JUPITER - Crestor 20mg Versus Placebo nella prevenzione degli eventi cardiovascolari (CV).
6 febbraio 2014 aggiornato da: AstraZeneca
Uno studio di fase 3 randomizzato, in doppio cieco, controllato con placebo, multicentrico su rosuvastatina (CRESTOR®) 20 mg nella prevenzione di eventi cardiovascolari tra soggetti con bassi livelli di colesterolo LDL e livelli elevati di proteina C-reattiva
Lo scopo di questo studio è determinare la sicurezza e l'efficacia della terapia a lungo termine con rosuvastatina rispetto a un placebo e valutare se il trattamento con rosuvastatina potrebbe essere efficace nel ridurre il rischio di eventi cardiovascolari maggiori.
Panoramica dello studio
Stato
Terminato
Intervento / Trattamento
Descrizione dettagliata
AstraZeneca ha annunciato di aver deciso di interrompere anticipatamente lo studio clinico CRESTOR JUPITER sulla base di una raccomandazione di un comitato indipendente di monitoraggio dei dati e del comitato direttivo di JUPITER, riunitisi il 29 marzo 2008.
Lo studio sarà interrotto in anticipo perché vi è evidenza inequivocabile di una riduzione della morbilità e della mortalità cardiovascolare tra i pazienti che hanno ricevuto CRESTOR rispetto al placebo.
Tipo di studio
Interventistico
Iscrizione (Effettivo)
17802
Fase
- Fase 3
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
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Salta, Argentina
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Buenos Aires
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Capital Federal, Buenos Aires, Argentina
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Pilar, Buenos Aires, Argentina
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Buenos Aires - Argentina
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Quilmes, Buenos Aires - Argentina, Argentina
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Buenos Aires Argentina
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Ramos Mejia, Buenos Aires Argentina, Argentina
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Buenos Aires- Argentina
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San Isidro, Buenos Aires- Argentina, Argentina
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Cordoba - Argentina
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Cordoba, Cordoba - Argentina, Argentina
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Santa Fe- Argentina
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Rosario, Santa Fe- Argentina, Argentina
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Tucuman / Argentina
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San Miguel de Tucuman, Tucuman / Argentina, Argentina
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Tucuman-argentina
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Tucuman, Tucuman-argentina, Argentina
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ANS, Belgio
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Alsemberg, Belgio
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Anthee, Belgio
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Auvelais, Belgio
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Baisy-thy, Belgio
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Bertrix, Belgio
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Betekom, Belgio
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Boechout, Belgio
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Braine-l 'alleud, Belgio
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Brussels, Belgio
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Burdinne, Belgio
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Cerexhe-heuseux, Belgio
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Champion, Belgio
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Chenee, Belgio
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De Pinte, Belgio
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Deurne (antwerpen), Belgio
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Dour, Belgio
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Ekeren, Belgio
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Embourg, Belgio
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Evergem, Belgio
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Genk, Belgio
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Genly, Belgio
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Gozee, Belgio
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Grivegnee, Belgio
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Halen, Belgio
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Hasselt, Belgio
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Heurne, Belgio
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Heusden, Belgio
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Hove, Belgio
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Kessel-lo, Belgio
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Komen, Belgio
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Kraainem, Belgio
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Landen, Belgio
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Lauwe, Belgio
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Leopoldsburg, Belgio
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Leuven, Belgio
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Libin, Belgio
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Linkebeek, Belgio
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Lommel, Belgio
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Marchienne-au-pont, Belgio
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Marchovelette, Belgio
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Massemen, Belgio
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Mechelen-aan-de-maas, Belgio
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Melsbroek, Belgio
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Moerkerke, Belgio
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Mont-sur-marchienne, Belgio
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Moorsel, Belgio
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Mouscron, Belgio
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Natoye, Belgio
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Oostham, Belgio
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Opgrimbie (maasmechelen), Belgio
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Oudenaarde, Belgio
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Paal, Belgio
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Puurs, Belgio
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Ronquieres, Belgio
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Ronse, Belgio
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Rumst, Belgio
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Saint-medard, Belgio
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Schoonaarde, Belgio
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Schuiferskapelle, Belgio
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Sint-gillis-waas, Belgio
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Steenokkerzeel, Belgio
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Tavier, Belgio
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Tessenderlo, Belgio
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Thuin, Belgio
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Tielt, Belgio
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Tremelo, Belgio
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Trois-ponts, Belgio
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Turnhout, Belgio
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Vilvoorde, Belgio
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Waremme, Belgio
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Weerde, Belgio
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Wezembeek- Oppem, Belgio
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Zoersel, Belgio
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Campinas, Brasile
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Sao Paulo, Brasile
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Alagoas
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Maceio, Alagoas, Brasile
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BA
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Salvador, BA, Brasile
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CE
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Fortaleza, CE, Brasile
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Goias
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Goiagoianiania, Goias, Brasile
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MG
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Belo Horizonte, MG, Brasile
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RJ
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Rio de Janeiro, RJ, Brasile
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RS
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Porto Alegre, RS, Brasile
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Rio Grande Do Sul
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Passo Fundo, Rio Grande Do Sul, Brasile
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SP
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Botucatu, SP, Brasile
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S.j.rio Preto, SP, Brasile
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Sao Paulo
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Santos, Sao Paulo, Brasile
