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Effects of Dancing on Cardiovascular and Functional Risk Factors in Older Women.

keskiviikko 23. elokuuta 2017 päivittänyt: Alvaro Reischak-Oliveira, Federal University of Rio Grande do Sul

Effects of Dancing and Walking on Cardiovascular Risk Factors and Functional Capacity in Older Women: a Randomized Controlled Trial.

The goal of this randomized controlled trial is to investigate the effects of a dance intervention on cardiovascular risk factors and functional capacity of older women, comparing dancing to a walking exercise intervention and to an active control condition (stretching). The participants will include women between 60 and 80 years old, with body mass index inferior to 35 Kg /m2. The main outcome of this study is the peak oxygen consumption (VO2peak). The secondary outcomes are cardiovascular risk associated factors (C-reactive protein, TNF-alpha, lipid profile, etc) and functional performance (muscle strength and power, balance, gate ability, etc). The experimental design will include 3 parts: 1) Pre-intervention assessments: medical evaluation, fasting blood exams, maximum exercise test, assessments of body composition, balance, gate ability, muscular strength and power. 2) Period of interventions: patients will be randomized to one of the three following groups: dance, walking or stretching. The duration of the interventions will be 8 weeks, including 3 sessions per week for dance and walking, and once a week for the stretching group. Each session will last 60 min. 3) Post-intervention assessments: the same protocols of testing as pre-intervention.

Tutkimuksen yleiskatsaus

Yksityiskohtainen kuvaus

The aging process is characterized by reductions of lean mass simultaneously to increases in visceral adipose tissue. Metabolically, this is related to insulin resistance and higher risk to develop cardiovascular diseases. Functionally, loss of strength and cardiorespiratory fitness may lead to early muscle fatigue onset, which may limit the performance of daily activities, and eventually lead to loss of independence with aging. Dancing has been used as a form of exercise to improve functional and metabolic outcomes during aging. However, the field lacks of randomized controlled trials (RCT) evaluating metabolic outcomes related to dance interventions, as well as comparisons of dancing with other types of exercise on functional performance and metabolic health of older adults. Therefore, the goal of this randomized controlled trial is to investigate the effects of a dance intervention on cardiovascular risk factors and functional capacity of older women, comparing dancing to a walking exercise intervention and to an active control condition (stretching). Additionally, we aim to investigate the acute cardiorespiratory responses of a dance session. The participants will include women between 60 and 80 years old, with body mass index inferior to 35 Kg /m2 and independent for performing daily activities. They should not be engaged in any type of regular physical activity in the past 6 months. Exclusion criteria will include type 2 diabetes mellitus, cardiovascular complications and neurodegenerative diseases. The main outcome of this study is the peak oxygen consumption (VO2peak), as it has been associated with both, cardiovascular risk and functional performance in aging individuals. The secondary outcomes are: (1) cardiovascular risk associated factors: C-reactive protein, TNF-alpha, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, fasting glucose and insulin, and homeostatic model assessment of insulin resistance (HOMA-IR). (2) Functional performance: muscle strength and power, balance, gate ability and muscle quality. The experimental design will include 3 parts: 1) Pre-intervention assessments: medical evaluation, fasting blood exams, maximum exercise test, assessments of body composition, balance, gate ability, muscular strength and power. 2) Period of interventions: patients will be randomized in blocks (randomization.com), in accordance to their VO2peak , to one of the three following groups: dance, walking or control. The duration of the dance and walking interventions will be 8 weeks, including 3 sessions per week, each lasting 60 min. Dance classes will be performed in group in a dance studio, including a variety of rhythms such as salsa, jazz and aerobics. Walking sessions will be performed individually or in groups of two people, in a treadmill, at the gym. The control group will have 60min stretching classes once a week, also for 8 weeks. 3) Post-intervention assessments: the same protocols of testing of the pre-interventions assessments will be repeated. All the assessments and interventions will be held at the Laboratory of Research in Exercise (LAPEX-UFRGS).

Opintotyyppi

Interventio

Ilmoittautuminen (Odotettu)

30

Vaihe

  • Ei sovellettavissa

Yhteystiedot ja paikat

Tässä osiossa on tutkimuksen suorittajien yhteystiedot ja tiedot siitä, missä tämä tutkimus suoritetaan.

Opiskelupaikat

    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brasilia
        • Rekrytointi
        • Universidade Federal do Rio Grande do Sul
        • Ottaa yhteyttä:
        • Ottaa yhteyttä:
        • Alatutkija:
          • Josianne Rodrigues-Krause, MSc

Osallistumiskriteerit

Tutkijat etsivät ihmisiä, jotka sopivat tiettyyn kuvaukseen, jota kutsutaan kelpoisuuskriteereiksi. Joitakin esimerkkejä näistä kriteereistä ovat henkilön yleinen terveydentila tai aiemmat hoidot.

