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[Ensayo de dispositivo que no está aprobado o autorizado por la FDA de EE. UU.] (INSIGHT)

17 de junio de 2026 actualizado por: Sue Brown
This study is a randomized cross-over trial comparing AIDANET with Anticipation to AIDANET in FCL without Anticipation. Participants will complete 4 weeks of AID data collection which will be used to establish baseline and initialize the control algorithm. Participants will then be randomized to one of two groups: Group A: AIDANET in FCL with Anticipation (AIDANET+ACL), and Group B: AIDANET in FCL without Anticipation (AIDANET+FCL). The study duration of each group is 4 weeks each. The order of these two phases will be dependent upon randomization.

Descripción general del estudio

Descripción detallada

The UVA AIDANET algorithm is intended for use by patients with T1D to control the subcutaneous infusion of insulin and aid in their T1D self-management. AIDANET automatically adjusts insulin delivery every 5 minutes in response to CGM values. AIDANET can be used with meal announcement (hybrid closed loop, HCL), without meal announcement (full closed loop, FCL), and with meal anticipation (anticipatory closed loop, ACL).

The purpose of this study is to demonstrate superior glycemic control when using anticipation within our latest Automated Insulin Delivery as Adaptive NETwork (AIDANET) in FCL with Anticipation (AIDANET+ACL) vs. AIDANET in FCL without Anticipation.

Tipo de estudio

Intervencionista

Inscripción (Estimado)

20

Fase

  • No aplica

Contactos y Ubicaciones

Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.

Estudio Contacto

  • Nombre: Andrea Riana, MD
  • Número de teléfono: (434) 249-6251
  • Correo electrónico: rys6hm@uvahealth.org

Copia de seguridad de contactos de estudio

  • Nombre: Laura Kollar, RN
  • Número de teléfono: (434) 982-6479
  • Correo electrónico: llk7m@uvahealth.org

Ubicaciones de estudio

    • Virginia
      • Charlottesville, Virginia, Estados Unidos, 22903
        • Reclutamiento
        • University of Virginia Center for Diabetes Technology
        • Sub-Investigador:
          • Mark DeBoer, MD
        • Sub-Investigador:
          • Samina Afreen, MD
        • Sub-Investigador:
          • Marcela Moscoso-Vasquez, PhD
        • Contacto:
        • Sub-Investigador:
          • Driscoll Kimberly, PhD

Criterios de participación

Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.

Criterio de elegibilidad

Edades elegibles para estudiar

  • Adulto
  • Adulto Mayor

Acepta Voluntarios Saludables

No

Descripción

Participant Inclusion Criteria

  1. Age ≥18.0 years old at time of consent
  2. Clinical diagnosis, based on investigator assessment, of T1D for > 1 year.
  3. Having used an FDA approved AID system within the last 6 months (can be intermittent use).
  4. Currently using insulin for >6 months.
  5. Willingness to switch to use an FDA-approved personal insulin for the study pump (e.g., lispro or aspart, or biosimilar FDA-approved products) as directed by the study team.
  6. Has one or more supportive companions knowledgeable about emergency procedures for severe hypoglycemia and able to contact emergency services and study staff who either lives with participant or located within approximately 30 minutes of participant and able to locate participant in the event of an emergency.
  7. Participant not currently known to be pregnant or breastfeeding.
  8. If participant can become pregnant, they must agree to use a form of contraception to prevent pregnancy while a participant in the study. A negative serum or urine pregnancy test will be required for all participants of childbearing potential. Participants who become pregnant will be discontinued from the study. Also, participants who during the study develop and express the intention to become pregnant within the timespan of the study will be discontinued.
  9. Willingness to wear a Dexcom CGM during each of the study phases.
  10. Willingness to use the study AIDANET system (CGM, pump, and phone) during the relevant study periods.
  11. Willingness not to start any new non-insulin glucose-lowering agent during the trial.
  12. Willingness to participate in all study procedures including in person training.
  13. Access to internet at home and willingness to upload data during the study as needed.
  14. Investigator has confidence that the participant can successfully operate all study devices and can adhere to the protocol.
  15. Participant is proficient in reading and verbal communication in English.

Participant Exclusion Criteria The participant must not have any exclusion criteria to be eligible to participate in the study.

  1. Plans to start a new non-insulin glucose-lowering agent (e.g., GLP-1 receptor agonists, Symlin, DPP-4 inhibitors,). Participants may be on a stable dose of such an agent for at least the past month.
  2. Current use of sulfonylurea medications.
  3. Uncontrolled microvascular complications such as active proliferative retinopathy not being treated or not responsive to current treatment.
  4. Current use of an SGLT-2 or SGLT-1/2 inhibitor due to risk of euglycemic DKA.
  5. Hemophilia or any other bleeding disorder.
  6. History of severe hypoglycemic events with seizure or loss of consciousness in the last 12 months.
  7. History of DKA event in the last 12 months.
  8. Currently on peritoneal or hemodialysis.
  9. Currently being treated for adrenal insufficiency.
  10. Currently being treated for a seizure disorder.
  11. Hypothyroidism or hyperthyroidism that is not adequately treated.
  12. Use of oral or injectable steroids at the time of enrollment.
  13. Known ongoing adhesive intolerance that is not well managed.
  14. A condition, which in the opinion of the investigator or designee, would put the participant or study at risk.
  15. Participation in another interventional trial at the time of enrollment.
  16. Participant with a direct supervisor at work/school who is involved in the conduct of the trial.

Plan de estudios

Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.

¿Cómo está diseñado el estudio?

Detalles de diseño

  • Propósito principal: Tratamiento
  • Asignación: Aleatorizado
  • Modelo Intervencionista: Asignación cruzada
  • Enmascaramiento: Ninguno (etiqueta abierta)

Armas e Intervenciones

Grupo de participantes/brazo
Intervención / Tratamiento
Comparador activo: Group A: AID first followed by AIDANET+ACL then AIDANET+FCL
Participants will first complete 4 weeks of AID data collection which will be used to establish baseline and initialize the control algorithm. Participants will then complete 4 weeks of AIDANET + Anticipatory Closed Loop (ACL) and 4 weeks of AIDANET + Fully Closed-Loop (FCL)
Usual Care
All participants will use AIDANET in FCL mode with instructions to avoid announcing meal boluses whenever possible during the four weeks.
All insulin will be delivered automatically. The algorithm will review past behaviors to determine the amount of insulin that will be needed for a meal.
Comparador activo: Group B: AID first followed by AIDANET+FCL then AIDANET+ACL
Participants will first complete 4 weeks of AID data collection which will be used to establish baseline and initialize the control algorithm. Participants will then complete 4 weeks of AIDANET + Fully Closed Loop (FCL) and 4 weeks of AIDANET+ Anticipatory Closed Loop (ACL).
Usual Care
All participants will use AIDANET in FCL mode with instructions to avoid announcing meal boluses whenever possible during the four weeks.
All insulin will be delivered automatically. The algorithm will review past behaviors to determine the amount of insulin that will be needed for a meal.

¿Qué mide el estudio?

Medidas de resultado primarias

Medida de resultado
Medida Descripción
Periodo de tiempo
Time in range 70-140 mg/dL as computed by the study CGM
Periodo de tiempo: 8 weeks
Computed as the number of estimated glucose values ≥70mg/dL and <140mg/dL divided by the number of valid values (defined as a number between 39 and 401)
8 weeks
Time in range 70-140 mg/dL as computed by the study CGM
Periodo de tiempo: 8 weeks

Outcome is computed if:

  • >4032 values are recorded (availability condition, 2 weeks equivalent)
  • AND there is >70% values between the first recorded EGV of the analysis window and the last (density condition)
8 weeks

Colaboradores e Investigadores

Aquí es donde encontrará personas y organizaciones involucradas en este estudio.

Patrocinador

Investigadores

  • Investigador principal: Sue A Brown, MD, University of Virginia Center for Diabetes Technology

Fechas de registro del estudio

Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados ​​por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.

Fechas importantes del estudio

Inicio del estudio (Actual)

14 de mayo de 2026

Finalización primaria (Estimado)

31 de diciembre de 2026

Finalización del estudio (Estimado)

31 de diciembre de 2026

Fechas de registro del estudio

Enviado por primera vez

27 de marzo de 2026

Primero enviado que cumplió con los criterios de control de calidad

27 de marzo de 2026

Publicado por primera vez (Actual)

2 de abril de 2026

Actualizaciones de registros de estudio

Última actualización publicada (Actual)

22 de junio de 2026

Última actualización enviada que cumplió con los criterios de control de calidad

17 de junio de 2026

Última verificación

1 de junio de 2026

Más información

Términos relacionados con este estudio

Información sobre medicamentos y dispositivos, documentos del estudio

Estudia un producto farmacéutico regulado por la FDA de EE. UU.

No

Estudia un producto de dispositivo regulado por la FDA de EE. UU.

Sí

Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .

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