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Sao Jose Do Rio Preto, Sao Paulo, Brasile
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Dimitrovgrad, Bulgaria
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Haskovo, Bulgaria
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Pleven, Bulgaria
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Plovdiv, Bulgaria
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Russe, Bulgaria
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Sofia, Bulgaria
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Varna, Bulgaria
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Veliko Tarnovo, Bulgaria
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Quebec, Canada
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Alberta
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Calgary, Alberta, Canada
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Edmonton, Alberta, Canada
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British Columbia
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Chilliwack, British Columbia, Canada
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Coquitlam, British Columbia, Canada
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Kelowna, British Columbia, Canada
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Langley, British Columbia, Canada
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New Westminister, British Columbia, Canada
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Penticton, British Columbia, Canada
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Surrey, British Columbia, Canada
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Victoria, British Columbia, Canada
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Manitoba
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Portage La Prairie, Manitoba, Canada
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Winnipeg, Manitoba, Canada
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New Brunswick
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Grand Bay - Westfield, New Brunswick, Canada
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Moncton, New Brunswick, Canada
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Nackawic, New Brunswick, Canada
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Saint John, New Brunswick, Canada
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Woodstock, New Brunswick, Canada
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Newfoundland and Labrador
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Bay Roberts, Newfoundland and Labrador, Canada
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Carbonear, Newfoundland and Labrador, Canada
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Conception Bay South, Newfoundland and Labrador, Canada
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Holyrood, Newfoundland and Labrador, Canada
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Mount Pearl, Newfoundland and Labrador, Canada
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St. John's, Newfoundland and Labrador, Canada
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Nova Scotia
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Amherst, Nova Scotia, Canada
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Antigonish, Nova Scotia, Canada
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Digby, Nova Scotia, Canada
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Halifax, Nova Scotia, Canada
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Windsor, Nova Scotia, Canada
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Ontario
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Bolton, Ontario, Canada
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Brampton, Ontario, Canada
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Burlington, Ontario, Canada
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Cambridge, Ontario, Canada
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Corunna, Ontario, Canada
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Courtice, Ontario, Canada
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Etobicoke, Ontario, Canada
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Exeter, Ontario, Canada
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Hamilton, Ontario, Canada
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Ingersoll, Ontario, Canada
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Kingston, Ontario, Canada
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London, Ontario, Canada
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Markham, Ontario, Canada
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Newmarket, Ontario, Canada
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Niagara Falls, Ontario, Canada
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North Bay, Ontario, Canada
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North York, Ontario, Canada
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Orleans, Ontario, Canada
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Oshawa, Ontario, Canada
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Ottawa, Ontario, Canada
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Perth, Ontario, Canada
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Peterborough, Ontario, Canada
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Renfrew, Ontario, Canada
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Sarnia, Ontario, Canada
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Scarborough, Ontario, Canada
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Smith Falls, Ontario, Canada
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St Catherines, Ontario, Canada
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Stirling, Ontario, Canada
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Sudbury, Ontario, Canada
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Thornhill, Ontario, Canada
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Thunder Bay, Ontario, Canada
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Tillsonburg, Ontario, Canada
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Toronto, Ontario, Canada
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Windsor, Ontario, Canada
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Woodstock, Ontario, Canada
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Prince Edward Island
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Charlottetown, Prince Edward Island, Canada
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Quebec
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Chicoutimi, Quebec, Canada
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Courcelette, Quebec, Canada
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Drummonville, Quebec, Canada
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Gatineau, Quebec, Canada
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Granby, Quebec, Canada
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Greenfield Park, Quebec, Canada
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Lasalle, Quebec, Canada
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Laval, Quebec, Canada
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Longueuil, Quebec, Canada
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Montreal, Quebec, Canada
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Pointe-claire, Quebec, Canada
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Saint-georges, Quebec, Canada
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Saint-marc-des-carrieres, Quebec, Canada
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Sainte-catherine, Quebec, Canada
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Sainte-julie, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Trois-rivieres, Quebec, Canada
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Vanier, Quebec, Canada
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Saskatchewan
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Regina, Saskatchewan, Canada
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Saskatoon, Saskatchewan, Canada
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Novena Region
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Temuco, Novena Region, Chile
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Region Metropolitana
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Santiago, Region Metropolitana, Chile
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Bogota, Colombia
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Antioquia
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Medellin, Antioquia, Colombia
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Atlantico
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Barranquilla, Atlantico, Colombia
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Bolivar
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Cartagena, Bolivar, Colombia
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Risaralda
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Pereira, Risaralda, Colombia
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Santander
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Bucaramanga, Santander, Colombia
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Floridablanca, Santander, Colombia
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Valle
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Cali, Valle, Colombia
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Heredia, Costa Rica
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San Jose
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Desamparados, San Jose, Costa Rica
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Escazu, San Jose, Costa Rica
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San Pedro de Montes de Oca, San Jose, Costa Rica
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Gentofte, Danimarca
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Glostrup, Danimarca
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Herlev, Danimarca
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Hillerod, Danimarca
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Odense C, Danimarca
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Salvador, El Salvador
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San Salvador, El Salvador
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San Salvador
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El Salvador, San Salvador, El Salvador
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Parnu, Estonia
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Rakvere, Estonia
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Tallinn, Estonia
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Tartu, Estonia
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Viljandi County, Estonia
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Harju County
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Saku, Harju County, Estonia
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Ekaterinburg, Federazione Russa
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Kemerovo, Federazione Russa
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Krasnoyarsk, Federazione Russa
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Moscow, Federazione Russa
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Novosibirsk, Federazione Russa
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Saratov, Federazione Russa
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St-petersburg, Federazione Russa
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Toliatti, Federazione Russa
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Tomsk, Federazione Russa
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Tyumen, Federazione Russa
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Voronezh, Federazione Russa
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Yaroslavl, Federazione Russa
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Berlin, Germania
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Bochum, Germania
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Chemnitz, Germania
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Dortmund, Germania
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Dresden, Germania
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Frankfurt, Germania
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Gorlitz, Germania
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Hamburg, Germania
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Kunzing, Germania
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Leipzig, Germania
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Magdeburg, Germania
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Nurnberg, Germania
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ULM, Germania
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Witten, Germania
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Ashkelon Shore, Israele
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Beer Yakov, Israele
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Haifa, Israele
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Holon, Israele
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Jerusalem, Israele
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Kfar-saba, Israele
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Safed, Israele
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Tel Aviv, Israele
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Tel-hashomer, Israele
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Zrifin, Israele
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Jerusalem
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Kiryat Hadassah, Jerusalem, Israele
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Aguascalientes, Messico
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D.F
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Mexico City, D.F, Messico
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Jalisco
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Guadalajara, Jalisco, Messico
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Nuevo Leon
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Monterrey, Nuevo Leon, Messico
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SLP
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San Luis Potosi, SLP, Messico
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Sinaloa
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Culiacan, Sinaloa, Messico
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Bekkestua, Norvegia
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Bergen, Norvegia
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Boverbru, Norvegia
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Elverum, Norvegia
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Flatasen, Norvegia
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Fredrikstad, Norvegia
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Halden, Norvegia
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Heimdal, Norvegia
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Kristiansand, Norvegia
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Laksevag, Norvegia
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Lena, Norvegia
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Lierskogen, Norvegia
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Lovenstad, Norvegia
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Lysaker, Norvegia
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Moelv, Norvegia
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Moss, Norvegia
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Oslo, Norvegia
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Osteras, Norvegia
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Paradis, Norvegia
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Radal, Norvegia
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Randaberg, Norvegia
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SKI, Norvegia
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Skedsmokorset, Norvegia
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Skiptvet, Norvegia
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Snaroya, Norvegia
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Sogndal, Norvegia
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Spikkestad, Norvegia
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Stavanger, Norvegia
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Strommen, Norvegia
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Svelvik, Norvegia
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Trollasen, Norvegia
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Trondheim, Norvegia
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Alkmaar, Olanda
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Amersfoort, Olanda
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Amsterdam, Olanda
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Breda, Olanda
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Den Haag, Olanda
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Deventer, Olanda
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Eindhoven, Olanda
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Gouda, Olanda
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Groningen, Olanda
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Hoorn, Olanda
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Leiden, Olanda
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Nijmegen, Olanda
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Rotterdam, Olanda
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Tilburg, Olanda
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Utrecht, Olanda
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Velp, Olanda
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Zoetermeer, Olanda
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Panama, Panama
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Aleksandrow Lodzki, Polonia
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Bydgoszcz, Polonia
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Bytom, Polonia
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Chodziez, Polonia
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Chorzow, Polonia
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Gdansk, Polonia
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Gliwice, Polonia
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Jelcz-laskowice, Polonia
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Karpacz, Polonia
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Katowice, Polonia
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Koluszki, Polonia
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Krakow, Polonia
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Linia, Polonia
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Lodz, Polonia
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Lublin, Polonia