Kelpoisuusvaatimukset

Opintokelpoiset iät

60 vuotta - 80 vuotta (Aikuinen, Vanhempi Aikuinen)

Hyväksyy terveitä vapaaehtoisia

Joo

Sukupuolet, jotka voivat opiskella

Nainen

Kuvaus

Inclusion Criteria:

  • Women between 60 and 80 years old
  • BMI inferior to 35 kg/m2
  • Independent for performing daily activities (OARS scale)
  • Not engaged in any type of regular exercise programme for the past 6 months

Exclusion Criteria:

  • Type 2 diabetes mellitus, dyslipidemia, cardiovascular diseases or other non-controlled metabolic disorders
  • Chronic diseases such as fibromyalgia, cancer or neurodegenerative disorders
  • Bone, joints or muscle problems that could impair exercise performance
  • Not being able to perform the effort test in the first assessment session, abnormal electrocardiogram, or any other condition identified by the physician of the study that limit the engagement in an exercise training programme.

Opintosuunnitelma

Tässä osiossa on tietoja tutkimussuunnitelmasta, mukaan lukien kuinka tutkimus on suunniteltu ja mitä tutkimuksella mitataan.

Miten tutkimus on suunniteltu?

Suunnittelun yksityiskohdat

  • Ensisijainen käyttötarkoitus: Ennaltaehkäisy
  • Jako: Satunnaistettu
  • Inventiomalli: Rinnakkaistehtävä
  • Naamiointi: Yksittäinen

Aseet ja interventiot

Osallistujaryhmä / Arm
Interventio / Hoito
Kokeellinen: Dancing
Elderly women randomized to the dance intervention programme.
Participants randomized to the dance group will take part in a dance intervention programme for 8 weeks, including 3 sessions per week, each lasting 60 min. Dance classes will be performed in group in a dance studio, including a variety of rhythms such as salsa, jazz and aerobics. The dance session wil include a warm up of 15 min (posture, join mobility and dance technique), a main part of 40 min (learning of specific choreographies and practice of moves across the floor), and a cool down of 5 min (muscle stretching and relaxation).
Kokeellinen: Walking
Elderly women randomized to the walking intervention programme.
Participants randomized to the walking group will take part in a walking intervention programme for 8 weeks, including 3 sessions per week, each lasting 60 min. The walking session will include a warm up of 10 min (posture and join mobility), a main part of 40 min (walking on a treadmill with a heart rate corresponding to 60% of VO2peak), and a cool down of 10 min (muscle stretching and relaxation).
Active Comparator: Stretching
Elderly women randomized to the stretching intervention programme.
Participants randomized to the control group will take part in stretching classes, once a week, each lasting 60 min, also for 8 weeks. Stretching exercises for large muscle groups will be performed standing or in a match, holding the positions for a maximum of 10 s. There will be no music playing during the session.

Mitä tutkimuksessa mitataan?

Ensisijaiset tulostoimenpiteet

Tulosmittaus
Toimenpiteen kuvaus
Aikaikkuna
Change in Peak Oxygen Consumption (VO2peak)
Aikaikkuna: Baseline and 8 weeks
The maximum capacity of oxygen consumption measured during an incremental exercise test.
Baseline and 8 weeks

Toissijaiset tulostoimenpiteet

Tulosmittaus
Toimenpiteen kuvaus
Aikaikkuna
Change in C-reactive protein (CRP)
Aikaikkuna: Baseline and 8 weeks
Cardiovascular risk marker. It will be analyzed in plasma, using ELISA specific kits.
Baseline and 8 weeks
Change in Tumor necrosis factor alpha (TNF-alpha)
Aikaikkuna: Baseline and 8 weeks
Inflammatory marker. It will be analyzed in plasma, using ELISA specific kits.
Baseline and 8 weeks
Change in Triglycerides
Aikaikkuna: Baseline and 8 weeks
Lipid profile marker. It will be analyzed in plasma, by enzymatic colorimetric method, using an automatic analyzer (ROCHE, Cobas C111, Switzerland).
Baseline and 8 weeks
Change in Total Cholesterol
Aikaikkuna: Baseline and 8 weeks
Lipid profile marker. It will be analyzed in plasma, by enzymatic colorimetric method, using an automatic analyzer (ROCHE, Cobas C111, Switzerland).
Baseline and 8 weeks
Change in LDL-Cholesterol
Aikaikkuna: Baseline and 8 weeks
Lipid profile marker. Estimation of the LDL concentration will be calculate using the formula of Friedewald.
Baseline and 8 weeks
Change in HDL-Cholesterol
Aikaikkuna: Baseline and 8 weeks
Lipid profile marker. It will be analyzed in plasma, by enzymatic colorimetric method, using an automatic analyzer (ROCHE, Cobas C111, Switzerland).
Baseline and 8 weeks
Change in Fasting Glycemia
Aikaikkuna: Baseline and 8 weeks
Glycaemic profile marker. It will be analyzed in plasma, by enzymatic colorimetric method, using an automatic analyzer (ROCHE, Cobas C111, Switzerland).
Baseline and 8 weeks
Change in Fasting Insulin
Aikaikkuna: Baseline and 8 weeks
Glycaemic profile marker. It will be measured in plasma, usin a high sensitivity enzyme-linked immunosorbent assay.
Baseline and 8 weeks
Change in HOMA-IR
Aikaikkuna: Baseline and 8 weeks
Glycaemic profile marker. Homeostatic model of insulin resistance. It will be calculated according to the following formula: fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5.
Baseline and 8 weeks
Change in Muscle Strength
Aikaikkuna: Baseline and 8 weeks
Isometric peak torque of the knee extensors will be measured using an isokinetic dynamometer (Cybex Norm, EUA).
Baseline and 8 weeks
Change in Muscle Power
Aikaikkuna: Baseline and 8 weeks
Lower body muscle power will be measured by the performance of the counter movement jump in a force platform.
Baseline and 8 weeks
Change in Muscle Quality
Aikaikkuna: Baseline and 8 weeks
Echo intensity of the quadriceps will be analyzed by ultrasound images.
Baseline and 8 weeks
Change in Static Balance
Aikaikkuna: Baseline and 8 weeks
Static balance will be measured by a single leg support balance test, performed with both legs, with the eyes open and closed.
Baseline and 8 weeks
Change in Dynamic Balance
Aikaikkuna: Baseline and 8 weeks
Dynamic balance will be measured by the Time to Up ang Go (TUG) test.
Baseline and 8 weeks
Change in Gate ability
Aikaikkuna: Baseline and 8 weeks
Gate ability will be measured in a 10m track, picking up objects and passing over obstacles.
Baseline and 8 weeks
Change in Body Weight
Aikaikkuna: Baseline and 8 weeks
Measurements of body weight will be measured in a digital scale.
Baseline and 8 weeks
Change in Waist Circumference
Aikaikkuna: Baseline and 8 weeks
Measurements of waist circumference will be performed with a measuring tape.
Baseline and 8 weeks
Change in Percentage of Body Fat
Aikaikkuna: Baseline and 8 weeks
Measurements of skinfolds will be taken to calculate the percentage of body fat.
Baseline and 8 weeks
Change in Sit and Stand ability
Aikaikkuna: Baseline and 8 weeks
The ability to sit and stand in a chair 5 times, as fast as possible.
Baseline and 8 weeks
Changes in Fall Risk
Aikaikkuna: Baseline and 8 weeks
The risk of fall will be measured by the performance in the TUG test.
Baseline and 8 weeks
Changes in the Fear of Falling
Aikaikkuna: Baseline and 8 weeks
The fear of falling will be analyzed by the Falls Efficacy Scale-International Brazil (FES-I-Brazil).
Baseline and 8 weeks
Changes in Quality of Life
Aikaikkuna: Baseline and 8 weeks
Quality of life will be analyzed by the questionary WHOQOL (World Health Organization Quality of Life.
Baseline and 8 weeks

Yhteistyökumppanit ja tutkijat

Täältä löydät tähän tutkimukseen osallistuvat ihmiset ja organisaatiot.

Tutkijat

  • Päätutkija: Alvaro Reischak-Oliveira, PhD., Federal University of Rio Grande do Sul

Julkaisuja ja hyödyllisiä linkkejä

Tutkimusta koskevien tietojen syöttämisestä vastaava henkilö toimittaa nämä julkaisut vapaaehtoisesti. Nämä voivat koskea mitä tahansa tutkimukseen liittyvää.

Opintojen ennätyspäivät

Nämä päivämäärät seuraavat ClinicalTrials.gov-sivustolle lähetettyjen tutkimustietueiden ja yhteenvetojen edistymistä. National Library of Medicine (NLM) tarkistaa tutkimustiedot ja raportoidut tulokset varmistaakseen, että ne täyttävät tietyt laadunvalvontastandardit, ennen kuin ne julkaistaan ​​julkisella verkkosivustolla.

Opi tärkeimmät päivämäärät

Opiskelun aloitus (Todellinen)

Tiistai 1. elokuuta 2017

Ensisijainen valmistuminen (Odotettu)

Perjantai 1. joulukuuta 2017

Opintojen valmistuminen (Odotettu)

Keskiviikko 1. elokuuta 2018

Opintoihin ilmoittautumispäivät

Ensimmäinen lähetetty

Tiistai 8. elokuuta 2017

Ensimmäinen toimitettu, joka täytti QC-kriteerit

Keskiviikko 23. elokuuta 2017

Ensimmäinen Lähetetty (Todellinen)

Perjantai 25. elokuuta 2017

Tutkimustietojen päivitykset

Viimeisin päivitys julkaistu (Todellinen)

Perjantai 25. elokuuta 2017

Viimeisin lähetetty päivitys, joka täytti QC-kriteerit

Keskiviikko 23. elokuuta 2017

Viimeksi vahvistettu

Tiistai 1. elokuuta 2017

Lisää tietoa

Tähän tutkimukseen liittyvät termit

Muut tutkimustunnusnumerot

  • 53834516.0.0000.5347

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