Ralation Between Cardiorespiratory Fitness and Mean Corrected Intraocular Pressure
24. juni 2026 opdateret af: Sichuan Academy of Medical Sciences
Cardiorespiratory Fitness and Mean Corrected Intraocular Pressure: A Cross-Sectional Study in a Normotensive Health Check-up Population
Objective: To investigate the association between cardiorespiratory fitness and mean corrected intraocular pressure (IOP) in a normotensive health check-up population, and to evaluate potential differences across age and sex strata.
Methods: This cross-sectional study consecutively enrolled adults aged 18-70 years who completed cardiorespiratory fitness testing and ophthalmologic examinations at the Health Management Center of Sichuan Provincial People's Hospital between July 1, 2019 and December 31, 2025. Individuals were excluded if they had a history of glaucoma, ocular diseases interfering with IOP measurement, systemic diseases or medications affecting IOP, contraindications to fitness testing, or abnormal blood pressure. A final sample of 2,921 normotensive individuals was included. Cardiorespiratory fitness was assessed by estimated maximal oxygen uptake (VO₂max). After age- and sex-stratified grouping, low cardiorespiratory fitness was used as the reference, and the remainder were defined as the moderate-to-high cardiorespiratory fitness group. The primary outcome was the mean corrected IOP of both eyes. Multiple imputation, multivariable linear regression, and age- and sex-stratified analyses were used to evaluate the association.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Undersøgelsestype
Observationel
Tilmelding (Faktiske)
2921
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
Sichuan
-
Chengdu, Sichuan, Kina, 610000
- Sichuan Provinvial People's HSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital（ SAMS&SPPH，Affiliated Hospital of UESTC）ospital
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ja
Prøveudtagningsmetode
Ikke-sandsynlighedsprøve
Studiebefolkning
This single-center cross-sectional study enrolled adults who underwent health check-ups, completed standardized cardiorespiratory fitness testing, and underwent ophthalmologic examinations at the Health Management Center of Sichuan Provincial People's Hospital from July 1, 2019 to December 31, 2025.
After applying the predefined inclusion and exclusion criteria, 2,921 normotensive adults were included in the final analysis.
Beskrivelse
Inclusion Criteria:
- Age 18-70 years;
- Ability to complete standardized cardiorespiratory fitness testing and provide valid data; and
- Ability to cooperate with a comprehensive ophthalmologic examination.
Exclusion Criteria:
- Any history of glaucoma or ocular hypertension, or detection of glaucoma suspect signs such as cup-to-disc ratio ≥0.7, interocular cup-to-disc ratio asymmetry >0.2, or localized retinal nerve fiber layer defects;
- Ocular diseases or surgical history affecting IOP measurement or optic nerve head assessment, such as corneal disease, uveitis, intraocular surgery, high myopia (spherical equivalent ≤ -6.00 D), or other optic nerve/retinal diseases;
- Systemic diseases that could significantly interfere with IOP, optic nerve blood supply, or cardiorespiratory function, such as uncontrolled diabetes mellitus, severe cardiovascular or cerebrovascular disease, or chronic obstructive pulmonary disease;
- Current use of topical or systemic medications known to affect IOP, including IOP-lowering eyedrops, systemic beta-blockers, or glucocorticoids;
- Contraindications to cardiorespiratory fitness testing, such as severe musculoskeletal disorders or uncontrolled arrhythmias;
- A documented history of hypertension, current use of antihypertensive medications, or abnormal blood pressure on a single measurement that did not normalize on re-examination (systolic blood pressure [SBP] ≥140 mmHg or diastolic blood pressure [DBP] ≥90 mmHg); and
- Missing key study variables that precluded further analysis.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
|
low cardiorespiratory fitness
Cardiorespiratory fitness levels were classified based on age- and sex-stratified percentiles of VO₂max in the present study sample.
VO₂max ≤ the 25th percentile for the same age group and sex was defined as low cardiorespiratory fitness.
|
Intraocular pressure (IOP) was measured in both eyes using a non-contact tonometer (CT-1P, Topcon Corporation, Tokyo, Japan).
The corrected IOP was automatically calculated by the device's built-in algorithm based on central corneal thickness.
In Chinese healthy adults, corneal thickness is significantly associated with sex and age, which has important clinical implications for the correction of IOP measurements.
To minimize the influence of diurnal fluctuation on IOP measurements, all IOP assessments were uniformly scheduled between 7:30 AM and 11:00 AM.
Two measurements were taken for each eye and the average was recorded.
The mean corrected IOP, defined as the average of the corrected IOP values of both eyes, was used as the primary outcome measure in this study.
|
|
Moderate-to-high cardiorespiratory fitness
The remainder were defined as moderate-to-high cardiorespiratory fitness.
|
Intraocular pressure (IOP) was measured in both eyes using a non-contact tonometer (CT-1P, Topcon Corporation, Tokyo, Japan).
The corrected IOP was automatically calculated by the device's built-in algorithm based on central corneal thickness.
In Chinese healthy adults, corneal thickness is significantly associated with sex and age, which has important clinical implications for the correction of IOP measurements.
To minimize the influence of diurnal fluctuation on IOP measurements, all IOP assessments were uniformly scheduled between 7:30 AM and 11:00 AM.
Two measurements were taken for each eye and the average was recorded.
The mean corrected IOP, defined as the average of the corrected IOP values of both eyes, was used as the primary outcome measure in this study.
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Mean corrected intraocular pressure (IOP) of both eyes
Tidsramme: same day 1
|
same day 1
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Ocular hypertension
Tidsramme: same day 1
|
IOP > 21 mmHg in one eye
|
same day 1
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. juli 2025
Primær færdiggørelse (Faktiske)
31. december 2025
Studieafslutning (Faktiske)
1. marts 2026
Datoer for studieregistrering
Først indsendt
24. juni 2026
Først indsendt, der opfyldte QC-kriterier
24. juni 2026
Først opslået (Faktiske)
30. juni 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
30. juni 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
24. juni 2026
Sidst verificeret
1. juli 2019
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- SichuanAMS-2026-280
- 2023QN15 (Andet bevillings-/finansieringsnummer: Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital（ SAMS&SPPH，Affiliated Hospital of UESTC）)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
UBESLUTET
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ingen
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Kardiorespiratorisk fitness
-
Faculdade de Motricidade HumanaAfsluttetAnsigtsmaske Indvirkning på Cardiorespiratory PerformancePortugal