A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
27. maj 2026 opdateret af: Novo Nordisk A/S
A Clinical Study to Compare Efficacy and Safety of Two Different Doses of CagriSema and Semaglutide in Participants With Obesity With or Without Type 2 Diabetes
This clinical study is testing how the study medicine CagriSema helps people living with obesity, with or without type 2 diabetes (T2D), lose weight.
The purpose of the study is to find out how safe and effective CagriSema is for body weight loss in these participants.
Participants will receive either CagriSema or semaglutide, and which treatment participants receive is decided by chance.
CagriSema is a new study medicine being tested, while semaglutide is a medicine that doctors can already prescribe.
The study will last for about 83 weeks
Studieoversigt
Status
Rekruttering
Betingelser
Intervention / Behandling
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
2500
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Novo Nordisk
- Telefonnummer: (+1) 866-867-7178
- E-mail: clinicaltrials@novonordisk.com
Studiesteder
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Buenos Aires, Argentina, C1425AGC
- Rekruttering
- Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
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Buenos Aires, Argentina, C1119ACU
- Rekruttering
- Kynet Recoleta
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Buenos Aires, Argentina, C1015
- Rekruttering
- OMI- Organización Médica de Investigación
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Buenos Aires, Argentina, C1419
- Rekruttering
- Hospital Sirio Libanes
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CABA, Argentina, C1060ABA
- Ikke rekrutterer endnu
- CEDIC Centro de Investigación Clínica
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CABA, Argentina, C1061AAS.
- Ikke rekrutterer endnu
- CIPREC Arenales
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CABA, Argentina, C1120AAC
- Ikke rekrutterer endnu
- Centro Medico Viamonte SRL
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Ciudad de Buenos Aires, Argentina, C1204AAD
- Ikke rekrutterer endnu
- Instituto Centenario
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Santa Fe, Argentina, S3000FSO
- Ikke rekrutterer endnu
- CEDIR - Centro de diagnóstico y rehabilitación Santa Fe
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Santiago del Estero, Argentina, G4200
- Rekruttering
- Sanatorio Norte
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Buenos Aires
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CABA, Buenos Aires, Argentina, C1440CFD
- Rekruttering
- CEMEDIC
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Capital Federal, Buenos Aires, Argentina, C1056ABI
- Rekruttering
- Centro de Investigaciones Metabólicas
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Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1424CIQ
- Rekruttering
- CICEMO- Consultorio (Av Directorio)
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Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1427
- Ikke rekrutterer endnu
- Centro Médico Arsema
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Tucumán Province
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San Miguel de Tucumán, Tucumán Province, Argentina, T4000DPX
- Ikke rekrutterer endnu
- Centro de Investigación C.I.C.E 9 de Julio - Sanatorio 9 de Julio
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New South Wales
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Campbelltown, New South Wales, Australien, 2560
- Ikke rekrutterer endnu
- Sydney Clinical Trials
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Gosford, New South Wales, Australien, 2250
- Ikke rekrutterer endnu
- Gosford Renal Research
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Liverpool, New South Wales, Australien, 2170
- Ikke rekrutterer endnu
- Sydney Cardiometabolic Centre
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Merewether, New South Wales, Australien, 2291
- Ikke rekrutterer endnu
- Hunter Diabetes Centre
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Queensland
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Birtinya, Queensland, Australien, 4575
- Ikke rekrutterer endnu
- University of Sunshine Coast - Vitality Village
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South Brisbane, Queensland, Australien, 4101
- Ikke rekrutterer endnu
- University of Sunshine Coast - South Brisbane
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Victoria
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Camberwell, Victoria, Australien, 3124
- Ikke rekrutterer endnu
- Emeritus Research Melbourne
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Alken, Belgien, 3570
- Ikke rekrutterer endnu
- Anima Research Center
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Brussels, Belgien, 1200
- Ikke rekrutterer endnu
- Cliniques Universitaires Saint-luc
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Kluisbergen, Belgien, 9690
- Ikke rekrutterer endnu
- Kormont
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La Louvière, Belgien, 7100
- Ikke rekrutterer endnu
- Chu Tivoli
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Mechelen, Belgien, 2800
- Ikke rekrutterer endnu
- Meclinas
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Roeselare, Belgien, 8800
- Ikke rekrutterer endnu
- AZ Delta - Roeselare
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Zwalm, Belgien, 9630
- Ikke rekrutterer endnu
- Kormont
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Burgas, Bulgarien, 8000
- Ikke rekrutterer endnu
- MC For Life EOOD
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Kazanlak, Bulgarien, 6100
- Ikke rekrutterer endnu
- MC Kazanlak EOOD
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Kyustendil, Bulgarien, 2500
- Ikke rekrutterer endnu
- Medical center Medi City 21 OOD
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Pleven, Bulgarien, 5800
- Ikke rekrutterer endnu
- OCSOMCE - Dr. Albena Dinkova EOOD
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Plovdiv, Bulgarien, 4000
- Ikke rekrutterer endnu
- AIPSMCEMDID - Dr. Georgi Levterov EOOD
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Plovdiv, Bulgarien, 4002
- Ikke rekrutterer endnu
- DCC Sveti Georgi EOOD
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Sofia, Bulgarien, 1463
- Ikke rekrutterer endnu
- Hipocrat 9 - Dr. Rumyana Boykova - Draganova - AISPEMD EOOD
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Sofia, Bulgarien, 1618
- Ikke rekrutterer endnu
- DCC XX - Sofia EOOD, Endocrinology
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Sofia, Bulgarien, 1618
- Ikke rekrutterer endnu
- MC Diamedical - 2013 OOD, Sofia
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Sofia, Bulgarien, 1618
- Ikke rekrutterer endnu
- Medical Centre Medical Arts Medico-dental centre
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Sofia, Bulgarien, 1712
- Ikke rekrutterer endnu
- DCC XXV Sofia EOOD, Endocrinology Consulting room
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Stara Zagora, Bulgarien, 6003
- Ikke rekrutterer endnu
- UMHAT Prof. Dr. Stoyan Kirkovich AD
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Varna, Bulgarien, 9010
- Ikke rekrutterer endnu
- AIPSMC Dr. Evelina Zlatanova EOOD
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Veliko Tarnovo, Bulgarien, 5005
- Ikke rekrutterer endnu
- MC Nevromedics EOOD, Internal Diseases
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Québec, Canada, G1V 4T3
- Ikke rekrutterer endnu
- Diex Recherche Quebec
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Québec, Canada, G2J 0C4
- Ikke rekrutterer endnu
- Alpha Recherche Clinique - Lebourgneuf
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Alberta
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Calgary, Alberta, Canada, T2V 4J2
- Ikke rekrutterer endnu
- C-Health Partners
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British Columbia
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Kelowna, British Columbia, Canada, V1Y 5A8
- Ikke rekrutterer endnu
- Kelowna Health and Memory Centre Ltd.
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Kelowna, British Columbia, Canada, V1Y4N7
- Ikke rekrutterer endnu
- Medical Arts Health Research Group_Kelowna
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Surrey, British Columbia, Canada, V4A 0C1
- Ikke rekrutterer endnu
- Hilltop Medical Clinic
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Surrey, British Columbia, Canada, V3Z 2N6
- Ikke rekrutterer endnu
- Ocean West Research Clinic
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Victoria, British Columbia, Canada, V8V 4A1
- Ikke rekrutterer endnu
- Dr. M.B. Jones Inc
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New Brunswick
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Moncton, New Brunswick, Canada, E1G 1A7
- Ikke rekrutterer endnu
- G.A. Research Associates Ltd.
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3H1V7
- Ikke rekrutterer endnu
- Nova Scotia Hlth Halifax
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Sydney, Nova Scotia, Canada, B1M 0A1
- Ikke rekrutterer endnu
- Care Access Cape Breton
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Ontario
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Brampton, Ontario, Canada, L6S 0C6
- Ikke rekrutterer endnu
- Centricity Research Brampton Endocrinology
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Guelph, Ontario, Canada, N1G 0B4
- Ikke rekrutterer endnu
- Apex Trials
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Hamilton, Ontario, Canada, L8L 5G4
- Ikke rekrutterer endnu
- Hamilton Medical Research Group
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Hamilton, Ontario, Canada, L8L 5G4
- Ikke rekrutterer endnu
- Premier Clinical Trial Research Network (PCTRN)
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Hamilton, Ontario, Canada, L8L 5G8
- Ikke rekrutterer endnu
- Wharton Medical Clinic Clinical Trials (Hamilton)
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London, Ontario, Canada, N5W 6A2
- Ikke rekrutterer endnu
- Milestone Research
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Sarnia, Ontario, Canada, N7T 4X3
- Ikke rekrutterer endnu
- Bluewater Clin Res Group Inc
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Toronto, Ontario, Canada, M6G 1M2
- Ikke rekrutterer endnu
- Diabetes Heart Research Centre
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Quebec
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Montreal, Quebec, Canada, H4N 2W2
- Ikke rekrutterer endnu
- Centre Medical Acadie
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Pointe-Claire, Quebec, Canada, H9R 4S3
- Ikke rekrutterer endnu
- Centricity Res Pointe-Claire
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Alabama
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Birmingham, Alabama, Forenede Stater, 35294
- Ikke rekrutterer endnu
- Uni of Alabama at Birmingham
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Pelham, Alabama, Forenede Stater, 35124
- Rekruttering
- Cahaba Research
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Arizona
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Gilbert, Arizona, Forenede Stater, 85296
- Ikke rekrutterer endnu
- Elligo Health Research Inc
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Phoenix, Arizona, Forenede Stater, 85006
- Rekruttering
- Velocity Clinical Research-Phoenix
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Arkansas
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Little Rock, Arkansas, Forenede Stater, 72205
- Rekruttering
- Arkansas Clinical Research
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Little Rock, Arkansas, Forenede Stater, 72211
- Ikke rekrutterer endnu
- Woodland Int. Research Group
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California
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Escondido, California, Forenede Stater, 92025
- Rekruttering
- Neighborhood Healthcare
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Escondido, California, Forenede Stater, 92025
- Rekruttering
- Headlands Research California, LLC
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La Mesa, California, Forenede Stater, 91942
- Rekruttering
- Diabetes & Endocrine Specialists - La Mesa
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Lincoln, California, Forenede Stater, 95648
- Rekruttering
- Clinical Trials Research_Sacramento
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Loma Linda, California, Forenede Stater, 92354
- Ikke rekrutterer endnu
- Loma Linda University Faculty Medical Clinics
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Los Alamitos, California, Forenede Stater, 90720
- Rekruttering
- Pacific Clinical Studies
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Northridge, California, Forenede Stater, 91325
- Rekruttering
- Valley Clinical Trials
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Palm Springs, California, Forenede Stater, 92262
- Rekruttering
- Desert Oasis Healthcare
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San Diego, California, Forenede Stater, 92111
- Rekruttering
- Linda Vista Health Care Ctr
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Van Nuys, California, Forenede Stater, 91405
- Rekruttering
- Velocity Clin Res - Van Nuys
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Walnut Creek, California, Forenede Stater, 94598
- Rekruttering
- Flourish Research - CA
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Colorado
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Aurora, Colorado, Forenede Stater, 80045
- Ikke rekrutterer endnu
- University of Colorado Hospital
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Florida
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Clearwater, Florida, Forenede Stater, 33761
- Rekruttering
- TBMR & Alcanza
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Fleming Island, Florida, Forenede Stater, 32003
- Rekruttering
- Northeast Research Institute
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Jacksonville, Florida, Forenede Stater, 32204
- Rekruttering
- Northeast Research Institute
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Jacksonville, Florida, Forenede Stater, 32205
- Ikke rekrutterer endnu
- Westside Center for Clinical Research
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Miami, Florida, Forenede Stater, 33165
- Rekruttering
- New Horizon Research Center
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Miami, Florida, Forenede Stater, 33155
- Rekruttering
- Bioclinical Research Alliance
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Miramar, Florida, Forenede Stater, 33027
- Rekruttering
- South Broward Research LLC
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Ocoee, Florida, Forenede Stater, 34761
- Rekruttering
- West Orange Endocrinology
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Oviedo, Florida, Forenede Stater, 32765
- Rekruttering
- Oviedo Medical Research, LLC
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Pembroke Pines, Florida, Forenede Stater, 33024
- Ikke rekrutterer endnu
- Clinical Trial Services Corp
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Georgia
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Conyers, Georgia, Forenede Stater, 30094
- Rekruttering
- Hope Clin Res & Wellness
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Gainesville, Georgia, Forenede Stater, 30501
- Rekruttering
- Center for Adv Res & Education
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Roswell, Georgia, Forenede Stater, 30076
- Rekruttering
- Endocrine Research Solutions, Inc
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Woodstock, Georgia, Forenede Stater, 30189-4255
- Rekruttering
- North Georgia Clinical Research
-
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Idaho
-
Meridian, Idaho, Forenede Stater, 83646
- Rekruttering
- Solaris Clinical Research
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Illinois
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Chicago, Illinois, Forenede Stater, 60607
- Ikke rekrutterer endnu
- Cedar-Crosse Research Center
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Gillespie, Illinois, Forenede Stater, 62033
- Rekruttering
- Macoupin Fam Practice Ctr, LLP
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Gurnee, Illinois, Forenede Stater, 60031
- Rekruttering
- Clinical Investigation Spec Gurnee
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Skokie, Illinois, Forenede Stater, 60077
- Rekruttering
- Evanston Premier Hlthcr Res
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Skokie, Illinois, Forenede Stater, 60077
- Ikke rekrutterer endnu
- Endeavor Health
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Iowa
-
West Des Moines, Iowa, Forenede Stater, 50266
- Ikke rekrutterer endnu
- Iowa Diabetes Research
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Kansas
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Newton, Kansas, Forenede Stater, 67114
- Rekruttering
- Alliance for Multispecialty Research
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Topeka, Kansas, Forenede Stater, 66606
- Rekruttering
- Cotton O'Neil Diab & Endo Ctr
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Kentucky
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Lexington, Kentucky, Forenede Stater, 40503
- Rekruttering
- The Research Group of Lexington LLC
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Maryland
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Rockville, Maryland, Forenede Stater, 20852
- Ikke rekrutterer endnu
- Endo and Metabolic Consultants
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Michigan
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Buckley, Michigan, Forenede Stater, 49620
- Rekruttering
- Northern Pines Hlth Ctr, PC
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Minnesota
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Minneapolis, Minnesota, Forenede Stater, 55416
- Ikke rekrutterer endnu
- International Diabetes Center
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Richfield, Minnesota, Forenede Stater, 55423
- Rekruttering
- AES Minneapolis DRS
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Mississippi
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Belzoni, Mississippi, Forenede Stater, 39038
- Ikke rekrutterer endnu
- Belzoni Clinical Research
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Missouri
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Chesterfield, Missouri, Forenede Stater, 63005
- Rekruttering
- Clinical Research Professionals
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St Louis, Missouri, Forenede Stater, 63128
- Rekruttering
- Amicis Centers of Clinical Research
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New York
-
West Seneca, New York, Forenede Stater, 14224
- Rekruttering
- Southgate Medical Group, LLP
-
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North Carolina
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Greensboro, North Carolina, Forenede Stater, 27408
- Rekruttering
- PharmQuest Life Sciences LLC
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Greenville, North Carolina, Forenede Stater, 27834
- Rekruttering
- Physician's East Endocrinology
-
Morehead City, North Carolina, Forenede Stater, 28557
- Rekruttering
- Carteret Medical Group
-
Morehead City, North Carolina, Forenede Stater, 28557
- Rekruttering
- Centricity Rsrch MHCity Multi
-
Statesville, North Carolina, Forenede Stater, 28625
- Rekruttering
- Piedmont Healthcare/Research
-
Wilmington, North Carolina, Forenede Stater, 28401
- Rekruttering
- Accellacare Wilmington
-
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North Dakota
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Fargo, North Dakota, Forenede Stater, 58104
- Rekruttering
- Lillestol Research LLC
-
Fargo, North Dakota, Forenede Stater, 58104
- Ikke rekrutterer endnu
- Plains Clinical Research Center, LLC
-
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Ohio
-
Maumee, Ohio, Forenede Stater, 43537
- Rekruttering
- Advanced Medical Research
-
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Oklahoma
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Norman, Oklahoma, Forenede Stater, 73069
- Rekruttering
- Alliance for Multispecialty Research
-
Norman, Oklahoma, Forenede Stater, 73072
- Rekruttering
- Lynn Institute of Norman
-
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Pennsylvania
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Beaver, Pennsylvania, Forenede Stater, 15009
- Ikke rekrutterer endnu
- Heritage Valley Medical Group
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Hatboro, Pennsylvania, Forenede Stater, 19040
- Rekruttering
- Hatboro Med Associates
-
Philadelphia, Pennsylvania, Forenede Stater, 19114
- Ikke rekrutterer endnu
- Northeast Endocrine Metabolic Associates
-
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Rhode Island
-
Cumberland, Rhode Island, Forenede Stater, 02864
- Rekruttering
- Clinical Res Collaborative
-
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South Carolina
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Gaffney, South Carolina, Forenede Stater, 29340
- Ikke rekrutterer endnu
- Velocity Clinical Research-Gaffney
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Spartanburg, South Carolina, Forenede Stater, 29303
- Rekruttering
- Spartanburg Medical Research
-
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Tennessee
-
Jackson, Tennessee, Forenede Stater, 38305
- Rekruttering
- Jackson Clinic
-
Kingsport, Tennessee, Forenede Stater, 37660
- Rekruttering
- Holston Medical Group
-
Memphis, Tennessee, Forenede Stater, 38119
- Rekruttering
- CNS Healthcare
-
Morristown, Tennessee, Forenede Stater, 37813
- Rekruttering
- HealthStar Physicians, PC
-
Nashville, Tennessee, Forenede Stater, 37203
- Rekruttering
- Clinical Research Associates
-
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Texas
-
Amarillo, Texas, Forenede Stater, 79124
- Rekruttering
- Amarillo Med Spec LLP
-
Austin, Texas, Forenede Stater, 78759
- Rekruttering
- Velocity Clinical Research Austin
-
Austin, Texas, Forenede Stater, 78731
- Rekruttering
- Texas Diab & Endo, P.A.
-
Dallas, Texas, Forenede Stater, 75231
- Rekruttering
- North Texas Endocrine Center
-
Dallas, Texas, Forenede Stater, 75230
- Rekruttering
- Velocity Clin Res, Dallas
-
Euless, Texas, Forenede Stater, 76040
- Ikke rekrutterer endnu
- Cedar Health Research
-
Houston, Texas, Forenede Stater, 77079
- Rekruttering
- The Endocrine Center
-
Houston, Texas, Forenede Stater, 77040
- Rekruttering
- JCCT- Juno NW Houston
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Katy, Texas, Forenede Stater, 77450
- Ikke rekrutterer endnu
- Medical Colleagues-Texas LLP
-
Kerrville, Texas, Forenede Stater, 78028
- Rekruttering
- Sante Clinical Research
-
Lampasas, Texas, Forenede Stater, 76550
- Rekruttering
- Radiance Clinical Research
-
Laredo, Texas, Forenede Stater, 78041
- Rekruttering
- Aeres Clinical Research
-
Longview, Texas, Forenede Stater, 75605
- Rekruttering
- DCOL Ctr for Clin Res
-
McAllen, Texas, Forenede Stater, 78503
- Rekruttering
- RGV Endocrine Center
-
San Antonio, Texas, Forenede Stater, 78233
- Rekruttering
- Northeast Clinical Research of San Antonio
-
San Antonio, Texas, Forenede Stater, 78229
- Rekruttering
- AES San Antonio
-
San Antonio, Texas, Forenede Stater, 78209
- Rekruttering
- Quality Research Inc
-
Shavano Park, Texas, Forenede Stater, 78231
- Rekruttering
- Consano Clinical Research, LLC
-
Sugar Land, Texas, Forenede Stater, 77478
- Rekruttering
- Mt Olympus Medical Research, LLC
-
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Utah
-
Salt Lake City, Utah, Forenede Stater, 84109
- Rekruttering
- J.Lewis Research Inc
-
Salt Lake City, Utah, Forenede Stater, 84121
- Rekruttering
- J.Lewis Research Inc
-
Sandy City, Utah, Forenede Stater, 84093
- Ikke rekrutterer endnu
- Diabetes & Endo Tx Specialists
-
South Jordan, Utah, Forenede Stater, 84095
- Rekruttering
- J.Lewis Research Inc
-
-
Virginia
-
Newport News, Virginia, Forenede Stater, 23606
- Rekruttering
- Tidewater Physicians Multispecialty Group
-
Newport News, Virginia, Forenede Stater, 23606
- Rekruttering
- Health Res of Hampton Roads
-
Richmond, Virginia, Forenede Stater, 23294
- Rekruttering
- National Clin Res Inc.
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Wisconsin
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Ikke rekrutterer endnu
- Prevea Health
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-
-
-
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Bois-Guillaume, Frankrig, 76230
- Ikke rekrutterer endnu
- CHU ROUEN_HOPITAL DE BOIS GUILLAUME_Service de Nutrition
-
Colmar, Frankrig, 68024
- Ikke rekrutterer endnu
- CENTRE HOSPITALIER DE COLMAR_Endocrinologie/Diabetologie/Centre Nutritionnel
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Le Coudray, Frankrig, 28630
- Ikke rekrutterer endnu
- LES HOPITAUX DE CHARTRES_HOPITAL LOUIS PASTEUR_Service d'endocrinologie
-
Paris, Frankrig, 75015
- Ikke rekrutterer endnu
- HOPITAL EUROPEEN GEORGES POMPIDOU_Service de nutrition et diabétologie
-
Paris, Frankrig, 75013
- Ikke rekrutterer endnu
- APHP - LA PITIE SALPETRIERE _ Service de Nutrition
-
Pessac, Frankrig, 33600
- Ikke rekrutterer endnu
- CHU DE BORDEAUX-HOPITAL HAUT LEVEQUE_Service d'Endocrinologie, Diabétologie et Maladies Métaboliques
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Pierre-Bénite, Frankrig, 69310
- Ikke rekrutterer endnu
- HCL-HOPITAL LYON SUD_Service d'Endocrinologie-Diabète-Nutrition
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Saint-Herblain, Frankrig, 44800
- Ikke rekrutterer endnu
- CHU NANTES - HOPITAL NORD LAENNEC_Service d'Endocrinologie-Diabétologie-Nutrition
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Vénissieux, Frankrig, 69200
- Ikke rekrutterer endnu
- CENTRE DE RECHERCHE CLINIQUE PORTES DU SUD_Service d'Endocrinologie-Diabétologie-Maladies Métaboliques
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Alexandroupoli, Grækenland, 68100
- Ikke rekrutterer endnu
- University General Hospital Of Alexandroupoli - First Department of Internal Medicine
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Athens, Grækenland, 115 27
- Ikke rekrutterer endnu
- Laiko General Hospital Of Athens - 1st department of Internal Medicine
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Athens, Grækenland, 11525
- Ikke rekrutterer endnu
- Athens Medical Center S.A. (Iatriko Psychicou) - Department of Internal Medicine & Metabolic Diseases
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Athens, Grækenland, 11528
- Ikke rekrutterer endnu
- General Hospital Of Athens Alexandra - Clinical Therapeutics
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Athens, Grækenland, 10676
- Ikke rekrutterer endnu
- Evangelismos S.A. - Endocrinology department
-
Lamia, Grækenland, 35100
- Ikke rekrutterer endnu
- General Hospital Of Lamia - Internal Medicine Clinic
-
Marousi, Grækenland, 15125
- Ikke rekrutterer endnu
- Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit
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Palaió Fáliro, Grækenland, 17562
- Ikke rekrutterer endnu
- Athens Medical Center S.A. (Iatriko P. Falirou) - Diabetes and Clinical Research Center
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Peristeri, Grækenland, 121 31
- Ikke rekrutterer endnu
- Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department
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Thessaloniki, Grækenland, 54635
- Ikke rekrutterer endnu
- NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes
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Thessaloniki, Grækenland, 57001
- Ikke rekrutterer endnu
- Thermi Clinic S.A. - Diabetes and Internal Medicine Department
-
Thessaloniki, Grækenland, 546 39
- Ikke rekrutterer endnu
- Athens Medical Center S.A., European Interbalkan Medical Center - Department of Internal Medicine
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Thessaloniki, Grækenland, 54635
- Ikke rekrutterer endnu
- General Hospital Of Thessaloniki G Gennimatas - Internal Medicine Clinic
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Arnhem, Holland, 6815 AD
- Ikke rekrutterer endnu
- Rijnstate Ziekenhuis
-
Eindhoven, Holland, 5623 EJ
- Ikke rekrutterer endnu
- Catharina Zkh Eindhoven - Interne geneeskunde
-
Hoofddorp, Holland, 2134 TM
- Ikke rekrutterer endnu
- Spaarne Gasthuis Hoofddorp - Interne
-
Hoogeveen, Holland, 7909 AA
- Ikke rekrutterer endnu
- Bethesda Diabetes Research Center
-
Rotterdam, Holland, 3083 AN
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- Ikazia Ziekenhuis
-
The Hague, Holland, 2565 KV
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- Medisch Centrum Thomsonplein
-
-
Limburg
-
Born, Limburg, Holland, 6121 XK
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- PreCare Trial & Recruitment
-
-
North Brabant
-
's-Hertogenbosch, North Brabant, Holland, 5223 LA
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- Progress Clinical Research Den Bosch
-
-
-
-
-
Catanzaro, Italien, 88100
- Ikke rekrutterer endnu
- Azienda Ospedaliero-Universitaria Renato Dulbecco
-
-
Emilia-Romagna
-
Bologna, Emilia-Romagna, Italien, 40138
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- AOU IRCCS Policlinico di Sant'Orsola Malpighi - UOC Endocrinologia e Prevenzione e Cura del Diabete
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Liguria
-
Genoa, Liguria, Italien, 16132
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- IRCCS Ospedale Policlinico San Martino - U.O.D. Dietetica e Nutrizione Clinica
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Lombardy
-
Brescia, Lombardy, Italien, 25123
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- Spedali Civili Brescia - SSD Endocrinologia
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Milan, Lombardy, Italien, 20132
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- Ospedale San Raffaele S.r.l. - Unità di Cardio-metabolismo e Trials Clinici
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Pg
-
Perugia, Pg, Italien, 06129
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- Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia
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Sicily
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Messina, Sicily, Italien, 98124
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- D.A.I. Oncologico - U.O.C. di Chirurgia Generale ad indirizzo Oncologico
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The Marches
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Ancorna, The Marches, Italien, 60127
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- INRCA Ancona - UOC Clinica Medica e Geriatrica
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Tuscany
-
Pisa, Tuscany, Italien, 56126
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- Azienda Ospedaliero Universitaria Pisana
-
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-
-
Bialystok, Polen, 15-276
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- Uniwersytecki Szpital Kliniczny w Bialymstoku
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Bialystok, Polen, 15-281
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- Gabinet Leczenia Otylosci i Chorob Dietozaleznych
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Bialystok, Polen, 15-481
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- Kresmed Sp. z o. o.
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Bialystok, Polen, 15-797
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- Renew Clinic Sp. z o.o.
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Bygdoszcz, Polen, 85-796
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- Gierach-Med
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Dębica, Polen, 39-200
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Katowice, Polen, 40-648
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Katowice, Polen, 40-748
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Poznan, Polen, 61-251
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Rzeszów, Polen, 35-055
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Warsaw, Polen, 02-679
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Warsaw, Polen, 00-124
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Wroclaw, Polen, 52-416
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Wroclaw, Polen, 51-149
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Almada, Portugal, 2805-267
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- ULS Almada-Seixal E.P.E. - HGO_Serviço de Endocrinologia
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Caldas da Rainha, Portugal, 2500-176
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Figueira da Foz Municipality, Portugal, 3094-001
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- ULS Do Baixo Mondego, E.P.E. - HDFF_Serviço Cardiologia
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Lisbon, Portugal, 1500-650
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Senhora Da Hora, Matosinhos, Portugal, 4464-513
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- ULS De Matosinhos, E.P.E - HPH_Serviço de Endocrinologia
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Torres Novas, Portugal, 2350-111
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- Ucardio Centro Clinico Unidade Cardiovascular
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Vila Nova de Gaia, Portugal, 4400-346
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- Hospital da Luz Arrábida, S.A_Serviço de Endocrinologia
-
Vila do Conde, Portugal, 4480-565
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-
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Brasov, Rumænien, 500101
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Bucharest, Rumænien, 010507
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- SC Nicodiab SRL
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Buzău, Rumænien, 120133
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Oradea, Rumænien, 410469
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Piteşti, Rumænien, 110424
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Timișoara, Rumænien, 300288
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Timișoara, Rumænien, 300723
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Bihor County
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Oradea, Bihor County, Rumænien, 410159
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- Grandmed SRL
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Dolj
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Craiova, Dolj, Rumænien, 200515
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Maramureş
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Baia Mare, Maramureş, Rumænien, 430222
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- CMI Dr Pop Lavinia
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Mureș County
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Târgu Mureş, Mureș County, Rumænien, 540142
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- Sc Mediab Srl
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Bojnice, Slovakiet, 97201
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Bratislava, Slovakiet, 851 01
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Bratislava, Slovakiet, 84108
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Bytča, Slovakiet, 014 01
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Košice, Slovakiet, 04013
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Košice, Slovakiet, 040 01
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Martin, Slovakiet, 036 01
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Spišská Nová Ves, Slovakiet, 05201
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- LUDIA, s. r. o.
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A Coruña, Spanien, 15006
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Barcelona, Spanien, 08035
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Barcelona, Spanien, 08028
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Centelles (Barcelona), Spanien, 08540
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Girona, Spanien, 17002
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Madrid, Spanien, 28006
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Madrid, Spanien, 28006
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Madrid, Spanien, 28016
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Madrid, Spanien, 28942
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Manresa, Spanien, 08243
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Málaga, Spanien, 29010
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Valladolid, Spanien, 47004
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-
-
-
-
Eastern Cape
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Port Elizabeth, Eastern Cape, Sydafrika, 6001
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- Phoenix Pharma
-
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Free State
-
Bloemfontein, Free State, Sydafrika, 9301
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- Iatros International
-
Bloemfontein, Free State, Sydafrika, 9301
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- Medi-Clinic Bloemfontein
-
-
Gauteng
-
Johannesburg, Gauteng, Sydafrika, 2013
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- Wits Bara Clinical Trial Site
-
Johannesburg, Gauteng, Sydafrika, 1827
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- Hemant Makan
-
Johannesburg, Gauteng, Sydafrika, 1818
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- Soweto Clinical Trial Centre
-
Johannesburg, Gauteng, Sydafrika, 2001
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- Newtown Clinical Research
-
Johannesburg, Gauteng, Sydafrika, 2196
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- Sandton Medical Research
-
Lenasia, Gauteng, Sydafrika, 1827
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- Lenasia Clinical Trial Centre
-
Pretoria, Gauteng, Sydafrika, 0186
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- Clinical Trial Systems (CTC)
-
-
KwaZulu-Natal
-
Durban, KwaZulu-Natal, Sydafrika, 4450
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- Dr Pillay's Rooms
-
-
Western Cape
-
Cape Town, Western Cape, Sydafrika, 7500
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- Tread Research (Pty)Ltd
-
Mossel Bay, Western Cape, Sydafrika, 6500
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- Dr Hendrik Snyman's Practice
-
Paarl, Cape Town, Western Cape, Sydafrika, 7646
- Ikke rekrutterer endnu
- Paarl Research Centre
-
Somerset West, Western Cape, Sydafrika, 7130
- Ikke rekrutterer endnu
- Clinical Trials Network (Pty) Ltd
-
-
-
-
-
Brno, Tjekkiet, 656 91
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- Fakultni nemocnice u sv. Anny v Brne
-
Dolní Břežany, Tjekkiet, 252 41
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- Centrum zdraví Dolní Břežany, a.s.
-
Liberec, Tjekkiet, 460 01
- Ikke rekrutterer endnu
- KARDIOLOGIE - LIBEREC s.r.o.
-
Náchod, Tjekkiet, 54701
- Ikke rekrutterer endnu
- Interní a diabetologická ordinace s.r.o.
-
Plzeň 3, Tjekkiet, 301 00
- Ikke rekrutterer endnu
- DIALINE s.r.o.
-
Prague, Tjekkiet, 149 00
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- MILAN KVAPIL s.r.o.
-
Prague, Tjekkiet, 10400
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- ENDOTRIAL s.r.o.
-
Prague, Tjekkiet, 150 00
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- EUC Klinika Praha a.s.
-
Prague, Tjekkiet, 160 00
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- Fledip s.r.o.
-
-
-
-
-
Baja, Ungarn, 6500
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- EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság
-
Biatorbágy, Ungarn, 2051
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- Biatros Kft.
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Budapest, Ungarn, 1083
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- Semmelweis Egyetem
-
Budapest, Ungarn, H-1141
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- Cardiogeneral Kft.
-
Békéscsaba, Ungarn, 5600
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- Békés Vármegyei Központi Kórház
-
Békéscsaba, Ungarn, 5600
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- Trial Pharma Kft.
-
Szolnok, Ungarn, 5000
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- Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet
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Székesfehérvár, Ungarn, 8000
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- Mentaház Kft.
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Bekes County
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Békéscsaba, Bekes County, Ungarn, 5600
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- Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés
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Bács-Kiskun county
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Baja, Bács-Kiskun county, Ungarn, 6500
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- Lausmed Kft.
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Csongrád-Csanád
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Szeged, Csongrád-Csanád, Ungarn, 6725
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- Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ
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Pest County
-
Budapest, Pest County, Ungarn, 1036
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- Óbudai Egészségügyi Centrum
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Budapest, Pest County, Ungarn, 1213
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Szabolcs-Szatmár-Bereg
-
Nyíregyháza, Szabolcs-Szatmár-Bereg, Ungarn, 4400
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- Medifarma-98 Kft.
-
-
-
-
-
Graz, Østrig, 8036
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- Medical University of Graz
-
Mattersburg, Østrig, 7210
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- Ordination Winhofer-Stöckl
-
Saint Stefan, Østrig, 8511
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- Fließer-Görzer [Ordination]
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Vienna, Østrig, 1090
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- Universitätsklinikum AKH Wien
-
Vienna, Østrig, 1030
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- Klinik Landstraße
-
Vienna, Østrig, 1120
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- Ordination Dr. Günter Sokol
-
Vienna, Østrig, 1130
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- Klinik Hietzing 3. Med. Abt.
-
Vienna, Østrig, 1180
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- Itariu [Ordination]
-
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ingen
Beskrivelse
Inclusion Criteria :
- Male or female (sex assigned at birth, inclusive of all gender identities).
- Age 18 years or above at the time of signing the informed consent.
- BMI≥ 35.0 kg/m^2.
- Participants without T2D: No history of T2D and HbA1c < 6.5% (48 millimoles per mole (mmol/mol)) Participants with T2D: A history of T2D and HbA1c < 10% (< 86 mmol/mol). If a participant without a history of diabetes during the screening period receives an HbA1c result of 6.5% (48 mmol/mol) or higher, the investigator or the participant's healthcare provider must confirm the diagnosis of type 2 diabetes before the participant is randomised.
Exclusion Criteria:
- A self-reported change in body weight > 5% within 90 days before screening, irrespective of medical records.
- Use of any glucagon-like-peptide-1 receptor agonist (GLP-1 RA), including medication with GLP-1 RA activity, or amylin analogues, including medication with amylin activity, within 6 months before screening.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Firedobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Cagrisema - dose level 1
Participants will receive CagriSema at dose level 1 once weekly subcutaneously during the treatment period for 72 weeks.
|
Cagrisema (Cagrilintide and Semaglutide) will be administered subcutaneously.
|
|
Aktiv komparator: Cagrisema - dose level 2
Participants will receive CagriSema at dose level 2 once weekly subcutaneously during the treatment period for 72 weeks.
|
Cagrisema (Cagrilintide and Semaglutide) will be administered subcutaneously.
|
|
Aktiv komparator: Semaglutide
Participants will receive Semaglutide once weekly subcutaneously during the treatment period for 72 weeks.
|
Semaglutid vil blive administreret subkutant.
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Relative change in body weight
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured as percentage (%).
|
From randomisation (week 0) to end of treatment (week 72)
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Relative change in body weight
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured as %.
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Change in Body Mass Index (BMI)
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured as kilograms per square metre (kg/m^2).
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Number of participants who achieve greater than or equal to (≥) 30% weight reduction
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured as count of participants.
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Number of participants who achieve ≥25% weight reduction
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured as count of participants.
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Number of participants who achieve greater ≥ 20% weight reduction
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured as count of participants.
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Change in waist circumference
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured in centimetre (cm).
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Mean change in body weight
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured in kilograms (kg).
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Number of participants who achieve a BMI less than (<) 30 kg/m^2
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured as count of participants.
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Number of participants who achieve BMI <27 kg/m^2
Tidsramme: end of treatment (week 72)
|
Measured as count of participants.
|
end of treatment (week 72)
|
|
Number of participants who achieve normal BMI, defined as 18.5 lesser than or equal to (≤) BMI < 25 kg/m^2
Tidsramme: At end of treatment (week 72)
|
Measured as count of participants.
|
At end of treatment (week 72)
|
|
Number of participants who achieve a waist-to-height ratio < 0.53
Tidsramme: At end of treatment (week 72)
|
Measured as count of participants.
|
At end of treatment (week 72)
|
|
Ratio to baseline : Total cholesterol
Tidsramme: From baseline (week 0) to end of treatment (week 72)
|
Measured in terms of ratio.
|
From baseline (week 0) to end of treatment (week 72)
|
|
Ratio to baseline : High density lipoprotein (HDL) cholesterol
Tidsramme: From baseline (week 0) to end of treatment (week 72)
|
Measured in terms of ratio.
|
From baseline (week 0) to end of treatment (week 72)
|
|
Ratio to baseline : Low density lipoprotein (LDL) cholesterol
Tidsramme: From baseline (week 0) to end of treatment (week 72)
|
Measured in terms of ratio.
|
From baseline (week 0) to end of treatment (week 72)
|
|
Ratio to baseline : Very low density lipoprotein ( VLDL) cholesterol
Tidsramme: From baseline (week 0) to end of treatment (week 72)
|
Measured in terms of ratio.
|
From baseline (week 0) to end of treatment (week 72)
|
|
Ratio to baseline : Triglycerides
Tidsramme: From baseline (week 0) to end of treatment (week 72)
|
Measured in terms of ratio.
|
From baseline (week 0) to end of treatment (week 72)
|
|
Ratio to baseline: Free fatty acids
Tidsramme: From baseline (week 0) to end of treatment (week 72)
|
Measured in terms of ratio.
|
From baseline (week 0) to end of treatment (week 72)
|
|
Ratio to baseline : Non-HDL cholesterol
Tidsramme: From baseline (week 0) to end of treatment (week 72)
|
Measured in terms of ratio.
|
From baseline (week 0) to end of treatment (week 72)
|
|
Change in Short-Form-36 Health Survey Version 2.0 (SF-36v2) physical Function
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured as score on a scale.
The SF-36v2 acute measures health-related quality of life (HRQOL).
The measure consists of 36 items yielding 8 health domain scores and 2 component summary scores.
SF-36v2 acute scores are norm-based scores, i.e. transformed to a scale where the 2009 United States general population has a mean of 50 and a standard deviation of 10.
Physical functioning score ranges from 19.0-57.6, with higher scores indicating better functional health and well-being.
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Change in Impact of Weight on Quality of Life-Lite Clinical Trials (IWQOL-Lite-CT) physical function
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured as score on a scale.
IWQOL-Lite-CT measures weight-related physical and psychosocial functioning.
The measure consists of 20 items yielding 3 composite scores, and 1 total score.
Physical function score ranges from 0 to 100, with higher scores indicating better levels of functioning.
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Change in glycated haemoglobin (HbA1c)
Tidsramme: From randomisation (week 0) to end of treatment (week 72)
|
Measured in %-points.
|
From randomisation (week 0) to end of treatment (week 72)
|
|
Number of participants who achieve HbA1c <6.5%
Tidsramme: At end of treatment (week 72)
|
Measured as count of participants.
|
At end of treatment (week 72)
|
|
Number of participants who achieve normal HbA1c <5.7%
Tidsramme: At end of treatment (week 72)
|
Measured as count of participants.
|
At end of treatment (week 72)
|
|
Number of treatment-emergent adverse events (TEAEs)
Tidsramme: From randomisation (week 0) to end of study (week 80)
|
Measured in number of events.
|
From randomisation (week 0) to end of study (week 80)
|
|
Number of treatment-emergent serious adverse events (TESAEs)
Tidsramme: From randomisation (week 0) to end of study (week 80)
|
Measured in number of events.
|
From randomisation (week 0) to end of study (week 80)
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Studieleder: Clinical Transparency (dept. 2834), Novo Nordisk A/S
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
21. maj 2026
Primær færdiggørelse (Anslået)
23. februar 2028
Studieafslutning (Anslået)
19. april 2028
Datoer for studieregistrering
Først indsendt
27. april 2026
Først indsendt, der opfyldte QC-kriterier
27. april 2026
Først opslået (Faktiske)
4. maj 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
29. maj 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
27. maj 2026
Sidst verificeret
1. maj 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Sygdomme i det endokrine system
- Ernæringsforstyrrelser
- Metaboliske sygdomme
- Overernæring
- Kropsvægt
- Glukosemetabolismeforstyrrelser
- Diabetes mellitus
- Overvægtig
- Patologiske tilstande, tegn og symptomer
- Ernæringsmæssige og metaboliske sygdomme
- Tegn og symptomer
- Fedme
- Diabetes mellitus, type 2
- Semaglutid
Andre undersøgelses-id-numre
- NN9838-7910
- U1111-1323-0372 (Anden identifikator: World Health Organization)
- 2025-522488-14 (Anden identifikator: European Medical Agency (EMA))
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
JA
IPD-planbeskrivelse
According to the Novo Nordisk disclosure commitment on novonordisk-trials.com
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ja
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Semaglutid
-
Novo Nordisk A/SAfsluttet
-
Novo Nordisk A/SAfsluttetDiabetes mellitus, type 2Japan
-
Novo Nordisk A/SAfsluttetDiabetes mellitus, type 2Tyskland
-
Novo Nordisk A/SAfsluttetType 2 diabetes | Sunde frivilligeForenede Stater, Canada
-
University of LuebeckIkke rekrutterer endnuAtrieflimren (AF)
-
Novo Nordisk A/SAfsluttet
-
Novo Nordisk A/SAfsluttet
-
Novo Nordisk A/SAfsluttetFedme | OvervægtigForenede Stater, Italien, Spanien, Canada, Ungarn
-
Novo Nordisk A/SAfsluttetFedme | OvervægtigJapan, Korea, Republikken
-
Novo Nordisk A/SAfsluttetOvervægt eller fedme | Metabolisme og ernæringsforstyrrelserForenede Stater, Indien, Mexico, Den Russiske Føderation, Det Forenede Kongerige, Canada, Danmark, Finland, Belgien, Japan, Taiwan, Frankrig, Polen, Tyskland, Bulgarien, Argentina, Puerto Rico