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Chronic Periodontitis and Polycystic Ovary Syndrome

13. januar 2020 opdateret af: Bezmialem Vakif University

Evaluation Of Lipid Peroxidation, Oxidative DNA Damage And Total Antioxidant Status In Patients With Periodontitis And Polycystic Ovary Syndrome: A Cross Sectional Study

Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic periodontitis (CP) and to compared healthy individuals.

Materials and Methods: A total of 88 women were into four groups each which were consisted of twenty-two subjects. Groups were designed as periodontally and systemically healthy women (PCOS-CP-); periodontally healthy women with polycystic ovary syndrome (PCOS) (PCOS+CP-), systemically healthy women with CP (PCOS-,CP+) and women with PCOS and CP (PCOS+CP+). Serum and salivary samples were obtained, clinical periodontal parameters were recorded. MDA, TAS, 8-OHdG levels were measured as biochemically.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

RESULTS:

Salivary 8-OHdG levels in the PCOSCP and CP groups were statistically higher than those in both the PCOSPH and the PH groups (P < 0.05). There was no statistical difference between the PCOSCP, CP, and PCOSPH groups with regard to salivary MDA and TAS levels (P > 0.05). Highest serum 8-OHdG and MDA levels and lowest serum TAS levels were seen in the PCOSCP group (P < 0.05). Serum 8-OHdG and MDA levels in the PCOSPH group were higher than those in both systemically healthy groups (PH and CP) (P < 0.05). Salivary TAS levels were highest (P < 0.05) in the PH group. There was no statistical difference between the CP and PCOSPH groups, but serum TAS levels were lower than those in the PH group (P < 0.05).

CONCLUSIONS:

CP, which led to an increase in serum and salivary 8-OHdG and MDA levels and a decrease in serum TAS levels in patients with PCOS, contributed to increased OS. This effect was more prominent in serum levels than in salivary levels.

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

88

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Kalkun
    • Fatih
      • İstanbul, Fatih, Kalkun, 34093
        • Department of Periodontics, Faculty of Dentistry, Bezmialem Vakif University

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 40 år (Voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Kvinde

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

All participants were recruited among women at the Department of Obstetrics and Gynecology, School of Medicine, Ataturk University

Beskrivelse

Inclusion Criteria:

  • Newly diagnosed non-obese PCOS patients
  • Never smokers
  • Had no history of systemic disease
  • BMI<25 kg/m2
  • Participants had ≥20 teeth present.

Exclusion Criteria:

  • Pregnancy
  • Lactation
  • Hemoglobin A1c (HbA1c) ≥ 6.5%
  • 2-h oral glucose tolerance test (OGTT-2h) ≥200
  • Cushing syndrome, non-classic congenital adrenal hyperplasia, hyperprolactinemia, thyroid dysfunction, and androgen-secreting tumors
  • Any drug use within the past 6 months
  • Periodontal treatment within the past 6 months

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Observationsmodeller: Case-Control
  • Tidsperspektiver: Tværsnit

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
(PCOS-CP-)
systemically and periodontally healthy participants
Andet: no intervention provided
(PCOS-CP+)
systemically healthy participants with CP
Andet: no intervention provided
(PCOS+CP-)
PCOS participants with periodontally healthy
Andet: no intervention provided
(PCOS+CP+)
PCOS participants with CP
Andet: no intervention provided

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
8-OHdG levels (nanogram per mililiter(ng/mL))
Tidsramme: appoximately 2 years
by ELISA test
appoximately 2 years
MDA levels (micromole per liter (µmol/L))
Tidsramme: appoximately 2 years
by ELISA test
appoximately 2 years
TAS levels (millimolar per liter (mmol /L))
Tidsramme: appoximately 2 years
by ELISA test
appoximately 2 years
Plaque Index (PI)
Tidsramme: appoximately 2 years
Silnes-Löe Periodondal İndex
appoximately 2 years
Gingival Index (GI)
Tidsramme: appoximately 2 years
Löe-Silness Periodontal Index
appoximately 2 years
Bleeding on probing (BOP)
Tidsramme: appoximately 2 years
Gİngival Bleeding Index
appoximately 2 years
Clinical attachment level (CAL)
Tidsramme: Patients were seen one time
by measuring the distance between the cementoenamel junction and the periodontal pocket base
Patients were seen one time
Probing pocket depth (PD))
Tidsramme: appoximately 2 years
distance between free gingival margin and periodontal pocket base by usin periodontal probe
appoximately 2 years

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
number of individuals with chronic periodontitis
Tidsramme: appoximately 2 years
individuals in the group
appoximately 2 years
numberer of individuals with polycystic ovary syndrome
Tidsramme: appoximately 2 years
individuals in the group
appoximately 2 years

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Bezmialem Vakif University

Efterforskere

  • Ledende efterforsker: Nesrin Saruhan, PhD, Eskisehir Osmangazi Universitesi
  • Studieleder: Cenk Fatih Çanakcı, Prof, Atatürk Üniversitesi
  • Ledende efterforsker: Saime Ozbek Sebin, Dr, Atatürk Üniversitesi
  • Ledende efterforsker: Humeyra Canakcı, Dr, Buhara Hastanesi
  • Ledende efterforsker: Metin İngeç, Prof, Atatürk Üniversitesi
  • Ledende efterforsker: Ufuk Sezer, Phd, Özel Klinik
  • Ledende efterforsker: Ebru Saglam, PhD, Saglik Bilimleri Universitesi

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. maj 2013

Primær færdiggørelse (Faktiske)

1. maj 2015

Studieafslutning (Faktiske)

1. september 2015

Datoer for studieregistrering

Først indsendt

28. oktober 2016

Først indsendt, der opfyldte QC-kriterier

1. november 2016

Først opslået (Skøn)

3. november 2016

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

18. januar 2020

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

13. januar 2020

Sidst verificeret

1. januar 2020

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • PCOSandCP

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