THE EFFECT OF AEROBIC AND RESISTANCE TRAINING ON THE IMMUNE SYSTEM
2. juni 2026 opdateret af: ZEYNEP ÜNVER, Inonu University
AEROBİC AND RESİSTANCE TRAİNİNG EFFECTS ON INFLAMMATORY AND IMMUNE BİOMARKERS İN YOUNG SEDENTARY WOMEN
Six-week exercise interventions in sedentary young women demonstrated that aerobic exercise and resistance exercise differentially optimize inflammatory and immune responses through their effects on osteocalcin and IgM, and IgA, respectively.
These distinct effects of exercise modality on immune biomarkers can be utilized to design personalized exercise programs.
Studieoversigt
Status
Tilmelding efter invitation
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
The effects of exercise on the immune system have been studied for many years.
Regular physical activity is known to enhance the effectiveness of the immune system by modulating the inflammatory response.
Regular exercise has been shown to increase individuals' physical fitness levels.
Exercise is used in the prevention and treatment of various diseases.
Consequently, a review of the literature reveals numerous studies indicating that regular exercise positively impacts an individual's health.
Regular exercise positively affects all systems of the organism, including the immune system.
Changes in the immune system after acute and chronic exercise differ.
The effects of exercise on the immune system vary depending on the intensity of the exercise and the physical characteristics of the individuals.
While light to moderate exercise strengthens the immune system, intense exercise can suppress it.
The effects of exercise on the immune system have been the subject of much research in recent years.
However, the effects of different types of exercise (aerobic and resistance training) on immune markers are still not fully understood.
Inflammatory markers, particularly C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), play a critical role in assessing the effect of exercise on the immune system.
In addition, immunoglobulins (IgA, IgG, IgM) are important biomarkers in evaluating the immune response.
This study aims to investigate the chronic effects of a 4-week aerobic and resistance exercise program on the immune system and inflammation.
Blood and saliva samples will be collected and analyzed for CRP, IL-6, TNF-α, and immunoglobulin levels.
The data obtained will help us understand the specific effects of different types of exercise on inflammatory and immune responses, contributing to more informed exercise prescriptions.
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
36
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Malatya, Tyrkiet (Türkiye)
- Inonu University
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
Tager imod sunde frivillige
Ja
Beskrivelse
Inclusion Criteria:
- University students aged 18-30
- Individuals who have engaged in recreational exercise at least two days a week for the past three months
- Those with low or no smoking or alcohol consumption who volunteer to participate in the study.
Exclusion Criteria:
- Individuals who have had an infection or chronic illness in the last 6 months,
- Those with a history of autoimmune disease,
- Metabolic syndrome, or cardiovascular disease,
- Those who have used antibiotics or anti-inflammatory drugs in the last 3 months,
- Those who have suffered a serious injury during exercise or are unable to continue are not eligible.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Forebyggelse
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Enkelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
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Eksperimentel: Resistance exercise group
Exercise group completed a 6-week supervised training program consisting of three sessions per week on non-consecutive days.
Each session lasted 45-60 minutes and included a standardized warm-up, main exercise phase, and cool-down.
Training stimulus was controlled using both internal and external load parameters.
Internal load was monitored via heart rate (HR) and rating of perceived exertion (RPE), whereas external load was defined by exercise duration, intensity, and training volume.
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Because it was done on young girls who lead a sedentary lifestyle.
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Eksperimentel: Aerobic Group
The aerobic training group performed continuous exercise on a treadmill or cycle ergometer at 60-75% of heart rate reserve (HRR), corresponding to moderate-to-vigorous intensity.
Exercise intensity was continuously monitored using HR and verified with RPE (target: 12-15).
A progressive overload approach was applied, with intensity increasing from 60% HRR in the initial weeks to 70-75% HRR in the final phase.
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Because it was done on young girls who lead a sedentary lifestyle.
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Eksperimentel: Control group
The control group maintained habitual activities and refrained from structured exercise.
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Because it was done on young girls who lead a sedentary lifestyle.
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
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Change in C-Reactive Protein (CRP) Levels
Tidsramme: Baseline (Week 0) and Post-intervention (Week 6)
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Serum C-reactive protein levels will be measured using an ELISA kit to evaluate systemic inflammation.
(Unit of measurement: mg/L)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Interleukin-6 (IL-6) Levels
Tidsramme: Baseline (Week 0) and Post-intervention (Week 6)
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Serum interleukin-6 levels will be analyzed to assess pro-inflammatory cytokine response.
(Unit of measurement: pg/mL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Tumor Necrosis Factor-Alpha (TNF-α) Levels
Tidsramme: Baseline (Week 0) and Post-intervention (Week 6)
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Serum tumor necrosis factor-alpha levels will be measured to evaluate pro-inflammatory cytokine activity.
(Unit of measurement: pg/mL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Salivary Immunoglobulin A (IgA) Levels
Tidsramme: Baseline (Week 0) and Post-intervention (Week 6)
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Salivary Immunoglobulin A levels will be measured to evaluate mucosal immune response.
(Unit of measurement: mg/dL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Immunoglobulin M (IgM) Levels
Tidsramme: Baseline (Week 0) and Post-intervention (Week 6)
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Serum Immunoglobulin M levels will be measured to assess acute infection and humoral immune response.
(Unit of measurement: mg/dL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Immunoglobulin G (IgG) Levels
Tidsramme: Baseline (Week 0) and Post-intervention (Week 6)
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Serum Immunoglobulin G levels will be measured to assess long-term immune memory and humoral immune response.
(Unit of measurement: mg/dL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Leukocyte (WBC) Count
Tidsramme: Baseline (Week 0) and Post-intervention (Week 6)
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Total leukocyte (White Blood Cell) count will be analyzed to assess general immune and inflammatory status.
(Unit of measurement: cells/µL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Fahri Safa Çınarlı, Doç. Dr., Inonu University
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Nash D, Hughes MG, Butcher L, Aicheler R, Smith P, Cullen T, Webb R. IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance. Scand J Med Sci Sports. 2023 Jan;33(1):4-19. doi: 10.1111/sms.14241. Epub 2022 Oct 8.
- Henson J, Yates T, Edwardson CL, Khunti K, Talbot D, Gray LJ, Leigh TM, Carter P, Davies MJ. Sedentary time and markers of chronic low-grade inflammation in a high risk population. PLoS One. 2013 Oct 29;8(10):e78350. doi: 10.1371/journal.pone.0078350. eCollection 2013.
- Coughlin GH, Antush MT, Vella CA. Associations of sedentary behavior and screen time with biomarkers of inflammation and insulin resistance. J Behav Med. 2024 Oct;47(5):828-838. doi: 10.1007/s10865-024-00498-y. Epub 2024 May 25.
- Thomas NE, Williams DR. Inflammatory factors, physical activity, and physical fitness in young people. Scand J Med Sci Sports. 2008 Oct;18(5):543-56. doi: 10.1111/j.1600-0838.2008.00824.x. Epub 2008 Jul 9.
- Dogra S, Wolf M, Jeffrey MP, Foley RCA, Logan-Sprenger H, Jones-Taggart H, Green-Johnson JM. Disrupting prolonged sitting reduces IL-8 and lower leg swell in active young adults. BMC Sports Sci Med Rehabil. 2019 Oct 18;11:23. doi: 10.1186/s13102-019-0138-4. eCollection 2019.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
2. januar 2025
Primær færdiggørelse (Anslået)
15. juni 2026
Studieafslutning (Anslået)
1. december 2026
Datoer for studieregistrering
Først indsendt
21. maj 2026
Først indsendt, der opfyldte QC-kriterier
2. juni 2026
Først opslået (Faktiske)
8. juni 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
8. juni 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
2. juni 2026
Sidst verificeret
1. juni 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 11/03/2025-7252
Plan for individuelle deltagerdata (IPD)
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Kliniske forsøg med Aerobic and resistance exercise
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University of Illinois at ChicagoAktiv, ikke rekrutterendeMultipel sclerose | Kognitiv svækkelse | Ældre voksne | GangbesværForenede Stater