- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT04822181
Forskningsundersøgelse om, hvorvidt Semaglutid virker hos mennesker med ikke-alkoholisk Steatohepatitis (NASH) (ESSENCE)
Virkningen af Semaglutid hos personer med ikke-cirrhotisk ikke-alkoholisk Steatohepatitis
Semaglutid er et lægemiddel, der er undersøgt hos patienter med NASH. Semaglutid er et velkendt lægemiddel, som allerede bruges af læger til behandling af type 2-diabetes i mange lande.
Deltagerne får enten semaglutid eller en dummy-medicin - hvilken behandling deltagerne får afgøres tilfældigt.
Deltagerne skal injicere sig selv med medicin under huden. Deltagerne skal gøre dette en gang om ugen.
Studiet vil vare i omkring 5 år. Deltagerne vil have op til 21 klinikbesøg og 9 telefonopkald med det kliniske personale i løbet af undersøgelsen. Nogle af klinikbesøgene kan være spredt over mere end én dag.
Deltagere med andre kroniske leversygdomme kan ikke deltage i denne undersøgelse. Kvinder kan ikke deltage i undersøgelsen, hvis de er gravide, ammer eller planlægger at blive gravide i løbet af undersøgelsesperioden.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Fase 3
Kontakter og lokationer
Studiesteder
-
-
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Buenos Aires, Argentina, B1704ETD
- DIM Clínica Privada
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CABA, Argentina, C1120AAC
- Centro Medico Viamonte SRL
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CABA, Argentina, C1199ABH
- Hospital Italiano Departamento Hepatologia
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CABA, Argentina, C1430CKE
- Glenny Corp. S.A
-
Capital Federal, Argentina, C1056ABJ
- Centro de Investigaciones Metabólicas
-
Florencio Varela, Buenos Aires, Argentina, 1888
- Hospital El Cruce
-
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Buenos Aires
-
Capital Federal, Buenos Aires, Argentina, C1056ABI
- Centro de Investigaciones Metabólicas
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Ciudad de Buenos Aires, Buenos Aires, Argentina, 1280
- Hospital Britanico de Buenos Aires
-
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Santa Fe Province
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Rosario, Santa Fe, Santa Fe Province, Argentina, S2002KDT
- Hospital del Centenario
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-
-
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New South Wales
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Camperdown, New South Wales, Australien, 2050
- A.W. Morrow Gastroenterology and Liver Centre
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Kingswood, New South Wales, Australien, 2747
- Nepean Hospital
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Liverpool, New South Wales, Australien, 2170
- Liverpool Hospital
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Westmead, New South Wales, Australien, 2145
- Westmead Hospital
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Westmead, New South Wales, Australien, 2145
- Westmead Hospital - Storr Liver Centre
-
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Queensland
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Southport, Queensland, Australien, 4222
- Griffith University Clinical Trial Unit
-
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South Australia
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Adelaide, South Australia, Australien, 5000
- Royal Adelaide Hospital - Hepatology Department
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Elizabeth Vale, South Australia, Australien, 5112
- Lyell McEwin Hospital
-
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Victoria
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Fitzroy, Victoria, Australien, 3065
- St Vincent's Hospital Melbourne - Gastroenterology Department
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Heidelberg, Victoria, Australien, 3084
- Austin Hospital
-
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Western Australia
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Murdoch, Western Australia, Australien, 6150
- Fiona Stanley Hospital - Hepatology
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Nedlands, Western Australia, Australien, 6009
- Sir Charles Gairdner Hospital - Hepatology Department
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-
-
-
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Brussels, Belgien, 1070
- CUB Hôpital Erasme_Brussels_0
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Brussels, Belgien, 1200
- Cliniques Universitaires Saint-Luc - Serv. Hépato-gastroentérology
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Edegem, Belgien, 2650
- UZA
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Genk, Belgien, 3600
- Ziekenhuis Oost-Limburg AV - Gastro
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Ghent, Belgien, 9000
- UZ Gent - Department Gastro-enterology
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Ghent, Belgien, 9000
- AZ Maria Middelares - Gent - Gastro-Enterology
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-
-
-
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Rio de Janeiro, Brasilien, 21941-617
- Hospital Universitario Clementino Fraga Filho
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São Paulo, Brasilien, 04543-011
- Rocco E Nazato Servicos Medicos LTDA
-
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Estado de Bahia
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Salvador, Estado de Bahia, Brasilien, 40110160
- Fundação Bahiana de Infectologia
-
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Goiás
-
Goiânia, Goiás, Brasilien, 74605-020
- Hospital das Clinicas da Universidade Federal de Goias
-
-
Rio Grande do Sul
-
Porto Alegre, Rio Grande do Sul, Brasilien, 90035-903
- Hospital de Clínicas de Porto Alegre_Porto Alegre
-
-
São Paulo
-
Barretos, São Paulo, Brasilien, 14780-070
- Fundação Pio XII
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Barretos, São Paulo, Brasilien, 14784-400
- Fundação Pio XII - Hospital de Amor de Barretos
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Botucatu, São Paulo, Brasilien, 18618-686
- UPECLIN- Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu
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São José do Rio Preto, São Paulo, Brasilien, 15090-000
- CIP Centro Integrado de Pesquisas do Hospital de Base
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São Paulo, São Paulo, Brasilien, 04024-002
- Assoc. Paulista para o Desenvolvimento da Medicina - UNIFESP
-
São Paulo, São Paulo, Brasilien, 05403-000
- Departamento de Gastroenterologia - HCFMUSP
-
-
-
-
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Panagyurishte, Bulgarien, 4500
- MHAT - UniHospital OOD
-
Plovdiv, Bulgarien, 4000
- MHAT Med Line Clinic
-
Sofia, Bulgarien, 1784
- Medical Center Synexus Sofia EOOD
-
Sofia, Bulgarien, 1618
- "DCC XX - Sofia" EOOD
-
Sofia, Bulgarien, 1407
- "Acibadem City Clinic UMHAT Tokuda"
-
Sofia, Bulgarien, 1527
- "UMHAT "Tsaritsa Yoanna-ISUL"" EAD, Gastroenterology clinic
-
Sofia, Bulgarien, 1750
- "UMHAT "Sveta Anna" Sofia" AD
-
Sofia, Bulgarien, 1431
- DCC Aleksandrovska EOOD
-
Sofia, Bulgarien, 1504
- Medical Center Vertebra OOD
-
Sofia, Bulgarien, 1407
- Acibadem City Clinic UMHAT Tokuda EAD, Gastroenterology
-
Sofia, Bulgarien, 1618
- DCC XX - Sofia EOOD, Gastroenterology
-
Sofia, Bulgarien, 1527
- UMHAT Tsaritsa Yoanna - ISUL EAD, Gastroenterology
-
Sofia, Bulgarien, 1784
- Acibadem City Clinic UMHAT EOOD, Gastroenterology
-
Sofia, Bulgarien, 1431
- UMHAT Sveti Ivan Rilski EAD, Gastroenterology
-
Varna, Bulgarien, 9010
- UMHAT Sveta Marina EAD, Clinic of Gastroenterology
-
-
-
-
Alberta
-
Calgary, Alberta, Canada, T2N 4Z6
- University of Calgary Liver Unit-(HMRC)
-
-
British Columbia
-
Vancouver, British Columbia, Canada, V6Z 2K5
- GI Research Inst Foundation
-
-
Nova Scotia
-
Halifax, Nova Scotia, Canada, B3H 2Y9
- Nova Scotia Hlth Halifax
-
-
Ontario
-
Brampton, Ontario, Canada, L6S 0C6
- LMC ClinRsrh Inc.Brampton
-
London, Ontario, Canada, N6A 5A5
- London Hlth Sci Ctr- Univ Camp
-
Toronto, Ontario, Canada, M6H 3M1
- Toronto Liver Centre
-
Toronto, Ontario, Canada, M4G 3E8
- Centricity Research LMC (Toronto)
-
Vaughan, Ontario, Canada, L4L 4Y7
- TDDA Specialty Research
-
-
Quebec
-
Chicoutimi, Quebec, Canada, G7H 7K9
- Ecogene-21
-
Montreal, Quebec, Canada, H4A 3J1
- McGill University Health Centre
-
Montreal, Quebec, Canada, QC H2L 4E9
- Clinique Medicine Urbaine du Quartier Latin, Inc.
