Genetic Determinants of the Metabolism of Non-nucleoside Reverse Transcriptase Inhibitors

Inclusion Criteria:

• Healthy African American men and women.
• 18-55 years of age.
• Willing and able to provide written informed consent.

Exclusion Criteria:

• Currently or recently (within the previous 30 days) received medications known or likely to be metabolized by, or interact wth the CYP450 enzymes.
• Prior or current hepatic or psychiatric disease illness that in the judgment of the investigator would interfere in the study performance.
• Active alcohol or illicit drug abuse use that in the judgment of the investigator would interfere in the study performance.
• Alanine Aminotransferase (ALT) or Aspartate Aminotransferase (AST) >1.5 X upper limit of normal.
• Positive pregnancy test in women of childbearing potential.