- ICH GCP
- Registro de ensayos clínicos de EE. UU.
- Ensayo clínico NCT03262714
Effects of Dancing on Cardiovascular and Functional Risk Factors in Older Women.
23 de agosto de 2017 actualizado por: Alvaro Reischak-Oliveira, Federal University of Rio Grande do Sul
Effects of Dancing and Walking on Cardiovascular Risk Factors and Functional Capacity in Older Women: a Randomized Controlled Trial.
The goal of this randomized controlled trial is to investigate the effects of a dance intervention on cardiovascular risk factors and functional capacity of older women, comparing dancing to a walking exercise intervention and to an active control condition (stretching).
The participants will include women between 60 and 80 years old, with body mass index inferior to 35 Kg /m2.
The main outcome of this study is the peak oxygen consumption (VO2peak).
The secondary outcomes are cardiovascular risk associated factors (C-reactive protein, TNF-alpha, lipid profile, etc) and functional performance (muscle strength and power, balance, gate ability, etc).
The experimental design will include 3 parts: 1) Pre-intervention assessments: medical evaluation, fasting blood exams, maximum exercise test, assessments of body composition, balance, gate ability, muscular strength and power.
2) Period of interventions: patients will be randomized to one of the three following groups: dance, walking or stretching.
The duration of the interventions will be 8 weeks, including 3 sessions per week for dance and walking, and once a week for the stretching group.
Each session will last 60 min.
3) Post-intervention assessments: the same protocols of testing as pre-intervention.
Descripción general del estudio
Estado
Desconocido
Intervención / Tratamiento
Descripción detallada
The aging process is characterized by reductions of lean mass simultaneously to increases in visceral adipose tissue.
Metabolically, this is related to insulin resistance and higher risk to develop cardiovascular diseases.
Functionally, loss of strength and cardiorespiratory fitness may lead to early muscle fatigue onset, which may limit the performance of daily activities, and eventually lead to loss of independence with aging.
Dancing has been used as a form of exercise to improve functional and metabolic outcomes during aging.
However, the field lacks of randomized controlled trials (RCT) evaluating metabolic outcomes related to dance interventions, as well as comparisons of dancing with other types of exercise on functional performance and metabolic health of older adults.
Therefore, the goal of this randomized controlled trial is to investigate the effects of a dance intervention on cardiovascular risk factors and functional capacity of older women, comparing dancing to a walking exercise intervention and to an active control condition (stretching).
Additionally, we aim to investigate the acute cardiorespiratory responses of a dance session.
The participants will include women between 60 and 80 years old, with body mass index inferior to 35 Kg /m2 and independent for performing daily activities.
They should not be engaged in any type of regular physical activity in the past 6 months.
Exclusion criteria will include type 2 diabetes mellitus, cardiovascular complications and neurodegenerative diseases.
The main outcome of this study is the peak oxygen consumption (VO2peak), as it has been associated with both, cardiovascular risk and functional performance in aging individuals.
The secondary outcomes are: (1) cardiovascular risk associated factors: C-reactive protein, TNF-alpha, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, fasting glucose and insulin, and homeostatic model assessment of insulin resistance (HOMA-IR).
(2) Functional performance: muscle strength and power, balance, gate ability and muscle quality.
The experimental design will include 3 parts: 1) Pre-intervention assessments: medical evaluation, fasting blood exams, maximum exercise test, assessments of body composition, balance, gate ability, muscular strength and power.
2) Period of interventions: patients will be randomized in blocks (randomization.com), in accordance to their VO2peak , to one of the three following groups: dance, walking or control.
The duration of the dance and walking interventions will be 8 weeks, including 3 sessions per week, each lasting 60 min.
Dance classes will be performed in group in a dance studio, including a variety of rhythms such as salsa, jazz and aerobics.
Walking sessions will be performed individually or in groups of two people, in a treadmill, at the gym.
The control group will have 60min stretching classes once a week, also for 8 weeks.
3) Post-intervention assessments: the same protocols of testing of the pre-interventions assessments will be repeated.
All the assessments and interventions will be held at the Laboratory of Research in Exercise (LAPEX-UFRGS).
Tipo de estudio
Intervencionista
Inscripción (Anticipado)
30
Fase
- No aplica
Contactos y Ubicaciones
Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.
Ubicaciones de estudio
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Rio Grande do Sul
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Porto Alegre, Rio Grande do Sul, Brasil
- Reclutamiento
- Universidade Federal do Rio Grande do Sul
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Contacto:
- Josianne Rodrigues-Krause, MSc
- Número de teléfono: 55-51-999101821
- Correo electrónico: rodrigues.krause@ufrgs.br
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Contacto:
- Alvaro Reischak-Oliveira, PhD
- Número de teléfono: 55-51-3308-5862
- Correo electrónico: alvaro.oliveira@ufrgs.br
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Sub-Investigador:
- Josianne Rodrigues-Krause, MSc
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Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
60 años a 80 años (Adulto, Adulto Mayor)
Acepta Voluntarios Saludables
Sí
Géneros elegibles para el estudio
Femenino
Descripción
Inclusion Criteria:
- Women between 60 and 80 years old
- BMI inferior to 35 kg/m2
- Independent for performing daily activities (OARS scale)
- Not engaged in any type of regular exercise programme for the past 6 months
Exclusion Criteria:
- Type 2 diabetes mellitus, dyslipidemia, cardiovascular diseases or other non-controlled metabolic disorders
- Chronic diseases such as fibromyalgia, cancer or neurodegenerative disorders
- Bone, joints or muscle problems that could impair exercise performance
- Not being able to perform the effort test in the first assessment session, abnormal electrocardiogram, or any other condition identified by the physician of the study that limit the engagement in an exercise training programme.
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Prevención
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación paralela
- Enmascaramiento: Único
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
|---|---|
|
Experimental: Dancing
Elderly women randomized to the dance intervention programme.
|
Participants randomized to the dance group will take part in a dance intervention programme for 8 weeks, including 3 sessions per week, each lasting 60 min.
Dance classes will be performed in group in a dance studio, including a variety of rhythms such as salsa, jazz and aerobics.
The dance session wil include a warm up of 15 min (posture, join mobility and dance technique), a main part of 40 min (learning of specific choreographies and practice of moves across the floor), and a cool down of 5 min (muscle stretching and relaxation).
|
|
Experimental: Walking
Elderly women randomized to the walking intervention programme.
|
Participants randomized to the walking group will take part in a walking intervention programme for 8 weeks, including 3 sessions per week, each lasting 60 min.
The walking session will include a warm up of 10 min (posture and join mobility), a main part of 40 min (walking on a treadmill with a heart rate corresponding to 60% of VO2peak), and a cool down of 10 min (muscle stretching and relaxation).
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Comparador activo: Stretching
Elderly women randomized to the stretching intervention programme.
|
Participants randomized to the control group will take part in stretching classes, once a week, each lasting 60 min, also for 8 weeks.
Stretching exercises for large muscle groups will be performed standing or in a match, holding the positions for a maximum of 10 s.
There will be no music playing during the session.
|
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Change in Peak Oxygen Consumption (VO2peak)
Periodo de tiempo: Baseline and 8 weeks
|
The maximum capacity of oxygen consumption measured during an incremental exercise test.
|
Baseline and 8 weeks
|
Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Change in C-reactive protein (CRP)
Periodo de tiempo: Baseline and 8 weeks
|
Cardiovascular risk marker.
It will be analyzed in plasma, using ELISA specific kits.
|
Baseline and 8 weeks
|
|
Change in Tumor necrosis factor alpha (TNF-alpha)
Periodo de tiempo: Baseline and 8 weeks
|
Inflammatory marker.
It will be analyzed in plasma, using ELISA specific kits.
|
Baseline and 8 weeks
|
|
Change in Triglycerides
Periodo de tiempo: Baseline and 8 weeks
|
Lipid profile marker.
It will be analyzed in plasma, by enzymatic colorimetric method, using an automatic analyzer (ROCHE, Cobas C111, Switzerland).
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Baseline and 8 weeks
|
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Change in Total Cholesterol
Periodo de tiempo: Baseline and 8 weeks
|
Lipid profile marker.
It will be analyzed in plasma, by enzymatic colorimetric method, using an automatic analyzer (ROCHE, Cobas C111, Switzerland).
|
Baseline and 8 weeks
|
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Change in LDL-Cholesterol
Periodo de tiempo: Baseline and 8 weeks
|
Lipid profile marker.
Estimation of the LDL concentration will be calculate using the formula of Friedewald.
|
Baseline and 8 weeks
|
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Change in HDL-Cholesterol
Periodo de tiempo: Baseline and 8 weeks
|
Lipid profile marker.
It will be analyzed in plasma, by enzymatic colorimetric method, using an automatic analyzer (ROCHE, Cobas C111, Switzerland).
|
Baseline and 8 weeks
|
|
Change in Fasting Glycemia
Periodo de tiempo: Baseline and 8 weeks
|
Glycaemic profile marker.
It will be analyzed in plasma, by enzymatic colorimetric method, using an automatic analyzer (ROCHE, Cobas C111, Switzerland).
|
Baseline and 8 weeks
|
|
Change in Fasting Insulin
Periodo de tiempo: Baseline and 8 weeks
|
Glycaemic profile marker.
It will be measured in plasma, usin a high sensitivity enzyme-linked immunosorbent assay.
|
Baseline and 8 weeks
|
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Change in HOMA-IR
Periodo de tiempo: Baseline and 8 weeks
|
Glycaemic profile marker.
Homeostatic model of insulin resistance.
It will be calculated according to the following formula: fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5.
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Baseline and 8 weeks
|
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Change in Muscle Strength
Periodo de tiempo: Baseline and 8 weeks
|
Isometric peak torque of the knee extensors will be measured using an isokinetic dynamometer (Cybex Norm, EUA).
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Baseline and 8 weeks
|
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Change in Muscle Power
Periodo de tiempo: Baseline and 8 weeks
|
Lower body muscle power will be measured by the performance of the counter movement jump in a force platform.
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Baseline and 8 weeks
|
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Change in Muscle Quality
Periodo de tiempo: Baseline and 8 weeks
|
Echo intensity of the quadriceps will be analyzed by ultrasound images.
|
Baseline and 8 weeks
|
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Change in Static Balance
Periodo de tiempo: Baseline and 8 weeks
|
Static balance will be measured by a single leg support balance test, performed with both legs, with the eyes open and closed.
|
Baseline and 8 weeks
|
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Change in Dynamic Balance
Periodo de tiempo: Baseline and 8 weeks
|
Dynamic balance will be measured by the Time to Up ang Go (TUG) test.
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Baseline and 8 weeks
|
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Change in Gate ability
Periodo de tiempo: Baseline and 8 weeks
|
Gate ability will be measured in a 10m track, picking up objects and passing over obstacles.
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Baseline and 8 weeks
|
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Change in Body Weight
Periodo de tiempo: Baseline and 8 weeks
|
Measurements of body weight will be measured in a digital scale.
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Baseline and 8 weeks
|
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Change in Waist Circumference
Periodo de tiempo: Baseline and 8 weeks
|
Measurements of waist circumference will be performed with a measuring tape.
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Baseline and 8 weeks
|
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Change in Percentage of Body Fat
Periodo de tiempo: Baseline and 8 weeks
|
Measurements of skinfolds will be taken to calculate the percentage of body fat.
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Baseline and 8 weeks
|
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Change in Sit and Stand ability
Periodo de tiempo: Baseline and 8 weeks
|
The ability to sit and stand in a chair 5 times, as fast as possible.
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Baseline and 8 weeks
|
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Changes in Fall Risk
Periodo de tiempo: Baseline and 8 weeks
|
The risk of fall will be measured by the performance in the TUG test.
|
Baseline and 8 weeks
|
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Changes in the Fear of Falling
Periodo de tiempo: Baseline and 8 weeks
|
The fear of falling will be analyzed by the Falls Efficacy Scale-International Brazil (FES-I-Brazil).
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Baseline and 8 weeks
|
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Changes in Quality of Life
Periodo de tiempo: Baseline and 8 weeks
|
Quality of life will be analyzed by the questionary WHOQOL (World Health Organization Quality of Life.
|
Baseline and 8 weeks
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Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Investigadores
- Investigador principal: Alvaro Reischak-Oliveira, PhD., Federal University of Rio Grande do Sul
Publicaciones y enlaces útiles
La persona responsable de ingresar información sobre el estudio proporciona voluntariamente estas publicaciones. Estos pueden ser sobre cualquier cosa relacionada con el estudio.
Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio (Actual)
1 de agosto de 2017
Finalización primaria (Anticipado)
1 de diciembre de 2017
Finalización del estudio (Anticipado)
1 de agosto de 2018
Fechas de registro del estudio
Enviado por primera vez
8 de agosto de 2017
Primero enviado que cumplió con los criterios de control de calidad
23 de agosto de 2017
Publicado por primera vez (Actual)
25 de agosto de 2017
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
25 de agosto de 2017
Última actualización enviada que cumplió con los criterios de control de calidad
23 de agosto de 2017
Última verificación
1 de agosto de 2017
Más información
Términos relacionados con este estudio
Palabras clave
Otros números de identificación del estudio
- 53834516.0.0000.5347
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
No
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
No
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