Endocardial Stem Cells Approach Efficacy (ESCAPE)

Inclusion Criteria:

• Men and women who are not of childbearing potential
• Age 21-75 years.
• Patients with CAD, NYHA and CCS angina III-IV functional class
• LVEF less than 35% measured by echocardiography or SPECT within three months of study entry
• Unsuitable for initial or repeated conventional revascularization (CABG or PCI)

Exclusion Criteria:

• Failure to provide informed consent.
• Plan for PCI or CABG.
• Non-cardiac illness with a life expectancy of less than 3 year.
• Conditions/circumstances likely to lead to poor treatment adherence (e.g., history of poor compliance, alcohol or drug dependency, psychiatric illness, no fixed abode).
• Previous heart, kidney, liver, or lung transplantation.
• Current participation in another clinical trial in which a patient is taking an investigational drug or receiving an investigational medical device.
• Recent acute myocardial infarction (AMI) within 90 days of study entry
• Successful coronary revascularization (СABG or PCI) within 12 months of study enrollment
• History of moderate to severe aortic stenosis or prosthetic aortic valve
• Permanent atrial fibrillation
• Thrombosis in LV, based on echocardiography data