Doxorubicin, Paclitaxel, and Carboplatin in Treating Patients With Primary Stage III, Stage IV, or Recurrent Endometrial Cancer

DISEASE CHARACTERISTICS:

• Histologically proven primary stage III or IV or recurrent endometrial cancer

• Bidimensionally measurable disease by x-ray, CT scan, MRI scan, or physical exam

  • Sole site may be within a previously irradiated area if documented disease progression since prior radiotherapy

PATIENT CHARACTERISTICS:

Age:

• Adult

Performance status:

• Karnofsky 70-100%

Life expectancy:

• At least 12 weeks

Hematopoietic:

• Absolute neutrophil count greater than 1,000/mm^3
• Platelet count at least 100,000/mm^3

Hepatic:

• Bilirubin, SGOT, and alkaline phosphatase no greater than 1.5 times normal

Renal:

• Creatinine no greater than 1.8 mg/dL

Cardiovascular:

• Left ventricular ejection fraction at least 50%

Other:

• No active uncontrolled infection
• No greater than grade II neuropathy
• No other active malignancy
• Not pregnant
• Negative pregnancy test
• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• No prior doxorubicin
• Greater than 6 months since prior paclitaxel, carboplatin, or other platinum compounds

Endocrine therapy:

• Not specified

Radiotherapy:

• See Disease Characteristics
• At least 4 weeks since prior radiotherapy and recovered

Surgery:

• Not specified