Denne side blev automatisk oversat, og nøjagtigheden af oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab versus TPC i TNBC, der ikke opnåede pCR

3. november 2026 opdateret af: Merck Sharp & Dohme LLC

En fase 3, randomiseret, åben-label, undersøgelse for at sammenligne effektiviteten og sikkerheden af adjuvans MK-2870 i kombination med Pembrolizumab (MK-3475) versus behandling af lægens valg (TPC) hos deltagere med triple-negativ brystkræft (TNBC) Hvem modtog neoadjuverende terapi og ikke opnåede en patologisk fuldstændig respons (pCR) ved operationen

This is a randomized, open-label study comparing the efficacy and safety of adjuvant sacituzumab tirumotecan (MK-2870) in combination with pembrolizumab compared to treatment of physician's choice (TPC) in participants with triple-negative breast cancer (TNBC) who received neoadjuvant therapy and did not achieve a pathological complete response (pCR) at surgery. The primary objective is to compare sacituzumab tirumotecan plus pembrolizumab to TPC (pembrolizumab or pembrolizumab plus capecitabine) with respect to invasive disease-free survival (iDFS) per investigator assessment. It is hypothesized that sacituzumab tirumotecan plus pembrolizumab is superior to TPC with respect to iDFS per investigator assessment.

Studieoversigt

Status

Rekruttering

Betingelser

Triple-negativ brystkræft

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

1530

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Navn: Toll Free Number
Telefonnummer: 1-888-577-8839
E-mail: Trialsites@msd.com

Studiesteder

Argentina
- - Buenos Aires, Argentina, C1187AAN
    - Rekruttering
    - Sanatorio Finochietto ( Site 0513)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +54 113752-8000
  - Buenos Aires, Argentina, C1431FWO
    - Rekruttering
    - Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 0508)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +54 9115596-3681
- Buenos Aires
  - Capital Federal, Buenos Aires, Argentina, C1118AAT
    - Rekruttering
    - Hospital Aleman-Oncology ( Site 0501)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +541148277000
  - Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1280AEB
    - Rekruttering
    - Hospital Británico de Buenos Aires-Oncology ( Site 0502)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +54911563819972
- Buenos Aires F.D.
  - Buenos Aires, Buenos Aires F.D., Argentina, C1417
    - Rekruttering
    - Instituto de Oncología Angel H. Roffo ( Site 0503)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 5491152375236
  - Buenos Aires, Buenos Aires F.D., Argentina, C1426ANZ
    - Rekruttering
    - Instituto Alexander Fleming-Alexander Fleming ( Site 0509)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +5491138850425
- Santa Fe Province
  - Rosario, Santa Fe Province, Argentina, S2000DSV
    - Rekruttering
    - Sanatorio Parque ( Site 0512)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 543414929663
Australien
- New South Wales
  - Macquarie University, New South Wales, Australien, 2109
    - Rekruttering
    - Macquarie University-MQ Health Clinical Trials Unit ( Site 2703)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +61298122979
  - Westmead, New South Wales, Australien, 2145
    - Rekruttering
    - Westmead Hospital ( Site 2700)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +61288906728
- Queensland
  - Brisbane, Queensland, Australien, 4029
    - Rekruttering
    - Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Site 2701)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +610736470209
- Victoria
  - Frankston, Victoria, Australien, 3199
    - Rekruttering
    - Frankston Hospital-Oncology and Haematology ( Site 2704)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +61397847777
Belgien
- - Namur, Belgien, 5530
    - Rekruttering
    - Université Catholique de Louvain-Namur - Centre Hospitalier -Oncology ( Site 0902)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +32 (0)81 42 38 53
- Bruxelles-Capitale, Region de
  - Brussels, Bruxelles-Capitale, Region de, Belgien, 1200
    - Rekruttering
    - Cliniques universitaires Saint-Luc-Medical Oncology ( Site 0901)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 02 764 42 14
- Oost-Vlaanderen
  - Ghent, Oost-Vlaanderen, Belgien, 9000
    - Rekruttering
    - AZ Maria Middelares-IKG ( Site 0903)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +3292468464
Brasilien
- - São Paulo, Brasilien, 04014-002
    - Rekruttering
    - IBCC - Núcleo de Pesquisa e Ensino ( Site 0601)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +551144500300
- Ceará
  - Fortaleza, Ceará, Brasilien, 60810-180
    - Rekruttering
    - PRONUTRIR-CLINICAL RESEARCH ( Site 0609)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +558530480533
- Espírito Santo
  - Vitória, Espírito Santo, Brasilien, 29043-260
    - Rekruttering
    - Hospital Santa Rita de Cassia ( Site 0617)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +55 027 99846-9004
- Piauí
  - Teresina, Piauí, Brasilien, 64049-200
    - Rekruttering
    - Oncoclínica Oncologistas Associados-Clinical Research ( Site 0607)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +5586999007799
- Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brasilien, 90110-270
    - Rekruttering
    - Hospital do Câncer Mãe de Deus ( Site 0604)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +555133072943
  - Santa Cruz do Sul, Rio Grande do Sul, Brasilien, 96830-180
    - Rekruttering
    - Instituto de Oncologia Saint Gallen ( Site 0614)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +55513056-8686
- Santa Catarina
  - Lages, Santa Catarina, Brasilien, 88501-001
    - Rekruttering
    - ANIMI - Unidade de Tratamento Oncologico ( Site 0616)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +55 49 33805241
- São Paulo
  - Taubaté, São Paulo, Brasilien, 12030-200
    - Rekruttering
    - Instituto do Câncer Brasil - Unidade Taubaté ( Site 0608)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +551236318559
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 5G2
    - Rekruttering
    - Arthur J.E. Child Comprehensive Cancer Centre ( Site 0421)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 587-231-6050
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Rekruttering
    - Cross Cancer Institute ( Site 0407)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 7804328956
- British Columbia
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - Rekruttering
    - BC Cancer Vancouver ( Site 0404)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 6048776000
- Manitoba
  - Winnipeg, Manitoba, Canada, R2H 2A6
    - Rekruttering
    - CancerCare Manitoba ( Site 0411)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 2047872127
- New Brunswick
  - Moncton, New Brunswick, Canada, E1C 6Z8
    - Rekruttering
    - The Moncton Hospital ( Site 0401)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 5068575756
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - Rekruttering
    - QEII Health Sciences Centre - Victoria General Site ( Site 0418)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 9024732160
- Ontario
  - Hamilton, Ontario, Canada, L8V 5C2
    - Rekruttering
    - Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0424)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 905-387-9495
  - Kingston, Ontario, Canada, K7L 2V7
    - Rekruttering
    - Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0422)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 613-549-6666
  - Newmarket, Ontario, Canada, L3Y 2P9
    - Afsluttet
    - Southlake Health ( Site 0413)
  - Ottawa, Ontario, Canada, K1H 8L6
    - Rekruttering
    - The Ottawa Hospital - General Campus ( Site 0414)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 6137377700x70208
  - Toronto, Ontario, Canada, M2K 1E1
    - Rekruttering
    - North York General Hospital ( Site 0415)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 4167566000
  - Toronto, Ontario, Canada, M5G 2M9
    - Rekruttering
    - Princess Margaret Cancer Centre ( Site 0400)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 4169464501x2245
- Quebec
  - Greenfield Park, Quebec, Canada, J4V 2H1
    - Rekruttering
    - Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0417)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 4504665000x3226
  - Montreal, Quebec, Canada, H3T 1E2
    - Rekruttering
    - Jewish General Hospital ( Site 0416)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 5143405222x27562
  - Montreal, Quebec, Canada, H1T 2M4
    - Rekruttering
    - CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 0419)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 5142523400x6244
  - Montreal, Quebec, Canada, H2X 3E4
    - Rekruttering
    - Centre Hospitalier de l'Université de Montréal ( Site 0403)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 5148908000
  - Rimouski, Quebec, Canada, G5L 5T1
    - Rekruttering
    - Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski ( Site 0409)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 4187243000x8029
  - Trois-Rivières, Quebec, Canada, G8Z 3R9
    - Rekruttering
    - Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0406)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 8196973333x63238
Colombia
- Antioquia
  - Rionegro, Antioquia, Colombia, 054040
    - Rekruttering
    - Clinica Somer ( Site 3704)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 57 3125891661
- Bogota D.C.
  - Bogotá, Bogota D.C., Colombia, 110131
    - Rekruttering
    - FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 3700)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +573183662238
  - Bogotá, Bogota D.C., Colombia, 111511
    - Rekruttering
    - Instituto Nacional De Cancerologia ( Site 3701)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 57 3145017596
- Cesar Department
  - Valledupar, Cesar Department, Colombia, 200001
    - Rekruttering
    - Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 3705)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +5715602310
Danmark
- Capital Region
  - Herlev, Capital Region, Danmark, 2730
    - Rekruttering
    - Herlev og Gentofte Hospital. ( Site 3203)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 00 45 38689193
- Central Jutland
  - Aarhus N, Central Jutland, Danmark, 8200
    - Rekruttering
    - Aarhus Universitets hospital ( Site 3202)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4578450000
- North Denmark
  - Aalborg, North Denmark, Danmark, 9000
    - Rekruttering
    - Aalborg Universitetshospital, Syd ( Site 3206)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4597661400
- Region Syddanmark
  - Odense C, Region Syddanmark, Danmark, 5000
    - Rekruttering
    - Odense Universitetshospital ( Site 3201)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4566113333
  - Sønderborg, Region Syddanmark, Danmark, 6400
    - Rekruttering
    - Sygehus Soenderjylland ( Site 3204)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4579970000
  - Vejle, Region Syddanmark, Danmark, 7100
    - Rekruttering
    - Vejle Sygehus. ( Site 3205)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 00 45 79406060
Det Forenede Kongerige
- - Leeds, Det Forenede Kongerige, LS9 7TF
    - Rekruttering
    - St James's University Hospital-Leeds Cancer Centre ( Site 2608)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 0113 243 3144
- Bristol, City of
  - Bristol, Bristol, City of, Det Forenede Kongerige, BS2 8ED
    - Rekruttering
    - University Hospitals Bristol NHS Foundation Trust ( Site 2601)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 441173426733
- Cambridgeshire
  - Hills Road, Cambridgeshire, Det Forenede Kongerige, CB2 0QQ
    - Rekruttering
    - Addenbrooke's Hospital ( Site 2609)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 01223216083
- England
  - Truro, England, Det Forenede Kongerige, TR1 3LJ
    - Rekruttering
    - The Royal Cornwall Hospital ( Site 2603)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 01872258345
- London, City of
  - London, London, City of, Det Forenede Kongerige, EC1A 7BE
    - Rekruttering
    - St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 2602)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +44 20 7377 7000
  - London, London, City of, Det Forenede Kongerige, NW1 2PG
    - Rekruttering
    - University College London Hospital ( Site 2604)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +44 20 3456 7890
- Midlothian
  - Edinburgh, Midlothian, Det Forenede Kongerige, EH4 2XU
    - Rekruttering
    - Western General Hospital ( Site 2607)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 0300 123 1600
Finland
- Northern Savonia
  - Kuopio, Northern Savonia, Finland, 70210
    - Rekruttering
    - Kuopion Yliopistollinen Sairaala-Syöpäkeskus ( Site 1101)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +35817173311
- Pirkanmaa
  - Tampere, Pirkanmaa, Finland, 33520
    - Rekruttering
    - Tampereen yliopistollinen sairaala ( Site 1102)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +358331166764
- Southwest Finland
  - Turku, Southwest Finland, Finland, 20520
    - Rekruttering
    - Turku University Hospital-Department of Oncology ( Site 1103)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +35823130721
- Uusimaa
  - Helsinki, Uusimaa, Finland, 00029
    - Rekruttering
    - Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1100)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +358947174900