-
Sherbrooke, Quebec, Canada, J1H 5N4
- Hospital Fleurimont / CIUSS
-
Terrebonne, Quebec, Canada, J6X 4P7
- Ctr de méd métab de Lanaudière
-
-
-
-
-
Aarhus N, Danmark, 8200
- Aarhus Universitetshospital Skejby Mave-Tarm
-
Hvidovre, Danmark, 2650
- Hvidovre Hospital - Gastroenheden
-
København NV, Danmark, 2400
- Bispebjerg Hospital - Abdominal Center K, Research Unit
-
Odense C, Danmark, 5000
- Odense University Hospital - FLASH - Centre for Liver Research
-
-
-
-
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Belfast, Det Forenede Kongerige, BT12 6BA
- Royal Victoria Hospital
-
Birmingham, Det Forenede Kongerige, B15 2TH
- Queen Elizabeth Hospital, Birmingham
-
Coventry, Det Forenede Kongerige, CV2 2DX
- University Hospital Coventry - WISDEM Centre
-
Derby, Det Forenede Kongerige, DE22 3NE
- Royal Derby Hospital
-
Derby, Det Forenede Kongerige, DE22 3DT
- Royal Derby Hospital
-
Dundee, Det Forenede Kongerige, DD1 9SY
- Ninewells Hospital
-
Exeter, Det Forenede Kongerige, EX2 5DW
- Royal Devon and Exeter Hospital
-
Hull, Det Forenede Kongerige, HU3 2GZ
- Hull Royal Infirmary_Hull
-
Hull, Det Forenede Kongerige, HU3 2GZ
- Hull Royal Infirmary
-
Ipswich, Det Forenede Kongerige, IP4 5RH
- The Diabetes Centre
-
Ipswich, Det Forenede Kongerige, IP4 5RH
- Ipswich Hospital - Diabetes
-
Leeds, Det Forenede Kongerige, LS9 7TF
- St James's University Hospital
-
Leeds, Det Forenede Kongerige, LS9 7TF
- St. James University Hospital
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London, Det Forenede Kongerige, SW10 9NH
- Chelsea & Westminster Hospital
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London, Det Forenede Kongerige, SE5 9RS
- Institute of Liver Studies
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London, Det Forenede Kongerige, W2 1NY
- Imperial College London
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London, Det Forenede Kongerige, E1 1FR
- The Royal London Hospital - Grahame Hayton Unit
-
London, Det Forenede Kongerige, NW3 2QG
- Royal Free Hospital - Immunity & Transplantation
-
Newcastle upon Tyne, Det Forenede Kongerige, NE7 7DN
- Freeman Hospital, Newcastle
-
Nottingham, Det Forenede Kongerige, NG7 2UH
- Nottingham University Hospitals Nhs Trust
-
Nottingham, Det Forenede Kongerige, NG7 2UH
- Nottingham University Hospital
-
Oxford, Det Forenede Kongerige, OX3 9DU
- John Radcliffe Hospital
-
Plymouth, Det Forenede Kongerige, PL6 8DH
- Derriford Hospital - Plymouth
-
Sheffield, Det Forenede Kongerige, S5 7AU
- Northern General Hospital
-
Southampton, Det Forenede Kongerige, SO16 6YD
- Southampton General Hospital
-
Swansea, Det Forenede Kongerige, SA2 8PP
- Joint Clinical Research Facility - Swansea
-
-
-
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Alabama
-
Huntsville, Alabama, Forenede Stater, 35801
- North AL Health Res, LLC
-
-
Arizona
-
Chandler, Arizona, Forenede Stater, 85224
- The Institute for Liver Health
-
Peoria, Arizona, Forenede Stater, 85381
- Inst-Liver Hlth dba AZ Liver H
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Tucson, Arizona, Forenede Stater, 85715
- Del Sol Research Management, LLC
-
Tucson, Arizona, Forenede Stater, 85712
- Inst. Liver H II dba AZ Liver H
-
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Arkansas
-
Jonesboro, Arkansas, Forenede Stater, 72401
- ARcare Center for Clinical Research
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Little Rock, Arkansas, Forenede Stater, 72205
- ARcare Center for Clinical Research
-
Little Rock, Arkansas, Forenede Stater, 72205
- Arkansas Diagnostic Center, PA
-
-
California
-
Escondido, California, Forenede Stater, 92025
- Gastroenterology & Liver Institute
-
Hacienda Heights, California, Forenede Stater, 91745
- Shang Wu M.D. Inc.
-
La Jolla, California, Forenede Stater, 92037
- Scripps Whittier Diabetes Inst
-
La Jolla, California, Forenede Stater, 92037
- UCSD NAFLD Research Center
-
Lancaster, California, Forenede Stater, 93534
- Om Research LLC
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Long Beach, California, Forenede Stater, 90808
- Digestive Hlth Res of SoCa
-
Oxnard, California, Forenede Stater, 93030
- Om Research LLC
-
Pasadena, California, Forenede Stater, 90048
- Cedars-Sinai Medical Center
-
Pasadena, California, Forenede Stater, 91105
- Pasedena Liver Center
-
Rialto, California, Forenede Stater, 92377
- Inland Empire Clin Trials LLC
-
Sacramento, California, Forenede Stater, 95817
- UC Davis Hlth -Midtwn Ambu Cen
-
San Francisco, California, Forenede Stater, 94143
- University of California, San Francisco
-
San Jose, California, Forenede Stater, 95116
- Silicon Valley Res Inst
-
-
Colorado
-
Colorado Springs, Colorado, Forenede Stater, 80907
- Peak Gastro Assoc-Col Springs
-
-
Connecticut
-
New Haven, Connecticut, Forenede Stater, 06519
- Yale Ctr for Clin Invest
-
-
Florida
-
Boynton Beach, Florida, Forenede Stater, 33436
- Encore Medical Research of Boynton Beach LLC
-
Doral, Florida, Forenede Stater, 33122
- Integrity Clinical Research, LLC
-
Fort Myers, Florida, Forenede Stater, 33912
- Covenant Metabolic Specialists, Ft. Myers
-
Gainesville, Florida, Forenede Stater, 32610
- University of Florida-CTRB
-
Hialeah, Florida, Forenede Stater, 33012
- Miguel Rebollar PA
-
Hialeah, Florida, Forenede Stater, 33016
- Direct Helpers Research Center
-
Lakewood Rch, Florida, Forenede Stater, 34211-4930
- Florida Research Institute, LLC
-
Maitland, Florida, Forenede Stater, 32751
- Sandhill Research, LLC
-
Maitland, Florida, Forenede Stater, 32751
- Tandem Clinical Research - Maitland
-
Miami, Florida, Forenede Stater, 33173
- Genoma Research Group, Inc
-
Miami, Florida, Forenede Stater, 33135
- Optimus U, Corp
-
Miami, Florida, Forenede Stater, 33136
- Univ of Miami/Schiff Ctr
-
Miami, Florida, Forenede Stater, 33176
- IMIC Inc
-
Miami Lakes, Florida, Forenede Stater, 33014
- San Marcus Res Clin Miami Lakes
-
Ocala, Florida, Forenede Stater, 34471
- Ocala GI Research
-
Ocoee, Florida, Forenede Stater, 34761
- Sensible Healthcare LLC
-
Sarasota, Florida, Forenede Stater, 34240
- Covenant Metabolic Specialists LLC
-
Sarasota, Florida, Forenede Stater, 34243
- Headlands Research - Sarasota
-
St. Petersburg, Florida, Forenede Stater, 33710
- Theia Clinical Research Centers LLC
-
Viera E., Florida, Forenede Stater, 32940
- ClinCloud, LLC
-
Zephyrhills, Florida, Forenede Stater, 33542
- Florida Medical Clinic Orlando Health
-
-
Georgia
-
Atlanta, Georgia, Forenede Stater, 30322-1059
- Emory University Hospital
-
Columbus, Georgia, Forenede Stater, 31904
- Columbus Regional Research Institute
-
Macon, Georgia, Forenede Stater, 31201
- Gastroenterology Assoc_ CGA
-
Marietta, Georgia, Forenede Stater, 30060
- Gastroint Spec of Georgia
-
-
Illinois
-
Chicago, Illinois, Forenede Stater, 60637
- University of Chicago
-
Chicago, Illinois, Forenede Stater, 60612
- Rush University Med. Cntr
-
Skokie, Illinois, Forenede Stater, 60077
- Endeavor Health
-
-
Indiana
-
Indianapolis, Indiana, Forenede Stater, 46202
- Indiana University Hospital
-
South Bend, Indiana, Forenede Stater, 46635
- Digestive Research Alliance of Michiana
-
-
Iowa
-
Clive, Iowa, Forenede Stater, 50325
- Iowa Digestive Disease Center
-
-
Kansas
-
Kansas City, Kansas, Forenede Stater, 66160
- University of Kansas Hospital
-
Topeka, Kansas, Forenede Stater, 66606
- Kansas Medical Clinic, PA
-
-
Louisiana
-
Houma, Louisiana, Forenede Stater, 70363
- Tandem Clinical Research - Houma
-
Marrero, Louisiana, Forenede Stater, 70072
- Tandem Clinical Research
-
Metairie, Louisiana, Forenede Stater, 70006
- Tandem Clinical Research - Metairie
-
Shreveport, Louisiana, Forenede Stater, 71105
- Louisiana Research Center, LLC
-
-
Maryland
-
Baltimore, Maryland, Forenede Stater, 21202
- Mercy Medical Center, GI Research
-
Bethesda, Maryland, Forenede Stater, 20889
- Walter Reed Nat Mil Md Ctr
-
Glen Burnie, Maryland, Forenede Stater, 21061
- Woodholme Gastroenterology Associates
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02118
- Boston Medical Center_Cary
-
-
Michigan
-
Ann Arbor, Michigan, Forenede Stater, 48109
- University of Michigan Medicine
-
Detroit, Michigan, Forenede Stater, 48202
- Henry Ford Health System
-
-
Minnesota
-
Rochester, Minnesota, Forenede Stater, 55905-0001
- Mayo Clinic
-
-
Mississippi
-
Jackson, Mississippi, Forenede Stater, 39216
- Southern Therapy and Advanced Research LLC
-
-
Missouri
-
Chesterfield, Missouri, Forenede Stater, 63005
- Clinical Research Professionals
-
Kansas City, Missouri, Forenede Stater, 64131
- Kansas City Research Institute
-
-
Nebraska
-
Omaha, Nebraska, Forenede Stater, 68198-3020
- Univ of Nebraska Medical CTR
-
-
Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- Jubilee Clinical Research, Inc.
-
Las Vegas, Nevada, Forenede Stater, 89106
- Sierra Clinical Research-Las Vegas
-
-
New Jersey
-
Florham Park, New Jersey, Forenede Stater, 07932
- AIG Digestive Disease Research
-
Sparta, New Jersey, Forenede Stater, 07871
- Premier Health Research, LLC
-
-
New York
-
New York, New York, Forenede Stater, 10016
- NYU Grossman School of Med
-
New York, New York, Forenede Stater, 10021
- Weill Cornell Med Coll-NYPH
-
New York, New York, Forenede Stater, 10029
- Icahn Sch of Med-Mt Sinai Hosp
-
-
North Carolina
-
Charlotte, North Carolina, Forenede Stater, 28210
- AtriumHealth Liver Care, Pineville
-
Concord, North Carolina, Forenede Stater, 28027
- Northeast GI Research Division
-
Durham, North Carolina, Forenede Stater, 27710
- Duke Univ. Med CNTR_Durham_2
-
-
Ohio
-
Columbus, Ohio, Forenede Stater, 43210
- Ohio State Univ Wexner Med Ctr
-
Springboro, Ohio, Forenede Stater, 45066
- Objective GI
-
Westlake, Ohio, Forenede Stater, 44145
- CRIOH
-
-
Oklahoma
-
Tulsa, Oklahoma, Forenede Stater, 74104
- Options Health Research, LLC
-
-
Pennsylvania
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Clinic
-
Hershey, Pennsylvania, Forenede Stater, 17033
- Pennsylvania State University
-
Philadelphia, Pennsylvania, Forenede Stater, 19104
- Univ of Pennsylvania Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19107-5244
- Thomas Jefferson University Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15213
- UPMC Center for Liver Diseases
-
Pittsburgh, Pennsylvania, Forenede Stater, 15213
- UPMC_Center for Liver Care
-
Pottsville, Pennsylvania, Forenede Stater, 17901
- Care Access Research, Pottsville
-
-
Rhode Island
-
Cumberland, Rhode Island, Forenede Stater, 02864
- Clinical Res Collaborative
-
Lincoln, Rhode Island, Forenede Stater, 02865
- Ocean St Clin Res Partnrs, LLC
-
-
South Carolina
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
-
Tennessee
-
Chattanooga, Tennessee, Forenede Stater, 37421
- WR-Clinsearch, LLC
-
Hermitage, Tennessee, Forenede Stater, 37076
- Digestive Health Res-TSMC
-
Johnson City, Tennessee, Forenede Stater, 37604
- East Tennessee Research Institute
-
Nashville, Tennessee, Forenede Stater, 37211
- Quality Medical Research
-
-
Texas
-
Amarillo, Texas, Forenede Stater, 79106
- Amarillo Center for Clinical Research, Ltd.
-
Arlington, Texas, Forenede Stater, 76012
- Texas Clin Res Inst, LLC
-
Dallas, Texas, Forenede Stater, 75230
- Velocity Clinical Res-Dallas
-
Dallas, Texas, Forenede Stater, 75390-9302
- UT Southwestern Med Cntr
-
Dallas, Texas, Forenede Stater, 75203
- Liver Ins@ Mthdist DTX Med Cen
-
Edinburg, Texas, Forenede Stater, 78539
- South Texas Research Institute
-
Fort Sam Houston, Texas, Forenede Stater, 78234
- Brooke Army Medical Ctr.
-
Fort Worth, Texas, Forenede Stater, 76104
- GI Alliance Research
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine
-
Houston, Texas, Forenede Stater, 77030
- Houston Methodist Hospital
-
Houston, Texas, Forenede Stater, 77089
- Amir Ali Hassan, MD, PA
-
Houston, Texas, Forenede Stater, 77079
- Houston Research Institute
-
Houston, Texas, Forenede Stater, 77043
- Bipharma Informatic Inc.
-
Houston, Texas, Forenede Stater, 77054
- Bylr Coll Md-Ben Taub Gen Hos
-
Houston, Texas, Forenede Stater, 77084
- Biopharma Informatic
-
McAllen, Texas, Forenede Stater, 78504
- Centex Studies - McAllen
-
Pearland, Texas, Forenede Stater, 77584
- LinQ Research, LLC
-
San Antonio, Texas, Forenede Stater, 78229
- Clinical Trials of Texas, LLC
-
San Antonio, Texas, Forenede Stater, 78215
- Amer. Rrsch Corp-TX Liver Inst
-
Sugar Land, Texas, Forenede Stater, 77479
- Mt Olympus Medical Research, LLC
-
Wichita Falls, Texas, Forenede Stater, 76301
- Digestive Hlth Res of N Texas
-
-
Utah
-
Ogden, Utah, Forenede Stater, 84405
- South Ogden Family Medicine/ CCT Research
-
Riverton, Utah, Forenede Stater, 84065
- Velocity Clinical Research, Riverton
-
Salt Lake City, Utah, Forenede Stater, 84132
- University of Utah
-
-
Virginia
-
Charlottesville, Virginia, Forenede Stater, 22908
- University Of Virginia Hospital
-
Falls Church, Virginia, Forenede Stater, 22042
- Inova Fairfax Medical Campus
-
Norfolk, Virginia, Forenede Stater, 23502
- Digestive and Liver Disease Specialists
-
Richmond, Virginia, Forenede Stater, 23249
- McGuire VA Medical Center
-
Richmond, Virginia, Forenede Stater, 23226
- Bon Secours Richmond Community Hospital LLC
-
Richmond, Virginia, Forenede Stater, 23298
- VCU Health System
-
Roanoke, Virginia, Forenede Stater, 24014
- Gastroent Consult of SW VA
-
-
-
-
-
Angers, Frankrig, 49100
- Centre Hospitalier Universitaire d'Angers
-
Angers, Frankrig, 49100
- Centre Hospitalier Universitaire D'Angers-1
-
Clichy, Frankrig, 92110
- Ap-Hp-Hopital Beaujon
-
Lille, Frankrig, 59000
- Centre Hospitalier Universitaire de Lille-Hopital Claude Huriez
-
Lyon, Frankrig, 69317
- Hospices Civils de Lyon-Hopital de La Croix Rousse
-
Nice, Frankrig, 06200
- Centre Hospitalier Universitaire de Nice-Hopital de L'Archet
-
Paris, Frankrig, 75014
- Ap-Hp-Hopital Cochin
-
Paris, Frankrig, 75013
- APHP-HOPITAL LA PITIE SALPETRIERE_Service Hépato-Gastro-Enterologie
-
Pessac, Frankrig, 33600
- Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque
-
Pierre-Bénite, Frankrig, 69310
- Hospices Civils de Lyon-Hopital Lyon Sud
-
Strasbourg, Frankrig, 67091
- Les Hopitaux Universitaires de Strasbourg-Hopital Civil
-
-
-
-
-
Athens, Grækenland, 11527
- Gen Hospital of Athens Laiko,1st Dpt. of Propaedeutic Inter
-
Athens, Grækenland, 11527
- Gen Hospital of Athens Ippokrateio,B' Uni Clinic of Inte Med
-
Goudi, Athens, Grækenland, 115 27
- General Hospital of Athens "Laiko"
-
Ioannina, Grækenland, 45500
- Univ Gen Hospital of Ioannina,Gastroenterology-Endoscopy Uni
-
Larissa, Grækenland, 41110
- Univ Gen Hospital Larisa, Cardiology Medicine Clinic
-
Thessaloniki, Grækenland, 54642
- General Hospital of Thessaloniki "Ippokrateio"
-
Thessaloniki, Grækenland, 54636
- AHEPA General University Hospital
-
Thessaloniki, Grækenland, 54621
- "AHEPA" University Hospital of Thessaloniki
-
-
-
-
-
Alkmaar, Holland, 1815 JD
- Noordwest Ziekenhuisgroep
-
Amsterdam, Holland, 1105 AZ
- AmsterdamUMC AMC
-
Leiden, Holland, 2333 ZA
- Leids Universitair Medisch Centrum
-
Rotterdam, Holland, 3045 PM
- Franciscus Gasthuis en Vlietland
-
-
-
-
-
New Delhi, Indien, 110025
- Fortis Escort Heart Institute
-
-
Andhra Pradesh
-
Secunderabad, Andhra Pradesh, Indien, 500003
- Yashoda Hospital
-
-
Gujarat
-
Surat, Gujarat, Indien, 395002
- Surat Institute of Digestive Science
-
Surat, Gujarat, Indien, 395009
- BAPS Pramukh Swami Hospital
-
-
Haryana
-
Gurgaon, Haryana, Indien, 122001
- Medanta - The Medicity Multi-Speciality Hospital, Gurugram
-
-
Karnataka
-
Mangalore, Karnataka, Indien, 575001
- Kasturba Medical College Hospitals (KMC Hospitals), Mangalore
-
-
Maharashtra
-
Mumbai, Maharashtra, Indien, 400012
- Seth GS medical college and KEM Hospital
-
Mumbai, Maharashtra, Indien, 400012
- Gleneagles Hospital, Super-speciality and Transplant Centre, Parel
-
Nagpur, Maharashtra, Indien, 441108
- MIDAS Multispeciality Hospital
-
-
New Delhi
-
Delhi, New Delhi, Indien, 110029
- All India Institute of Medical Sciences
-
Ghitorni, New Delhi, Indien, 110070
