater, 43616
        • St. Charles Mercy Hospital
      • Oregon, Ohio, Forenede Stater, 43616
        • Toledo Clinic - Oregon
      • Sandusky, Ohio, Forenede Stater, 44870
        • Firelands Regional Medical Center
      • Sandusky, Ohio, Forenede Stater, 44870
        • North Coast Cancer Care, Incorporated
      • Springfield, Ohio, Forenede Stater, 45505
        • Community Hospital of Springfield and Clark County
      • Springfield, Ohio, Forenede Stater, 45504
        • Mercy Medical Center
      • Sylvania, Ohio, Forenede Stater, 43560
        • Flower Hospital Cancer Center
      • Tiffin, Ohio, Forenede Stater, 44883
        • Mercy Hospital of Tiffin
      • Toledo, Ohio, Forenede Stater, 43608
        • St. Vincent Mercy Medical Center
      • Toledo, Ohio, Forenede Stater, 43606
        • Toledo Hospital
      • Toledo, Ohio, Forenede Stater, 43617
        • CCOP - Toledo Community Hospital
      • Toledo, Ohio, Forenede Stater, 43623
        • Toledo Clinic, Incorporated - Main Clinic
      • Troy, Ohio, Forenede Stater, 45373-1300
        • UVMC Cancer Care Center at Upper Valley Medical Center
      • Wauseon, Ohio, Forenede Stater, 43567
        • Fulton County Health Center
      • Westerville, Ohio, Forenede Stater, 43081
        • Mount Carmel St. Ann's Cancer Center
      • Wilmington, Ohio, Forenede Stater, 45177
        • Clinton Memorial Hospital
      • Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
        • United States Air Force Medical Center - Wright-Patterson
      • Xenia, Ohio, Forenede Stater, 45385
        • Ruth G. McMillan Cancer Center at Greene Memorial Hospital
      • Zanesville, Ohio, Forenede Stater, 43701
        • Genesis - Good Samaritan Hospital
    • Oklahoma
      • Lawton, Oklahoma, Forenede Stater, 73505
        • Cleo Craig Cancer Research Clinic
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • Oklahoma University Cancer Institute
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Cancer Care Associates - Mercy Campus
    • Pennsylvania
      • Bethlehem, Pennsylvania, Forenede Stater, 18015
        • St. Luke's Cancer Network at St. Luke's Hospital
      • Bryn Mawr, Pennsylvania, Forenede Stater, 19010
        • Bryn Mawr Hospital
      • Danville, Pennsylvania, Forenede Stater, 17822-0001
        • Geisinger Cancer Institute at Geisinger Health
      • Hershey, Pennsylvania, Forenede Stater, 17033-0850
        • Penn State Cancer Institute at Milton S. Hershey Medical Center
      • Lewistown, Pennsylvania, Forenede Stater, 17044
        • Lewistown Hospital
      • Paoli, Pennsylvania, Forenede Stater, 19301-1792
        • Cancer Center of Paoli Memorial Hospital
      • Phoenixville, Pennsylvania, Forenede Stater, 19460
        • Cancer Center at Phoenixville Hospital
      • Pottstown, Pennsylvania, Forenede Stater, 19464
        • Pottstown Memorial Regional Cancer Center
      • Sayre, Pennsylvania, Forenede Stater, 18840
        • Guthrie Cancer Center at Guthrie Clinic Sayre
      • State College, Pennsylvania, Forenede Stater, 16803
        • Mount Nittany Medical Center
      • State College, Pennsylvania, Forenede Stater, 16801
        • Geisinger Medical Group - Scenery Park
      • West Chester, Pennsylvania, Forenede Stater, 19380
        • Chester County Hospital
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Lankenau Cancer Center at Lankenau Hospital
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • CCOP - Main Line Health
    • South Carolina
      • Anderson, South Carolina, Forenede Stater, 29621
        • AnMed Cancer Center
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • CCOP - Upstate Carolina
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
    • Texas
      • Temple, Texas, Forenede Stater, 76508
        • CCOP - Scott and White Hospital
    • Vermont
      • Berlin, Vermont, Forenede Stater, 05602
        • Mountainview Medical
      • Burlington, Vermont, Forenede Stater, 05401
        • Fletcher Allen Health Care - University Health Center Campus
    • Virginia
      • Fredericksburg, Virginia, Forenede Stater, 22401
        • Fredericksburg Oncology, Incorporated
    • Washington
      • Bellingham, Washington, Forenede Stater, 98225
        • St. Joseph Cancer Center
      • Kirkland, Washington, Forenede Stater, 98033
        • Cascade Cancer Center at Evergreen Hospital Medical Center
      • Port Angeles, Washington, Forenede Stater, 98362
        • Olympic Medical Center
      • Renton, Washington, Forenede Stater, 98055
        • Valley Medical Center
      • Seattle, Washington, Forenede Stater, 98101
        • CCOP - Virginia Mason Research Center
      • Seattle, Washington, Forenede Stater, 98112
        • Group Health Central Hospital
      • Seattle, Washington, Forenede Stater, 98195-6043
        • University Cancer Center at University of Washington Medical Center
    • Wisconsin
      • Fond Du Lac, Wisconsin, Forenede Stater, 54935
        • Central Wisconsin Cancer Program at Agnesian HealthCare
      • Glendale, Wisconsin, Forenede Stater, 53212-1038
        • Oncology Alliance, SC - Milwaukee - East
      • Green Bay, Wisconsin, Forenede Stater, 54307-3508
        • St. Vincent Hospital Regional Cancer Center
      • Green Bay, Wisconsin, Forenede Stater, 54301-3526
        • Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Green Bay Oncology, Limited at St. Mary's Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • St. Mary's Hospital Medical Center - Green Bay
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
      • Madison, Wisconsin, Forenede Stater, 53792-6164
        • University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Bay Area Cancer Care Center at Bay Area Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53201-0342
        • Aurora Sinai Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Medical Consultants, Limited
      • Oconto Falls, Wisconsin, Forenede Stater, 54154
        • Green Bay Oncology, Limited - Oconto Falls
      • Racine, Wisconsin, Forenede Stater, 53405
        • All Saints Cancer Center at Wheaton Franciscan Healthcare
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235
        • Green Bay Oncology, Limited - Sturgeon Bay
      • Wausau, Wisconsin, Forenede Stater, 54401
        • University of Wisconcin Cancer Center at Aspirus Wausau Hospital
    • Wyoming
      • Sheridan, Wyoming, Forenede Stater, 82801
        • Welch Cancer Center at Sheridan Memorial Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Kvinde

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

Patienter med diagnosticeret brystkræft.

Beskrivelse

SYGDOMS KARAKTERISTIKA:

  • Histologisk bekræftet invasiv brystkræft
  • Fuldstændig resekeret sygdom

  • Et intakt, ikke-kræftfremkaldende bryst uden forudgående brystoperation i det bryst undtagen brystbiopsi

    • Mammogram tilgængeligt taget inden for 12 måneder før tilmelding, der inkluderer side- og top-down visninger af det intakte, ikke-kræftfremkaldende bryst
  • Østrogenreceptor- og/eller progesteronreceptorpositiv tumor

PATIENT KARAKTERISTIKA:

  • Kvinde
  • Postmenopausal
  • Indvilliger i at hente og digitalisere mammografi taget før registreringen (inden for 12 måneder før studiestart) og ca. 1 og 2 år efter registreringen til denne undersøgelse
  • Indvilliger i at få udtaget en ekstra blodbankprøve samtidig med at der udtages præ-behandlingsprøver til forældreprotokol CAN-NCIC-MA27
  • Indvilliger i at få taget blodprøve 12 måneder efter registreringen af ​​denne undersøgelse

FORUDSÆTNING SAMTYDLIG TERAPI:

  • Se Sygdomskarakteristika
  • Mere end 6 måneder siden forudgående hormonsubstitutionsbehandling, orale præventionsmidler, tamoxifen, raloxifen, andre selektive østrogenreceptormodulatorer eller gonadotropinfrigivende hormonanaloger før præregistreringsmammografi

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
Gruppe 1
Patienterne udfylder et 10-minutters spørgeskema om faktorer, der kan påvirke ændringer i brysttæthed ved baseline og et andet spørgeskema 1 år og 2 år efter registrering. Blodprøver udtages ved baseline (før påbegyndelse af behandling) og 1 år efter registrering til hormon- og lægemiddelniveauanalyse. Mammogrammer taget før registrering (inden for 12 måneder før tilmelding) og ca. 1 og 2 år efter registrering til denne undersøgelse, hentes og digitaliseres til bestemmelse af procent brysttæthed og tæt område.
Procedure: mammografi

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Tidsramme
Ændringer i brysttæthed målt i procent og areal efter 1 og 2 år
Tidsramme: Op til 2 år
Op til 2 år
Korrelation af ændringer i brysttæthed med plasmahormoner og lægemiddelniveauer målt ved østron, østronsulfat, østradiol, kønshormonbindende globulin, anastrozol eller exemestan niveauer ved 1 og 2 år
Tidsramme: Op til 2 år
Op til 2 år

Sekundære resultatmål

Resultatmål
Tidsramme
Korrelation af brysttæthed med kontralateral brystkræft efter 1 og 2 år
Tidsramme: Op til 2 år
Op til 2 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbejdspartnere

National Cancer Institute (NCI)
NCIC Clinical Trials Group

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. april 2006

Primær færdiggørelse (Faktiske)

1. oktober 2010

Studieafslutning (Faktiske)

1. februar 2012

Datoer for studieregistrering

Først indsendt

19. april 2006

Først indsendt, der opfyldte QC-kriterier

19. april 2006

Først opslået (Skøn)

21. april 2006

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

24. januar 2019

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

22. januar 2019

Sidst verificeret

1. januar 2019

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • NCCTG-N0434
  • CAN-NCIC-MA27D
  • CDR0000462330 (Registry Identifier: NCI Physician Data Query)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Brystkræft

Kliniske forsøg med mammografi

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Egypt

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

3
Abonner