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Nowogard, Polonia
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Olawa, Polonia
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Olsztyn, Polonia
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Opalenica, Polonia
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Opole, Polonia
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Ostrow Wielkopolski, Polonia
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Piekary Slaskie, Polonia
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Poznan, Polonia
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Pulawy, Polonia
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Radom, Polonia
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Radziejow, Polonia
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Rybnik, Polonia
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Sieradz, Polonia
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Skierniewice, Polonia
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Slupca, Polonia
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Sobotka, Polonia
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Sopot, Polonia
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Szczecin, Polonia
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Tarnow, Polonia
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Torun, Polonia
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Trzcianka, Polonia
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Turek, Polonia
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Wabrzezno, Polonia
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Warszawa, Polonia
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Wejherowo, Polonia
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Wroclaw, Polonia
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Zabrze, Polonia
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Aguas Buenas, Porto Rico
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Caguas, Porto Rico
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Cidra, Porto Rico
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Levittown-toa Baja, Porto Rico
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Ponce, Porto Rico
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San Juan, Porto Rico
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Barrhead, Regno Unito
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Bellshill, Regno Unito
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Birmingham, Regno Unito
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Cambuslang, Regno Unito
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Cardiff, Regno Unito
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Chorley, Regno Unito
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Cumbernauld, Regno Unito
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Gourock, Regno Unito
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Greenock, Regno Unito
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Helensburgh, Regno Unito
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Kirkintilloch, Regno Unito
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Liverpool, Regno Unito
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Lockerbie, Regno Unito
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Manchester, Regno Unito
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New Stevenson, Regno Unito
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Renfrew, Regno Unito
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Stranraer, Regno Unito
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Strathblane, Regno Unito
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Thornhill, Regno Unito
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Wolverhampton, Regno Unito
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Berkshire
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Reading, Berkshire, Regno Unito
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Dumfries and Galloway
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Annan, Dumfries and Galloway, Regno Unito
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Lanarkshire
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Blantyre, Lanarkshire, Regno Unito
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Hamilton, Lanarkshire, Regno Unito
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Strathaven, Lanarkshire, Regno Unito
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Wishaw, Lanarkshire, Regno Unito
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Renfrewshire
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Paisley, Renfrewshire, Regno Unito
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Scotland
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Airdrie, Scotland, Regno Unito
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Glasgow, Scotland, Regno Unito
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Brasov, Romania
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Bucharest, Romania
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Bucuresti, Romania
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Cluj
-
Cluj Napoca, Cluj, Romania
- Research Site
-
-
Timis
-
Timisoara, Timis, Romania
- Research Site
-
-
-
-
Alabama
-
Birmingham, Alabama, Stati Uniti
- Research Site
-
Calera, Alabama, Stati Uniti
- Research Site
-
Columbiana, Alabama, Stati Uniti
- Research Site
-
Decatur, Alabama, Stati Uniti
- Research Site
-
Graysville, Alabama, Stati Uniti
- Research Site
-
Haleyville, Alabama, Stati Uniti
- Research Site
-
Hartselle, Alabama, Stati Uniti
- Research Site
-
Huntsville, Alabama, Stati Uniti
- Research Site
-
Mobile, Alabama, Stati Uniti
- Research Site
-
Montgomery, Alabama, Stati Uniti
- Research Site
-
Muscle Shoals, Alabama, Stati Uniti
- Research Site
-
South Birmingham, Alabama, Stati Uniti
- Research Site
-
Tuscumbia, Alabama, Stati Uniti
- Research Site
-
-
Arizona
-
Mesa, Arizona, Stati Uniti
- Research Site
-
Phoenix, Arizona, Stati Uniti
- Research Site
-
Scottsdale, Arizona, Stati Uniti
- Research Site
-
Tucson, Arizona, Stati Uniti
- Research Site
-
-
Arkansas
-
Fayetteville, Arkansas, Stati Uniti
- Research Site
-
Hot Springs, Arkansas, Stati Uniti
- Research Site
-
Little Rock, Arkansas, Stati Uniti
- Research Site
-
Pine Bluff, Arkansas, Stati Uniti
- Research Site
-
-
California
-
Alhambra, California, Stati Uniti
- Research Site
-
Azusa, California, Stati Uniti
- Research Site
-
Berkeley, California, Stati Uniti
- Research Site
-
Beverly Hills, California, Stati Uniti
- Research Site
-
Burlingame, California, Stati Uniti
- Research Site
-
Carmichael, California, Stati Uniti
- Research Site
-
Concord, California, Stati Uniti
- Research Site
-
Culver City, California, Stati Uniti
- Research Site
-
Daly City, California, Stati Uniti
- Research Site
-
Folsom, California, Stati Uniti
- Research Site
-
Foothill Ranch, California, Stati Uniti
- Research Site
-
Fountain Valley, California, Stati Uniti
- Research Site
-
Fresno, California, Stati Uniti
- Research Site
-
Garden Grove, California, Stati Uniti
- Research Site
-
Inglewood, California, Stati Uniti
- Research Site
-
Irvine, California, Stati Uniti
- Research Site
-
La Jolla, California, Stati Uniti
- Research Site
-
La Mesa, California, Stati Uniti
- Research Site
-
Languna Niguel, California, Stati Uniti
- Research Site
-
Long Beach, California, Stati Uniti
- Research Site
-
Los Angeles, California, Stati Uniti
- Research Site
-
Los Gatos, California, Stati Uniti
- Research Site
-
Mission Hills, California, Stati Uniti
- Research Site
-
Mission Viejo, California, Stati Uniti
- Research Site
-
Modesto, California, Stati Uniti
- Research Site
-
Newport Beach, California, Stati Uniti
- Research Site
-
Norwalk, California, Stati Uniti
- Research Site
-
Orange, California, Stati Uniti
- Research Site
-
Orangevale, California, Stati Uniti
- Research Site
-
Palm Desert, California, Stati Uniti
- Research Site
-
Pasadena, California, Stati Uniti
- Research Site
-
Pismo Beach, California, Stati Uniti
- Research Site
-
Pomona, California, Stati Uniti
- Research Site
-
Riverside, California, Stati Uniti
- Research Site
-
Roseville, California, Stati Uniti
- Research Site
-
Sacramento, California, Stati Uniti
- Research Site
-
San Diego, California, Stati Uniti
- Research Site
-
San Jose, California, Stati Uniti
- Research Site
-
San Ramon, California, Stati Uniti
- Research Site
-
Santa Ana, California, Stati Uniti
- Research Site
-
Santa Monica, California, Stati Uniti
- Research Site
-
Thousand Oaks, California, Stati Uniti
- Research Site
-
Torrance, California, Stati Uniti
- Research Site
-
Upland, California, Stati Uniti
- Research Site
-
Ventura, California, Stati Uniti
- Research Site
-
Vista, California, Stati Uniti
- Research Site
-
Walnut Creek, California, Stati Uniti
- Research Site
-
Westlake Village, California, Stati Uniti
- Research Site
-
-
Colorado
-
Aurora, Colorado, Stati Uniti
- Research Site
-
Colorado Springs, Colorado, Stati Uniti
- Research Site
-
Denver, Colorado, Stati Uniti
- Research Site
-
Fort Collins, Colorado, Stati Uniti
- Research Site
-
Golden, Colorado, Stati Uniti
- Research Site
-
Highlands Ranch, Colorado, Stati Uniti
- Research Site
-
Littleton, Colorado, Stati Uniti
- Research Site
-
Loveland, Colorado, Stati Uniti
- Research Site
-
-
Connecticut
-
Avon, Connecticut, Stati Uniti
- Research Site
-
Bristol, Connecticut, Stati Uniti
- Research Site
-
Hartford, Connecticut, Stati Uniti
- Research Site
-
Stamford, Connecticut, Stati Uniti
- Research Site
-
Trumbull, Connecticut, Stati Uniti
- Research Site
-
West Hartford, Connecticut, Stati Uniti
- Research Site
-
-
Delaware
-
Newark, Delaware, Stati Uniti
- Research Site
-
Wlimington, Delaware, Stati Uniti
- Research Site
-
-
District of Columbia
-
Washington, District of Columbia, Stati Uniti
- Research Site
-
-
Florida
-
Apopka, Florida, Stati Uniti
- Research Site
-
Beverly Hills, Florida, Stati Uniti
- Research Site
-
Cape Coral, Florida, Stati Uniti
- Research Site
-
Clearwater, Florida, Stati Uniti
- Research Site
-
Cooper City, Florida, Stati Uniti
- Research Site
-
Crystal River, Florida, Stati Uniti
- Research Site
-
Davie, Florida, Stati Uniti
- Research Site
-
Deerfield Beach, Florida, Stati Uniti
- Research Site
-
Delray Beach, Florida, Stati Uniti
- Research Site
-
Fort Lauderdale, Florida, Stati Uniti
- Research Site
-
Gainesville, Florida, Stati Uniti
- Research Site
-
Jacksonville, Florida, Stati Uniti
- Research Site
-
Lakeland, Florida, Stati Uniti
- Research Site
-
Largo, Florida, Stati Uniti
- Research Site
-
Margate, Florida, Stati Uniti
- Research Site
-
Miami, Florida, Stati Uniti
- Research Site
-
North Miami Beach, Florida, Stati Uniti
- Research Site
-
Orlando, Florida, Stati Uniti
- Research Site
-
Ormond Beach, Florida, Stati Uniti
- Research Site
-
Palm Harbor, Florida, Stati Uniti
- Research Site
-
Pensacola, Florida, Stati Uniti
- Research Site
-
Port Charlotte, Florida, Stati Uniti
- Research Site
-
Port Orange, Florida, Stati Uniti
- Research Site
-
Sarasota, Florida, Stati Uniti
- Research Site
-
Sebastian, Florida, Stati Uniti
- Research Site
-
Tamarac, Florida, Stati Uniti
- Research Site
-
Tampa, Florida, Stati Uniti
- Research Site
-
Vero Beach, Florida, Stati Uniti
- Research Site
-
West Palm Beach, Florida, Stati Uniti
- Research Site
-
-
Georgia
-
Atlanta, Georgia, Stati Uniti
- Research Site
-
Augusta, Georgia, Stati Uniti
- Research Site
-
Blue Ridge, Georgia, Stati Uniti
- Research Site
-
Brunswick, Georgia, Stati Uniti
- Research Site
-
Columbus, Georgia, Stati Uniti
- Research Site
-
Conyers, Georgia, Stati Uniti
- Research Site
-
Decatur, Georgia, Stati Uniti
- Research Site
-
Fayetteville, Georgia, Stati Uniti
- Research Site
-
Suwanee, Georgia, Stati Uniti
- Research Site
-
Woodstock, Georgia, Stati Uniti
- Research Site
-
-
Idaho
-
Idaho Falls, Idaho, Stati Uniti
- Research Site
-
Meridian, Idaho, Stati Uniti
- Research Site
-
-
Illinois
-
Aurora, Illinois, Stati Uniti
- Research Site
-
Champaign, Illinois, Stati Uniti
- Research Site
-
Chicago, Illinois, Stati Uniti
- Research Site
-
Gurnee, Illinois, Stati Uniti
- Research Site
-
Lake Road, Illinois, Stati Uniti
- Research Site
-
Melrose Park, Illinois, Stati Uniti
- Research Site
-
Morton, Illinois, Stati Uniti
- Research Site
-
O'fallon, Illinois, Stati Uniti
- Research Site
-
Orland Park, Illinois, Stati Uniti
- Research Site
-
Springfield, Illinois, Stati Uniti
- Research Site
-
Sterling, Illinois, Stati Uniti
- Research Site
-
Vernon Hills, Illinois, Stati Uniti
- Research Site
-
-
Indiana
-
Avon, Indiana, Stati Uniti
- Research Site
-
Evansville, Indiana, Stati Uniti
- Research Site
-
Granger, Indiana, Stati Uniti
- Research Site
-
Indianapolis, Indiana, Stati Uniti
- Research Site
-
Jeffersonville, Indiana, Stati Uniti
- Research Site
-
Munster, Indiana, Stati Uniti
- Research Site
-
Newburgh, Indiana, Stati Uniti
- Research Site
-
Valparaiso, Indiana, Stati Uniti
- Research Site
-
-
Iowa
-
Des Moines, Iowa, Stati Uniti
- Research Site
-
Dubuque, Iowa, Stati Uniti
- Research Site
-
Iowa City, Iowa, Stati Uniti
- Research Site
-
West Des Moines, Iowa, Stati Uniti
- Research Site
-
-
Kansas
-
Leavenworth, Kansas, Stati Uniti
- Research Site
-
Olathe, Kansas, Stati Uniti
- Research Site
-
Overland Park, Kansas, Stati Uniti
- Research Site
-
Shawnee Mission, Kansas, Stati Uniti
- Research Site
-
Topeka, Kansas, Stati Uniti
- Research Site
-
Wichita, Kansas, Stati Uniti
- Research Site
-
-
Kentucky
-
Evansville, Kentucky, Stati Uniti
- Research Site
-
Lexington, Kentucky, Stati Uniti
- Research Site
-
Louisville, Kentucky, Stati Uniti
- Research Site
-
-
Louisiana
-
Baton Rouge, Louisiana, Stati Uniti
- Research Site
-
Covington, Louisiana, Stati Uniti
- Research Site
-
Houma, Louisiana, Stati Uniti
- Research Site
-
Lake Charles, Louisiana, Stati Uniti
- Research Site
-
Marrero, Louisiana, Stati Uniti
- Research Site
-
New Orleans, Louisiana, Stati Uniti
- Research Site
-
Shreveport, Louisiana, Stati Uniti
- Research Site
-
-
Maine
-
Auburn, Maine, Stati Uniti
- Research Site
-
Bangor, Maine, Stati Uniti
- Research Site
-
Portland, Maine, Stati Uniti
- Research Site
-
S Portland, Maine, Stati Uniti
- Research Site
-
Sanford, Maine, Stati Uniti
- Research Site
-
-
Maryland
-
Baltimore, Maryland, Stati Uniti
- Research Site
-
Charlotte Hall, Maryland, Stati Uniti
- Research Site
-
Glen Burnie, Maryland, Stati Uniti
- Research Site
-
Hagerstown, Maryland, Stati Uniti
- Research Site
-
Prince Frederick, Maryland, Stati Uniti
- Research Site
-
Rockville, Maryland, Stati Uniti
- Research Site
-
Towson, Maryland, Stati Uniti
- Research Site
-
-
Massachusetts
-
Ayer, Massachusetts, Stati Uniti
- Research Site
-
Boston, Massachusetts, Stati Uniti
- Research Site
-
Burlington, Massachusetts, Stati Uniti
- Research Site
-
East Bridgewater, Massachusetts, Stati Uniti
- Research Site
-
Haverhill, Massachusetts, Stati Uniti
- Research Site
-
Natick, Massachusetts, Stati Uniti
- Research Site
-
Newton, Massachusetts, Stati Uniti
- Research Site
-
Springfield, Massachusetts, Stati Uniti
- Research Site
-
West Yarmouth, Massachusetts, Stati Uniti
- Research Site
-
Worcester, Massachusetts, Stati Uniti
- Research Site
-
-
Michigan
-
Berkley, Michigan, Stati Uniti
- Research Site
-
Dearborn, Michigan, Stati Uniti
- Research Site
-
Grand Rapids, Michigan, Stati Uniti
- Research Site
-
Livonia, Michigan, Stati Uniti
- Research Site
-
Petoskey, Michigan, Stati Uniti
- Research Site
-
Portage, Michigan, Stati Uniti
- Research Site
-
St. Joseph, Michigan, Stati Uniti
- Research Site
-
Troy, Michigan, Stati Uniti
- Research Site
-
Warren, Michigan, Stati Uniti
- Research Site
-
-
Minnesota
-
Chaska, Minnesota, Stati Uniti
- Research Site
-
Duluth, Minnesota, Stati Uniti
- Research Site
-
Minneapolis, Minnesota, Stati Uniti
- Research Site
-
Rochester, Minnesota, Stati Uniti
- Research Site
-
St. Paul, Minnesota, Stati Uniti
- Research Site
-
-
Mississippi
-
Gulfport, Mississippi, Stati Uniti
- Research Site
-
Jackson, Mississippi, Stati Uniti
- Research Site
-
Olive Branch, Mississippi, Stati Uniti
- Research Site
-
Picayune, Mississippi, Stati Uniti
- Research Site
-
Port Gibson, Mississippi, Stati Uniti
- Research Site
-
-
Missouri
-
Chesterfield, Missouri, Stati Uniti
- Research Site
-
Excelsior Springs, Missouri, Stati Uniti
- Research Site
-
Jefferson City, Missouri, Stati Uniti
- Research Site
-
Kansas City, Missouri, Stati Uniti
- Research Site
-
Manchester, Missouri, Stati Uniti
- Research Site
-
Mexico, Missouri, Stati Uniti
- Research Site
-
Rolla, Missouri, Stati Uniti
- Research Site
-
Shawnee Mission, Missouri, Stati Uniti
- Research Site
-
Springfield, Missouri, Stati Uniti
- Research Site
-
St Charles, Missouri, Stati Uniti
- Research Site
-
St Louis, Missouri, Stati Uniti
- Research Site
-
Washington, Missouri, Stati Uniti
- Research Site
-
Wentzville, Missouri, Stati Uniti
- Research Site
-
-
Montana
-
Anaconda, Montana, Stati Uniti
- Research Site
-
Butte, Montana, Stati Uniti
- Research Site
-
Kalispell, Montana, Stati Uniti
- Research Site
-
Missoula, Montana, Stati Uniti
- Research Site
-
-
Nebraska
-
Grand Island, Nebraska, Stati Uniti
- Research Site
-
Omaha, Nebraska, Stati Uniti
- Research Site
-
-
Nevada
-
Henderson, Nevada, Stati Uniti
- Research Site
-
Las Vegas, Nevada, Stati Uniti
- Research Site
-
Pahrump, Nevada, Stati Uniti
- Research Site
-
-
New Hampshire
-
Nashua, New Hampshire, Stati Uniti
- Research Site
-
-
New Jersey
-
Bloomfield, New Jersey, Stati Uniti
- Research Site
-
Brick, New Jersey, Stati Uniti
- Research Site
-
Cherry Hill, New Jersey, Stati Uniti
- Research Site
-
Elizabeth, New Jersey, Stati Uniti
- Research Site
-
Englewood Cliffs, New Jersey, Stati Uniti
- Research Site
-
Morristown, New Jersey, Stati Uniti
- Research Site
-
Newark, New Jersey, Stati Uniti
- Research Site
-
Northbrunswick, New Jersey, Stati Uniti
- Research Site
-
Passaic, New Jersey, Stati Uniti
- Research Site
-
Teaneck, New Jersey, Stati Uniti
- Research Site
-
Trenton, New Jersey, Stati Uniti
- Research Site
-
West Caldwell, New Jersey, Stati Uniti
- Research Site
-
-
New Mexico
-
Albuquerque, New Mexico, Stati Uniti
- Research Site
-
Los Alamos, New Mexico, Stati Uniti
- Research Site
-
Rio Rancho, New Mexico, Stati Uniti
- Research Site
-
-
New York
-
Albany, New York, Stati Uniti
- Research Site
-
Binghamton, New York, Stati Uniti
- Research Site
-
Bowmansville, New York, Stati Uniti
- Research Site
-
Bronx, New York, Stati Uniti
- Research Site
-
Bronxville, New York, Stati Uniti
- Research Site
-
Brooklyn, New York, Stati Uniti
- Research Site
-
Buffalo, New York, Stati Uniti
- Research Site
-
Camillus, New York, Stati Uniti
- Research Site
-
E Syracuse, New York, Stati Uniti
- Research Site
-
East Islip, New York, Stati Uniti
- Research Site
-
Fayetteville, New York, Stati Uniti
- Research Site
-
Lake Success, New York, Stati Uniti
- Research Site
-
Mamaroneck, New York, Stati Uniti
- Research Site
-
Mount Vernon, New York, Stati Uniti
- Research Site
-
New Hartford, New York, Stati Uniti
- Research Site
-
New Hyde Park, New York, Stati Uniti
- Research Site
-
New York, New York, Stati Uniti
- Research Site
-
Niagara Falls, New York, Stati Uniti
- Research Site
-
Poughkeepsie, New York, Stati Uniti
- Research Site
-
Riverhead, New York, Stati Uniti
- Research Site
-
Rochester, New York, Stati Uniti
- Research Site
-
Syracuse, New York, Stati Uniti
- Research Site
-
Tonawanda, New York, Stati Uniti
- Research Site
-
Williamsville, New York, Stati Uniti
- Research Site
-
-
North Carolina
-
Asheville, North Carolina, Stati Uniti
- Research Site
-
Burlington, North Carolina, Stati Uniti
- Research Site
-
Cary, North Carolina, Stati Uniti
- Research Site
-
Chapel Hill, North Carolina, Stati Uniti
- Research Site
-
Charlotte, North Carolina, Stati Uniti
- Research Site
-
Durham, North Carolina, Stati Uniti
- Research Site
-
Fayetteville, North Carolina, Stati Uniti
- Research Site
-
Lenoir, North Carolina, Stati Uniti
- Research Site
-
Lexington, North Carolina, Stati Uniti
- Research Site
-
Raleigh, North Carolina, Stati Uniti
- Research Site
-
Statesville, North Carolina, Stati Uniti
- Research Site
-
Winston-salem, North Carolina, Stati Uniti
- Research Site
-
-
North Dakota
-
Fargo, North Dakota, Stati Uniti
- Research Site
-
-
Ohio
-
Akron, Ohio, Stati Uniti
- Research Site
-
Athens, Ohio, Stati Uniti
- Research Site
-
Bellbrook, Ohio, Stati Uniti
- Research Site
-
Canal Fulton, Ohio, Stati Uniti
- Research Site
-
Centerville, Ohio, Stati Uniti
- Research Site
-
Chesterland, Ohio, Stati Uniti
- Research Site
-
Cincinnati, Ohio, Stati Uniti
- Research Site
-
Columbus, Ohio, Stati Uniti
- Research Site
-
Dayton, Ohio, Stati Uniti
- Research Site
-
Mansfield, Ohio, Stati Uniti
- Research Site
-
Massillon, Ohio, Stati Uniti
- Research Site
-
Maumee, Ohio, Stati Uniti
- Research Site
-
Wadsworth, Ohio, Stati Uniti
- Research Site
-
Warren, Ohio, Stati Uniti
- Research Site
-
Zanesville, Ohio, Stati Uniti
- Research Site
-
-
Oklahoma
-
Guthrie, Oklahoma, Stati Uniti
- Research Site
-
Muskogee, Oklahoma, Stati Uniti
- Research Site
-
Oklahoma City, Oklahoma, Stati Uniti
- Research Site
-
Tulsa, Oklahoma, Stati Uniti
- Research Site
-
Yukon, Oklahoma, Stati Uniti
- Research Site
-
-
Oregon
-
Corvallis, Oregon, Stati Uniti
- Research Site
-
Dallas, Oregon, Stati Uniti
- Research Site
-
Eugene, Oregon, Stati Uniti
- Research Site
-
Lake Oswego, Oregon, Stati Uniti
- Research Site
-
Medford, Oregon, Stati Uniti
- Research Site
-
Milwaukie, Oregon, Stati Uniti
- Research Site
-
Portland, Oregon, Stati Uniti
- Research Site
-
Springfield, Oregon, Stati Uniti
- Research Site
-
-
Pennsylvania
-
Altoona, Pennsylvania, Stati Uniti
- Research Site
-
Beaver, Pennsylvania, Stati Uniti
- Research Site
-
Bloomsburg, Pennsylvania, Stati Uniti
- Research Site
-
Broomall, Pennsylvania, Stati Uniti
- Research Site
-
Camp Hill, Pennsylvania, Stati Uniti
- Research Site
-
Connellsville, Pennsylvania, Stati Uniti
- Research Site
-
Downingtown, Pennsylvania, Stati Uniti
- Research Site
-
Erie, Pennsylvania, Stati Uniti
- Research Site
-
Feasterville, Pennsylvania, Stati Uniti
- Research Site
-
Fleetwood, Pennsylvania, Stati Uniti
- Research Site
-
Harleysville, Pennsylvania, Stati Uniti
- Research Site
-
Harrisburg, Pennsylvania, Stati Uniti
- Research Site
-
Jersey Shore, Pennsylvania, Stati Uniti
- Research Site
-
King of Prussia, Pennsylvania, Stati Uniti
- Research Site
-
Lansdale, Pennsylvania, Stati Uniti
- Research Site
-
Lansdowne, Pennsylvania, Stati Uniti
- Research Site
-
Lewisburg, Pennsylvania, Stati Uniti
- Research Site
-
Lewistown, Pennsylvania, Stati Uniti
- Research Site
-
Lock Haven, Pennsylvania, Stati Uniti
- Research Site
-
McMurry, Pennsylvania, Stati Uniti
- Research Site
-
Melrose Park, Pennsylvania, Stati Uniti
- Research Site
-
Norristown, Pennsylvania, Stati Uniti
- Research Site
-
Philadelphia, Pennsylvania, Stati Uniti
- Research Site
-
Pittsburgh, Pennsylvania, Stati Uniti
- Research Site
-
Plymouth Meeting, Pennsylvania, Stati Uniti
- Research Site
-
Reading, Pennsylvania, Stati Uniti
- Research Site
-
Scotland, Pennsylvania, Stati Uniti
- Research Site
-
Sellersville, Pennsylvania, Stati Uniti
- Research Site
-
Souderton, Pennsylvania, Stati Uniti
- Research Site
-
Springfield, Pennsylvania, Stati Uniti
- Research Site
-
State College, Pennsylvania, Stati Uniti
- Research Site
-
Stoneboro, Pennsylvania, Stati Uniti
- Research Site
-
Tipton, Pennsylvania, Stati Uniti
- Research Site
-
Uniontown, Pennsylvania, Stati Uniti
- Research Site
-
Upland, Pennsylvania, Stati Uniti
- Research Site
-
Wallingford, Pennsylvania, Stati Uniti
- Research Site
-
Warminster, Pennsylvania, Stati Uniti
- Research Site
-
West Grove, Pennsylvania, Stati Uniti
- Research Site
-
West Reading, Pennsylvania, Stati Uniti
- Research Site
-
Wilkes-barre, Pennsylvania, Stati Uniti
- Research Site
-
York, Pennsylvania, Stati Uniti
- Research Site
-
-
Rhode Island
-
Cranston, Rhode Island, Stati Uniti
- Research Site
-
Johnston, Rhode Island, Stati Uniti
- Research Site
-
Pawtucket, Rhode Island, Stati Uniti
- Research Site
-
Providence, Rhode Island, Stati Uniti
- Research Site
-
-
South Carolina
-
Charleston, South Carolina, Stati Uniti
- Research Site
-
Greenville, South Carolina, Stati Uniti
- Research Site
-
Greer, South Carolina, Stati Uniti
- Research Site
-
Hampton, South Carolina, Stati Uniti
- Research Site
-
Moncks Corner, South Carolina, Stati Uniti
- Research Site
-
Mt Pleasant, South Carolina, Stati Uniti
- Research Site
-
Orangeburg, South Carolina, Stati Uniti
- Research Site
-
Simpsonville, South Carolina, Stati Uniti
- Research Site
-
-
South Dakota
-
Sioux Falls, South Dakota, Stati Uniti
- Research Site
-
-
Tennessee
-
Bristol, Tennessee, Stati Uniti
- Research Site
-
Chattanooga, Tennessee, Stati Uniti
- Research Site
-
Clarksville, Tennessee, Stati Uniti
- Research Site
-
Fayetteville, Tennessee, Stati Uniti
- Research Site
-
Germantown, Tennessee, Stati Uniti
- Research Site
-
Hendersonville, Tennessee, Stati Uniti
- Research Site
-
Jefferson City, Tennessee, Stati Uniti
- Research Site
-
Johnson City, Tennessee, Stati Uniti
- Research Site
-
Memphis, Tennessee, Stati Uniti
- Research Site
-
Morristown, Tennessee, Stati Uniti
- Research Site
-
Nashville, Tennessee, Stati Uniti
- Research Site
-
-
Texas
-
Arlington, Texas, Stati Uniti
- Research Site
-
Austin, Texas, Stati Uniti
- Research Site
-
Carrollton, Texas, Stati Uniti
- Research Site
-
Colleyville, Texas, Stati Uniti
- Research Site
-
Corpus Christi, Texas, Stati Uniti
- Research Site
-
Dallas, Texas, Stati Uniti
- Research Site
-
El Paso, Texas, Stati Uniti
- Research Site
-
Fort Worth, Texas, Stati Uniti
- Research Site
-
Friendswood, Texas, Stati Uniti
- Research Site
-
Ft Worth, Texas, Stati Uniti
- Research Site
-
Grapevine, Texas, Stati Uniti
- Research Site
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Houston, Texas, Stati Uniti
- Research Site
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Irving, Texas, Stati Uniti
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Lake Jackson, Texas, Stati Uniti
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Lubbock, Texas, Stati Uniti
- Research Site
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N Richland Hills, Texas, Stati Uniti
- Research Site
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New Braunfels, Texas, Stati Uniti
- Research Site
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Pharr, Texas, Stati Uniti
- Research Site
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Plano, Texas, Stati Uniti
- Research Site
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San Antonio, Texas, Stati Uniti
- Research Site
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Seguin, Texas, Stati Uniti
- Research Site
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Sugar Land, Texas, Stati Uniti
- Research Site
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The Woodlands, Texas, Stati Uniti
- Research Site
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Tyler, Texas, Stati Uniti
- Research Site
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Utah
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Bountiful, Utah, Stati Uniti
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Nephi, Utah, Stati Uniti
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Salt Lake City, Utah, Stati Uniti
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Vermont
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Burlington, Vermont, Stati Uniti
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Virginia
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Alexandria, Virginia, Stati Uniti
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Arlington, Virginia, Stati Uniti
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Burke, Virginia, Stati Uniti
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Charlottesville, Virginia, Stati Uniti
- Research Site
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Hampton, Virginia, Stati Uniti
- Research Site
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Hayes, Virginia, Stati Uniti
- Research Site
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Norfolk, Virginia, Stati Uniti
- Research Site
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Quinton, Virginia, Stati Uniti
- Research Site
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Richmond, Virginia, Stati Uniti
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Springfield, Virginia, Stati Uniti
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Stuart, Virginia, Stati Uniti
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Suffolk, Virginia, Stati Uniti
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Weber City, Virginia, Stati Uniti
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Yorktown, Virginia, Stati Uniti
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Washington
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Burien, Washington, Stati Uniti
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Everett, Washington, Stati Uniti
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Gig Harbor, Washington, Stati Uniti
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Olympia, Washington, Stati Uniti
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Seattle, Washington, Stati Uniti
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Spokane, Washington, Stati Uniti
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Wenatchee, Washington, Stati Uniti
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West Virginia
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Charleston, West Virginia, Stati Uniti
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Lewisburg, West Virginia, Stati Uniti
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Wisconsin
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Beloit, Wisconsin, Stati Uniti
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Green Bay, Wisconsin, Stati Uniti
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Madison, Wisconsin, Stati Uniti
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Menomonee Falls, Wisconsin, Stati Uniti
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Milwaukee, Wisconsin, Stati Uniti
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Benoni, Sud Africa
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Halfway House, Sud Africa
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Johannesburg, Sud Africa
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Lakeview, Retreat, Sud Africa
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Rustenburg, Sud Africa
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Somerset West, Sud Africa
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Vanderbijlpark, Sud Africa
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Worcester, Sud Africa
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Cape Province
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Claremont, Cape Province, Sud Africa
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Cape Town
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Athlone, Cape Town, Sud Africa
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Gauteng
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Florida Park, Gauteng, Sud Africa
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Lenasia, Gauteng, Sud Africa
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Pretoria, Gauteng, Sud Africa
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Witbank, Gauteng, Sud Africa
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Kwazulu Natal
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Durban, Kwazulu Natal, Sud Africa
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Umkomaas, Kwazulu Natal, Sud Africa
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Morningside
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Morningside Manor, Morningside, Sud Africa
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Port Elizabeth
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Korsten, Port Elizabeth, Sud Africa
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Pretoria
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Hillcrest, Pretoria, Sud Africa
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Schweiz
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Olten, Schweiz, Svizzera
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Montevideo, Uruguay
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Caracas, Venezuela
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Puerto Ordaz, Estado Bolivar, Venezuela
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Estado Carabobo
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Estado Lara
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Estado Zulia
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Municipio Baruta
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Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
50 anni e precedenti (ADULTO, ANZIANO_ADULTO)
Accetta volontari sani
No
Sessi ammissibili allo studio
Tutto
Descrizione
Criterio di inclusione:
- Uomini di età pari o superiore a 50 anni, donne di età pari o superiore a 60 anni
- Livelli da bassi a normali di colesterolo lipoproteico a bassa densità (LDL) (< 130 mg/dL)
- Livelli elevati di proteina C-reattiva (PCR) > 2,0 mg/L
Criteri di esclusione:
- Storia di eventi cardiovascolari o cerebrovascolari
- Malattia epatica attiva
- Diabete mellito
- Ipertensione incontrollata o ipotiroidismo
- Storia di alcuni tumori maligni
- Condizioni infiammatorie croniche
- Storia di abuso di alcol o droghe
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: PREVENZIONE
- Assegnazione: RANDOMIZZATO
- Modello interventistico: PARALLELO
- Mascheramento: QUADRUPLICARE
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
PLACEBO_COMPARATORE: Placebo
Placebo una volta al giorno
|
Orale
|
|
SPERIMENTALE: Rosuvastatina
Rosuvastatina 20 mg una volta al giorno
|
Orale
Altri nomi:
|
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Tempo all'evento cardiaco maggiore (morte cardiovascolare, ictus, infarto miocardico, ricovero dovuto ad angina instabile o rivascolarizzazione arteriosa)
Lasso di tempo: fino a 5 anni
|
Giorni dalla randomizzazione al primo di morte CV, ictus, IM, ricovero per angina instabile o rivascolarizzazione arteriosa.
In assenza di eventi, la censura si verifica prima della data di cessazione o della data limite di efficacia del 30 marzo 2008.
Gli eventi sono stati giudicati da un comitato endpoint.
Stima di Kaplan-Meier della media
|
fino a 5 anni
|
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Tempo di morte per qualsiasi causa
Lasso di tempo: fino a 5 anni
|
Giorni dalla randomizzazione alla morte.
Se non ci sono decessi, la censura si verifica prima della data di cessazione o della data limite di efficacia del 30 marzo 2008.
Stima di Kaplan-Meier della media
|
fino a 5 anni
|
|
Tempo alla morte non cardiovascolare
Lasso di tempo: fino a 5 anni
|
Giorni dalla randomizzazione alla morte per causa non cardiovascolare.
In assenza di eventi, la censura si verifica prima della data di cessazione o della data limite di efficacia del 30 marzo 2008.
Gli eventi sono stati giudicati da un comitato endpoint.
Stima di Kaplan-Meier della media
|
fino a 5 anni
|
|
Tempo di sviluppo del diabete mellito
Lasso di tempo: fino a 5 anni
|
Giorni dalla randomizzazione fino allo sviluppo del diabete.
Se non è stato sviluppato alcun diabete, la censura è avvenuta alla data di cessazione.
Stima di Kaplan-Meier della media
|
fino a 5 anni
|
|
Tempo di evento tromboembolico venoso
Lasso di tempo: fino a 5 anni
|
Tempo dalla randomizzazione al primo evento tromboembolico venoso.
Stima di Kaplan-Meier della media
|
fino a 5 anni
|
|
Tempo di frattura ossea
Lasso di tempo: Fino a 5 anni
|
Giorni dalla randomizzazione fino alla frattura ossea.
In assenza di eventi, la censura si verifica prima della data di cessazione o della data limite di efficacia del 30 marzo 2008.
Stima di Kaplan-Meier della media
|
Fino a 5 anni
|
Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Investigatori
- Direttore dello studio: Judith Hsia, MD, AstraZeneca
- Cattedra di studio: Paul Ridker, MD, Brigham and Women's Hospital
Pubblicazioni e link utili
La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.
Pubblicazioni generali
- Ajala ON, Demler OV, Liu Y, Farukhi Z, Adelman SJ, Collins HL, Ridker PM, Rader DJ, Glynn RJ, Mora S. Anti-Inflammatory HDL Function, Incident Cardiovascular Events, and Mortality: A Secondary Analysis of the JUPITER Randomized Clinical Trial. J Am Heart Assoc. 2020 Sep;9(17):e016507. doi: 10.1161/JAHA.119.016507. Epub 2020 Aug 15.
- Akinkuolie AO, Lawler PR, Chu AY, Caulfield M, Mu J, Ding B, Nyberg F, Glynn RJ, Ridker PM, Hurt-Camejo E, Chasman DI, Mora S. Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1182-1190. doi: 10.1161/ATVBAHA.118.311894.
- Dagenais GR, Jung H, Lonn E, Bogaty PM, Dehghan M, Held C, Avezum A, Jansky P, Keltai M, Leiter LA, Lopez-Jaramillo P, Toff WD, Bosch J, Yusuf S. Effects of Lipid-Lowering and Antihypertensive Treatments in Addition to Healthy Lifestyles in Primary Prevention: An Analysis of the HOPE-3 Trial. J Am Heart Assoc. 2018 Jul 22;7(15):e008918. doi: 10.1161/JAHA.118.008918.
- Khera AV, Demler OV, Adelman SJ, Collins HL, Glynn RJ, Ridker PM, Rader DJ, Mora S. Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin). Circulation. 2017 Jun 20;135(25):2494-2504. doi: 10.1161/CIRCULATIONAHA.116.025678. Epub 2017 Apr 27.
- Akinkuolie AO, Glynn RJ, Padmanabhan L, Ridker PM, Mora S. Circulating N-Linked Glycoprotein Side-Chain Biomarker, Rosuvastatin Therapy, and Incident Cardiovascular Disease: An Analysis From the JUPITER Trial. J Am Heart Assoc. 2016 Jul 13;5(7):e003822. doi: 10.1161/JAHA.116.003822.
- Dugani SB, Akinkuolie AO, Paynter N, Glynn RJ, Ridker PM, Mora S. Association of Lipoproteins, Insulin Resistance, and Rosuvastatin With Incident Type 2 Diabetes Mellitus : Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2016 May 1;1(2):136-45. doi: 10.1001/jamacardio.2016.0096.
- Lawler PR, Akinkuolie AO, Chandler PD, Moorthy MV, Vandenburgh MJ, Schaumberg DA, Lee IM, Glynn RJ, Ridker PM, Buring JE, Mora S. Circulating N-Linked Glycoprotein Acetyls and Longitudinal Mortality Risk. Circ Res. 2016 Apr 1;118(7):1106-15. doi: 10.1161/CIRCRESAHA.115.308078. Epub 2016 Mar 7.
- Mora S, Caulfield MP, Wohlgemuth J, Chen Z, Superko HR, Rowland CM, Glynn RJ, Ridker PM, Krauss RM. Atherogenic Lipoprotein Subfractions Determined by Ion Mobility and First Cardiovascular Events After Random Allocation to High-Intensity Statin or Placebo: The Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial. Circulation. 2015 Dec 8;132(23):2220-9. doi: 10.1161/CIRCULATIONAHA.115.016857. Epub 2015 Sep 25.
- Chu AY, Giulianini F, Barratt BJ, Ding B, Nyberg F, Mora S, Ridker PM, Chasman DI. Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein-Related Measures. Circ Cardiovasc Genet. 2015 Oct;8(5):688-95. doi: 10.1161/CIRCGENETICS.114.000962. Epub 2015 Aug 13.
- Everett BM, Zeller T, Glynn RJ, Ridker PM, Blankenberg S. High-sensitivity cardiac troponin I and B-type natriuretic Peptide as predictors of vascular events in primary prevention: impact of statin therapy. Circulation. 2015 May 26;131(21):1851-60. doi: 10.1161/CIRCULATIONAHA.114.014522. Epub 2015 Mar 30.
- Everett BM, Mora S, Glynn RJ, MacFadyen J, Ridker PM. Safety profile of subjects treated to very low low-density lipoprotein cholesterol levels (<30 mg/dl) with rosuvastatin 20 mg daily (from JUPITER). Am J Cardiol. 2014 Dec 1;114(11):1682-9. doi: 10.1016/j.amjcard.2014.08.041. Epub 2014 Sep 16.
- Pena JM, Aspberg S, MacFadyen J, Glynn RJ, Solomon DH, Ridker PM. Statin therapy and risk of fracture: results from the JUPITER randomized clinical trial. JAMA Intern Med. 2015 Feb;175(2):171-7. doi: 10.1001/jamainternmed.2014.6388.
- Khera AV, Everett BM, Caulfield MP, Hantash FM, Wohlgemuth J, Ridker PM, Mora S. Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: an analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin). Circulation. 2014 Feb 11;129(6):635-42. doi: 10.1161/CIRCULATIONAHA.113.004406. Epub 2013 Nov 17.
- Mora S, Glynn RJ, Ridker PM. High-density lipoprotein cholesterol, size, particle number, and residual vascular risk after potent statin therapy. Circulation. 2013 Sep 10;128(11):1189-97. doi: 10.1161/CIRCULATIONAHA.113.002671. Epub 2013 Sep 3.
- Ridker PM, Pradhan A, MacFadyen JG, Libby P, Glynn RJ. Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial. Lancet. 2012 Aug 11;380(9841):565-71. doi: 10.1016/S0140-6736(12)61190-8.
- Mora S, Glynn RJ, Boekholdt SM, Nordestgaard BG, Kastelein JJ, Ridker PM. On-treatment non-high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin). J Am Coll Cardiol. 2012 Apr 24;59(17):1521-8. doi: 10.1016/j.jacc.2011.12.035.
- Stein EA, Vidt DG, Shepherd J, Cain VA, Anzalone D, Cressman MD. Renal safety of intensive cholesterol-lowering treatment with rosuvastatin: a retrospective analysis of renal adverse events among 40,600 participants in the rosuvastatin clinical development program. Atherosclerosis. 2012 Apr;221(2):471-7. doi: 10.1016/j.atherosclerosis.2011.12.011. Epub 2012 Jan 3.
- Dorresteijn JA, Visseren FL, Ridker PM, Wassink AM, Paynter NP, Steyerberg EW, van der Graaf Y, Cook NR. Estimating treatment effects for individual patients based on the results of randomised clinical trials. BMJ. 2011 Oct 3;343:d5888. doi: 10.1136/bmj.d5888.
- Albert MA, Glynn RJ, Fonseca FA, Lorenzatti AJ, Ferdinand KC, MacFadyen JG, Ridker PM. Race, ethnicity, and the efficacy of rosuvastatin in primary prevention: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Am Heart J. 2011 Jul;162(1):106-14.e2. doi: 10.1016/j.ahj.2011.03.032. Epub 2011 Jun 12.
- Ridker PM, MacFadyen JG, Glynn RJ, Chasman DI. Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention. Circ Cardiovasc Genet. 2011 Jun;4(3):312-7. doi: 10.1161/CIRCGENETICS.110.959353. Epub 2011 Apr 14.
- Koenig W, Ridker PM. Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk >/= 5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities. Eur Heart J. 2011 Jan;32(1):75-83. doi: 10.1093/eurheartj/ehq370. Epub 2010 Oct 22.
- Ridker PM, Macfadyen JG, Nordestgaard BG, Koenig W, Kastelein JJ, Genest J, Glynn RJ. Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk". Circ Cardiovasc Qual Outcomes. 2010 Sep;3(5):447-52. doi: 10.1161/CIRCOUTCOMES.110.938118. Epub 2010 Aug 24.
- Ridker PM, Genest J, Boekholdt SM, Libby P, Gotto AM, Nordestgaard BG, Mora S, MacFadyen JG, Glynn RJ, Kastelein JJ; JUPITER Trial Study Group. HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial. Lancet. 2010 Jul 31;376(9738):333-9. doi: 10.1016/S0140-6736(10)60713-1. Epub 2010 Jul 23.
- Ridker PM, MacFadyen J, Cressman M, Glynn RJ. Efficacy of rosuvastatin among men and women with moderate chronic kidney disease and elevated high-sensitivity C-reactive protein: a secondary analysis from the JUPITER (Justification for the Use of Statins in Prevention-an Intervention Trial Evaluating Rosuvastatin) trial. J Am Coll Cardiol. 2010 Mar 23;55(12):1266-1273. doi: 10.1016/j.jacc.2010.01.020. Epub 2010 Mar 4.
- Mora S, Glynn RJ, Hsia J, MacFadyen JG, Genest J, Ridker PM. Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and meta-analysis of women from primary prevention trials. Circulation. 2010 Mar 9;121(9):1069-77. doi: 10.1161/CIRCULATIONAHA.109.906479. Epub 2010 Feb 22.
- Ridker PM, MacFadyen JG, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER). Circ Cardiovasc Qual Outcomes. 2009 Nov;2(6):616-23. doi: 10.1161/CIRCOUTCOMES.109.848473. Epub 2009 Sep 22.
- Everett BM, Glynn RJ, MacFadyen JG, Ridker PM. Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). Circulation. 2010 Jan 5;121(1):143-50. doi: 10.1161/CIRCULATIONAHA.109.874834. Epub 2009 Dec 21.
- Glynn RJ, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Ridker PM. A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med. 2009 Apr 30;360(18):1851-61. doi: 10.1056/NEJMoa0900241. Epub 2009 Mar 29.
- Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, Macfadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Trial Study Group. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet. 2009 Apr 4;373(9670):1175-82. doi: 10.1016/S0140-6736(09)60447-5. Epub 2009 Mar 28.
- Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008 Nov 20;359(21):2195-207. doi: 10.1056/NEJMoa0807646. Epub 2008 Nov 9.
Collegamenti utili
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio
1 febbraio 2003
Completamento primario (EFFETTIVO)
1 settembre 2008
Completamento dello studio (EFFETTIVO)
1 settembre 2008
Date di iscrizione allo studio
Primo inviato
13 ottobre 2005
Primo inviato che soddisfa i criteri di controllo qualità
13 ottobre 2005
Primo Inserito (STIMA)
17 ottobre 2005
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (STIMA)
24 marzo 2014
Ultimo aggiornamento inviato che soddisfa i criteri QC
6 febbraio 2014
Ultimo verificato
1 febbraio 2014
Maggiori informazioni
Termini relativi a questo studio
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- D3560L00030
- Jupiter
- 4522US/0011
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .