Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) (ESSENCE)

April 16, 2026 updated by: Novo Nordisk A/S

The Effect of Semaglutide in Subjects With Non-cirrhotic Non-alcoholic Steatohepatitis

Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries.

Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance.

Participants will need to inject themselves with medicine under the skin. Participants will need to do this once a week.

The study will last for about 5 years. Participants will have up to 21 clinic visits and 9 phone calls with the clinical staff during the study. Some of the clinic visits may be spread over more than one day.

Participants with other chronic liver diseases cannot take part in this study. Women cannot take part in the study if they are pregnant, breast-feeding or plan to become pregnant during the study period.

Study Overview

Status

Active, not recruiting

Conditions

Non-alcoholic Steatohepatitis

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

1205

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Buenos Aires, Argentina, B1704ETD
    - DIM Clínica Privada
  - CABA, Argentina, C1120AAC
    - Centro Médico Viamonte SRL
  - CABA, Argentina, C1199ABH
    - Hospital Italiano Departamento Hepatologia
  - CABA, Argentina, C1430CKE
    - Glenny Corp. S.A
  - Capital Federal, Argentina, C1056ABJ
    - Centro de Investigaciones Metabólicas
  - Florencio Varela, Buenos Aires, Argentina, 1888
    - Hospital El Cruce
- Buenos Aires
  - Capital Federal, Buenos Aires, Argentina, C1056ABI
    - Centro de Investigaciones Metabólicas
  - Ciudad de Buenos Aires, Buenos Aires, Argentina, 1280
    - Hospital Británico de Buenos Aires
- Santa Fe Province
  - Rosario, Santa Fe, Santa Fe Province, Argentina, S2002KDT
    - Hospital del Centenario
Australia
- New South Wales
  - Camperdown, New South Wales, Australia, 2050
    - A.W. Morrow Gastroenterology and Liver Centre
  - Kingswood, New South Wales, Australia, 2747
    - Nepean Hospital
  - Liverpool, New South Wales, Australia, 2170
    - Liverpool Hospital
  - Westmead, New South Wales, Australia, 2145
    - Westmead Hospital
  - Westmead, New South Wales, Australia, 2145
    - Westmead Hospital - Storr Liver Centre
- Queensland
  - Southport, Queensland, Australia, 4222
    - Griffith University Clinical Trial Unit
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Royal Adelaide Hospital - Hepatology Department
  - Elizabeth Vale, South Australia, Australia, 5112
    - Lyell McEwin Hospital
- Victoria
  - Fitzroy, Victoria, Australia, 3065
    - St Vincent's Hospital Melbourne - Gastroenterology Department
  - Heidelberg, Victoria, Australia, 3084
    - Austin Hospital
- Western Australia
  - Murdoch, Western Australia, Australia, 6150
    - Fiona Stanley Hospital - Hepatology
  - Nedlands, Western Australia, Australia, 6009
    - Sir Charles Gairdner Hospital - Hepatology Department
Austria
- - Graz, Austria, 8036
    - Klin.Abt. f. Gastroenterologie u. Hepatologie
  - Saint Stefan, Austria, 8511
    - Fließer-Görzer [Ordination]
  - Salzburg, Austria, 5020
    - LKH Salzburg Universitätsklinikum
  - Vienna, Austria, 1030
    - Klinik Landstraße
  - Wels, Austria, 4600
    - Klinikum Wels-Grieskirchen
Belgium
- - Brussels, Belgium, 1070
    - CUB Hôpital Erasme_Brussels_0
  - Brussels, Belgium, 1200
    - Cliniques Universitaires Saint-Luc - Serv. Hépato-gastroentérology
  - Edegem, Belgium, 2650
    - UZA
  - Genk, Belgium, 3600
    - Ziekenhuis Oost-Limburg AV - Gastro
  - Ghent, Belgium, 9000
    - UZ Gent - Department Gastro-enterology
  - Ghent, Belgium, 9000
    - AZ Maria Middelares - Gent - Gastro-Enterology
Brazil
- - Rio de Janeiro, Brazil, 21941-617
    - Hospital Universitario Clementino Fraga Filho
  - São Paulo, Brazil, 04543-011
    - Rocco E Nazato Servicos Medicos LTDA
- Estado de Bahia
  - Salvador, Estado de Bahia, Brazil, 40110160
    - Fundação Bahiana de Infectologia
- Goiás
  - Goiânia, Goiás, Brazil, 74605-020
    - Hospital das Clinicas da Universidade Federal de Goias
- Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
    - Hospital de Clínicas de Porto Alegre_Porto Alegre
- São Paulo
  - Barretos, São Paulo, Brazil, 14780-070
    - Fundação Pio XII
  - Barretos, São Paulo, Brazil, 14784-400
    - Fundação Pio XII - Hospital de Amor de Barretos
  - Botucatu, São Paulo, Brazil, 18618-686
    - UPECLIN- Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu
  - São José do Rio Preto, São Paulo, Brazil, 15090-000
    - CIP Centro Integrado de Pesquisas do Hospital de Base
  - São Paulo, São Paulo, Brazil, 04024-002
    - Assoc. Paulista para o Desenvolvimento da Medicina - UNIFESP
  - São Paulo, São Paulo, Brazil, 05403-000
    - Departamento de Gastroenterologia - HCFMUSP
Bulgaria
- - Panagyurishte, Bulgaria, 4500
    - MHAT - UniHospital OOD
  - Plovdiv, Bulgaria, 4000
    - MHAT Med Line Clinic
  - Sofia, Bulgaria, 1784
    - Medical Center Synexus Sofia EOOD
  - Sofia, Bulgaria, 1618
    - "DCC XX - Sofia" EOOD
  - Sofia, Bulgaria, 1407
    - "Acibadem City Clinic UMHAT Tokuda"
  - Sofia, Bulgaria, 1527
    - "UMHAT "Tsaritsa Yoanna-ISUL"" EAD, Gastroenterology clinic
  - Sofia, Bulgaria, 1750
    - "UMHAT "Sveta Anna" Sofia" AD
  - Sofia, Bulgaria, 1431
    - DCC Aleksandrovska EOOD
  - Sofia, Bulgaria, 1504
    - Medical Center Vertebra OOD
  - Sofia, Bulgaria, 1407
    - Acibadem City Clinic UMHAT Tokuda EAD, Gastroenterology
  - Sofia, Bulgaria, 1618
    - DCC XX - Sofia EOOD, Gastroenterology
  - Sofia, Bulgaria, 1527
    - UMHAT Tsaritsa Yoanna - ISUL EAD, Gastroenterology
  - Sofia, Bulgaria, 1784
    - Acibadem City Clinic UMHAT EOOD, Gastroenterology
  - Sofia, Bulgaria, 1431
    - UMHAT Sveti Ivan Rilski EAD, Gastroenterology
  - Varna, Bulgaria, 9010
    - UMHAT Sveta Marina EAD, Clinic of Gastroenterology
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4Z6
    - University of Calgary Liver Unit-(HMRC)
- British Columbia
  - Vancouver, British Columbia, Canada, V6Z 2K5
    - GI Research Inst Foundation
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - Nova Scotia Hlth Halifax
- Ontario
  - Brampton, Ontario, Canada, L6S 0C6
    - LMC ClinRsrh Inc.Brampton
  - London, Ontario, Canada, N6A 5A5
    - London Hlth Sci Ctr- Univ Camp
  - Toronto, Ontario, Canada, M6H 3M1
    - Toronto Liver Centre
  - Toronto, Ontario, Canada, M4G 3E8
    - Centricity Research LMC (Toronto)
  - Vaughan, Ontario, Canada, L4L 4Y7
    - TDDA Specialty Research
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 7K9
    - Ecogene-21
  - Montreal, Quebec, Canada, H4A 3J1
    - McGill University Health Centre
  - Montreal, Quebec, Canada, QC H2L 4E9
    - Clinique Medicine Urbaine du Quartier Latin, Inc.
  - Sherbrooke, Quebec, Canada, J1H 5N4
    - Hospital Fleurimont / CIUSS
  - Terrebonne, Quebec, Canada, J6X 4P7
    - Ctr de méd métab de Lanaudière
China
- - Hangzhou, China, 310030
    - Zhejiang Hospital-Infectious Diseases
  - Shenzhen, China, 518112
    - The Third People's Hospital of Shenzhen
  - Tianjin, China, 300211
    - Tianjin Second People's Hospital-Liver Disease Department III
- Beijing Municipality
  - Beijing, Beijing Municipality, China, 100050
    - Beijing Friendship Hospital, Capital Medical University-Endocrinology
  - Beijing, Beijing Municipality, China, 100015
    - Beijing Ditan Hospital Capital Medical University-Hepatology
  - Beijing, Beijing Municipality, China, 100034
    - Peking University People's Hospital-(White Pagoda Temple Area) - Hepatopathy
  - Beijing, Beijing Municipality, China, 100069
    - Beijing You'an Hospital, Capital Medical University-Hepatology center
  - Beijing, Beijing Municipality, China, 102218
    - Beijing Tsinghua Changgung Hospital-Hepatology
- Chongqing Municipality
  - Chongqing, Chongqing Municipality, China, 404140
    - Chongqing University Three Gorges Hospital-Hepatology
- Guangdong
  - Foshan, Guangdong, China, 528000
    - The First People's Hospital of Foshan-Infectious Disease
  - Guangzhou, Guangdong, China, 510080
    - The first Affiliated hospital, Sun Yat-Sen University
  - Guangzhou, Guangdong, China, 510180
    - Guangzhou First People's Hospital-Gastroenterology
  - Guangzhou, Guangdong, China, 510515
    - Nanfang Hospital, Southern Medical University-Infectious Diseases
  - Guangzhou, Guangdong, China, 510650
    - The Third Affiliated Hospital, Sun Yat-sen University-Infectious
  - Guangzhou, Guangdong, China, 510060
    - Guangzhou Eighth People's Hospital, Guangzhou Medical University-Hepatology
  - Shenzhen, Guangdong, China, 518036
    - Peking University Shenzhen Hospital
  - Shenzhen, Guangdong, China, 518112
    - The Third People's Hospital of Shenzhen-Hepatology
- Hebei
  - Shijiazhuang, Hebei, China, 050051
    - The Third Hospital of Hebei Medical University-Hepatology
- Hunan
  - Changsha, Hunan, China, 410005
    - Hunan Provincial People's Hospital
  - Changsha, Hunan, China, 410005
    - Hunan Provincial People's Hospital-Hepatology
- Jiangsu
  - Changzhou, Jiangsu, China, 213003
    - Changzhou No.2 People's Hospital
  - Nanjing, Jiangsu, China, 210003
    - The Second Affiliated Hospital of Nanjing Medical University-Hepatology
  - Xuzhou, Jiangsu, China, 221011
    - The Affiliated Hospital of Xuzhou Medical University (East) - Infectious Diseases
  - Zhenjiang, Jiangsu, China, 212021
    - The Third People's Hospital of Zhenjiang-Hepatology
- Jiangxi
  - Nanchang, Jiangxi, China, 330006
    - The First Affiliated Hospital of Nanchang University
- Jilin
  - Changchun, Jilin, China, 130021
    - The First Bethune Hospital of Jilin University-Hepatic Biliary Pancreatic Medicine
- Ningxia
  - Yinchuan, Ningxia, China, 750004
    - General Hosp of Ningxia Medical University,Infectious Depart
- Shandong
  - Jinan, Shandong, China, 250013
    - Jinan Central Hospital
  - Liaocheng, Shandong, China, 252000
    - Liaocheng People's Hospital
  - Liaocheng, Shandong, China, 252000
    - Liaocheng People's Hospital-Infectious Diseases
  - Qingdao, Shandong, China, 266011
    - Qingdao Municipal Hospital (Group)-Infectious Diseases
- Shanghai Municipality
  - Shanghai, Shanghai Municipality, China, 200001
    - Shanghai Jiao Tong University School of Medicine Renji Hospital-Gastroenterology
  - Shanghai, Shanghai Municipality, China, 200025
    - Ruijin Hospital Affiliate to The Shanghai Jiaotong University-Infectious Diseases
  - Shanghai, Shanghai Municipality, China, 200025
    - Ruijin Hospital Affiliate to The Shanghai Jiaotong Universit
  - Shanghai, Shanghai Municipality, China, 201999
    - Shanghai Ninth People's Hospital-Infection Disease
  - Shanghai, Shanghai Municipality, China, 201999
    - Shanghai Ninth People's Hospital
- Sichuan
  - Chengdu, Sichuan, China, 610044
    - West China Hospital Sichuan University-Infectious Diseases
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, China, 300170
    - Tianjin Third Central Hospital-Gastroenterology
  - Tianjin, Tianjin Municipality, China, 300211
    - Tianjin Second People's Hospital-Liver Disease Department III
- Zhejiang
  - Hangzhou, Zhejiang, China, 310030
    - Zhejiang Hospital-Infectious Diseases
  - Wenzhou, Zhejiang, China, 325000
    - The First Affiliated Hospital of WMU
Croatia
- - Osijek, Croatia, 31 000
    - Klinicki bolnicki centar Osijek
  - Osijek, Croatia, 31 000
    - Klinicki bolnicki centar Osijek_Endocrinology
  - Rijeka, Croatia, 51000
    - KBC Rijeka, Zavod za gastroenterologiju
  - Split, Croatia, 21000
    - KBC Split/ Firule/ Gastroenterologija
  - Split, Croatia, 21000
    - KBC Split_Gastroenterology
  - Zagreb, Croatia, 10000
    - KB Dubrava, Zavod za gastroenterologiju
  - Zagreb, Croatia, 10000
    - Klinički bolnički centar Zagreb, Zavod za gastroenterologiju
Czechia
- - Liberec, Czechia, 460 01
    - Krajská nemocice Liberec, a.s
  - Pilsen, Czechia, 301 00
    - Researchsite s.r.o.
  - Prague, Czechia, 128 08
    - Vseobecna Fakultni Nemocnice v Praze
Denmark
- - Aarhus N, Denmark, 8200
    - Aarhus Universitetshospital Skejby Mave-Tarm
  - Hvidovre, Denmark, 2650
    - Hvidovre Hospital - Gastroenheden
  - København NV, Denmark, 2400
    - Bispebjerg Hospital - Abdominal Center K, Research Unit
  - Odense C, Denmark, 5000
    - Odense University Hospital - FLASH - Centre for Liver Research
France
- - Angers, France, 49100
    - Centre Hospitalier Universitaire d'Angers
  - Angers, France, 49100
    - Centre Hospitalier Universitaire D'Angers-1
  - Clichy, France, 92110
    - Ap-Hp-Hopital Beaujon
  - Lille, France, 59000
    - Centre Hospitalier Universitaire de Lille-Hopital Claude Huriez
  - Lyon, France, 69317
    - Hospices Civils de Lyon-Hopital de La Croix Rousse
  - Nice, France, 06200
    - Centre Hospitalier Universitaire de Nice-Hopital de L'Archet
  - Paris, France, 75014
    - Ap-Hp-Hopital Cochin
  - Paris, France, 75013
    - APHP-HOPITAL LA PITIE SALPETRIERE_Service Hépato-Gastro-Enterologie
  - Pessac, France, 33600
    - Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque
  - Pierre-Bénite, France, 69310
    - Hospices Civils de Lyon-Hopital Lyon Sud
  - Strasbourg, France, 67091
    - Les Hopitaux Universitaires de Strasbourg-Hopital Civil
Germany
- - Berlin, Germany, 10825
    - Gastro am Bayerischen Platz - Hofmann W.-P.n
  - Berlin, Germany, 13353
    - Charité - Campus Virchow-Klinikum - Med. Klinik für Hepatologie und Gastroenterologie
  - Bochum, Germany, 44892
    - Uniklinik Knappschaftskrankenhaus Bochum GmbH - Med. Klinik - Gastroenterologie & Hepatologie
  - Bonn, Germany, 53127
    - Universitätsklinikum Bonn - Med. Klinik und Poliklinik I
  - Frankfurt, Germany, 60590
    - Uniklinik FFM - Hepatologie
  - Hanover, Germany, 30625
    - Medizinische Hochschule Hannover - Gastroentero-, Hepato-, Endokrinologie
  - Leipzig, Germany, 04103
    - Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH
  - Leipzig, Germany, 04103
    - Universitätsklinikum Leipzig - Klinik und Poliklinik für Onkologie, Gastroenterologie, Hepatologie und Pneumologie
  - Lübeck, Germany, 23538
    - Uniklinik Schleswig-Holstein - Medizinischen Klinik I am Campus Lübeck
  - Magdeburg, Germany, 39120
    - Uniklinik Otto Von Guericke Magdeburg - Gastroenterologie, Hepatologie and Infektiologie
  - Mainz, Germany, 55131
    - Universitätsmedizin der JGU Mainz - Hepatologie
  - Mannheim, Germany, 68167
    - Universitätsmedizin Mannheim - II. Medizinische Klinik
  - Würzburg, Germany, 97080
    - Universitätsklinikum Würzburg - Zentrum für Innere Medizin (ZIM)
Greece
- - Athens, Greece, 11527
    - Gen Hospital of Athens Laiko,1st Dpt. of Propaedeutic Inter
  - Athens, Greece, 11527
    - Gen Hospital of Athens Ippokrateio,B' Uni Clinic of Inte Med
  - Goudi, Athens, Greece, 115 27
    - General Hospital of Athens "Laiko"
  - Ioannina, Greece, 45500
    - Univ Gen Hospital of Ioannina,Gastroenterology-Endoscopy Uni
  - Larissa, Greece, 41110
    - Univ Gen Hospital Larisa, Cardiology Medicine Clinic
  - Thessaloniki, Greece, 54642
    - General Hospital of Thessaloniki "Ippokrateio"
  - Thessaloniki, Greece, 54636
    - AHEPA General University Hospital
  - Thessaloniki, Greece, 54621
    - "AHEPA" University Hospital of Thessaloniki
India
- - New Delhi, India, 110025
    - Fortis Escort Heart Institute
- Andhra Pradesh
  - Secunderabad, Andhra Pradesh, India, 500003
    - Yashoda Hospital
- Gujarat
  - Surat, Gujarat, India, 395002
    - Surat Institute of Digestive Science
  - Surat, Gujarat, India, 395009
    - BAPS Pramukh Swami Hospital
- Haryana
  - Gurgaon, Haryana, India, 122001
    - Medanta - The Medicity Multi-Speciality Hospital, Gurugram
- Karnataka
  - Mangalore, Karnataka, India, 575001
    - Kasturba Medical College Hospitals (KMC Hospitals), Mangalore
- Maharashtra
  - Mumbai, Maharashtra, India, 400012
    - Seth GS medical college and KEM Hospital
  - Mumbai, Maharashtra, India, 400012
    - Gleneagles Hospital, Super-speciality and Transplant Centre, Parel
  - Nagpur, Maharashtra, India, 441108
    - MIDAS Multispeciality Hospital
- New Delhi
  - Delhi, New Delhi, India, 110029
    - All India Institute of Medical Sciences
  - Ghitorni, New Delhi, India, 110070
    - Institute of Liver and Biliary Sciences
- Punjab
  - Chandigarh, Punjab, India, 160012
    - Post Graduate Institute of Medical Education & Research_Chandigarh
  - Ludhiana, Punjab, India, 141001
    - Dayanand Medical College & Hospital
  - Mohali, Punjab, India, 160062
    - Fortis Heart Institute and Multispeciality Hospital
- Rajasthan
  - Jaipur, Rajasthan, India, 302001
    - S.R.Kalla Memorial Gastro & General Hospital
  - Jaipur, Rajasthan, India, 302004
    - SMS Super speciality Hospital, Department of Gastroenterology
- Telangana
  - Hyderabad, Telangana, India, 50082
    - Dr P V Rao - Diabetes Research Centre
  - Hyderabad, Telangana, India, 500012
    - Osmania General Hospital_Hyderabad
- Uttar Pradesh
  - Lucknow, Uttar Pradesh, India, 226003
    - MV Hospital and Research Centre
Ireland
- - Dublin, Ireland, D08 NHY1
    - Hepatology St James's
  - Dublin, Ireland, D09V2N0
    - Beaumont Hospital Hepatology Dept
Israel
- - Haifa, Israel, 3434104
    - Carmel Medical Center Liver Unit
  - Haifa, Israel, 3434104
    - Carmel MC - Liver Unit
  - Jerusalem, Israel, 91031
    - Shaare Zedek Medical Center
  - Jerusalem, Israel, 91031
    - Shaare Zedek MC - Liver Unit
  - Jerusalem, Israel, 91120
    - Hadassah Ein Karam MC - Liver Unit
  - Nahariya, Israel, 2210001
    - Western Galilee MC - Internal Medicine A
  - Petah Tikva, Israel, 49100
    - Liver Institute, Rabin Medical Center, Beilinson Campuse
  - Petah Tikva, Israel, 49100
    - Rabin MC Beilinson - Liver Institute
  - Ramat Gan, Israel, 52621
    - Sheba MC - Liver Diseases Center
  - Tel Aviv, Israel, 64239
    - Sourasky MC - Liver Unit
Italy
- - Bologna, Italy, 40138
    - Azieda Ospedaliero-Universitaria, Policlinico S. Orsola-Malp
  - Florence, Italy, 50134
    - AOU Careggi Padiglione 16 San Luca, 3° piano
  - Foggia, Italy, 71122
    - Azienda Ospedaliero Universitaria Ospedali Riuniti - Foggia
  - Milan, Italy, 20122
    - Osp Magg Policlinico Centro Malattie metaboliche del Fegato
  - Roma, Italy, 00168
    - Fondazione Policlinico Universitario Agostino Gemelli IRCS
  - Rome, Italy, 00128
    - Policlinico Università Campus Biomedico di Roma
  - Torino, Italy, 10126
    - Città della salute e della scienza - university of Torino
- Cz
  - Catanzaro, Cz, Italy, 88100
    - Azienda Ospedaliero-Universitaria Renato Dulbecco
- Foggia
  - San Giovanni Rotondo, Foggia, Italy, 71013
    - IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo
- Sicily
  - Palermo, Sicily, Italy, 90127
    - AOUP Giaccone Palermo
Japan
- - Bunkyo-ku, Tokyo, Japan, 113-8431
    - Juntendo University Hospital, Gastroenterology
  - Bunkyo-ku, Tokyo, Japan, 113-8655
    - The University of Tokyo Hospital, Gastroenterology
  - Bunkyo-ku, Tokyo, Japan, 113-8431
    - Juntendo University Hospital_Gastroenterology
  - Fukui-shi, Fukui, Japan, 918-8503
    - Fukui-ken Saiseikai Hospital, Internal Medicine
  - Fukui-shi, Fukui, Japan, 918-8503
    - Fukui-ken Saiseikai Hospital_Internal Medicine
  - Fukushima, Japan, 963-8801
    - Hoshi General Hospital_Gastroenterology
  - Gifu, Japan, 500-8513
    - Gifu Municipal Hospital_Hepatology
  - Gifu, Japan, 503-8502
    - Ogaki Municipal Hospital_Gastroenterology and Hepatology
  - Hamamatsu-shi, Shizuoka, Japan, 431-3192
    - Hamamatsu University Hospital_Liver Internal Medicine
  - Hatsukaichi-shi, Hiroshima, Japan, 783-8503
    - JA Hiroshima General Hospital_Gastroenterology and Hepatology
  - Hiroshima-shi, Hiroshima, Japan, 730-8619
    - Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hosp.
  - Hiroshima-shi, Hiroshima, Japan, 734-8551
    - Hiroshima University Hospital
  - Hiroshima-shi, Hiroshima, Japan, 730-8619
    - Hiroshima Red Cross & Atomic-b_Hepatology
  - Hiroshima-shi, Hiroshima, Japan, 734-8551
    - Hiroshima University Hospital_Department of Gastro.&Metabo.
  - Izunokuni-shi, Shizuoka, Japan, 410-2295
    - Juntendo University Shizuoka Hospital
  - Izunokuni-shi, Shizuoka, Japan, 410-2295
    - Juntendo University Shizuoka Hospital_Gastroenterology & Hepatology
  - Kagoshima-shi, Kagoshima, Japan, 890-8520
    - Kagoshima University Hospital, Gastroenterology
  - Kagoshima-shi, Kagoshima, Japan, 890-8520
    - Kagoshima University Hospital_Gastroenterology
  - Kamigyo-ku, Kyoto, Japan, 602-8566
    - University Hospital Kyoto Prefectual University of Medicine
  - Kanazawa-shi, Ishikawa, Japan, 920-8641
    - Kanazawa University Hospital
  - Kanazawa-shi, Ishikawa, Japan, 920-8641
    - Kanazawa University Hospital_Gastroenterology
  - Kashihara-shi, Nara, Japan, 634-8522
    - Nara Medical University Hospital_Kashihara-shi, Nara
  - Kashihara-shi, Nara, Japan, 634-8522
    - Nara Medical University Hospital_Department of Gastro.& Metabo.
  - Kawasaki-shi, Kanagawa, Japan, 216-8511
    - St. Marianna University School of Medicine Hospital
  - Kumamoto-shi, Kumamoto, Japan, 862-8655
    - Kumamoto Shinto General Hospital_Liver・Gastroenterology
  - Minato-ku, Tokyo, Japan, 105-8470
    - Toranomon Hospital, Hepatology
  - Musashino-shi, Tokyo, Japan, 180-8610
    - Japanese Red Cross Musashino Hospital
  - Musashino-shi, Tokyo, Japan, 180-8610
    - Japanese Red Cross Musashino Hospital_Gastroenterology
  - Nagakute-shi, Aichi, Japan, 480-1195
    - Aichi Medical University Hospital
  - Nagakute-shi, Aichi, Japan, 480-1195
    - Aichi Medical University Hospital_Hepatology and pancreology
  - Nakagamigun, Okinawa, Japan, 901-2492
    - Heartlife Hospital_Liver internal medicine
  - Nara-shi, Nara, Japan, 630-8305
    - Nara City Hospital, Gastroenterology and Hepatology
  - Nishinomiya-shi, Hyogo, Japan, 663-8501
    - Hyogo Medical University Hospital_Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine
  - Oita-shi, Oita, Japan, 870-0837
    - Oita Cardiovascular Hospital_Gastroenterology
  - Okayama-shi, Okayama, Japan, 700-8505
    - Kawasaki Medical School General Medical Center
  - Okayama-shi, Okayama, Japan, 700-8505
    - Kawasaki Medical School General Medical Center_Internal Medicine
  - Osaka, Japan, 591-8025
    - Japan Organization of Occupational Health and Safety Osaka Rosai Hospital_Gastroenterology
  - Osaka-shi, Osaka, Japan, 545-8586
    - Osaka Metropolitan University Hospital, Department of Hepatology
  - Osaka-shi, Osaka, Japan, 545-8586
    - Osaka Metropolitan University Hospital_Department of Hepatology
  - Otsu-shi, Shiga, Japan, 520-0804
    - Otsu City Hospital, Gastroenterological Medicine
  - Saga-shi, Saga, Japan, 849-8501
    - Saga University Hospital_Liver Center
  - Sapporo-shi, Hokkaido, Japan, 062-8618
    - Japan Community Health Care Organization Hokkaido Hospital
  - Sapporo-shi, Hokkaido, Japan, 062-8618
    - JCHO Hokkaido Hospital_Digestive Disease Center
  - Sendai-shi, Miyagi, Japan, 981-0914
    - Sendai Kousei Hospital
  - Sendai-shi, Miyagi, Japan, 981-0914
    - Sendai Kousei Hospital_Liver Internal Medicine
  - Shinjuku-ku, Tokyo, Japan, 162-8666
    - Tokyo Women's Medical University Hospital
  - Suita-shi, Osaka, Japan, 564-0013
    - Saiseikai Suita Hospital, Gastroenterology
  - Suita-shi, Osaka, Japan, 565-0871
    - Osaka University Hospital_Department of Gastro. & Hepato
  - Takamatsu-shi, Kagawa, Japan, 760-8557
    - Kagawa Prefectural Central Hospital
  - Takamatsu-shi, Kagawa, Japan, 760-8557
    - Kagawa Prefectural Central Hospital_Liver internal medicine
  - Takasaki-shi, Gunma, Japan, 370-0829
    - National Hospital Organization Takasaki General Medical Ctr._Gastroenterology
  - Tokyo, Japan, 173-8610
    - Nihon University Itabashi Hospital
  - Tokyo, Japan, 173-8610
    - Nihon University Itabashi Hospital_Division of Gastro.&Hepa.
  - Toon-shi, Ehime, Japan, 791-0295
    - Ehime University Hospital
  - Toon-shi, Ehime, Japan, 791-0295
    - Ehime University Hospital_Department of Gastro.& Metabo.
  - Wakayama-shi, Wakayama, Japan, 640-8158
    - Saiseikai Wakayama Hospital
  - Wakayama-shi, Wakayama, Japan, 640-8158
    - Saiseikai Wakayama Hospital_Gastroenterology
  - Yokohama-shi, Kanagawa, Japan, 236-0004
    - Yokohama City University Hospital_Gastrointestinal Medicine
Malaysia
- - Batu Caves, Malaysia, 68100
    - Hospital Selayang
- Kelantan
  - Kota Bharu, Kelantan, Malaysia, 16150
    - Hospital Universiti Sains Malaysia
- Kuala Lumpur
  - Kuala Lumpur, Kuala Lumpur, Malaysia, 59100
    - University Malaya Medical Centre
  - Lembah Pantai, Kuala Lumpur, Malaysia, 59100
    - University Malaya Medical Centre
Mexico
- - México, Mexico, 03330
    - Centro de Investigación y Gastroenterología_ Hospital Angeles Universidad
- Guerrero
  - Acapulco de Juárez, Guerrero, Mexico, 39670
    - Centro de Investigacion Clinica del Pacifico, S.A. de C.V.
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44130
    - Centro de Investigación Médico Biológica y Terapia
- México, D.F.
  - Mexico City, México, D.F., Mexico, 06700
    - Centro de Investigacion y Gastroenterologia, S.C.
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64000
    - Investigaciones Médicas Cisneros, S.C.
  - San Pedro Garza García, Nuevo León, Mexico, 66220
    - Servicios de Oncologia Medica Integral S.A de C.V (ONCARE)
- Sinaloa
  - Culiacán, Sinaloa, Mexico, 80020
    - Hospital Angeles de Culiacan
- Yucatán
  - Mérida, Yucatán, Mexico, 97070
    - Medical Care and Research S. A de C.V
Netherlands
- - Alkmaar, Netherlands, 1815 JD
    - Noordwest Ziekenhuisgroep
  - Amsterdam, Netherlands, 1105 AZ
    - AmsterdamUMC AMC
  - Leiden, Netherlands, 2333 ZA
    - Leids Universitair Medisch Centrum
  - Rotterdam, Netherlands, 3045 PM
    - Franciscus Gasthuis en Vlietland
Norway
- - Gjettum, Norway, 1346
    - Bærum sykehus
  - Gjettum, Norway, 1346
    - Bærum sykehus - Vestre Viken HF
  - Oslo, Norway, 0450
    - Oslo universitetssykehus, Ullevål
Poland
- - Bydgoszcz, Poland, 85-676
    - Gizinscy Centrum Medyczne
  - Warsaw, Poland, 03-712
    - BodyClinic
  - Wroclaw, Poland, 51-162
    - Centrum Badan Klinicznych
  - Wroclaw, Poland, 53-673
    - FutureMeds Sp. z o.o.
- Lesser Poland Voivodeship
  - Myslowice, Lesser Poland Voivodeship, Poland, 41-400
    - ID Clinic Arkadiusz Pisula
- Świętokrzyskie Voivodeship
  - Staszów, Świętokrzyskie Voivodeship, Poland, 28-200
    - Velocity Nova Sp. z o.o.
  - Staszów, Świętokrzyskie Voivodeship, Poland, 28-200
    - KO-MED Centra Kliniczne Staszow
Portugal
- - Almada, Portugal, 2805-267
    - Hospital Garcia de Orta
  - Almada, Portugal, 2805-267
    - ULS De Almada-Seixal E.P.E. - Hospital Garcia de Orta
  - Aveiro, Portugal, 3814-501
    - ULS Da Regiao De Aveiro E.P.E. - Hospital Infante D. Pedro
  - Braga, Portugal, 4710-243
    - ULS De Braga, E.P.E. - Hospital de Braga
  - Guarda, Portugal, 6301-858
    - ULS Da Guarda E.P.E. - Hospital Sousa Martins
  - Guimarães, Portugal, 4835-044
    - ULS Do Alto Ave, E.P.E. - Hospital Senhora da Oliveira - Guimarães
  - Lisbon, Portugal, 1250-189
    - APDP - Associação Protectora dos Diabéticos de Portugal
  - Lisbon, Portugal, 1649-035
    - Unidade Local De Saúde De Santa Maria E.P.E.
  - Porto, Portugal, 4200-319
    - ULS De São João, E.P.E. - Hospital de São João
  - Porto, Portugal, 4099-001
    - ULS De Santo António, E.P.E. - Hospital de Santo António
  - Viana do Castelo, Portugal, 4904-858
    - ULS Do Alto Minho E.P.E. - Hospital de Santa Luzia
  - Vila Nova de Gaia, Portugal, 4400-346
    - Hospital da Luz Arrabida, S.A.
  - Vila Nova de Gaia, Portugal, 4434-502
    - ULS De Gaia/Espinho E.P.E. - Hospital Eduardo Santos Silva
  - Vila Real, Portugal, 5000-508
    - ULS De Tras-Os-Montes E Alto Douro E.P.E. - Unidade Hospitalar de Vila Real
- Matosinhos
  - Senhora Da Hora, Matosinhos, Matosinhos, Portugal, 4464-513
    - ULS De Matosinhos E.P.E.- Hospital Pedro Hispano
Puerto Rico
- - San Juan, Puerto Rico, 00927
    - FDI Clinical Research
Romania
- - Bucharest, Romania, 022328
    - Institutul Clinic Fundeni
  - Bucharest, Romania, 050098
    - Spitalul Universitar de Urgenta Bucuresti
  - Bucharest, Romania, 011025
    - Sana Monitoring SRL
  - Bucharest, Romania, 011053
    - Hightech Medical Services S.R.L.
  - Cluj-Napoca, Romania, 400015
    - Spitalul Clinic CF Cluj Napoca
  - Cluj-Napoca, Romania, 400162
    - Institutul Gastroenterologie-Hepatologie Cluj-Napoca
  - Constanța, Romania, 900591
    - Gastroenterologie Spitalul Judetean Constanta
  - Galati, Romania, 800291
    - SC Diamed Obesity SRL
  - Iași, Romania, 700506
    - Gastromedica
  - Satu Mare, Romania, 440055
    - Spital Judetean De Urgenta Satu Mare
Russia
- - Arkhangelsk, Russia, 163001
    - Volosevich First City Clinical Hospital
  - Barnaul, Russia, 656045
    - City Hospital #5
  - Kazan', Russia, 420111
    - LLC "Clinic of Aesthetic Medicine & Laser Technologies"
  - Kazan', Russia, 420097
    - Kazan Federal University
  - Moscow, Russia, 119435
    - Setchenov First Moscow State Medical University
  - Moscow, Russia, 117292
    - Friendship University of Russia
  - Moscow, Russia, 125367
    - PHI "Central Clinical Hospital RZD- Medicine"
  - Novosibirsk, Russia, 630099
    - Limited Law Company "Healthy Family" Medicine Center"
  - Penza, Russia, 440026
    - Penza Regional Clinical Hospital named after N.N. Burdenko
  - Saint Petersburg, Russia, 197110
    - Consultative & Diagnostic Center with a Outpatient Hospital
  - Saint Petersburg, Russia, 190013
    - Joint Stock Company "Polyclinic Complex"
  - Saint Petersburg, Russia, 194156
    - Limited Liability Company "Energiya Zdoroviya"
  - Saint Petersburg, Russia, 195067
    - North-Western State Medical Univer. based on Med-Prof Center
  - Saint Petersburg, Russia, 192283
    - SPb SBHI City Outpatient clinic #109
  - Tomsk, Russia, 634050
    - Siberian State Medical University
  - Ulyanovsk, Russia, 432063
    - Ulianovsk Regional Clinical Hospital
  - Yoshkar-Ola, Russia, 424004
    - Polyclinic #2 in Yoshkar-Ola
Serbia
- - Belgrade, Serbia, 11000
    - Clinic for gastroenterology and hepatology
  - Belgrade, Serbia, 11000
    - Endocrinology, Diabetes and Metabolism Diseases Clinic
  - Belgrade, Serbia, 11020
    - Clinical-hospital centre Zvezdara
- Vojvodina
  - Novi Sad, Vojvodina, Serbia, 21000
    - Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
Singapore
- - Singapore, Singapore, 169608
    - Singapore General Hospital
  - Singapore, Singapore, 529889
    - Changi General Hospital
  - Singapore, Singapore, 119228
    - National University Hospital Singapore_Tahir Building
  - Singapore, Singapore, 119228
    - National University Hospital_Tahir Building
  - Singapore, Singapore, 529905
    - Changi General Hospital
Slovakia
- - Bratislava, Slovakia, 851 01
    - MEDISPEKTRUM s.r.o.
  - Bratislava, Slovakia, 833 05
    - Nemocnica akademika L. Derera, UNB
  - Košice, Slovakia, 040 11
    - II. Interna klinika, Univerzitna nemocnica L. Pasteura Kosice
  - Michalovce, Slovakia, 071 01
    - Hepatobiliarne centrum - Michalovce
  - Trnava, Slovakia, 91701
    - JAL s.r.o.
South Africa
- - Johannesburg, South Africa, 2193
    - Wits Health Consortium
- Eastern Cape
  - Port Elizabeth, Eastern Cape, South Africa, 6001
    - Phoenix Pharma
- Gauteng
  - Johannesburg, Gauteng, South Africa, 2193
    - Wits Clinical Research
  - Johannesburg, Gauteng, South Africa, 2013
    - Chris Hani Baragwanath Hospital
  - Lenasia, Gauteng, South Africa, 1827
    - Lenasia Clinical Trial Centre
- KwaZulu-Natal
  - Durban, KwaZulu-Natal, South Africa, 4001
    - Maxwell Centre
  - Durban, KwaZulu-Natal, South Africa, 4901
    - Lenmed Shifa Private Hospital
- Western Cape
  - Cape Town, Western Cape, South Africa, 7530
    - Tiervlei Trial Centre
  - Cape Town, Western Cape, South Africa, 7800
    - Dr Rajabally's Practice
South Korea
- - Daegu, South Korea, 42601
    - Keimyung University Dongsan Hospital
  - Daegu, South Korea, 41944
    - Kyungpook National University Hospital
  - Daegu, South Korea, 42415
    - Yeungnam Univ. Medical Center
  - Gangwon-do, South Korea, 26426
    - Wonju Severance Christian Hospital
  - Gyeonggi-do, South Korea, 14584
    - Soon Chun Hyang University Hospital Bucheon
  - Seoul, South Korea, 03722
    - Severance Hospital, Yonsei University Health System
  - Seoul, South Korea, 08308
    - Korea University Guro Hospital
  - Seoul, South Korea, 06973
    - Chung-Ang University Hospital
  - Seoul, South Korea, 07061
    - SMG-SNU Boramae Medical Center
Spain
- - Barcelona, Spain, 08035
    - Hospital Vall d'Hebron
  - Majadahonda, Spain, 28222
    - Hospital Universitario Puerta De Hierro Majadahonda
  - Pontevedra, Spain, 36004
    - Complejo Hospitalario de Pontevedra - Hospital de Montecelo
  - Santander, Spain, 39008
    - Hospital Universitario Marqués de Valdecilla
  - Seville, Spain, 41013
    - Hospital Universitario Virgen del Rocio
  - Valencia, Spain, 46026
    - Hospital Universitario y Politecnico La Fe
  - Valencia, Spain, 46014
    - Hospital General de Valencia
  - Valladolid, Spain, 47010
    - Hospital Clínico de Valladolid
- Galicia
  - Pontevedra, Galicia, Spain, 36004
    - Complejo Hospitalario de Pontevedra - Hospital de Montecelo
Switzerland
- - Bern, Switzerland, 3010
    - Universitätsklinik für Viszerale Chirurgie und Medizin
  - Geneva, Switzerland, 1211
    - Hopitaux Universitaires de Geneve
  - Olten, Switzerland, 4600
    - Kantonsspital Olten
  - Sankt Gallen, Switzerland, 9007
    - Kantonsspital St. Gallen
  - Zurich, Switzerland, 8091
    - USZ Klinik für Gastroenterologie und Hepatologie
Taiwan
- - Chiayi City, Taiwan, 600
    - Ditmanson Medical Foundation Chia-Yi Christian Hospital
  - Kaohsiung City, Taiwan, 807
    - Kaohsiung Medical University Chung-Ho Memorial Hospital
  - New Taipei City, Taiwan, 231
    - Taipei Tzu Chi Hospital
  - Taichung, Taiwan, 404
    - China Medical University Hospital
  - Tainan, Taiwan, 704
    - National Cheng Kung University Hospital
  - Taipei, Taiwan, 110
    - Taipei Medical University Hospital
  - Taipei, Taiwan, 106
    - Cathay General Hospital
  - Taipei, Taiwan, 104
    - Taipei Mackay Memorial Hospital
  - Taipei, Taiwan, 100
    - National Taiwan University Hospital_main
  - Taipei, Taiwan, 112
    - Taipei-Veterans General Hospital - Dept of Gastrointestinal
Turkey (Türkiye)
- - Adana, Turkey (Türkiye), 01000
    - T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan
  - Ankara, Turkey (Türkiye), 06230
    - Hacettepe Universitesi Tıp Fakültesi- Gastroenteroloji
  - Ankara, Turkey (Türkiye), 06590
    - Ankara Universitesi Tıp Fakultesi Gastroenteroloji Bilim Da
  - Ankara, Turkey (Türkiye), 06800
    - Ankara Sehir Hastanesi,Gastroenteroloji Klinigi
  - Ankara, Turkey (Türkiye), 06590
    - Ankara Üniversitesi Tıp Fakültesi Cebeci Araştırma Ve Uygulama Hastanesi-Gastroenteroloji
  - Ankara, Turkey (Türkiye), 06800
    - Ankara Bilkent Şehir Hastanesi-Gastroenteroloji
  - Bursa, Turkey (Türkiye), 16059
    - Uludag Universitesi Tıp Fakultesi-Gastroenteroloji
  - Bursa, Turkey (Türkiye), 16059
    - Bursa Uludağ Üniversitesi Hastanesi-Gastroenteroloji
  - Istanbul, Turkey (Türkiye), 34010
    - Koc Universitesi Hastanesi-Gastroenteroloji
  - Istanbul, Turkey (Türkiye), 34093
    - Bezmialem Vakıf Üniversitesi Hastanesi-Gastroenteroloji
  - Istanbul, Turkey (Türkiye), 34093
    - Istanbul Universitesi Istanbul Tip Fakultesi-Gastroenterolog
  - Istanbul, Turkey (Türkiye), 34764
    - Umraniye Egitim ve Arastirma Hastanesi, Gastroenteroloji
  - Istanbul, Turkey (Türkiye), 34899
    - Marmara Üniversitesi Pendik EAH- Gastroenteroloji
  - Izmir, Turkey (Türkiye), 35100
    - Ege Universitesi Tip Fakultesi Hastanesi, Gastroenteroloji
  - Kocaeli, Turkey (Türkiye), 41000
    - Kocaeli Üniversitesi Hastanesi - Gastroenteroloji
  - Mersin, Turkey (Türkiye), 33343
    - Mersin Universitesi Tip Fakultesi Gastroenteroloji Bilim Dal
  - Mersin, Turkey (Türkiye), 33343
    - Mersin Üniversitesi Tip Fakültesi Hastanesi -Gastroenteroloji
  - Yüreğir/Adana, Turkey (Türkiye), 1370
    - Adana Şehir Eğitim ve Araştırma Hastanesi-Endokrinoloji
United Kingdom
- - Belfast, United Kingdom, BT12 6BA
    - Royal Victoria Hospital
  - Birmingham, United Kingdom, B15 2TH
    - Queen Elizabeth Hospital, Birmingham
  - Coventry, United Kingdom, CV2 2DX
    - University Hospital Coventry - WISDEM Centre
  - Derby, United Kingdom, DE22 3NE
    - Royal Derby Hospital
  - Derby, United Kingdom, DE22 3DT
    - Royal Derby Hospital
  - Dundee, United Kingdom, DD1 9SY
    - Ninewells Hospital
  - Exeter, United Kingdom, EX2 5DW
    - Royal Devon and Exeter Hospital
  - Hull, United Kingdom, HU3 2GZ
    - Hull Royal Infirmary_Hull
  - Hull, United Kingdom, HU3 2GZ
    - Hull Royal Infirmary
  - Ipswich, United Kingdom, IP4 5RH
    - The Diabetes Centre
  - Ipswich, United Kingdom, IP4 5RH
    - Ipswich Hospital - Diabetes
  - Leeds, United Kingdom, LS9 7TF
    - St James's University Hospital
  - Leeds, United Kingdom, LS9 7TF
    - St. James University Hospital
  - London, United Kingdom, SW10 9NH
    - Chelsea & Westminster Hospital
  - London, United Kingdom, SE5 9RS
    - Institute of Liver Studies
  - London, United Kingdom, W2 1NY
    - Imperial College London
  - London, United Kingdom, E1 1FR
    - The Royal London Hospital - Grahame Hayton Unit
  - London, United Kingdom, NW3 2QG
    - Royal Free Hospital - Immunity & Transplantation
  - Newcastle upon Tyne, United Kingdom, NE7 7DN
    - Freeman Hospital, Newcastle
  - Nottingham, United Kingdom, NG7 2UH
    - Nottingham University Hospitals NHS Trust
  - Nottingham, United Kingdom, NG7 2UH
    - Nottingham University Hospital
  - Oxford, United Kingdom, OX3 9DU
    - John Radcliffe Hospital
  - Plymouth, United Kingdom, PL6 8DH
    - Derriford Hospital - Plymouth
  - Sheffield, United Kingdom, S5 7AU
    - Northern General Hospital
  - Southampton, United Kingdom, SO16 6YD
    - Southampton General Hospital
  - Swansea, United Kingdom, SA2 8PP
    - Joint Clinical Research Facility - Swansea
United States
- Alabama
  - Huntsville, Alabama, United States, 35801
    - North AL Health Res, LLC
- Arizona
  - Chandler, Arizona, United States, 85224
    - The Institute for Liver Health
  - Peoria, Arizona, United States, 85381
    - Inst-Liver Hlth dba AZ Liver H
  - Tucson, Arizona, United States, 85715
    - Del Sol Research Management, LLC
  - Tucson, Arizona, United States, 85712
    - Inst. Liver H II dba AZ Liver H
- Arkansas
  - Jonesboro, Arkansas, United States, 72401
    - ARcare Center for Clinical Research
  - Little Rock, Arkansas, United States, 72205
    - ARcare Center for Clinical Research
  - Little Rock, Arkansas, United States, 72205
    - Arkansas Diagnostic Center, PA
- California
  - Escondido, California, United States, 92025
    - Gastroenterology & Liver Institute
  - Hacienda Heights, California, United States, 91745
    - Shang Wu M.D. Inc.
  - La Jolla, California, United States, 92037
    - Scripps Whittier Diabetes Inst
  - La Jolla, California, United States, 92037
    - UCSD NAFLD Research Center
  - Lancaster, California, United States, 93534
    - Om Research Llc
  - Long Beach, California, United States, 90808
    - Digestive Hlth Res of SoCa
  - Oxnard, California, United States, 93030
    - Om Research Llc
  - Pasadena, California, United States, 90048
    - Cedars-Sinai Medical Center
  - Pasadena, California, United States, 91105
    - Pasedena Liver Center
  - Rialto, California, United States, 92377
    - Inland Empire Clin Trials LLC
  - Sacramento, California, United States, 95817
    - UC Davis Hlth -Midtwn Ambu Cen
  - San Francisco, California, United States, 94143
    - University of California, San Francisco
  - San Jose, California, United States, 95116
    - Silicon Valley Res Inst
- Colorado
  - Colorado Springs, Colorado, United States, 80907
    - Peak Gastro Assoc-Col Springs
- Connecticut
  - New Haven, Connecticut, United States, 06519
    - Yale Ctr for Clin Invest
- Florida
  - Boynton Beach, Florida, United States, 33436
    - Encore Medical Research of Boynton Beach LLC
  - Doral, Florida, United States, 33122
    - Integrity Clinical Research, LLC
  - Fort Myers, Florida, United States, 33912
    - Covenant Metabolic Specialists, Ft. Myers
  - Gainesville, Florida, United States, 32610
    - University of Florida-CTRB
  - Hialeah, Florida, United States, 33012
    - Miguel Rebollar PA
  - Hialeah, Florida, United States, 33016
    - Direct Helpers Research Center
  - Lakewood Rch, Florida, United States, 34211-4930
    - Florida Research Institute, LLC
  - Maitland, Florida, United States, 32751
    - Sandhill Research, LLC
  - Maitland, Florida, United States, 32751
    - Tandem Clinical Research - Maitland
  - Miami, Florida, United States, 33173
    - Genoma Research Group, Inc
  - Miami, Florida, United States, 33135
    - Optimus U, Corp
  - Miami, Florida, United States, 33136
    - Univ of Miami/Schiff Ctr
  - Miami, Florida, United States, 33176
    - IMIC Inc
  - Miami Lakes, Florida, United States, 33014
    - San Marcus Res Clin Miami Lakes
  - Ocala, Florida, United States, 34471
    - Ocala GI Research
  - Ocoee, Florida, United States, 34761
    - Sensible Healthcare LLC
  - Sarasota, Florida, United States, 34240
    - Covenant Metabolic Specialists LLC
  - Sarasota, Florida, United States, 34243
    - Headlands Research - Sarasota
  - St. Petersburg, Florida, United States, 33710
    - Theia Clinical Research Centers LLC
  - Viera E., Florida, United States, 32940
    - ClinCloud, LLC
  - Zephyrhills, Florida, United States, 33542
    - Florida Medical Clinic Orlando Health
- Georgia
  - Atlanta, Georgia, United States, 30322-1059
    - Emory University Hospital
  - Columbus, Georgia, United States, 31904
    - Columbus Regional Research Institute
  - Macon, Georgia, United States, 31201
    - Gastroenterology Assoc_ CGA
  - Marietta, Georgia, United States, 30060
    - Gastroint Spec of Georgia
- Illinois
  - Chicago, Illinois, United States, 60637
    - University of Chicago
  - Chicago, Illinois, United States, 60612
    - Rush University Med. Cntr
  - Skokie, Illinois, United States, 60077
    - Endeavor Health
- Indiana
  - Indianapolis, Indiana, United States, 46202
    - Indiana University Hospital
  - South Bend, Indiana, United States, 46635
    - Digestive Research Alliance of Michiana
- Iowa
  - Clive, Iowa, United States, 50325
    - Iowa Digestive Disease Center
- Kansas
  - Kansas City, Kansas, United States, 66160
    - University of Kansas Hospital
  - Topeka, Kansas, United States, 66606
    - Kansas Medical Clinic, PA
- Louisiana
  - Houma, Louisiana, United States, 70363
    - Tandem Clinical Research - Houma
  - Marrero, Louisiana, United States, 70072
    - Tandem Clinical Research
  - Metairie, Louisiana, United States, 70006
    - Tandem Clinical Research - Metairie
  - Shreveport, Louisiana, United States, 71105
    - Louisiana Research Center, LLC
- Maryland
  - Baltimore, Maryland, United States, 21202
    - Mercy Medical Center, GI Research
  - Bethesda, Maryland, United States, 20889
    - Walter Reed Nat Mil Md Ctr
  - Glen Burnie, Maryland, United States, 21061
    - Woodholme Gastroenterology Associates
- Massachusetts
  - Boston, Massachusetts, United States, 02118
    - Boston Medical Center_Cary
- Michigan
  - Ann Arbor, Michigan, United States, 48109
    - University of Michigan Medicine
  - Detroit, Michigan, United States, 48202
    - Henry Ford Health System
- Minnesota
  - Rochester, Minnesota, United States, 55905-0001
    - Mayo Clinic
- Mississippi
  - Jackson, Mississippi, United States, 39216
    - Southern Therapy and Advanced Research LLC
- Missouri
  - Chesterfield, Missouri, United States, 63005
    - Clinical Research Professionals
  - Kansas City, Missouri, United States, 64131
    - Kansas City Research Institute
- Nebraska
  - Omaha, Nebraska, United States, 68198-3020
    - Univ of Nebraska Medical CTR
- Nevada
  - Las Vegas, Nevada, United States, 89106
    - Jubilee Clinical Research, Inc.
  - Las Vegas, Nevada, United States, 89106
    - Sierra Clinical Research-Las Vegas
- New Jersey
  - Florham Park, New Jersey, United States, 07932
    - AIG Digestive Disease Research
  - Sparta, New Jersey, United States, 07871
    - Premier Health Research, LLC
- New York
  - New York, New York, United States, 10016
    - NYU Grossman School of Med
  - New York, New York, United States, 10021
    - Weill Cornell Med Coll-NYPH
  - New York, New York, United States, 10029
    - Icahn Sch of Med-Mt Sinai Hosp
- North Carolina
  - Charlotte, North Carolina, United States, 28210
    - AtriumHealth Liver Care, Pineville
  - Concord, North Carolina, United States, 28027
    - Northeast GI Research Division
  - Durham, North Carolina, United States, 27710
    - Duke Univ. Med CNTR_Durham_2
- Ohio
  - Columbus, Ohio, United States, 43210
    - Ohio State Univ Wexner Med Ctr
  - Springboro, Ohio, United States, 45066
    - Objective GI
  - Westlake, Ohio, United States, 44145
    - CRIOH
- Oklahoma
  - Tulsa, Oklahoma, United States, 74104
    - Options Health Research, LLC
- Pennsylvania
  - Danville, Pennsylvania, United States, 17822
    - Geisinger Clinic
  - Hershey, Pennsylvania, United States, 17033
    - Pennsylvania State University
  - Philadelphia, Pennsylvania, United States, 19104
    - Univ of Pennsylvania Hospital
  - Philadelphia, Pennsylvania, United States, 19107-5244
    - Thomas Jefferson University Hospital
  - Pittsburgh, Pennsylvania, United States, 15213
    - UPMC Center for Liver Diseases
  - Pittsburgh, Pennsylvania, United States, 15213
    - UPMC_Center for Liver Care
  - Pottsville, Pennsylvania, United States, 17901
    - Care Access Research, Pottsville
- Rhode Island
  - Cumberland, Rhode Island, United States, 02864
    - Clinical Res Collaborative
  - Lincoln, Rhode Island, United States, 02865
    - Ocean St Clin Res Partnrs, LLC
- South Carolina
  - Charleston, South Carolina, United States, 29425
    - Medical University of South Carolina
- Tennessee
  - Chattanooga, Tennessee, United States, 37421
    - WR-Clinsearch, LLC
  - Hermitage, Tennessee, United States, 37076
    - Digestive Health Res-TSMC
  - Johnson City, Tennessee, United States, 37604
    - East Tennessee Research Institute
  - Nashville, Tennessee, United States, 37211
    - Quality Medical Research
- Texas
  - Amarillo, Texas, United States, 79106
    - Amarillo Center for Clinical Research, Ltd.
  - Arlington, Texas, United States, 76012
    - Texas Clin Res Inst, LLC
  - Dallas, Texas, United States, 75230
    - Velocity Clinical Res-Dallas
  - Dallas, Texas, United States, 75390-9302
    - UT Southwestern Med Cntr
  - Dallas, Texas, United States, 75203
    - Liver Ins@ Mthdist DTX Med Cen
  - Edinburg, Texas, United States, 78539
    - South Texas Research Institute
  - Fort Sam Houston, Texas, United States, 78234
    - Brooke Army Medical Ctr.
  - Fort Worth, Texas, United States, 76104
    - GI Alliance Research
  - Houston, Texas, United States, 77030
    - Baylor College of Medicine
  - Houston, Texas, United States, 77030
    - Houston Methodist Hospital
  - Houston, Texas, United States, 77089
    - Amir Ali Hassan, MD, PA
  - Houston, Texas, United States, 77079
    - Houston Research Institute
  - Houston, Texas, United States, 77043
    - Bipharma Informatic Inc.
  - Houston, Texas, United States, 77054
    - Bylr Coll Md-Ben Taub Gen Hos
  - Houston, Texas, United States, 77084
    - Biopharma Informatic
  - McAllen, Texas, United States, 78504
    - Centex Studies - McAllen
  - Pearland, Texas, United States, 77584
    - LinQ Research, LLC
  - San Antonio, Texas, United States, 78229
    - Clinical Trials of Texas, LLC
  - San Antonio, Texas, United States, 78215
    - Amer. Rrsch Corp-TX Liver Inst
  - Sugar Land, Texas, United States, 77479
    - Mt Olympus Medical Research, LLC
  - Wichita Falls, Texas, United States, 76301
    - Digestive Hlth Res of N Texas
- Utah
  - Ogden, Utah, United States, 84405
    - South Ogden Family Medicine/ CCT Research
  - Riverton, Utah, United States, 84065
    - Velocity Clinical Research, Riverton
  - Salt Lake City, Utah, United States, 84132
    - University of Utah
- Virginia
  - Charlottesville, Virginia, United States, 22908
    - University Of Virginia Hospital
  - Falls Church, Virginia, United States, 22042
    - Inova Fairfax Medical Campus
  - Norfolk, Virginia, United States, 23502
    - Digestive and Liver Disease Specialists
  - Richmond, Virginia, United States, 23249
    - McGuire VA Medical Center
  - Richmond, Virginia, United States, 23226
    - Bon Secours Richmond Community Hospital LLC
  - Richmond, Virginia, United States, 23298
    - VCU Health System
  - Roanoke, Virginia, United States, 24014
    - Gastroent Consult of SW VA

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Age above or equal to 18 years at the time of signing informed consent.
Histological evidence of NASH based on a central pathologist evaluation of the baseline liver biopsy. The baseline liver biopsy can be a historical biopsy obtained within 180 days prior to the screening visit (V1).
Histological evidence of fibrosis stage 2 or stage 3 according to the NASH CRN (Clinical Research Network) classification based on a central pathologist evaluation of the baseline liver biopsy.
A histological NAS (Non-alcoholic fatty liver disease Activity Score) above or equal to 4 with a score of 1 or more in steatosis, lobular inflammation and hepatocyte ballooning based on a central pathologist evaluation of the baseline liver biopsy.

Exclusion Criteria:

Documented causes of chronic liver disease other than non-alcoholic fatty liver disease (NAFLD)
Positive HBsAg, positive anti-HIV, positive HCV RNA at screening (V2A) or any known presence of HCV RNA or HBsAg within 2 years of screening (V2A).
Presence or history of ascites, variceal bleeding, hepatic encephalopathy, spontaneous bacterial peritonitis or liver transplantation at randomisation.
Known or suspected excessive consumption of alcohol (greater than 20 g/day for women or greater than 30 g/day for men) or alcohol dependence (assessed by the Alcohol Use Disorders Identification Test (AUDIT questionnaire)).
Treatment with vitamin E (at doses greater than or equal to 800 IU/day) or pioglitazone or medications approved for treatment of NASH which has not been at a stable dose in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, treatment should be at a stable dose from time of biopsy until screening.
Treatment with GLP-1 RAs in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, any treatment with GLP-1 RAs from time of biopsy until screening (V2A).
Treatment with glucose-lowering agent(s) (other than GLP-1 RAs), lipid-lowering medication or weight loss medication not stable in the opinion of the investigator in the period from 90 days prior to the screening visit (V2A). In addition, for subjects with historical liver biopsies taken more than 90 days prior to screening, treatment should be at a stable dose in the opinion of the investigator from time of biopsy until screening.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Double

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Semaglutide OW (once weekly ) Semaglutide administrated subcutaneously once weekly	Drug: Semaglutide Semaglutide administrated subcutaneously (under the skin) once weekly there will be a period of dose escalation before reaching the target dose.
Placebo Comparator: Placebo Placebo administrated subcutaneously once weekly	Drug: Placebo Placebo administrated subcutaneously (under the skin) once weekly.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Part 1: Resolution of steatohepatitis and no worsening of liver fibrosis (Yes/No) Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
Part 1: Improvement in liver fibrosis and no worsening of steatohepatitis (Yes/No) Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
Part 2: Cirrhosis-free survival (Yes/No) Time Frame: From randomisation (week 0) to week 240	Count of subject	From randomisation (week 0) to week 240

Secondary Outcome Measures

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Novo Nordisk A/S

Investigators

Study Director: Clinical Transparency (dept. 2834), Novo Nordisk A/S

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 1, 2021

Primary Completion (Estimated)

April 25, 2029

Study Completion (Estimated)

April 25, 2029

Study Registration Dates

First Submitted

March 26, 2021

First Submitted That Met QC Criteria

March 26, 2021

First Posted (Actual)

March 30, 2021

Study Record Updates

Last Update Posted (Actual)

April 17, 2026

Last Update Submitted That Met QC Criteria

April 16, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

NN9931-4553
U1111-1244-3678 (Other Identifier: World Health Organization (WHO))
2019-004594-44 (Registry Identifier: European Medicines Agency (EudraCT))
jRCT2031210033 (Registry Identifier: JAPIC)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Outcome Measure	Measure Description	Time Frame
Change in body weight Time Frame: From randomisation (week 0) to week 72	Percentage	From randomisation (week 0) to week 72
Change in SF-36 (Short Form 36) Bodily Pain Time Frame: From randomisation (week 0) to week 72	Score points	From randomisation (week 0) to week 72
Change in body weight Time Frame: From randomisation (week 0) to week 240	Percentage	From randomisation (week 0) to week 240
Change in histology-assessed liver collagen proportionate area Time Frame: From randomisation (week 0) to week 72	Ratio to baseline	From randomisation (week 0) to week 72
Resolution of steatohepatitis and improvement in liver fibrosis (Yes/No) Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
Improvement in steatohepatitis with at least a 2-point reduction in NAS and no worsening of fibrosis (Yes/No) Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
Worsening in steatohepatitis (Yes/No) Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
Improvement in histology-assessed ballooning (Yes/No) Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
Improvement in histology-assessed inflammation (Yes/No) Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
Improvement in histology-assessed steatosis (Yes/No) Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
NASH resolution (ballooning of 0, inflammation of 0-1) and above or equal to 2point NAS reduction with no worsening of fibrosis Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
Progression of liver fibrosis in patients with F2 at baseline (Yes/No) Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
Progression of liver fibrosis Time Frame: From randomisation (week 0) to week 72	Count of subject	From randomisation (week 0) to week 72
Resolution of steatohepatitis and no worsening of liver fibrosis (Yes/No) Time Frame: From randomisation (week 0) to week 240	Count of subject	From randomisation (week 0) to week 240
Improvement in liver fibrosis and no worsening of steatohepatitis (Yes/No) Time Frame: From randomisation (week 0) to week 240	Count of subject	From randomisation (week 0) to week 240
Changes in liver stiffness values assessed by transient elastography (FibroScan®) Time Frame: From randomisation (week 0) to week 72 and week 240	Ratio to baseline	From randomisation (week 0) to week 72 and week 240
Change in ELF (Enhanced Liver Fibrosis) score Time Frame: From randomisation (week 0) to week 72 and week 240	Logarithm	From randomisation (week 0) to week 72 and week 240
Change in ALT (alanine aminotransferase) Time Frame: From randomisation (week 0) to week 72 and week 240	Ratio to baseline	From randomisation (week 0) to week 72 and week 240
Change in AST (aspartate aminotransferase) Time Frame: From randomisation (week 0) to week 72 and week 240	Ratio to baseline	From randomisation (week 0) to week 72 and week 240
Change in CAP (Controlled Attenuation Parameter) values assessed by transient elastography (FibroScan) Time Frame: From randomisation (week 0) to week 72 and week 240	Absolute change	From randomisation (week 0) to week 72 and week 240
Change in FAST (FibroScan-AST) score Time Frame: From randomisation (week 0) to week 72 and week 240	Probability (absolute change)	From randomisation (week 0) to week 72 and week 240
Change in Pro-C3 (pro-peptide of type III collagen) Time Frame: From randomisation (week 0) to week 72 and week 240	Logarithm	From randomisation (week 0) to week 72 and week 240
Change in inflammation assessed by hsCRP (High Sensitive C-Reactive Protein) Time Frame: From randomisation (week 0) to week 72 and week 240	Ratio to baseline	From randomisation (week 0) to week 72 and week 240
Change in HbA1c (glycated haemoglobin) Time Frame: From randomisation (week 0) to week 72 and week 240	Percentage-points (absolute change)	From randomisation (week 0) to week 72 and week 240
Change in triglyceride Time Frame: From randomisation (week 0) to week 72 and week 240	Ratio to baseline	From randomisation (week 0) to week 72 and week 240
Change in free fatty acids Time Frame: From randomisation (week 0) to week 72 and week 240	Ratio to baseline	From randomisation (week 0) to week 72 and week 240
Change in LDL (low-density lipoprotein) cholesterol Time Frame: From randomisation (week 0) to week 72 and week 240	Ratio to baseline	From randomisation (week 0) to week 72 and week 240
Change in HDL (High density lipoprotein ) cholesterol Time Frame: From randomisation (week 0) to week 72 and week 240	Ratio to baseline	From randomisation (week 0) to week 72 and week 240
Time to first MACE(Major Adverse Cardiovascular event ) (composite endpoint) Time Frame: From randomisation (week 0) to week 240	Days	From randomisation (week 0) to week 240
Major cardio-hepatic event-free survival (Yes/No) Time Frame: From randomisation (week 0) to week 240	Count of subject	From randomisation (week 0) to week 240
Changes in SF-36 (Short Form 36 v2.0 acute ) Physical Component Summary Time Frame: From randomisation (week 0) to week 72 and week 240	Score points	From randomisation (week 0) to week 72 and week 240
Changes in SF-36 Mental Component Summary Time Frame: From randomisation (week 0) to week 72 and week 240	Score points	From randomisation (week 0) to week 72 and week 240
Change in SF-36 Bodily Pain Time Frame: From randomisation (week 0) to week 240	Score points	From randomisation (week 0) to week 240
Changes in NASH-CHECK Abdominal Pain Time Frame: From randomisation (week 0) to week 72 and week 240	Score points	From randomisation (week 0) to week 72 and week 240
Absence of histological evidence of NASH (Yes/No) Time Frame: From randomisation (week 0) to week 240	Count of subject	From randomisation (week 0) to week 240

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) (ESSENCE)

The Effect of Semaglutide in Subjects With Non-cirrhotic Non-alcoholic Steatohepatitis

Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Publications and helpful links

General Publications

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Non-alcoholic Steatohepatitis

Clinical Trials on Semaglutide

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Uzbekistan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations