Clinical, Dermoscopic, and Mycological Characteristics of Tinea Capitis in Children
Clinical, Dermoscopic, and Mycological Characteristics of Tinea Capitis in Children: A Cross-sectional Study
Aperçu de l'étude
Statut
Les conditions
Description détaillée
Clinical types of tinea capitis include : scaly type (characterized by fine scaling and circular alopecia), black dot (characterized by non-inflammatory patches with broken-off, swollen hair stubs), tinea agminate (patchy alopecia with scattered pustules or low-grade folliculitis), kerion (painful, boggy, inflammatory masses with alopecia, often confused with bacterial abscess) and favus (scutula, mousy odor) . Tinea incognito (steroid modified tinea) refers to dermatophytosis that has lost their usual clinical appearance due to the use of steroids.
The main clinical feature of dermatophyte scalp infections is the appearance of scaling of the scalp skin, which is associated with a variable degree of inflammation and itching . In some cases, the infection closely resembles seborrheic dermatitis or dandruff of the scalp. A pathognomonic feature is hair loss; hair often breaks a few millimeters or more above the skin surface. Broken or infected hairs are also slightly swollen and have a dull appearance .
Trichoscopy is a non-invasive and very useful technique for the diagnosis and follow-up of hair and scalp disorders. The presence of certain trichoscopic features allows accurate identifying of tinea capitis. In tinea capitis, specific signs can be seen like comma hair, corkscrew hair, bar code-like hair and zigzag hair . In tinea incognito trichoscopic finding include erythema, scaling, bent hair, Morse code hair, and micropustules .
Mycological examination was first performed using Potassium Hydroxide(KOH) to confirm the diagnosis of tinea capitis where the patients with positive KOH were considered to have endothrix when observing arthroconidia inside the hair shaft and ectothrix when observing arthroconidia outside the hair shaft. The fungal culture also done to accurately recognize the organism through inoculation of samples on Sabouraud medium agar (SDA) with and without chloramphenicol(nonspecific medium) . And Dermasel medium agar act as specific medium.
The increase in antifungal resistance has recently been observed worldwide and resistant strains of the dermatophytes T. rubrum and T. indotineae have spread globally, causing outbreaks of extensive, difficult to treat infections , so we need rapid and reliable diagnostic tools that provide clues regarding the causative organisms.
Type d'étude
Inscription (Estimé)
Contacts et emplacements
Coordonnées de l'étude
- Nom: Noha Shafik, Assistant professor
- Numéro de téléphone: 01067261504
- E-mail: nohasaber@med.sohag.edu.eg
Sauvegarde des contacts de l'étude
- Nom: Walaa Hemdan Abu Alhassan, Demonstrator
Lieux d'étude
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Sohag, Egypte
- Faculty of Medicine , Sohag university
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Contact:
- Noha Shafik
- Numéro de téléphone: 01067261504
- E-mail: nohasaber@med.sohag.edu.eg
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Contact:
- Walaa Hemdan
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Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
- Enfant
- Adulte
Accepte les volontaires sains
Méthode d'échantillonnage
Population étudiée
The study will be conducted at the Dermatology Outpatient Clinic in Sohag University Hospitals.
Study population: The study population will be all patients with tinea capitis both male and female in childhood period, Aged 1-18 years old
La description
Inclusion Criteria:
- Both male and female in childhood period (1-18 years) with tinea capitis
Exclusion Criteria:
- Topical or systemic antifungal medications one month prior to enrollment in the study
- Presence of systemic disease, such as hepatic,renal, cardiac, autoimmune diseases, or malignancy
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
Cohortes et interventions
Groupe / Cohorte |
Intervention / Traitement |
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patients with tinea capitis both male and female in childhood period
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Specimen will be cultured on sabouraud's dextrose agar (SDA) at 25 -30 c for 2 to 4 weeks and another specimen will be cultured on a Dermasel agar base (Oxoid, UK), both supplemented with chloramphenicol and cycloheximide , staining the fungal colonies by Lactophenol cotton blue to help the examination of colonial morphology and microscopic examination of the macro-conidia allow the identification of the dermatophyte species and suitable treatment
Antifungal susceptibility testing will be performed to determine the specific sensitivity profiles of the fungal isolates.
Antifungal susceptibility testing will be performed using seven antifungal agents: Terbinafine, Itraconazole, Griseofulvin, Fluconazole, Ketoconazole, Vorioconole and Miconazole.
Dermatophytes colonies will be probed from Dermasel agar cultures.
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Percentage of participants presenting with specific clinical patterns of tinea capitis
Délai: At the time of initial clinical evaluation
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Clinical evaluation will be performed to identify and classify the presentation of tinea capitis lesions (e.g., scaly patches, black dots, kerion, favus).
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At the time of initial clinical evaluation
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Percentage of participants exhibiting specific dermoscopic features of tinea capitis
Délai: At the time of initial dermoscopic evaluation
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Dermoscopic examination using a handheld dermatoscope to identify characteristic signs including comma hairs, corkscrew hairs, broken hairs, and scaling.
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At the time of initial dermoscopic evaluation
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Prevalence of isolated fungal species among pediatric tinea capitis cases
Délai: At the time of initial sample collection and culture identification
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Mycological evaluation including direct microscopic KOH preparation and fungal culture on agar media to isolate and identify the causative fungal pathogens.
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At the time of initial sample collection and culture identification
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Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chaise d'étude: Mohammed Abu El Hamd Ali, Faculty of Medicine , Sohag university
- Chaise d'étude: Doaa Gaber Abdelbaset, Faculty of Medicine , Sohag university
Publications et liens utiles
Liens utiles
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Estimé)
Achèvement primaire (Estimé)
Achèvement de l'étude (Estimé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- Soh-Med-26-8-10MS
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
Informations sur les médicaments et les dispositifs, documents d'étude
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