- Institute of Liver and Biliary Sciences
-
-
Punjab
-
Chandigarh, Punjab, Indien, 160012
- Post Graduate Institute of Medical Education & Research_Chandigarh
-
Ludhiana, Punjab, Indien, 141001
- Dayanand Medical College & Hospital
-
Mohali, Punjab, Indien, 160062
- Fortis Heart Institute and Multispeciality Hospital
-
-
Rajasthan
-
Jaipur, Rajasthan, Indien, 302001
- S.R.Kalla Memorial Gastro & General Hospital
-
Jaipur, Rajasthan, Indien, 302004
- SMS Super speciality Hospital, Department of Gastroenterology
-
-
Telangana
-
Hyderabad, Telangana, Indien, 50082
- Dr P V Rao - Diabetes Research Centre
-
Hyderabad, Telangana, Indien, 500012
- Osmania General Hospital_Hyderabad
-
-
Uttar Pradesh
-
Lucknow, Uttar Pradesh, Indien, 226003
- MV Hospital and Research Centre
-
-
-
-
-
Dublin, Irland, D08 NHY1
- Hepatology St James's
-
Dublin, Irland, D09V2N0
- Beaumont Hospital Hepatology Dept
-
-
-
-
-
Haifa, Israel, 3434104
- Carmel Medical Center Liver Unit
-
Haifa, Israel, 3434104
- Carmel MC - Liver Unit
-
Jerusalem, Israel, 91031
- Shaare Zedek Medical Center
-
Jerusalem, Israel, 91031
- Shaare Zedek MC - Liver Unit
-
Jerusalem, Israel, 91120
- Hadassah Ein Karam MC - Liver Unit
-
Nahariya, Israel, 2210001
- Western Galilee MC - Internal Medicine A
-
Petah Tikva, Israel, 49100
- Liver Institute, Rabin Medical Center, Beilinson Campuse
-
Petah Tikva, Israel, 49100
- Rabin MC Beilinson - Liver Institute
-
Ramat Gan, Israel, 52621
- Sheba MC - Liver Diseases Center
-
Tel Aviv, Israel, 64239
- Sourasky MC - Liver Unit
-
-
-
-
-
Bologna, Italien, 40138
- Azieda Ospedaliero-Universitaria, Policlinico S. Orsola-Malp
-
Florence, Italien, 50134
- AOU Careggi Padiglione 16 San Luca, 3° piano
-
Foggia, Italien, 71122
- Azienda Ospedaliero Universitaria Ospedali Riuniti - Foggia
-
Milan, Italien, 20122
- Osp Magg Policlinico Centro Malattie metaboliche del Fegato
-
Roma, Italien, 00168
- Fondazione Policlinico Universitario Agostino Gemelli IRCS
-
Rome, Italien, 00128
- Policlinico Università Campus Biomedico di Roma
-
Torino, Italien, 10126
- Città della salute e della scienza - university of Torino
-
-
Cz
-
Catanzaro, Cz, Italien, 88100
- Azienda Ospedaliero-Universitaria Renato Dulbecco
-
-
Foggia
-
San Giovanni Rotondo, Foggia, Italien, 71013
- IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo
-
-
Sicily
-
Palermo, Sicily, Italien, 90127
- AOUP Giaccone Palermo
-
-
-
-
-
Bunkyo-ku, Tokyo, Japan, 113-8431
- Juntendo University Hospital, Gastroenterology
-
Bunkyo-ku, Tokyo, Japan, 113-8655
- The University of Tokyo Hospital, Gastroenterology
-
Bunkyo-ku, Tokyo, Japan, 113-8431
- Juntendo University Hospital_Gastroenterology
-
Fukui-shi, Fukui, Japan, 918-8503
- Fukui-ken Saiseikai Hospital, Internal Medicine
-
Fukui-shi, Fukui, Japan, 918-8503
- Fukui-ken Saiseikai Hospital_Internal Medicine
-
Fukushima, Japan, 963-8801
- Hoshi General Hospital_Gastroenterology
-
Gifu, Japan, 500-8513
- Gifu Municipal Hospital_Hepatology
-
Gifu, Japan, 503-8502
- Ogaki Municipal Hospital_Gastroenterology and Hepatology
-
Hamamatsu-shi, Shizuoka, Japan, 431-3192
- Hamamatsu University Hospital_Liver Internal Medicine
-
Hatsukaichi-shi, Hiroshima, Japan, 783-8503
- JA Hiroshima General Hospital_Gastroenterology and Hepatology
-
Hiroshima-shi, Hiroshima, Japan, 730-8619
- Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hosp.
-
Hiroshima-shi, Hiroshima, Japan, 734-8551
- Hiroshima University Hospital
-
Hiroshima-shi, Hiroshima, Japan, 730-8619
- Hiroshima Red Cross & Atomic-b_Hepatology
-
Hiroshima-shi, Hiroshima, Japan, 734-8551
- Hiroshima University Hospital_Department of Gastro.&Metabo.
-
Izunokuni-shi, Shizuoka, Japan, 410-2295
- Juntendo University Shizuoka Hospital
-
Izunokuni-shi, Shizuoka, Japan, 410-2295
- Juntendo University Shizuoka Hospital_Gastroenterology & Hepatology
-
Kagoshima-shi, Kagoshima, Japan, 890-8520
- Kagoshima University Hospital, Gastroenterology
-
Kagoshima-shi, Kagoshima, Japan, 890-8520
- Kagoshima University Hospital_Gastroenterology
-
Kamigyo-ku, Kyoto, Japan, 602-8566
- University Hospital Kyoto Prefectual University of Medicine
-
Kanazawa-shi, Ishikawa, Japan, 920-8641
- Kanazawa University Hospital
-
Kanazawa-shi, Ishikawa, Japan, 920-8641
- Kanazawa University Hospital_Gastroenterology
-
Kashihara-shi, Nara, Japan, 634-8522
- Nara Medical University Hospital_Kashihara-shi, Nara
-
Kashihara-shi, Nara, Japan, 634-8522
- Nara Medical University Hospital_Department of Gastro.& Metabo.
-
Kawasaki-shi, Kanagawa, Japan, 216-8511
- St. Marianna University School of Medicine Hospital
-
Kumamoto-shi, Kumamoto, Japan, 862-8655
- Kumamoto Shinto General Hospital_Liver・Gastroenterology
-
Minato-ku, Tokyo, Japan, 105-8470
- Toranomon Hospital, Hepatology
-
Musashino-shi, Tokyo, Japan, 180-8610
- Japanese Red Cross Musashino Hospital
-
Musashino-shi, Tokyo, Japan, 180-8610
- Japanese Red Cross Musashino Hospital_Gastroenterology
-
Nagakute-shi, Aichi, Japan, 480-1195
- Aichi Medical University Hospital
-
Nagakute-shi, Aichi, Japan, 480-1195
- Aichi Medical University Hospital_Hepatology and pancreology
-
Nakagamigun, Okinawa, Japan, 901-2492
- Heartlife Hospital_Liver internal medicine
-
Nara-shi, Nara, Japan, 630-8305
- Nara City Hospital, Gastroenterology and Hepatology
-
Nishinomiya-shi, Hyogo, Japan, 663-8501
- Hyogo Medical University Hospital_Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine
-
Oita-shi, Oita, Japan, 870-0837
- Oita Cardiovascular Hospital_Gastroenterology
-
Okayama-shi, Okayama, Japan, 700-8505
- Kawasaki Medical School General Medical Center
-
Okayama-shi, Okayama, Japan, 700-8505
- Kawasaki Medical School General Medical Center_Internal Medicine
-
Osaka, Japan, 591-8025
- Japan Organization of Occupational Health and Safety Osaka Rosai Hospital_Gastroenterology
-
Osaka-shi, Osaka, Japan, 545-8586
- Osaka Metropolitan University Hospital, Department of Hepatology
-
Osaka-shi, Osaka, Japan, 545-8586
- Osaka Metropolitan University Hospital_Department of Hepatology
-
Otsu-shi, Shiga, Japan, 520-0804
- Otsu City Hospital, Gastroenterological Medicine
-
Saga-shi, Saga, Japan, 849-8501
- Saga University Hospital_Liver Center
-
Sapporo-shi, Hokkaido, Japan, 062-8618
- Japan Community Health Care Organization Hokkaido Hospital
-
Sapporo-shi, Hokkaido, Japan, 062-8618
- JCHO Hokkaido Hospital_Digestive Disease Center
-
Sendai-shi, Miyagi, Japan, 981-0914
- Sendai Kousei Hospital
-
Sendai-shi, Miyagi, Japan, 981-0914
- Sendai Kousei Hospital_Liver Internal Medicine
-
Shinjuku-ku, Tokyo, Japan, 162-8666
- Tokyo Women's Medical University Hospital
-
Suita-shi, Osaka, Japan, 564-0013
- Saiseikai Suita Hospital, Gastroenterology
-
Suita-shi, Osaka, Japan, 565-0871
- Osaka University Hospital_Department of Gastro. & Hepato
-
Takamatsu-shi, Kagawa, Japan, 760-8557
- Kagawa Prefectural Central Hospital
-
Takamatsu-shi, Kagawa, Japan, 760-8557
- Kagawa Prefectural Central Hospital_Liver internal medicine
-
Takasaki-shi, Gunma, Japan, 370-0829
- National Hospital Organization Takasaki General Medical Ctr._Gastroenterology
-
Tokyo, Japan, 173-8610
- Nihon University Itabashi Hospital
-
Tokyo, Japan, 173-8610
- Nihon University Itabashi Hospital_Division of Gastro.&Hepa.
-
Toon-shi, Ehime, Japan, 791-0295
- Ehime University Hospital
-
Toon-shi, Ehime, Japan, 791-0295
- Ehime University Hospital_Department of Gastro.& Metabo.
-
Wakayama-shi, Wakayama, Japan, 640-8158
- Saiseikai Wakayama Hospital
-
Wakayama-shi, Wakayama, Japan, 640-8158
- Saiseikai Wakayama Hospital_Gastroenterology
-
Yokohama-shi, Kanagawa, Japan, 236-0004
- Yokohama City University Hospital_Gastrointestinal Medicine
-
-
-
-
-
Hangzhou, Kina, 310030
- Zhejiang Hospital-Infectious Diseases
-
Shenzhen, Kina, 518112
- The Third People's Hospital of Shenzhen
-
Tianjin, Kina, 300211
- Tianjin Second People's Hospital-Liver Disease Department III
-
-
Beijing Municipality
-
Beijing, Beijing Municipality, Kina, 100050
- Beijing Friendship Hospital, Capital Medical University-Endocrinology
-
Beijing, Beijing Municipality, Kina, 100015
- Beijing Ditan Hospital Capital Medical University-Hepatology
-
Beijing, Beijing Municipality, Kina, 100034
- Peking University People's Hospital-(White Pagoda Temple Area) - Hepatopathy
-
Beijing, Beijing Municipality, Kina, 100069
- Beijing You'an Hospital, Capital Medical University-Hepatology center
-
Beijing, Beijing Municipality, Kina, 102218
- Beijing Tsinghua Changgung Hospital-Hepatology
-
-
Chongqing Municipality
-
Chongqing, Chongqing Municipality, Kina, 404140
- Chongqing University Three Gorges Hospital-Hepatology
-
-
Guangdong
-
Foshan, Guangdong, Kina, 528000
- The First People's Hospital of Foshan-Infectious Disease
-
Guangzhou, Guangdong, Kina, 510080
- The First Affiliated Hospital, Sun Yat-sen University
-
Guangzhou, Guangdong, Kina, 510180
- Guangzhou First People's Hospital-Gastroenterology
-
Guangzhou, Guangdong, Kina, 510515
- Nanfang Hospital, Southern Medical University-Infectious Diseases
-
Guangzhou, Guangdong, Kina, 510650
- The Third Affiliated Hospital, Sun Yat-sen University-Infectious
-
Guangzhou, Guangdong, Kina, 510060
- Guangzhou Eighth People's Hospital, Guangzhou Medical University-Hepatology
-
Shenzhen, Guangdong, Kina, 518036
- Peking University Shenzhen Hospital
-
Shenzhen, Guangdong, Kina, 518112
- The Third People's Hospital of Shenzhen-Hepatology
-
-
Hebei
-
Shijiazhuang, Hebei, Kina, 050051
- The Third Hospital of Hebei Medical University-Hepatology
-
-
Hunan
-
Changsha, Hunan, Kina, 410005
- Hunan Provincial People's Hospital
-
Changsha, Hunan, Kina, 410005
- Hunan Provincial People's Hospital-Hepatology
-
-
Jiangsu
-
Changzhou, Jiangsu, Kina, 213003
- Changzhou No.2 People's Hospital
-
Nanjing, Jiangsu, Kina, 210003
- The Second Affiliated Hospital of Nanjing Medical University-Hepatology
-
Xuzhou, Jiangsu, Kina, 221011
- The Affiliated Hospital of Xuzhou Medical University (East) - Infectious Diseases
-
Zhenjiang, Jiangsu, Kina, 212021
- The Third People's Hospital of Zhenjiang-Hepatology
-
-
Jiangxi
-
Nanchang, Jiangxi, Kina, 330006
- The First Affiliated Hospital of Nanchang University
-
-
Jilin
-
Changchun, Jilin, Kina, 130021
- The First Bethune Hospital of Jilin University-Hepatic Biliary Pancreatic Medicine
-
-
Ningxia
-
Yinchuan, Ningxia, Kina, 750004
- General Hosp of Ningxia Medical University,Infectious Depart
-
-
Shandong
-
Jinan, Shandong, Kina, 250013
- Jinan Central Hospital
-
Liaocheng, Shandong, Kina, 252000
- Liaocheng People's Hospital
-
Liaocheng, Shandong, Kina, 252000
- Liaocheng People's Hospital-Infectious Diseases
-
Qingdao, Shandong, Kina, 266011
- Qingdao Municipal Hospital (Group)-Infectious Diseases
-
-
Shanghai Municipality
-
Shanghai, Shanghai Municipality, Kina, 200001
- Shanghai Jiao Tong University School of Medicine Renji Hospital-Gastroenterology
-
Shanghai, Shanghai Municipality, Kina, 200025
- Ruijin Hospital Affiliate to The Shanghai Jiaotong University-Infectious Diseases
-
Shanghai, Shanghai Municipality, Kina, 200025
- Ruijin Hospital Affiliate to The Shanghai Jiaotong Universit
-
Shanghai, Shanghai Municipality, Kina, 201999
- Shanghai Ninth People's Hospital-Infection Disease
-
Shanghai, Shanghai Municipality, Kina, 201999
- Shanghai Ninth People's Hospital
-
-
Sichuan
-
Chengdu, Sichuan, Kina, 610044
- West China Hospital Sichuan University-Infectious Diseases
-
-
Tianjin Municipality
-
Tianjin, Tianjin Municipality, Kina, 300170
- Tianjin Third Central Hospital-Gastroenterology
-
Tianjin, Tianjin Municipality, Kina, 300211
- Tianjin Second People's Hospital-Liver Disease Department III
-
-
Zhejiang
-
Hangzhou, Zhejiang, Kina, 310030
- Zhejiang Hospital-Infectious Diseases
-
Wenzhou, Zhejiang, Kina, 325000
- The First Affiliated Hospital of WMU
-
-
-
-
-
Osijek, Kroatien, 31 000
- Klinički bolnički centar Osijek
-
Osijek, Kroatien, 31 000
- Klinicki bolnicki centar Osijek_Endocrinology
-
Rijeka, Kroatien, 51000
- KBC Rijeka, Zavod za gastroenterologiju
-
Split, Kroatien, 21000
- KBC Split/ Firule/ Gastroenterologija
-
Split, Kroatien, 21000
- KBC Split_Gastroenterology
-
Zagreb, Kroatien, 10000
- KB Dubrava, Zavod za gastroenterologiju
-
Zagreb, Kroatien, 10000
- Klinički bolnički centar Zagreb, Zavod za gastroenterologiju
-
-
-
-
-
Batu Caves, Malaysia, 68100
- Hospital Selayang
-
-
Kelantan
-
Kota Bharu, Kelantan, Malaysia, 16150
- Hospital Universiti Sains Malaysia
-
-
Kuala Lumpur
-
Kuala Lumpur, Kuala Lumpur, Malaysia, 59100
- University Malaya Medical Centre
-
Lembah Pantai, Kuala Lumpur, Malaysia, 59100
- University Malaya Medical Centre
-
-
-
-
-
México, Mexico, 03330
- Centro de Investigación y Gastroenterología_ Hospital Angeles Universidad
-
-
Guerrero
-
Acapulco de Juárez, Guerrero, Mexico, 39670
- Centro de Investigacion Clinica del Pacifico, S.A. de C.V.
-
-
Jalisco
-
Guadalajara, Jalisco, Mexico, 44130
- Centro de Investigación Médico Biológica y Terapia
-
-
México, D.F.
-
Mexico City, México, D.F., Mexico, 06700
- Centro de Investigacion y Gastroenterologia, S.C.
-
-
Nuevo León
-
Monterrey, Nuevo León, Mexico, 64000
- Investigaciones Médicas Cisneros, S.C.
-
San Pedro Garza García, Nuevo León, Mexico, 66220
- Servicios de Oncologia Medica Integral S.A de C.V (ONCARE)
-
-
Sinaloa
-
Culiacán, Sinaloa, Mexico, 80020
- Hospital Angeles de Culiacan
-
-
Yucatán
-
Mérida, Yucatán, Mexico, 97070
- Medical Care and Research S. A de C.V
-
-
-
-
-
Gjettum, Norge, 1346
- Bærum sykehus
-
Gjettum, Norge, 1346
- Bærum sykehus - Vestre Viken HF
-
Oslo, Norge, 0450
- Oslo universitetssykehus, Ullevål
-
-
-
-
-
Bydgoszcz, Polen, 85-676
- Gizinscy Centrum Medyczne
-
Warsaw, Polen, 03-712
- Bodyclinic
-
Wroclaw, Polen, 51-162
- Centrum Badan Klinicznych
-
Wroclaw, Polen, 53-673
- FutureMeds Sp. z o.o.
-
-
Lesser Poland Voivodeship
-
Myslowice, Lesser Poland Voivodeship, Polen, 41-400
- ID Clinic Arkadiusz Pisula
-
-
Świętokrzyskie Voivodeship
-
Staszów, Świętokrzyskie Voivodeship, Polen, 28-200
- Velocity Nova Sp. z o.o.
-
Staszów, Świętokrzyskie Voivodeship, Polen, 28-200
- KO-MED Centra Kliniczne Staszow
-
-
-
-
-
Almada, Portugal, 2805-267
- Hospital Garcia de Orta
-
Almada, Portugal, 2805-267
- ULS De Almada-Seixal E.P.E. - Hospital Garcia de Orta
-
Aveiro, Portugal, 3814-501
- ULS Da Regiao De Aveiro E.P.E. - Hospital Infante D. Pedro
-
Braga, Portugal, 4710-243
- ULS De Braga, E.P.E. - Hospital de Braga
-
Guarda, Portugal, 6301-858
- ULS Da Guarda E.P.E. - Hospital Sousa Martins
-
Guimarães, Portugal, 4835-044
- ULS Do Alto Ave, E.P.E. - Hospital Senhora da Oliveira - Guimarães
-
Lisbon, Portugal, 1250-189
- APDP - Associação Protectora dos Diabéticos de Portugal
-
Lisbon, Portugal, 1649-035
- Unidade Local De Saúde De Santa Maria E.P.E.
-
Porto, Portugal, 4200-319
- ULS De São João, E.P.E. - Hospital de São João
-
Porto, Portugal, 4099-001
- ULS De Santo António, E.P.E. - Hospital de Santo António
-
Viana do Castelo, Portugal, 4904-858
- ULS Do Alto Minho E.P.E. - Hospital de Santa Luzia
-
Vila Nova de Gaia, Portugal, 4400-346
- Hospital da Luz Arrabida, S.A.
-
Vila Nova de Gaia, Portugal, 4434-502
- ULS De Gaia/Espinho E.P.E. - Hospital Eduardo Santos Silva
-
Vila Real, Portugal, 5000-508
- ULS De Tras-Os-Montes E Alto Douro E.P.E. - Unidade Hospitalar de Vila Real
-
-
Matosinhos
-
Senhora Da Hora, Matosinhos, Matosinhos, Portugal, 4464-513
- ULS De Matosinhos E.P.E.- Hospital Pedro Hispano
-
-
-
-
-
San Juan, Puerto Rico, 00927
- FDI Clinical Research
-
-
-
-
-
Bucharest, Rumænien, 022328
- Institutul Clinic Fundeni
-
Bucharest, Rumænien, 050098
- Spitalul Universitar de Urgență București
-
Bucharest, Rumænien, 011025
- Sana Monitoring SRL
-
Bucharest, Rumænien, 011053
- Hightech Medical Services S.R.L.
-
Cluj-Napoca, Rumænien, 400015
- Spitalul Clinic CF Cluj Napoca
-
Cluj-Napoca, Rumænien, 400162
- Institutul Gastroenterologie-Hepatologie Cluj-Napoca
-
Constanța, Rumænien, 900591
- Gastroenterologie Spitalul Judetean Constanta
-
Galati, Rumænien, 800291
- SC Diamed Obesity SRL
-
Iași, Rumænien, 700506
- Gastromedica
-
Satu Mare, Rumænien, 440055
- Spital Judetean de Urgenta Satu Mare
-
-
-
-
-
Arkhangelsk, Rusland, 163001
- Volosevich First City Clinical Hospital
-
Barnaul, Rusland, 656045
- City Hospital #5
-
Kazan', Rusland, 420111
- LLC "Clinic of Aesthetic Medicine & Laser Technologies"
-
Kazan', Rusland, 420097
- Kazan Federal University
-
Moscow, Rusland, 119435
- Setchenov First Moscow State Medical University
-
Moscow, Rusland, 117292
- Friendship University of Russia
-
Moscow, Rusland, 125367
- PHI "Central Clinical Hospital RZD- Medicine"
-
Novosibirsk, Rusland, 630099
- Limited Law Company "Healthy Family" Medicine Center"
-
Penza, Rusland, 440026
- Penza Regional Clinical Hospital named after N.N. Burdenko
-
Saint Petersburg, Rusland, 197110
- Consultative & Diagnostic Center with a Outpatient Hospital
-
Saint Petersburg, Rusland, 190013
- Joint Stock Company "Polyclinic Complex"
-
Saint Petersburg, Rusland, 194156
- Limited Liability Company "Energiya Zdoroviya"
-
Saint Petersburg, Rusland, 195067
- North-Western State Medical Univer. based on Med-Prof Center
-
Saint Petersburg, Rusland, 192283
- SPb SBHI City Outpatient clinic #109
-
Tomsk, Rusland, 634050
- Siberian State Medical University
-
Ulyanovsk, Rusland, 432063
- Ulianovsk Regional Clinical Hospital
-
Yoshkar-Ola, Rusland, 424004
- Polyclinic #2 in Yoshkar-Ola
-
-
-
-
-
Bern, Schweiz, 3010
- Universitätsklinik für Viszerale Chirurgie und Medizin
-
Geneva, Schweiz, 1211
- Hôpitaux Universitaires de Genève
-
Olten, Schweiz, 4600
- Kantonsspital Olten
-
Sankt Gallen, Schweiz, 9007
- Kantonsspital St. Gallen
-
Zurich, Schweiz, 8091
- USZ Klinik für Gastroenterologie und Hepatologie
-
-
-
-
-
Belgrade, Serbien, 11000
- Clinic for gastroenterology and hepatology
-
Belgrade, Serbien, 11000
- Endocrinology, Diabetes and Metabolism Diseases Clinic
-
Belgrade, Serbien, 11020
- Clinical-hospital centre Zvezdara
-
-
Vojvodina
-
Novi Sad, Vojvodina, Serbien, 21000
- Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
-
-
-
-
-
Singapore, Singapore, 169608
- Singapore General Hospital
-
Singapore, Singapore, 529889
- Changi General Hospital
-
Singapore, Singapore, 119228
- National University Hospital Singapore_Tahir Building
-
Singapore, Singapore, 119228
- National University Hospital_Tahir Building
-
Singapore, Singapore, 529905
- Changi General Hospital
-
-
-
-
-
Bratislava, Slovakiet, 851 01
- MEDISPEKTRUM s.r.o.
-
Bratislava, Slovakiet, 833 05
- Nemocnica akademika L. Derera, UNB
-
Košice, Slovakiet, 040 11
- II. Interna klinika, Univerzitna nemocnica L. Pasteura Kosice
-
Michalovce, Slovakiet, 071 01
- Hepatobiliarne centrum - Michalovce
-
Trnava, Slovakiet, 91701
- JAL s.r.o.
-
-
-
-
-
Barcelona, Spanien, 08035
- Hospital Vall d'Hebron
-
Majadahonda, Spanien, 28222
- Hospital Universitario Puerta de Hierro Majadahonda
-
Pontevedra, Spanien, 36004
- Complejo Hospitalario de Pontevedra - Hospital de Montecelo
-
Santander, Spanien, 39008
- Hospital Universitario Marques de Valdecilla
-
Seville, Spanien, 41013
- Hospital Universitario Virgen del Rocio
-
Valencia, Spanien, 46026
- Hospital Universitario y Politécnico La Fe
-
Valencia, Spanien, 46014
- Hospital General de Valencia
-
Valladolid, Spanien, 47010
- Hospital Clínico de Valladolid
-
-
Galicia
-
Pontevedra, Galicia, Spanien, 36004
- Complejo Hospitalario de Pontevedra - Hospital de Montecelo
-
-
-
-
-
Johannesburg, Sydafrika, 2193
- Wits Health Consortium
-
-
Eastern Cape
-
Port Elizabeth, Eastern Cape, Sydafrika, 6001
- Phoenix Pharma
-
-
Gauteng
-
Johannesburg, Gauteng, Sydafrika, 2193
- Wits Clinical Research
-
Johannesburg, Gauteng, Sydafrika, 2013
- Chris Hani Baragwanath Hospital
-
Lenasia, Gauteng, Sydafrika, 1827
- Lenasia Clinical Trial Centre
-
-
KwaZulu-Natal
-
Durban, KwaZulu-Natal, Sydafrika, 4001
- Maxwell Centre
-
Durban, KwaZulu-Natal, Sydafrika, 4901
- Lenmed Shifa Private Hospital
-
-
Western Cape
-
Cape Town, Western Cape, Sydafrika, 7530
- Tiervlei Trial Centre
-
Cape Town, Western Cape, Sydafrika, 7800
- Dr Rajabally's Practice
-
-
-
-
-
Daegu, Sydkorea, 42601
- Keimyung University Dongsan Hospital
-
Daegu, Sydkorea, 41944
- Kyungpook National University Hospital
-
Daegu, Sydkorea, 42415
- Yeungnam Univ. Medical Center
-
Gangwon-do, Sydkorea, 26426
- Wonju Severance Christian Hospital
-
Gyeonggi-do, Sydkorea, 14584
- Soon Chun Hyang University Hospital Bucheon
-
Seoul, Sydkorea, 03722
- Severance Hospital, Yonsei University Health System
-
Seoul, Sydkorea, 08308
- Korea University Guro Hospital
-
Seoul, Sydkorea, 06973
- Chung-Ang University Hospital
-
Seoul, Sydkorea, 07061
- SMG-SNU Boramae Medical Center
-
-
-
-
-
Chiayi City, Taiwan, 600
- Ditmanson Medical Foundation Chia-Yi Christian Hospital
-
Kaohsiung City, Taiwan, 807
- Kaohsiung Medical University Chung-Ho Memorial Hospital
-
New Taipei City, Taiwan, 231
- Taipei Tzu Chi Hospital
-
Taichung, Taiwan, 404
- China Medical University Hospital
-
Tainan, Taiwan, 704
- National Cheng Kung University Hospital
-
Taipei, Taiwan, 110
- Taipei Medical University Hospital
-
Taipei, Taiwan, 106
- Cathay General Hospital
-
Taipei, Taiwan, 104
- Taipei Mackay Memorial Hospital
-
Taipei, Taiwan, 100
- National Taiwan University Hospital_main
-
Taipei, Taiwan, 112
- Taipei-Veterans General Hospital - Dept of Gastrointestinal
-
-
-
-
-
Liberec, Tjekkiet, 460 01
- Krajská nemocice Liberec, a.s
-
Pilsen, Tjekkiet, 301 00
- Researchsite s.r.o.
-
Prague, Tjekkiet, 128 08
- Vseobecna Fakultni Nemocnice V Praze
-
-
-
-
-
Adana, Tyrkiet (Türkiye), 01000
- T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan
-
Ankara, Tyrkiet (Türkiye), 06230
- Hacettepe Universitesi Tıp Fakültesi- Gastroenteroloji
-
Ankara, Tyrkiet (Türkiye), 06590
- Ankara Universitesi Tıp Fakultesi Gastroenteroloji Bilim Da
-
Ankara, Tyrkiet (Türkiye), 06800
- Ankara Sehir Hastanesi,Gastroenteroloji Klinigi
-
Ankara, Tyrkiet (Türkiye), 06590
- Ankara Üniversitesi Tıp Fakültesi Cebeci Araştırma Ve Uygulama Hastanesi-Gastroenteroloji
-
Ankara, Tyrkiet (Türkiye), 06800
- Ankara Bilkent Şehir Hastanesi-Gastroenteroloji
-
Bursa, Tyrkiet (Türkiye), 16059
- Uludag Universitesi Tıp Fakultesi-Gastroenteroloji
-
Bursa, Tyrkiet (Türkiye), 16059
- Bursa Uludağ Üniversitesi Hastanesi-Gastroenteroloji
-
Istanbul, Tyrkiet (Türkiye), 34010
- Koc Universitesi Hastanesi-Gastroenteroloji
-
Istanbul, Tyrkiet (Türkiye), 34093
- Bezmialem Vakıf Üniversitesi Hastanesi-Gastroenteroloji
-
Istanbul, Tyrkiet (Türkiye), 34093
- Istanbul Universitesi Istanbul Tip Fakultesi-Gastroenterolog
-
Istanbul, Tyrkiet (Türkiye), 34764
- Umraniye Egitim ve Arastirma Hastanesi, Gastroenteroloji
-
Istanbul, Tyrkiet (Türkiye), 34899
- Marmara Üniversitesi Pendik EAH- Gastroenteroloji
-
Izmir, Tyrkiet (Türkiye), 35100
- Ege Universitesi Tip Fakultesi Hastanesi, Gastroenteroloji
-
Kocaeli, Tyrkiet (Türkiye), 41000
- Kocaeli Üniversitesi Hastanesi - Gastroenteroloji
-
Mersin, Tyrkiet (Türkiye), 33343
- Mersin Universitesi Tip Fakultesi Gastroenteroloji Bilim Dal
-
Mersin, Tyrkiet (Türkiye), 33343
- Mersin Üniversitesi Tip Fakültesi Hastanesi -Gastroenteroloji
-
Yüreğir/Adana, Tyrkiet (Türkiye), 1370
- Adana Şehir Eğitim ve Araştırma Hastanesi-Endokrinoloji
-
-
-
-
-
Berlin, Tyskland, 10825
- Gastro am Bayerischen Platz - Hofmann W.-P.n
-
Berlin, Tyskland, 13353
- Charité - Campus Virchow-Klinikum - Med. Klinik für Hepatologie und Gastroenterologie
-
Bochum, Tyskland, 44892
- Uniklinik Knappschaftskrankenhaus Bochum GmbH - Med. Klinik - Gastroenterologie & Hepatologie
-
Bonn, Tyskland, 53127
- Universitätsklinikum Bonn - Med. Klinik und Poliklinik I
-
Frankfurt, Tyskland, 60590
- Uniklinik FFM - Hepatologie
-
Hanover, Tyskland, 30625
- Medizinische Hochschule Hannover - Gastroentero-, Hepato-, Endokrinologie
-
Leipzig, Tyskland, 04103
- Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH
-
Leipzig, Tyskland, 04103
- Universitätsklinikum Leipzig - Klinik und Poliklinik für Onkologie, Gastroenterologie, Hepatologie und Pneumologie
-
Lübeck, Tyskland, 23538
- Uniklinik Schleswig-Holstein - Medizinischen Klinik I am Campus Lübeck
-
Magdeburg, Tyskland, 39120
- Uniklinik Otto Von Guericke Magdeburg - Gastroenterologie, Hepatologie and Infektiologie
-
Mainz, Tyskland, 55131
- Universitätsmedizin der JGU Mainz - Hepatologie
-
Mannheim, Tyskland, 68167
- Universitätsmedizin Mannheim - II. Medizinische Klinik
-
Würzburg, Tyskland, 97080
- Universitätsklinikum Würzburg - Zentrum für Innere Medizin (ZIM)
-
-
-
-
-
Graz, Østrig, 8036
- Klin.Abt. f. Gastroenterologie u. Hepatologie
-
Saint Stefan, Østrig, 8511
- Fließer-Görzer [Ordination]
-
Salzburg, Østrig, 5020
- LKH Salzburg Universitätsklinikum
-
Vienna, Østrig, 1030
- Klinik Landstraße
-
Wels, Østrig, 4600
- Klinikum Wels-Grieskirchen
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Beskrivelse
Inklusionskriterier:
- Alder over eller lig med 18 år på tidspunktet for underskrivelse af informeret samtykke.
- Histologiske beviser for NASH baseret på en central patologevaluering af baseline-leverbiopsien. Baseline-leverbiopsien kan være en historisk biopsi opnået inden for 180 dage før screeningsbesøget (V1).
- Histologiske beviser for fibrose trin 2 eller trin 3 i henhold til NASH CRN (Clinical Research Network) klassifikationen baseret på en central patologevaluering af baseline leverbiopsi.
- En histologisk NAS (Non-alcoholic fatty lever disease Activity Score) over eller lig med 4 med en score på 1 eller mere i steatose, lobulær inflammation og hepatocytballondannelse baseret på en central patologevaluering af baseline-leverbiopsien.
Ekskluderingskriterier:
- Dokumenterede årsager til kronisk leversygdom bortset fra ikke-alkoholisk fedtleversygdom (NAFLD)
- Positivt HBsAg, positivt anti-HIV, positivt HCV RNA ved screening (V2A) eller enhver kendt tilstedeværelse af HCV RNA eller HBsAg inden for 2 år efter screening (V2A).
- Tilstedeværelse eller historie af ascites, varicealblødning, hepatisk encefalopati, spontan bakteriel peritonitis eller levertransplantation ved randomisering.
- Kendt eller mistænkt overdreven indtagelse af alkohol (større end 20 g/dag for kvinder eller mere end 30 g/dag for mænd) eller alkoholafhængighed (vurderet af Alcohol Use Disorders Identification Test (AUDIT-spørgeskema)).
- Behandling med E-vitamin (ved doser større end eller lig med 800 IE/dag) eller pioglitazon eller medicin godkendt til behandling af NASH, som ikke har været i en stabil dosis i perioden fra 90 dage før screeningsbesøget (V2A). For forsøgspersoner med historiske leverbiopsier taget mere end 90 dage før screening, bør behandlingen desuden være i en stabil dosis fra tidspunktet for biopsien til screeningen.
- Behandling med GLP-1 RA i perioden fra 90 dage før screeningsbesøget (V2A). For forsøgspersoner med historiske leverbiopsier taget mere end 90 dage før screening, enhver behandling med GLP-1 RA'er fra tidspunktet for biopsi til screening (V2A).
- Behandling med glukosesænkende midler (bortset fra GLP-1 RA'er), lipidsænkende medicin eller vægttabsmedicin ikke stabil efter investigator i perioden fra 90 dage før screeningsbesøget (V2A). For forsøgspersoner med historiske leverbiopsier taget mere end 90 dage før screening, bør behandlingen desuden være i en stabil dosis efter investigator fra tidspunktet for biopsi til screening.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Dobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Semaglutid OW (en gang om ugen)
Semaglutid administreret subkutant én gang om ugen
|
Semaglutid administreret subkutant (under huden) en gang om ugen vil der være en periode med dosiseskalering, før måldosis nås.
|
|
Placebo komparator: Placebo
Placebo administreret subkutant én gang om ugen
|
Placebo administreret subkutant (under huden) en gang om ugen.
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Del 1: Opløsning af steatohepatitis og ingen forværring af leverfibrose (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
Del 1: Forbedring af leverfibrose og ingen forværring af steatohepatitis (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
Del 2: Cirrhose-fri overlevelse (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 240
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 240
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Ændring i kropsvægt
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Procent
|
Fra randomisering (uge 0) til uge 72
|
|
Ændring i SF-36 (kort form 36) kropslig smerte
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Score point
|
Fra randomisering (uge 0) til uge 72
|
|
Ændring i kropsvægt
Tidsramme: Fra randomisering (uge 0) til uge 240
|
Procent
|
Fra randomisering (uge 0) til uge 240
|
|
Ændring i histologi-vurderet leverkollagen proportionalt areal
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Forhold til baseline
|
Fra randomisering (uge 0) til uge 72
|
|
Opløsning af steatohepatitis og forbedring af leverfibrose (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
Forbedring af steatohepatitis med mindst en 2-punkts reduktion i NAS og ingen forværring af fibrose (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
Forværring af steatohepatitis (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
Forbedring i histologi-vurderet ballonflyvning (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
Forbedring af histologi-vurderet inflammation (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
Forbedring af histologi-vurderet steatose (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
NASH-opløsning (ballondannelse på 0, betændelse på 0-1) og over eller lig med 2-punkts NAS-reduktion uden forværring af fibrose
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
Progression af leverfibrose hos patienter med F2 ved baseline (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
Progression af leverfibrose
Tidsramme: Fra randomisering (uge 0) til uge 72
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 72
|
|
Opløsning af steatohepatitis og ingen forværring af leverfibrose (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 240
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 240
|
|
Forbedring af leverfibrose og ingen forværring af steatohepatitis (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 240
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 240
|
|
Ændringer i leverstivhedsværdier vurderet ved forbigående elastografi (FibroScan®)
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Forhold til baseline
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i ELF (Enhanced Liver Fibrosis) score
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Logaritme
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i ALT (alanin aminotransferase)
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Forhold til baseline
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i AST (aspartataminotransferase)
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Forhold til baseline
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i CAP-værdier (Controlled Attenuation Parameter) vurderet ved transient elastografi (FibroScan)
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Absolut forandring
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i FAST (FibroScan-AST) score
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Sandsynlighed (absolut ændring)
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i Pro-C3 (pro-peptid af type III kollagen)
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Logaritme
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i inflammation vurderet af hsCRP (High Sensitive C-Reactive Protein)
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Forhold til baseline
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i HbA1c (glykeret hæmoglobin)
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Procentpoint (absolut ændring)
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i triglycerid
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Forhold til baseline
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i frie fedtsyrer
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Forhold til baseline
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i LDL (low-density lipoprotein) kolesterol
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Forhold til baseline
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i HDL (High density lipoprotein) kolesterol
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Forhold til baseline
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Tid til første MACE (Major Adverse Cardiovascular Event) (sammensat endepunkt)
Tidsramme: Fra randomisering (uge 0) til uge 240
|
Dage
|
Fra randomisering (uge 0) til uge 240
|
|
Større kardio-hepatisk begivenhedsfri overlevelse (Ja/Nej)
Tidsramme: Fra randomisering (uge 0) til uge 240
|
Optælling af emne
|
Fra randomisering (uge 0) til uge 240
|
|
Ændringer i SF-36 (Short Form 36 v2.0 akut) Oversigt over fysiske komponenter
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Score point
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændringer i SF-36 Mental Component Summary
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Score point
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Ændring i SF-36 kropslig smerte
Tidsramme: Fra randomisering (uge 0) til uge 240
|
Score point
|
Fra randomisering (uge 0) til uge 240
|
|
Ændringer i NASH-CHECK Mavesmerter
Tidsramme: Fra randomisering (uge 0) til uge 72 og uge 240
|
Score point
|
Fra randomisering (uge 0) til uge 72 og uge 240
|
|
Fravær af histologisk bevis for NASH (ja/nej)
Tidsramme: Fra randomisering (uge 0) til uge 240
|
Tælling af emne
|
Fra randomisering (uge 0) til uge 240
|
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Studieleder: Clinical Transparency (dept. 2834), Novo Nordisk A/S
Publikationer og nyttige links
Generelle publikationer
- Newsome PN, Sanyal AJ, Engebretsen KA, Kliers I, Ostergaard L, Vanni D, Bugianesi E, Rinella ME, Roden M, Ratziu V. Semaglutide 2.4 mg in Participants With Metabolic Dysfunction-Associated Steatohepatitis: Baseline Characteristics and Design of the Phase 3 ESSENCE Trial. Aliment Pharmacol Ther. 2024 Dec;60(11-12):1525-1533. doi: 10.1111/apt.18331. Epub 2024 Oct 16.
- Sanyal AJ, Newsome PN, Kliers I, Ostergaard LH, Long MT, Kjaer MS, Cali AMG, Bugianesi E, Rinella ME, Roden M, Ratziu V; ESSENCE Study Group. Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis. N Engl J Med. 2025 Jun 5;392(21):2089-2099. doi: 10.1056/NEJMoa2413258. Epub 2025 Apr 30.
- Rowe IA, Allen AM. Hepatic steatosis provides the terroir that promotes the development of cardiovascular risk factors and disease. Hepatology. 2023 Jun 1;77(6):1843-1845. doi: 10.1097/HEP.0000000000000327. Epub 2023 Feb 6. No abstract available.
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- NN9931-4553
- U1111-1244-3678 (Anden identifikator: World Health Organization (WHO))
- 2019-004594-44 (Registry Identifier: European Medicines Agency (EudraCT))
- jRCT2031210033 (Registry Identifier: JAPIC)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
IPD-planbeskrivelse
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Studerer et amerikansk FDA-reguleret enhedsprodukt
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Ikke-alkoholisk Steatohepatitis
-
Tasly Biopharmaceuticals Co., Ltd.RekrutteringNAFLD (Non-alcoholic Fatty Lever Disease) | NASH (nonalkoholisk Steatohepatitis)Kina
-
Jeffrey BrowningNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)AfsluttetSund og rask | NASH (Ikke-alkoholisk Steatohepatitis) | NAFLD (Non-Alcoholic Fatty Lever Disease)Forenede Stater
-
Hinova Pharmaceuticals Inc.RekrutteringNAFLD (Non-alcoholic Fatty Lever Disease)Kina
-
University of SevilleAfsluttetNAFLD, Non-alcoholic Fatty Lever DiseaseSpanien
-
Ornit CohenProf Doron ZamirUkendtNAFLD - Non Alcoholic Fatty Lever DiseaseIsrael
-
Tel-Aviv Sourasky Medical CenterAfsluttetModstandstræning | NAFLD (Non-Alcoholic Fatty Lever Disease)Israel
-
Sulaimany Polytechnic universityAfsluttetNAFLD, Non-alcoholic Fatty Lever DiseaseIrak
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University of NottinghamNottingham University Hospitals NHS TrustRekrutteringNAFLD | Ikke-alkoholisk fedtleversygdom | Ikke-alkoholisk fedtleversygdom (NAFLD) | NAFLD - Nonalcoholic Fatty Lever Disease | NAFLD (Non-alcoholic Fatty Lever Disease) | NAFLD (Nonalcoholic Fatty Lever Disease) | NAFLD - Non-Alcoholic Fatty Lever Disease | MASLD | Metabolisk dysfunktion-associeret steatotisk... og andre forholdDet Forenede Kongerige
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ContextVision ABUniversity of WashingtonRekrutteringNAFLD - Non-Alcoholic Fatty Lever Disease | MASLD - Metabolic Dysfunction-Associated Steatotic Liver DiseaseForenede Stater
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Cyprus University of TechnologyCyprus State Heath Organization ServicesIkke rekrutterer endnuNAFLD | NAFLD (Nonalcoholic Fatty Lever Disease) | NAFLD - Non-Alcoholic Fatty Lever Disease | MASLD | MASLD - Metabolic Dysfunction-Associated Steatotic Liver DiseaseCypern
Kliniske forsøg med Semaglutid
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LMC Diabetes & Endocrinology Ltd.Ikke rekrutterer endnuType 2 diabetes | Diabetes (DM) | Fedme (lidelse)
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Novo Nordisk A/SAfsluttet
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Novo Nordisk A/SAfsluttetFedme | OvervægtigForenede Stater, Indien, Japan, Den Russiske Føderation, Det Forenede Kongerige, Canada, Spanien, Sydafrika, Tyskland, Grækenland, Forenede Arabiske Emirater, Argentina, Puerto Rico
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Anders Fink-Jensen, MD, DMSciNeurobiology Research Unit, RigshospitaletRekrutteringCannabis afhængighed | Cannabismisbrug | Misbrug af cannabis | Misbrug af cannabis | CannabisafhængighedDanmark
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Novo Nordisk A/SAktiv, ikke rekrutterende
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Novo Nordisk A/SAfsluttet
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Novo Nordisk A/SAfsluttet
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Novo Nordisk A/SAfsluttet
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Novo Nordisk A/SAfsluttet
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Novo Nordisk A/SAfsluttetDiabetes mellitus, type 2Japan