Forenede Stater
- Alabama
  - Mobile, Alabama, Forenede Stater, 36607
    - Rekruttering
    - Infirmary Cancer Care ( Site 0001)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 251-435-2273
- Arizona
  - Chandler, Arizona, Forenede Stater, 85224
    - Rekruttering
    - Ironwood Cancer & Research Centers-Research ( Site 0054)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 480-821-2838
- California
  - Fountain Valley, California, Forenede Stater, 92708
    - Rekruttering
    - MemorialCare Orange Coast Medical Center ( Site 9501)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 714-378-7000
  - La Jolla, California, Forenede Stater, 92037
    - Rekruttering
    - Scripps Cancer Center ( Site 0052)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 800-727-4777
  - Los Alamitos, California, Forenede Stater, 90720
    - Afsluttet
    - Cancer and Blood Specialty Clinic ( Site 0008)
  - Oakland, California, Forenede Stater, 94611
    - Rekruttering
    - Kaiser Permanente - Oakland ( Site 0079)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 877-642-4691
  - Oceanside, California, Forenede Stater, 92056
    - Rekruttering
    - Profound Research LLC ( Site 0105)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 760-826-2020
  - Roseville, California, Forenede Stater, 95661
    - Rekruttering
    - Kaiser Permanente - Roseville ( Site 0081)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 877-642-4691
  - San Francisco, California, Forenede Stater, 94115
    - Rekruttering
    - Kaiser Permanente - San Francisco ( Site 0080)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 877-642-4691
  - Santa Clara, California, Forenede Stater, 95051
    - Rekruttering
    - Kaiser Permanente - Santa Clara ( Site 0082)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 877-642-4691
  - Santa Rosa, California, Forenede Stater, 95403
    - Rekruttering
    - Providence Medical Foundation ( Site 9543)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 707-528-1050
  - Vallejo, California, Forenede Stater, 94589
    - Rekruttering
    - Kaiser Permanente Vallejo Medical Center ( Site 0060)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 877-642-4691
  - Walnut Creek, California, Forenede Stater, 94596
    - Rekruttering
    - Kaiser Permanente - Walnut Creek ( Site 0078)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 877-642-4691
  - Walnut Creek, California, Forenede Stater, 94598
    - Afsluttet
    - Bass Medical Group ( Site 0089)
- Colorado
  - Grand Junction, Colorado, Forenede Stater, 81501
    - Rekruttering
    - Cancer Centers of Colorado St. Mary's Regional Hospital ( Site 0046)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 970-298-7500
- Connecticut
  - Farmington, Connecticut, Forenede Stater, 06030
    - Rekruttering
    - University of Connecticut Health Center ( Site 0128)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 860-679-2100
  - New Haven, Connecticut, Forenede Stater, 06510
    - Rekruttering
    - Yale Cancer Center ( Site 0053)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 203-688-4242
- Delaware
  - Newark, Delaware, Forenede Stater, 19713
    - Rekruttering
    - Helen F. Graham Cancer Center & Research Institute ( Site 0018)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 302-366-1200
- Florida
  - Altamonte Springs, Florida, Forenede Stater, 32701
    - Rekruttering
    - AdventHealth Altamonte Springs ( Site 0125)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 407-834-5151
  - Orlando, Florida, Forenede Stater, 32806
    - Rekruttering
    - Orlando Health Cancer Institute ( Site 0030)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 321-843-8370
  - St. Petersburg, Florida, Forenede Stater, 33709
    - Afsluttet
    - Comprehensive Hematology Oncology ( Site 0091)
  - Stuart, Florida, Forenede Stater, 34994
    - Rekruttering
    - Cleveland Clinic Martin North Hospital ( Site 0114)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 772-419-2146
- Georgia
  - Thomasville, Georgia, Forenede Stater, 31792
    - Afsluttet
    - Archbold Memorial Hospital-Lewis Hall Singletary Oncology Center ( Site 0040)
- Illinois
  - Arlington Heights, Illinois, Forenede Stater, 60005
    - Rekruttering
    - Illinois Cancer Specialists (ICS) ( Site 8010)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 847-259-4482
  - Carterville, Illinois, Forenede Stater, 62918
    - Rekruttering
    - Southern Illinois Hospital Services ( Site 9547)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 618-549-0721
  - Skokie, Illinois, Forenede Stater, 60077
    - Rekruttering
    - Orchard Healthcare Research Inc. ( Site 0014)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 224-534-7580
- Indiana
  - Dyer, Indiana, Forenede Stater, 46311
    - Rekruttering
    - Northwest Cancer Center - Dyer Clinic ( Site 0097)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 615-785-5914
  - Fort Wayne, Indiana, Forenede Stater, 46845
    - Rekruttering
    - Parkview Research Center at Parkview Regional Medical Center ( Site 0011)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 260-266-6313
- Kansas
  - Wichita, Kansas, Forenede Stater, 67214
    - Afsluttet
    - Cancer Center of Kansas ( Site 0004)
- Kentucky
  - Edgewood, Kentucky, Forenede Stater, 41017
    - Rekruttering
    - Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0044)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 859-301-4000
- Louisiana
  - Alexandria, Louisiana, Forenede Stater, 71301
    - Rekruttering
    - CHRISTUS St. Frances Cabrini Hospital Center for Cancer Care ( Site 0109)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 318-528-6976
  - Monroe, Louisiana, Forenede Stater, 71202
    - Afsluttet
    - Ochsner LSU Health - Monroe Medical Center, Family Medicine Clinic ( Site 0063)
  - Shreveport, Louisiana, Forenede Stater, 71103
    - Rekruttering
    - Louisiana State University Health Sciences Shreveport ( Site 0029)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 318-813-1429
- Maryland
  - Silver Spring, Maryland, Forenede Stater, 20910
    - Rekruttering
    - Holy Cross Hospital ( Site 0069)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 301-754-7552
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - Rekruttering
    - University of Michigan ( Site 0103)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 800-865-1125
  - Detroit, Michigan, Forenede Stater, 48202
    - Rekruttering
    - Henry Ford Health ( Site 0010)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 313-598-2556
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Afsluttet
    - Profound Research LLC ( Site 0074)
- Minnesota
  - Saint Louis Park, Minnesota, Forenede Stater, 55426
    - Rekruttering
    - Metro-Minnesota Community Clinical Oncology ( Site 0031)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 952-993-3252
- Mississippi
  - Jackson, Mississippi, Forenede Stater, 39216
    - Rekruttering
    - University of Mississippi Medical Center ( Site 0043)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 601-984-5590
- Missouri
  - Fenton, Missouri, Forenede Stater, 63026
    - Afsluttet
    - SSM Health Cancer Care - Fenton ( Site 0088)
  - Osage Beach, Missouri, Forenede Stater, 65065
    - Rekruttering
    - Lake Regional Hospital ( Site 0009)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 573-302-2772
  - St Louis, Missouri, Forenede Stater, 63108
    - Rekruttering
    - Siteman Cancer Center ( Site 0099)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 314-362-0263
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89102
    - Rekruttering
    - Optum Care Cancer Center ( Site 9535)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 702-724-8787
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Rekruttering
    - Comprehensive Cancer Centers of Nevada - Peak ( Site 0047)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 702-609-9427
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87109
    - Rekruttering
    - New Mexico Oncology Hematology Consultants Ltd. ( Site 0090)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 505-842-8171
  - Santa Fe, New Mexico, Forenede Stater, 87505
    - Rekruttering
    - CHRISTUS St. Vincent Regional Cancer Center ( Site 0118)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 505-913-8953
- New York
  - New York, New York, Forenede Stater, 10029
    - Rekruttering
    - Icahn School of Medicine at Mount Sinai ( Site 0123)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 212-241-3300
  - New York, New York, Forenede Stater, 10065
    - Rekruttering
    - Memorial Sloan Kettering Cancer Center ( Site 0067)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 212-639-2000
  - New York, New York, Forenede Stater, 10011
    - Rekruttering
    - The Blavatnik Family- Chelsea Medical Center at Mount Sinai ( Site 0135)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 212-604-6000
  - Westbury, New York, Forenede Stater, 11590
    - Rekruttering
    - Clinical Research Alliance ( Site 0086)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 516-734-8906
- North Carolina
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Rekruttering
    - Levine Cancer Institute ( Site 0083)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 980-442-3130
  - Fayetteville, North Carolina, Forenede Stater, 28304
    - Rekruttering
    - Cape Fear Valley Health System ( Site 0136)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 472-210-8847
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Rekruttering
    - Sanford Cancer Center Bismarck ( Site 0058)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 701-323-5741
  - Fargo, North Dakota, Forenede Stater, 58102
    - Rekruttering
    - Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0056)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 701-234-2000
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Rekruttering
    - Altru Cancer Center ( Site 0104)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 701-780-5451
- Ohio
  - Canton, Ohio, Forenede Stater, 44708
    - Rekruttering
    - Cleveland Clinic - Mercy Hospital ( Site 0057)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 330-489-1274
  - Massillon, Ohio, Forenede Stater, 44646
    - Rekruttering
    - Tri-County Hematology & Oncology Associates, Inc. ( Site 0076)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 330-478-0001
  - Maumee, Ohio, Forenede Stater, 43537
    - Rekruttering
    - Taylor Cancer Research Center ( Site 9500)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 567-402-4501
  - Zanesville, Ohio, Forenede Stater, 43701
    - Rekruttering
    - Genesis Healthcare System ( Site 0025)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 740-454-5271
- Oklahoma
  - Oklahoma City, Oklahoma, Forenede Stater, 73102
    - Afsluttet
    - Hightower Clinical, LLC ( Site 0085)
  - Tulsa, Oklahoma, Forenede Stater, 74146
    - Rekruttering
    - Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0041)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 918-505-3200
- Oregon
  - Portland, Oregon, Forenede Stater, 97213
    - Rekruttering
    - Providence Portland Medical Center ( Site 0116)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 503-215-1979
  - Portland, Oregon, Forenede Stater, 97225
    - Rekruttering
    - Providence Oncology and Hematology Care Clinic - Westside ( Site 0126)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 503-215-1979
- Pennsylvania
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Rekruttering
    - Sidney Kimmel Cancer Center at Jefferson ( Site 0049)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 215-955-8874
  - York, Pennsylvania, Forenede Stater, 17403
    - Rekruttering
    - Cancer Care Associates Of York ( Site 9517)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 717-741-9229
- South Dakota
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Rekruttering
    - Sanford Cancer Center ( Site 0059)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 605-328-8000
- Tennessee
  - Germantown, Tennessee, Forenede Stater, 38138
    - Rekruttering
    - West Cancer Center and Research Institute ( Site 0084)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 901-683-0055
  - Memphis, Tennessee, Forenede Stater, 38120
    - Rekruttering
    - Baptist Cancer Center ( Site 0101)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 901-226-3077
  - Nashville, Tennessee, Forenede Stater, 37203
    - Rekruttering
    - SCRI Oncology Partners ( Site 7000)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 615-329-7274
  - Nashville, Tennessee, Forenede Stater, 37203
    - Rekruttering
    - One Oncology - Tennessee Oncology ( Site 0098)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 615-986-4350
  - Nashville, Tennessee, Forenede Stater, 37203
    - Rekruttering
    - Tennessee Oncology ( Site 0111)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 615-986-4350
  - Nashville, Tennessee, Forenede Stater, 37212
    - Rekruttering
    - Vanderbilt Health One Hundred Oaks ( Site 0042)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 800-811-8480
  - Nashville, Tennessee, Forenede Stater, 37208
    - Afsluttet
    - Nashville General Hospital ( Site 0072)
- Texas
  - Abilene, Texas, Forenede Stater, 79601
    - Rekruttering
    - Hendrick Medical Center ( Site 0117)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 325-670-2000
  - Amarillo, Texas, Forenede Stater, 79106
    - Rekruttering
    - Harrington Cancer Center ( Site 0061)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 806-359-4673
  - Dallas, Texas, Forenede Stater, 75246
    - Rekruttering
    - Texas Oncology - DFW ( Site 8000)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 214-370-1000
  - Dallas, Texas, Forenede Stater, 75390
    - Rekruttering
    - Parkland Health & Hospital System ( Site 0096)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 214-645-4673
  - Dallas, Texas, Forenede Stater, 75390
    - Rekruttering
    - University of Texas Southwestern Medical Center ( Site 0032)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 214-645-4673
  - Flower Mound, Texas, Forenede Stater, 75028
    - Rekruttering
    - Texas Oncology - Northeast Texas ( Site 8005)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 972-537-4100
  - Fort Worth, Texas, Forenede Stater, 76104
    - Rekruttering
    - John Peter Smith Hospital ( Site 0106)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 817-702-8049
  - Houston, Texas, Forenede Stater, 77030
    - Rekruttering
    - Oncology Consultants P.A. ( Site 0107)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 713-600-0900
  - Laredo, Texas, Forenede Stater, 78041
    - Rekruttering
    - Laguna Clinical Research Associates LLC ( Site 0068)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 956-724-8543
  - San Antonio, Texas, Forenede Stater, 78229
    - Rekruttering
    - Mays Cancer Center ( Site 0122)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 210-450-1000
  - Tyler, Texas, Forenede Stater, 75701
    - Rekruttering
    - The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0055)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 903-592-6152
  - Webster, Texas, Forenede Stater, 77598
    - Rekruttering
    - Texas Oncology - Gulf Coast ( Site 8009)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 281-332-7505
- Utah
  - Murray, Utah, Forenede Stater, 84107
    - Rekruttering
    - Intermountain Medical Center ( Site 0113)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 801-507-3630
- Virginia
  - Fredericksburg, Virginia, Forenede Stater, 22408
    - Rekruttering
    - Hematology Oncology Associates of Fredericksburg ( Site 9550)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 540-371-0079
  - Fredericksburg, Virginia, Forenede Stater, 22405
    - Rekruttering
    - Mary Washington Hospital ( Site 0129)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 540-300-6182
  - Midlothian, Virginia, Forenede Stater, 23114
    - Rekruttering
    - Bon Secours Memorial Regional Medical Center-Oncology Research Department ( Site 0020)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 804-893-8717
  - Norfolk, Virginia, Forenede Stater, 23502
    - Rekruttering
    - Virginia Oncology Associates (VOA) ( Site 8008)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 646-694-8125
  - Richmond, Virginia, Forenede Stater, 23229
    - Rekruttering
    - Virginia Cancer Institute ( Site 0034)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 804-287-3000
- Washington
  - Tacoma, Washington, Forenede Stater, 98405
    - Rekruttering
    - Northwest Medical Specialties, PLLC ( Site 0093)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 253-428-8700
- Wisconsin
  - Madison, Wisconsin, Forenede Stater, 53715
    - Rekruttering
    - SSM Health Dean Medical Group ( Site 0087)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 516-488-2918
Frankrig
- - Paris, Frankrig, 75020
    - Rekruttering
    - Hôpital Tenon ( Site 1303)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33156017825
- Alpes-Maritimes
  - Nice, Alpes-Maritimes, Frankrig, 06189
    - Rekruttering
    - Centre Antoine-Lacassagne ( Site 1308)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33492031000
- Aquitaine
  - Bayonne, Aquitaine, Frankrig, 64109
    - Rekruttering
    - Centre Hospitalier de la Cote Basque ( Site 1315)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33559443762
- Ardeche
  - Guilherand-Granges, Ardeche, Frankrig, 07500
    - Rekruttering
    - Hôpital Privé Drôme-Ardèche ( Site 1301)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33475756604
- Auvergne
  - Clermont-Ferrand, Auvergne, Frankrig, 63011
    - Rekruttering
    - Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 1307)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 0473278005
- Auvergne-Rhône-Alpes
  - Lyon Cedex08, Auvergne-Rhône-Alpes, Frankrig, 69373
    - Rekruttering
    - CENTRE LEON BERARD ( Site 1300)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33478782644
- Bouches-du-Rhone
  - Marseille, Bouches-du-Rhone, Frankrig, 13009
    - Rekruttering
    - Institut Paoli-Calmettes ( Site 1309)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33491223611
- Calvados
  - Caen, Calvados, Frankrig, 14076
    - Rekruttering
    - Centre François Baclesse ( Site 1318)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33231455050
- Cote-d Or
  - Dijon, Cote-d Or, Frankrig, 21079
    - Rekruttering
    - Centre Georges François Leclerc ( Site 1312)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 03 70 63 24 03
- Doubs
  - Besançon, Doubs, Frankrig, 25000
    - Afsluttet
    - CHU Besançon ( Site 1311)
- Finistere
  - Brest, Finistere, Frankrig, 29200
    - Rekruttering
    - CHRU Brest - Hopital Cavale Blanche ( Site 1304)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33230338161
- Gironde
  - Bordeaux, Gironde, Frankrig, 33000
    - Rekruttering
    - Clinique Tivoli Ducos ( Site 1322)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33556116296
- Hauts-de-Seine
  - Levallois-Perret, Hauts-de-Seine, Frankrig, 92300
    - Rekruttering
    - Hôpital Franco-Britannique - Fondation Cognacq-Jay ( Site 1321)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33147591915
- Loire-Atlantique
  - Saint-Herblain, Loire-Atlantique, Frankrig, 44805
    - Rekruttering
    - Institut de Cancérologie de l'Ouest ( Site 1305)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33240679900
- Maine-et-Loire
  - Angers, Maine-et-Loire, Frankrig, 49055
    - Rekruttering
    - Institut de Cancérologie de l'Ouest ( Site 1316)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 02 41 35 27 00
- Nord
  - Valenciennes, Nord, Frankrig, 59300
    - Rekruttering
    - Centre de Cancerologie Les Dentellieres ( Site 1306)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33327091010
- Pyrenees-Atlantiques
  - Pau, Pyrenees-Atlantiques, Frankrig, 64046
    - Rekruttering
    - Centre Hospitalier de Pau ( Site 1302)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +33559726996
- Seine-Maritime
  - Rouen, Seine-Maritime, Frankrig, 76038
    - Rekruttering
    - Centre Henri Becquerel ( Site 1319)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 02 32 08 22 22
Grækenland
- - Thessaloniki, Grækenland, 570 01
    - Rekruttering
    - European Interbalkan Medical Center ( Site 1502)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +302313252011
  - Thessaloniki, Grækenland, 570 01
    - Rekruttering
    - European Interbalkan Medical Center ( Site 1507)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +302310390671
- Achaia
  - Pátrai, Achaia, Grækenland, 26504
    - Rekruttering
    - UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 1509)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +302610999791
- Attica
  - Athens, Attica, Grækenland, 115 26
    - Rekruttering
    - Errikos Dunant Hospital Center-1st Medical Oncology Dept. ( Site 1508)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +302106972433
  - Athens, Attica, Grækenland, 115 28
    - Rekruttering
    - Aretaieio Hospital Oncology Unit ( Site 1505)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +302107286444
- Thessaly
  - Larissa, Thessaly, Grækenland, 411 10
    - Rekruttering
    - University General Hospital of Larissa ( Site 1503)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +302413502785
Hong Kong
- - Hong Kong, Hong Kong
    - Rekruttering
    - Queen Mary Hospital ( Site 3600)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +852 2255 3838
  - Kowloon, Hong Kong
    - Rekruttering
    - Hong Kong United Oncology Centre ( Site 3601)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +852 2386 8002
  - Shatin, Hong Kong, 000000
    - Rekruttering
    - Prince of Wales Hospital ( Site 3602)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: + 852 3505 2211
Irland
- - Cork, Irland, T12 DV56
    - Rekruttering
    - Bon Secours Cork Hospital ( Site 1600)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +353214542807
  - Dublin, Irland, D04 T6F4
    - Rekruttering
    - St. Vincent's University Hospital-Medical Oncology Research Department ( Site 1601)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +353 1 221 4982
  - Galway, Irland, Galway
    - Rekruttering
    - University College Hospital - Galway ( Site 1602)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +35391524222
Israel
- - Beersheba, Israel, 8410101
    - Rekruttering
    - Soroka Medical Center-Oncology ( Site 1704)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 0507425629
  - Jerusalem, Israel, 9112001
    - Rekruttering
    - Hadassah Medical Center ( Site 1700)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +972-2-6778510
  - Jerusalem, Israel, 9103102
    - Rekruttering
    - Shaare Zedek Medical Center ( Site 1706)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +97226555999
  - Petah Tikva, Israel, 4941492
    - Rekruttering
    - Rabin Medical Center ( Site 1702)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +972-3-9378076
  - Ramat Gan, Israel, 5265601
    - Rekruttering
    - Sheba Medical Center-ONCOLOGY ( Site 1701)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +972-35304436
  - Tel Aviv, Israel, 6423906
    - Rekruttering
    - Sourasky Medical Center ( Site 1705)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +972-3-6947557
Italien
- - Bologna, Italien, 40138
    - Rekruttering
    - IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1810)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +39 0512144548
  - Milan, Italien, 20132
    - Rekruttering
    - Ospedale San Raffaele-Oncologia Medica ( Site 1814)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +390226436530
  - Novara, Italien, 28100
    - Rekruttering
    - Azienda Ospedaliero Universitaria Maggiore della Carità-SCDU ONCOLOGIA ( Site 1804)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +3903213733822
- Campania
  - Naples, Campania, Italien, 80100
    - Rekruttering
    - University of Naples Federico II-Dipartimento di Medicina Clinica e Chirurgia ( Site 1803)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +390817463772
  - Naples, Campania, Italien, 80131
    - Rekruttering
    - Istituto Nazionale Tumori IRCCS Fondazione Pascale-S.C. Oncologia Clinica Sperimentale di Senologia ( Site 1800)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +3908117770442
- Catania
  - Misterbianco, Catania, Italien, 95045
    - Rekruttering
    - Humanitas Istituto Clinico Catanese ( Site 1811)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +39 9573390197
- Forli-Cesena
  - Meldola (FC), Forli-Cesena, Italien, 47014
    - Rekruttering
    - IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 1807)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +39 0543 739100
- Friuli Venezia Giulia
  - Aviano, Friuli Venezia Giulia, Italien, 33081
    - Rekruttering
    - CRO-IRCCS ( Site 1808)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +39 0434659253
- Lazio
  - Rome, Lazio, Italien, 00168
    - Rekruttering
    - Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1802)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +390630158545
- Lombardy
  - Brescia, Lombardy, Italien, 25123
    - Rekruttering
    - Azienda Ospedaliera Spedali Civili di Brescia ( Site 1812)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +390303996536
  - Milan, Lombardy, Italien, 20133
    - Rekruttering
    - Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1801)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +390223902597
  - Milan, Lombardy, Italien, 20141
    - Rekruttering
    - Istituto Europeo di Oncologia IRCCS-Divisione di Senologia Medica ( Site 1809)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 02 57489970
  - Monza, Lombardy, Italien, 20900
    - Rekruttering
    - Fondazione IRCCS San Gerardo dei Tintori ( Site 1813)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +39 0392339037
- Tuscany
  - Florence, Tuscany, Italien, 50134
    - Rekruttering
    - Azienda Ospedaliera Universitaria Careggi ( Site 1805)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +390057947264
Japan
- - Fukushima, Japan, 960-1295
    - Rekruttering
    - Fukushima Medical University Hospital ( Site 3401)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-24-547-1111
  - Gifu, Japan, 501-1194
    - Rekruttering
    - Gifu University Hospital ( Site 3426)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-58-230-6000
  - Hiroshima, Japan, 730-8518
    - Rekruttering
    - Hiroshima City Hiroshima Citizens Hospital ( Site 3418)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-82-221-2291
  - Kagoshima, Japan, 892-0833
    - Rekruttering
    - Social medical corporation Hakuaikai Sagara Hospital ( Site 3421)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-99-224-1800
  - Kumamoto, Japan, 860-8556
    - Rekruttering
    - Kumamoto University Hospital ( Site 3420)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-96-344-2111
  - Kyoto, Japan, 606-8507
    - Rekruttering
    - Kyoto University Hospital ( Site 3415)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-75-751-3111
  - Okayama, Japan, 700-8558
    - Rekruttering
    - Okayama University Hospital ( Site 3425)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-86-223-7151
  - Osaka, Japan, 541-8567
    - Rekruttering
    - Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 3417)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-6-6945-1181
- Aichi-ken
  - Nagoya, Aichi-ken, Japan, 467-8602
    - Rekruttering
    - Nagoya City University Hospital ( Site 3414)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-52-858-7215
- Chiba
  - Kashiwa, Chiba, Japan, 277-8577
    - Rekruttering
    - National Cancer Center Hospital East ( Site 3403)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-4-7133-1111
- Gunma
  - Ōta, Gunma, Japan, 373-8550
    - Rekruttering
    - Gunma Prefectural Cancer Center ( Site 3428)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-276-38-0771
- Hokkaido
  - Sapporo, Hokkaido, Japan, 060-8648
    - Rekruttering
    - Hokkaido University Hospital ( Site 3400)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-11-716-1161
- Kanagawa
  - Isehara, Kanagawa, Japan, 259-1193
    - Rekruttering
    - Tokai University Hospital ( Site 3413)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-463-93-1121
  - Kawasaki, Kanagawa, Japan, 216-8511
    - Rekruttering
    - St. Marianna University Hospital ( Site 3405)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-44-977-8111
  - Sagamihara, Kanagawa, Japan, 252-0375
    - Rekruttering
    - Kitasato University Hospital ( Site 3411)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-42-778-8111
  - Yokohama, Kanagawa, Japan, 241-8515
    - Rekruttering
    - Kanagawa Cancer Center ( Site 3412)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-45-520-2222
- Mie-ken
  - Tsu, Mie-ken, Japan, 514-8507
    - Rekruttering
    - Mie University Hospital ( Site 3423)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-59-231-5246
- Miyagi
  - Sendai, Miyagi, Japan, 980-8574
    - Rekruttering
    - Tohoku University Hospital ( Site 3422)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-22-717-7000
- Osaka
  - Suita, Osaka, Japan, 565-0871
    - Rekruttering
    - The University of Osaka Hospital ( Site 3416)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-6-6210-8290
- Saitama
  - Hidaka, Saitama, Japan, 350-1298
    - Rekruttering
    - Saitama Medical University International Medical Center ( Site 3402)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-42-984-4111
- Tokyo
  - Bunkyo, Tokyo, Japan, 113-8431
    - Rekruttering
    - Juntendo University Hospital ( Site 3408)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-3-3813-3111
  - Chūō, Tokyo, Japan, 104-8560
    - Rekruttering
    - St.Luke's International Hospital ( Site 3427)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 03-3541-5151
  - Koto, Tokyo, Japan, 135-8550
    - Rekruttering
    - Cancer Institute Hospital of JFCR ( Site 3404)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-3-3520-0111
  - Shinagawa, Tokyo, Japan, 142-8666
    - Rekruttering
    - Showa Medical University Hospital ( Site 3406)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-3-3784-8000
  - Shinjuku, Tokyo, Japan, 160-0023
    - Rekruttering
    - Tokyo Medical University Hospital ( Site 3407)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-3-3342-6111
  - Shinjuku, Tokyo, Japan, 162-8655
    - Rekruttering
    - National Center for Global Health and Medicine ( Site 3409)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +81-3-3202-7181
Malaysia
- - Kuala Lumpur, Malaysia, 59100
    - Rekruttering
    - Pantai Hospital Kuala Lumpur ( Site 2801)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +60327814519
  - Kuala Lumpur, Malaysia, 50450
    - Rekruttering
    - Prince Court Medical Centre ( Site 2802)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +60321600000
Mexico
- Mexico City
  - Benito Juárez, Mexico City, Mexico, 03100
    - Rekruttering
    - Grupo Médico ASSET SC ( Site 0705)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 5516217417
  - Mexico City, Mexico City, Mexico, 03100
    - Rekruttering
    - CENEIT Oncologicos ( Site 0706)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 5514817472
  - Mexico City, Mexico City, Mexico, 03100
    - Rekruttering
    - Health Pharma Professional Research S.A. de C.V: ( Site 0709)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +525575864856
  - Mexico City, Mexico City, Mexico, 04700
    - Rekruttering
    - COI Centro Oncologico Internacional S.A.P.I. de C.V. ( Site 0712)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +528008773264
- Nuevo León
  - San Pedro Garza García, Nuevo León, Mexico, 66220
    - Rekruttering
    - Oncare - Unidad Valle ( Site 0713)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +528182188555
  - San Pedro Garza García, Nuevo León, Mexico, 66278
    - Rekruttering
    - CENTRO MEDICO ZAMBRANO HELLION ( Site 0711)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +528188880000
Norge
- - Oslo, Norge, 0379
    - Rekruttering
    - Oslo universitetssykehus, Radiumhospitalet ( Site 2002)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4722934000
- Buskerud
  - Drammen, Buskerud, Norge, 3004
    - Rekruttering
    - Drammen Sykehus, Vestre Viken HF ( Site 2001)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4732803000
- Rogaland
  - Stavanger, Rogaland, Norge, 4011
    - Rekruttering
    - Stavanger Universitetssykehus ( Site 2004)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4751518000
Polen
- Kuyavian-Pomeranian Voivodeship
  - Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Polen, 85-796
    - Rekruttering
    - Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 2102)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +48523743029
- Lesser Poland Voivodeship
  - Krakow, Lesser Poland Voivodeship, Polen, 31-115
    - Rekruttering
    - Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Oddzial w Krakowie ( Site 2120)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +48225462758
- Masovian Voivodeship
  - Warsaw, Masovian Voivodeship, Polen, 02-781
    - Rekruttering
    - Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Piersi i Chirurgii ( Site 2100)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +48225462486
  - Wieliszew, Masovian Voivodeship, Polen, 05-135
    - Rekruttering
    - Mazowiecki Szpital Onkologiczny-BREAST CANCER ( Site 2101)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +48227661501
- Podlaskie Voivodeship
  - Bialystok, Podlaskie Voivodeship, Polen, 15-027
    - Afsluttet
    - Bialostockie Centrum Onkologii ( Site 2105)
- Pomeranian Voivodeship
  - Gdynia, Pomeranian Voivodeship, Polen, 81-519
    - Rekruttering
    - Szpitale Pomorskie Sp. z o. o.-Oddział Onkologii Klinicznej ( Site 2113)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +48587260105
- Silesian Voivodeship
  - Gliwice, Silesian Voivodeship, Polen, 44-102
    - Afsluttet
    - Narodowy Instytut Onkologii - Oddzial w Gliwicach-Centrum Diagnostyki i Leczenia Chorob Piersi ( Site 2110)
- West Pomeranian Voivodeship
  - Szczecin, West Pomeranian Voivodeship, Polen, 71-730
    - Rekruttering
    - Zachodniopomorskie Centrum Onkologii ( Site 2108)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +48914251544
- Świętokrzyskie Voivodeship
  - Kielce, Świętokrzyskie Voivodeship, Polen, 25-734
    - Rekruttering
    - Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch ( Site 2118)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +48885997850
Portugal
- - Lisbon, Portugal, 1649-035
    - Rekruttering
    - Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 2201)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 00351217805000
  - Lisbon, Portugal, 1400-038
    - Rekruttering
    - Fundacao Champalimaud ( Site 2200)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 00351210480200
  - Porto, Portugal, 4200-072
    - Rekruttering
    - Instituto Portugues de Oncologia do Porto ( Site 2202)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 00351225084000
- Lisbon District
  - Amadora, Lisbon District, Portugal, 2720-276
    - Rekruttering
    - Unidade Local de Saude Amadora/Sintra - Hospital Prof Dr Fernando Fonseca ( Site 2203)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 00351214348200
Schweiz
- - Fribourg, Schweiz, 1708
    - Rekruttering
    - HFR Fribourg - Hôpital Cantonal ( Site 2402)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +41263062260
- Canton of Bern
  - Thun, Canton of Bern, Schweiz, 3600
    - Rekruttering
    - Spital Thun ( Site 2400)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +41 58 636 22 27
- Canton of Geneva
  - Geneva, Canton of Geneva, Schweiz, 1206
    - Rekruttering
    - Clinique Générale-Beaulieu ( Site 2406)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +41228395798
- Canton of Zurich
  - Zurich, Canton of Zurich, Schweiz, 8008
    - Rekruttering
    - Brust-Zentrum ( Site 2401)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +41445338141
- Kanton Graubünden
  - Chur, Kanton Graubünden, Schweiz, 7000
    - Afsluttet
    - Kantonsspital Graubünden-Medizin ( Site 2404)
Singapore
- Central Singapore
  - Singapore, Central Singapore, Singapore, 168583
    - Rekruttering
    - National Cancer Centre Singapore-Medical Oncology ( Site 3002)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +6564368000
Spanien
- - Barcelona, Spanien, 08035
    - Rekruttering
    - Hospital Universitari Vall d'Hebron-Oncology ( Site 2300)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +34932746000/ 4691
  - Madrid, Spanien, 28007
    - Rekruttering
    - Hospital Beata María Ana-oncology ( Site 2309)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +34914097423
  - Madrid, Spanien, 28040
    - Rekruttering
    - Hospital Clinico San Carlos-Oncology Department ( Site 2306)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 34 913303000x7768
  - Valencia, Spanien, 46010
    - Rekruttering
    - HOSPITAL CLINICO DE VALENCIA-Oncology ( Site 2302)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +34961973583
- Andalusia
  - Seville, Andalusia, Spanien, 41013
    - Rekruttering
    - HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 2304)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 34955013068
- Barcelona
  - L'Hospitalet de Llobregat, Barcelona, Spanien, 08908
    - Rekruttering
    - Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2305)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +34 93 260 77 44
- La Coruna
  - A Coruña, La Coruna, Spanien, 15006
    - Rekruttering
    - CHUAC-Hospital Teresa Herrera-MEDICAL ONCOLOGY ( Site 2307)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +34981178000
- Madrid, Comunidad de
  - Madrid, Madrid, Comunidad de, Spanien, 28034
    - Rekruttering
    - Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2301)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +34913368263
  - Majadahonda, Madrid, Comunidad de, Spanien, 28222
    - Rekruttering
    - HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA-Medical Oncology ( Site 2308)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +34911917358
- Valenciana, Comunitat
  - Valencia, Valenciana, Comunitat, Spanien, 46009
    - Rekruttering
    - Fundación Instituto Valenciano de Oncología-Oncologico ( Site 2303)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +93663224875
Sverige
- Gävleborg County
  - Gävle, Gävleborg County, Sverige, 801 87
    - Rekruttering
    - Gävle sjukhus ( Site 3504)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4626154000
- Stockholm County
  - Stockholm, Stockholm County, Sverige, 171 76
    - Rekruttering
    - Karolinska Universitetssjukhuset Solna ( Site 3500)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +46851770000
  - Stockholm, Stockholm County, Sverige, 112 81
    - Rekruttering
    - Capio St. Gorans Sjukhus ( Site 3503)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +46858701000
- Uppsala County
  - Uppsala, Uppsala County, Sverige, 751 85
    - Rekruttering
    - Akademiska Sjukhuset ( Site 3501)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +46186110000
- Västra Götaland County
  - Borås, Västra Götaland County, Sverige, 501 82
    - Rekruttering
    - Södra Älvsborg Sjukhus ( Site 3502)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +46336161000
  - Gothenburg, Västra Götaland County, Sverige, 413 45
    - Rekruttering
    - Sahlgrenska Universitetssjukhuset. ( Site 3505)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +46313428503
Sydkorea
- - Seoul, Sydkorea, 03080
    - Rekruttering
    - Seoul National University Hospital-Internal Medicine ( Site 3102)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +82-2-2072-0850
  - Seoul, Sydkorea, 03722
    - Rekruttering
    - Severance Hospital, Yonsei University Health System-Medical oncology ( Site 3100)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +82-2-2228-8135
  - Seoul, Sydkorea, 05505
    - Rekruttering
    - Asan Medical Center-Department of Oncology ( Site 3103)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +8-2-3010-3216
  - Seoul, Sydkorea, 06273
    - Rekruttering
    - Gangnam Severance Hospital, Yonsei University Health System-Medical Oncology, Internal Medicine ( Site 3104)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +82-2-2019-3379
  - Seoul, Sydkorea, 06351
    - Rekruttering
    - Samsung Medical Center-Division of Hematology/Oncology ( Site 3101)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +82-2-3410-6488
Tjekkiet
- Brno-mesto
  - Brno, Brno-mesto, Tjekkiet, 656 53
    - Rekruttering
    - Masarykuv onkologicky ustav ( Site 1005)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +420543134000
- Olomouc Region
  - Olomouc, Olomouc Region, Tjekkiet, 779 00
    - Rekruttering
    - Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 1006)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +420588444295
- Praha 2
  - Prague, Praha 2, Tjekkiet, 128 08
    - Rekruttering
    - Vseobecna fakultni nemocnice v Praze-Onkologická klinika VFN ( Site 1002)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +420224966763
- Praha 4
  - Prague, Praha 4, Tjekkiet, 14059
    - Rekruttering
    - Fakultni Thomayerova nemocnice - Onkologicka klinika 1. LF UK a FTN ( Site 1008)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +420261083733
- Praha 5
  - Prague, Praha 5, Tjekkiet, 150 06
    - Rekruttering
    - Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 1000)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +420224434701
- South Bohemian Region
  - České Budějovice, South Bohemian Region, Tjekkiet, 37001
    - Rekruttering
    - Nemocnice Ceske Budejovice-Onkologicke oddeleni ( Site 1007)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +420387875001
Tyrkiet (Türkiye)
- - Adana, Tyrkiet (Türkiye), 01140
    - Rekruttering
    - Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2501)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +90 322 459 2222
  - Ankara, Tyrkiet (Türkiye), 06200
    - Rekruttering
    - Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi-oncology ( Site 2504)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 03123360909
  - Ankara, Tyrkiet (Türkiye), 06520
    - Rekruttering
    - Memorial Ankara Hastanesi-Medical Oncology ( Site 2502)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +90 312 253 6666
  - Istanbul, Tyrkiet (Türkiye), 34214
    - Rekruttering
    - Medipol Mega Universite Hastanesi-oncology ( Site 2503)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 444 70 44 - 17067
  - Samsun, Tyrkiet (Türkiye), 55200
    - Rekruttering
    - Samsun Medical Park Hastanesi-medical oncology ( Site 2500)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: 03623114040
Tyskland
- - Berlin, Tyskland, 13125
    - Rekruttering
    - Helios Klinikum Berlin-Buch-Klinik für Gynäkologie und Geburtshilfe ( Site 1413)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4930940113394
- Baden-Wurttemberg
  - Freiburg im Breisgau, Baden-Wurttemberg, Tyskland, 79106
    - Rekruttering
    - Praxis fuer interdisziplinaere Onkologie und Haematologie ( Site 1423)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +49761386870
  - Ludwigsburg, Baden-Wurttemberg, Tyskland, 71640
    - Rekruttering
    - Klinikum Ludwigsburg-Klinik für Geburtshilfe und Frauenheilkunde ( Site 1405)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4971419996433
  - Tübingen, Baden-Wurttemberg, Tyskland, 72076
    - Rekruttering
    - Universitaetsklinikum Tuebingen-Frauenklinik ( Site 1415)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4970712964226
- Bavaria
  - Erlangen, Bavaria, Tyskland, 91054
    - Rekruttering
    - Universitaetsklinikum Erlangen-Klinik für Gynäkologie und Geburtshilfe ( Site 1400)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4991318533553
  - Munich, Bavaria, Tyskland, 80336
    - Rekruttering
    - Klinikum der Ludwig-Maximilians-Universitaet Muenchen-Frauenklinik Brustzentrum ( Site 1402)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4989440034645
- Brandenburg
  - Potsdam, Brandenburg, Tyskland, 14467
    - Rekruttering
    - Klinikum Ernst von Bergmann-Frauenklinik ( Site 1408)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +493312415602
- Lower Saxony
  - Georgsmarienhütte, Lower Saxony, Tyskland, 49124
    - Rekruttering
    - Franziskus-Hospital Harderberg ( Site 1404)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +495415022466
  - Hanover, Lower Saxony, Tyskland, 30625
    - Rekruttering
    - Medizinische Hochschule Hannover ( Site 1419)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +495115329545
- North Rhine-Westphalia
  - Düsseldorf, North Rhine-Westphalia, Tyskland, 40225
    - Rekruttering
    - Universitaetsklinikum Duesseldorf-Klinik für Frauenheilkunde & Geburtshilfe ( Site 1409)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +492118117506
  - Essen, North Rhine-Westphalia, Tyskland, 45136
    - Rekruttering
    - Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung-Klinik für Senologie/ Brustzentrum ( Site 1401)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4920117433005
  - Mönchengladbach, North Rhine-Westphalia, Tyskland, 41061
    - Rekruttering
    - Evangelisches Krankenhaus Bethesda Mönchengladbach-Brustzentrum Niederrhein ( Site 1406)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4921618493577
  - Witten, North Rhine-Westphalia, Tyskland, 58452
    - Rekruttering
    - Marien Hospital Witten ( Site 1424)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +49 2302 1733290
- Rhineland-Palatinate
  - Mainz, Rhineland-Palatinate, Tyskland, 55131
    - Rekruttering
    - Universitätsmedizin Johannes Gutenberg Universität Mainz-Klinik und Poliklinik für Geburtshilfe und ( Site 1418)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +496131172683
  - Trier, Rhineland-Palatinate, Tyskland, 54290
    - Rekruttering
    - Klinikum Mutterhaus der Borromäerinnen ( Site 1420)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4906519470
- Saarland
  - Saarbrücken, Saarland, Tyskland, 66113
    - Rekruttering
    - CaritasKlinikum Saarbruecken St. Theresia ( Site 1410)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +496814061345
- Schleswig-Holstein
  - Lübeck, Schleswig-Holstein, Tyskland, 23538
    - Rekruttering
    - Universitätsklinikum Schleswig-Holstein ( Site 1411)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4945150041930
Østrig
- - Salzburg, Østrig, 5020
    - Rekruttering
    - Uniklinikum Salzburg-Universitätsklinik für Innere Medizin III der PMU mit Hämatologie, internistis ( Site 1202)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +435725525826
  - Vienna, Østrig, 1090
    - Rekruttering
    - Medizinische Universität Wien-Universitätsklinik für Innere Medizin I, Klinische Abteilung für Onko ( Site 1201)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4314040064470
- Tyrol
  - Innsbruck, Tyrol, Østrig, 6020
    - Rekruttering
    - Medizinische Universitaet Innsbruck ( Site 1200)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +435050423079
- Upper Austria
  - Linz, Upper Austria, Østrig, 4020
    - Rekruttering
    - Kepler Universitätsklinikum-Department for Oncology and Hematology ( Site 1206)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +43576808373652
  - Wels, Upper Austria, Østrig, 4600
    - Rekruttering
    - Klinikum Wels-Grieskirchen ( Site 1205)
    - Kontakt:
      
      Study Coordinator
      
      Telefonnummer: +4372424150

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

Has centrally confirmed TNBC, as defined by the most recent American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines
Has no evidence of locoregional or distant relapse, as assessed by the treating physician
Had neoadjuvant treatment based on the KEYNOTE-522 regimen (pembrolizumab with carboplatin/taxanes and pembrolizumab with anthracycline-based chemotherapy) followed by surgery according to National Comprehensive Cancer Network (NCCN) treatment guidelines for TNBC
Had adequate excision and surgical removal of all clinically evident disease in the breast and/or lymph nodes and have adequately recovered from surgery
Has non-pathologic complete response at surgery
Is able to continue on adjuvant pembrolizumab
Randomization must be conducted within 16 weeks from surgical resection
Completed adjuvant radiation therapy (if indicated) and recovered before randomization
Has provided tissue from the surgical resection for central laboratory determination of trophoblast cell surface antigen 2 (TROP2) status
If capable of producing sperm, the participant agrees to the following during the intervention period and for at least the time needed to eliminate each study intervention after the last dose of study intervention (120 days for sacituzumab tirumotecan and 95 days for capecitabine [no restriction for pembrolizumab]): agrees to refrain from donating sperm AND is either abstinent and agrees to remain abstinent or uses highly effective contraception
For females (assigned at birth), is not pregnant or breastfeeding and ≥1 of the following applies: is not a participant of childbearing potential (POCBP) OR is a POCBP and uses highly effective contraception after the last dose of study intervention (210 days for sacituzumab tirumotecan, 120 days for pembrolizumab, and 185 days for capecitabine). Abstains from breastfeeding during the study intervention period and for at least 120 days after study intervention
Participants who have AEs due to previous anticancer therapies must have recovered to ≤Grade 1 or baseline (except alopecia)
Human immunodeficiency virus (HIV)-infected participants must have well controlled HIV on antiretroviral therapy (ART)
An Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 assessed within 7 days before first dose of study treatment
Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B birus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load prior to randomization

Exclusion Criteria:

Has a known germline breast cancer gene (BRCA) mutation (deleterious or suspected deleterious) and is eligible for adjuvant therapy with olaparib where olaparib is approved and available
Has Grade >2 peripheral neuropathy
History of documented severe dry eye syndrome, severe Meibomian gland disease and/or blepharitis, or severe corneal disease that prevents/delays corneal healing
Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, or chronic diarrhea)
Has uncontrolled, significant cardiovascular disease or cerebrovascular disease including New York Heart Association Class III or IV congestive heart failure, unstable angina, myocardial infarction, uncontrolled symptomatic arrhythmia, prolongation of QTcF interval to >480 ms, and/or other serious cardiovascular and cerebrovascular diseases within 6 months prior to study intervention
Received prior treatment with a trophoblast cell-surface antigen 2 (TROP2)-directed antibody drug conjugate (ADC) or a topoisomerase I inhibitor-containing ADC
Received anticancer therapy in the adjuvant phase including but not limited to chemotherapy, small molecule anticancer drugs, poly (adenosine diphosphate ribose) polymerase (PARP) inhibitors, ADCs, and/or immunotherapy, with the exception of adjuvant radiation therapy
Is currently receiving a strong inducer/inhibitor of cytochrome P450 3A4 (CYP3A4) that cannot be discontinued for the duration of the study. The required washout period before starting sacituzumab tirumotecan is 2 weeks
Except for pembrolizumab as neoadjuvant therapy for early-stage TNBC: received prior therapy with an anti-programmed cell death 1 protein (anti-PD-1), anti-programmed cell death ligand 1 (anti-PD-L1), or anti-PD-L2 agent, or with an agent directed to another stimulatory or coinhibitory T-cell receptor (eg, cytotoxic T-lymphocyte-associated protein-4 [CTLA-4], OX-40 [cluster of differentiation (CD) 134], or CD137)
Except for chemotherapy as neoadjuvant therapy for early-stage TNBC: Received prior systemic anticancer therapy including investigational agents within 4 weeks before randomization
Received prior radiotherapy within 3 weeks of start of study intervention or required corticosteroids for radiation related toxicities that cannot be discontinued before the first dose of study intervention
Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines are allowed
Has received an investigational agent or has used an investigational device within 4 weeks prior to study intervention administration
Has known additional malignancy that is progressing or has required active treatment within the past 5 years
Has diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior the first dose of study medication
Has active autoimmune disease that has required systemic treatment in the past 2 years. Replacement therapy (eg, thyroxine, insulin, or physiologic corticosteroid) is allowed
Has history of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease
Has active infection requiring systemic therapy
HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease
Has concurrent active hepatitis B and hepatitis C virus infection
Has history of allogeneic tissue/solid organ transplant

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Pembrolizumab + sacituzumab tirumotecan Participants receive pembrolizumab every 6 weeks (q6w) in combination with sacituzumab tirumotecan every 2 weeks (q2w) for 24 weeks. In addition, participants receive an antihistamine, an H2 antagonist of investigator's choice, acetaminophen (or equivalent), and dexamethasone (or equivalent) per each drug's product label prior to sacituzumab tirumotecan infusions.	Biologisk: Pembrolizumab Pembrolizumab 400 mg intravenous (IV) infusion q6w Andre navne: MK-3475 SCH 900475 KEYTRUDA® Biologisk: Sacituzumab tirumotecan Sacituzumab tirumotecan 4 mg/kg IV infusion q2w Andre navne: MK-2870
Aktiv komparator: Treatment of Physician's Choice Participants receive pembrolizumab q6w or pembrolizumab q6w in combination with capecitabine (twice daily [BID] on Days 1 to 14 and 22 to 35 every 42 days x 4 [2 weeks 1, 1 week off]) for 24 weeks.	Biologisk: Pembrolizumab Pembrolizumab 400 mg intravenous (IV) infusion q6w Andre navne: MK-3475 SCH 900475 KEYTRUDA® Medicin: Capecitabine Capecitabine 1000 mg/m^2 to 1250 mg/m^2 by mouth BID Andre navne: XELODA

Deltagergruppe / Arm

Intervention / Behandling

Eksperimentel: Pembrolizumab + sacituzumab tirumotecan

Participants receive pembrolizumab every 6 weeks (q6w) in combination with sacituzumab tirumotecan every 2 weeks (q2w) for 24 weeks. In addition, participants receive an antihistamine, an H2 antagonist of investigator's choice, acetaminophen (or equivalent), and dexamethasone (or equivalent) per each drug's product label prior to sacituzumab tirumotecan infusions.

Biologisk: Pembrolizumab

Pembrolizumab 400 mg intravenous (IV) infusion q6w

Andre navne:

MK-3475
SCH 900475
KEYTRUDA®

Biologisk: Sacituzumab tirumotecan

Sacituzumab tirumotecan 4 mg/kg IV infusion q2w

Andre navne:

MK-2870

Aktiv komparator: Treatment of Physician's Choice

Participants receive pembrolizumab q6w or pembrolizumab q6w in combination with capecitabine (twice daily [BID] on Days 1 to 14 and 22 to 35 every 42 days x 4 [2 weeks 1, 1 week off]) for 24 weeks.

Biologisk: Pembrolizumab

Pembrolizumab 400 mg intravenous (IV) infusion q6w

Andre navne:

MK-3475
SCH 900475
KEYTRUDA®

Medicin: Capecitabine

Capecitabine 1000 mg/m^2 to 1250 mg/m^2 by mouth BID

Andre navne:

XELODA

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Invasive Disease-Free Survival (iDFS) Tidsramme: Up to ~77 months	iDFS is the time from randomization to invasive local, regional, or distant recurrence, invasive contralateral breast cancer, or death due to any cause, whichever occurs first.	Up to ~77 months

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Overall Survival (OS) Tidsramme: Up to ~101 months	OS is the time from randomization to death due to any cause.	Up to ~101 months
Distant recurrence-free survival (DRFS) Tidsramme: Up to ~101 months	DRFS is the time from randomization to distant recurrence or death due to any cause, whichever occurs first.	Up to ~101 months
Change from baseline in European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) Global Health Status (Item 29) and Quality of Life (Item 30) Combined Score Tidsramme: Baseline and up to ~60 months	EORTC QLQ-C30 is a 30-item scale to assess the overall quality of life in cancer patients. The overall functioning score is based on participant responses that are scored on a 7-point scale (1 = "Very poor" to 7 = "Excellent"). Higher scores indicate better overall health status.	Baseline and up to ~60 months
Change from baseline in EORTC QLQ-C30 Physical Functioning (Items 1-5) Combined Score Tidsramme: Baseline and up to ~60 months	EORTC QLQ-C30 is a 30-item scale to assess the overall quality of life of cancer patients. The physical functioning score is based on participant responses to questions that scored on a 4-point scale (1 = 'Not at All' to 4 = 'Very Much'). Higher scores indicate better physical functioning.	Baseline and up to ~60 months
Change from baseline in EORTC QLQ-C30 Role Functioning (Items 6 and 7) Combined Score Tidsramme: Baseline and up to ~60 months	EORTC QLQ-C30 is a 30-item scale to assess the overall quality of life of cancer patients. The role functioning score is based on participant responses to questions that scored on a 4-point scale (1 = 'Not at All' to 4 = 'Very Much'). Higher scores indicate better role functioning.	Baseline and up to ~60 months
Change from baseline in EORTC QLQ-C30 Fatigue (Items 10, 12, and 18) Combined Score Tidsramme: Baseline and up to ~60 months	EORTC QLQ-C30 is a 30-item scale to assess the overall quality of life of cancer patients. Participant responses to questions about their fatigue are scored on a 4-point scale (1 = "Not at All" to 4 = "Very Much"). Lower scores indicate a better level of fatigue.	Baseline and up to ~60 months
Number of participants who experience one or more adverse events (AEs) Tidsramme: Up to ~42 weeks	An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.	Up to ~42 weeks
Number of participants who discontinue study intervention due to an AE Tidsramme: Up to 24 weeks	An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.	Up to 24 weeks

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Merck Sharp & Dohme LLC

Efterforskere

Studieleder: Medical Director, Merck Sharp & Dohme LLC

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Hjælpsomme links

<p>Merck Clinical Trials Information</p>

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

24. juni 2024

Primær færdiggørelse (Anslået)

16. december 2030

Studieafslutning (Anslået)

14. december 2037

Datoer for studieregistrering

Først indsendt

26. april 2024

Først indsendt, der opfyldte QC-kriterier

26. april 2024

Først opslået (Faktiske)

1. maj 2024

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

5. november 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

3. november 2026

Sidst verificeret

1. oktober 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

2870-012
U1111-1289-8264 (Registry Identifier: UTN)
jRCT2031240476 (Registry Identifier: Japan Registry of Clinical Trials (jRCT))
2023-504962-52-00 (Registry Identifier: EU CT)
2023 (U.S. NIH-bevilling/kontrakt)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab versus TPC i TNBC, der ikke opnåede pCR

Studieoversigt

Status

Betingelser

Intervention / Behandling

Undersøgelsestype

Tilmelding (Anslået)

Fase

Kontakter og lokationer

Studiekontakt

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Efterforskere

Publikationer og nyttige links

Hjælpsomme links

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Anslået)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt