THE EFFECT OF AEROBIC AND RESISTANCE TRAINING ON THE IMMUNE SYSTEM
2 giugno 2026 aggiornato da: ZEYNEP ÜNVER, Inonu University
AEROBİC AND RESİSTANCE TRAİNİNG EFFECTS ON INFLAMMATORY AND IMMUNE BİOMARKERS İN YOUNG SEDENTARY WOMEN
Six-week exercise interventions in sedentary young women demonstrated that aerobic exercise and resistance exercise differentially optimize inflammatory and immune responses through their effects on osteocalcin and IgM, and IgA, respectively.
These distinct effects of exercise modality on immune biomarkers can be utilized to design personalized exercise programs.
Panoramica dello studio
Stato
Iscrizione su invito
Condizioni
Intervento / Trattamento
Descrizione dettagliata
The effects of exercise on the immune system have been studied for many years.
Regular physical activity is known to enhance the effectiveness of the immune system by modulating the inflammatory response.
Regular exercise has been shown to increase individuals' physical fitness levels.
Exercise is used in the prevention and treatment of various diseases.
Consequently, a review of the literature reveals numerous studies indicating that regular exercise positively impacts an individual's health.
Regular exercise positively affects all systems of the organism, including the immune system.
Changes in the immune system after acute and chronic exercise differ.
The effects of exercise on the immune system vary depending on the intensity of the exercise and the physical characteristics of the individuals.
While light to moderate exercise strengthens the immune system, intense exercise can suppress it.
The effects of exercise on the immune system have been the subject of much research in recent years.
However, the effects of different types of exercise (aerobic and resistance training) on immune markers are still not fully understood.
Inflammatory markers, particularly C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), play a critical role in assessing the effect of exercise on the immune system.
In addition, immunoglobulins (IgA, IgG, IgM) are important biomarkers in evaluating the immune response.
This study aims to investigate the chronic effects of a 4-week aerobic and resistance exercise program on the immune system and inflammation.
Blood and saliva samples will be collected and analyzed for CRP, IL-6, TNF-α, and immunoglobulin levels.
The data obtained will help us understand the specific effects of different types of exercise on inflammatory and immune responses, contributing to more informed exercise prescriptions.
Tipo di studio
Interventistico
Iscrizione (Stimato)
36
Fase
- Non applicabile
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
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Malatya, Turchia (Türkiye)
- Inonu University
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Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
- Adulto
Accetta volontari sani
Sì
Descrizione
Inclusion Criteria:
- University students aged 18-30
- Individuals who have engaged in recreational exercise at least two days a week for the past three months
- Those with low or no smoking or alcohol consumption who volunteer to participate in the study.
Exclusion Criteria:
- Individuals who have had an infection or chronic illness in the last 6 months,
- Those with a history of autoimmune disease,
- Metabolic syndrome, or cardiovascular disease,
- Those who have used antibiotics or anti-inflammatory drugs in the last 3 months,
- Those who have suffered a serious injury during exercise or are unable to continue are not eligible.
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Prevenzione
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Separare
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
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Sperimentale: Resistance exercise group
Exercise group completed a 6-week supervised training program consisting of three sessions per week on non-consecutive days.
Each session lasted 45-60 minutes and included a standardized warm-up, main exercise phase, and cool-down.
Training stimulus was controlled using both internal and external load parameters.
Internal load was monitored via heart rate (HR) and rating of perceived exertion (RPE), whereas external load was defined by exercise duration, intensity, and training volume.
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Because it was done on young girls who lead a sedentary lifestyle.
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Sperimentale: Aerobic Group
The aerobic training group performed continuous exercise on a treadmill or cycle ergometer at 60-75% of heart rate reserve (HRR), corresponding to moderate-to-vigorous intensity.
Exercise intensity was continuously monitored using HR and verified with RPE (target: 12-15).
A progressive overload approach was applied, with intensity increasing from 60% HRR in the initial weeks to 70-75% HRR in the final phase.
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Because it was done on young girls who lead a sedentary lifestyle.
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Sperimentale: Control group
The control group maintained habitual activities and refrained from structured exercise.
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Because it was done on young girls who lead a sedentary lifestyle.
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Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
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Change in C-Reactive Protein (CRP) Levels
Lasso di tempo: Baseline (Week 0) and Post-intervention (Week 6)
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Serum C-reactive protein levels will be measured using an ELISA kit to evaluate systemic inflammation.
(Unit of measurement: mg/L)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Interleukin-6 (IL-6) Levels
Lasso di tempo: Baseline (Week 0) and Post-intervention (Week 6)
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Serum interleukin-6 levels will be analyzed to assess pro-inflammatory cytokine response.
(Unit of measurement: pg/mL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Tumor Necrosis Factor-Alpha (TNF-α) Levels
Lasso di tempo: Baseline (Week 0) and Post-intervention (Week 6)
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Serum tumor necrosis factor-alpha levels will be measured to evaluate pro-inflammatory cytokine activity.
(Unit of measurement: pg/mL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Salivary Immunoglobulin A (IgA) Levels
Lasso di tempo: Baseline (Week 0) and Post-intervention (Week 6)
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Salivary Immunoglobulin A levels will be measured to evaluate mucosal immune response.
(Unit of measurement: mg/dL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Immunoglobulin M (IgM) Levels
Lasso di tempo: Baseline (Week 0) and Post-intervention (Week 6)
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Serum Immunoglobulin M levels will be measured to assess acute infection and humoral immune response.
(Unit of measurement: mg/dL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Immunoglobulin G (IgG) Levels
Lasso di tempo: Baseline (Week 0) and Post-intervention (Week 6)
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Serum Immunoglobulin G levels will be measured to assess long-term immune memory and humoral immune response.
(Unit of measurement: mg/dL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Change in Leukocyte (WBC) Count
Lasso di tempo: Baseline (Week 0) and Post-intervention (Week 6)
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Total leukocyte (White Blood Cell) count will be analyzed to assess general immune and inflammatory status.
(Unit of measurement: cells/µL)
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Baseline (Week 0) and Post-intervention (Week 6)
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Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Investigatori
- Investigatore principale: Fahri Safa Çınarlı, Doç. Dr., Inonu University
Pubblicazioni e link utili
La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.
Pubblicazioni generali
- Nash D, Hughes MG, Butcher L, Aicheler R, Smith P, Cullen T, Webb R. IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance. Scand J Med Sci Sports. 2023 Jan;33(1):4-19. doi: 10.1111/sms.14241. Epub 2022 Oct 8.
- Henson J, Yates T, Edwardson CL, Khunti K, Talbot D, Gray LJ, Leigh TM, Carter P, Davies MJ. Sedentary time and markers of chronic low-grade inflammation in a high risk population. PLoS One. 2013 Oct 29;8(10):e78350. doi: 10.1371/journal.pone.0078350. eCollection 2013.
- Coughlin GH, Antush MT, Vella CA. Associations of sedentary behavior and screen time with biomarkers of inflammation and insulin resistance. J Behav Med. 2024 Oct;47(5):828-838. doi: 10.1007/s10865-024-00498-y. Epub 2024 May 25.
- Thomas NE, Williams DR. Inflammatory factors, physical activity, and physical fitness in young people. Scand J Med Sci Sports. 2008 Oct;18(5):543-56. doi: 10.1111/j.1600-0838.2008.00824.x. Epub 2008 Jul 9.
- Dogra S, Wolf M, Jeffrey MP, Foley RCA, Logan-Sprenger H, Jones-Taggart H, Green-Johnson JM. Disrupting prolonged sitting reduces IL-8 and lower leg swell in active young adults. BMC Sports Sci Med Rehabil. 2019 Oct 18;11:23. doi: 10.1186/s13102-019-0138-4. eCollection 2019.
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
2 gennaio 2025
Completamento primario (Stimato)
15 giugno 2026
Completamento dello studio (Stimato)
1 dicembre 2026
Date di iscrizione allo studio
Primo inviato
21 maggio 2026
Primo inviato che soddisfa i criteri di controllo qualità
2 giugno 2026
Primo Inserito (Effettivo)
8 giugno 2026
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
8 giugno 2026
Ultimo aggiornamento inviato che soddisfa i criteri QC
2 giugno 2026
Ultimo verificato
1 giugno 2026
Maggiori informazioni
Termini relativi a questo studio
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- 11/03/2025-7252
Piano per i dati dei singoli partecipanti (IPD)
Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?
NO
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
No
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
No
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .