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Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension

23 luglio 2016 aggiornato da: Dr. Sara Jaison, Nitte University

Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension: A Prospective Randomised Controlled Study

Propofol is an intravenous anaesthetic agent used for both induction and maintenance of anaesthesia. An important adverse effect is the significant fall in blood pressure. The current clinical study will be done to determine the efficacy of leg elevation and wrapping in reducing the incidence and severity of propofol induced hypotension in patients undergoing general anaesthesia.

Panoramica dello studio

Stato

Sconosciuto

Condizioni

Intervento / Trattamento

Descrizione dettagliata

Propofol is an intravenous anaesthetic agent used for both induction and maintenance of anaesthesia. It is widely employed due to its quick onset of action, short half life and rapid recovery. An important adverse effect is the significant fall in blood pressure. Although the exact mechanism of propofol induced hypotension is not known, venodilation, decreased peripheral resistance and decrease in cardiac output has been suggested.2 Though the hypotension is transient, it can produce devastating effects. Hence there is a need to prevent it. Moreover, several attempts at treating propofol induced hypotension have been met with variable and limited success.

Hypotension following spinal anaesthesia is also a frequent problem. It is generally treated with intravenous fluids and vasopressors. Simple and non pharmacological measures like leg elevation and leg wrapping with Esmarch bandage were reported to be successful.3 These reduce the incidence and severity of hypotension associated with spinal anaesthesia by improving the venous return.

The mechanisms of hypotension following intravenous propofol and spinal anaesthesia are almost similar. Therefore, the investigators hypothesize that leg elevation and wrapping can be attempted to reduce propofol induced hypotension. They are simple and cost effective techniques that will reduce the need for pharmacological measures to control hypotension. As the literature search did not reveal any information regarding the usefulness of these techniques in propofol induced hypotension, the current clinical study will be done to determine the efficacy of leg elevation and wrapping in reducing the incidence and severity of propofol induced hypotension in patients undergoing general anaesthesia.

The current study will compare the efficacy of leg elevation and leg wrapping in reducing the incidence and severity of propofol induced hypotension in terms of incidence of hypotension, magnitude of decrease in systolic, diastolic and mean arterial blood pressures, need for pharmacological measures to treat hypotension, changes in heart rate and adverse clinical outcomes, if any. It will be a prospective randomised controlled open label study from January 2016 to August 2017 involving 150 adult patients undergoing general anaesthesia.

For statistical analysis, descriptive statistics - minimum, maximum, mean and standard deviation will be used. Independent sample t test for data following normal distribution and for data not following normal distribution, Mann-Whitney U test will be used. P value less than 0.05 will be considered statistically significant. To study relationship between hypotension and other variables, Pearson's correlation will be used. Confidence interval will be calculated to 95%.

Tipo di studio

Interventistico

Iscrizione (Anticipato)

150

Fase

  • Non applicabile

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

  • India
    • Dakshina Kannada
      • Mangalore, Dakshina Kannada, India, 575018
        • Reclutamento
        • Justice K. S. Hegde Hospital, K S Hegde Medical Academy, Nitte University
        • Contatto:
        • Contatto:
        • Investigatore principale:
          • Sara Jaison, MBBS

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

Da 18 anni a 60 anni (Adulto)

Accetta volontari sani

No

Sessi ammissibili allo studio

Tutto

Descrizione

Inclusion Criteria:

  • Patients belonging to ASA physical status I and II undergoing endotracheal general anaesthesia

Exclusion Criteria:

  • Patient refusal
  • Contraindication to application of bandage
  • Partial or complete limb amputation
  • Difficult airway
  • Use of extraglottic airway device
  • Pregnancy
  • On antihypertensive or vasoactive medication
  • Autonomic neuropathy

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Prevenzione
  • Assegnazione: Randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Nessuno (etichetta aperta)

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Comparatore placebo: Group C Control
Patient will be shifted to operation theatre. Electrocardiography (ECG), pulse oximeter and non-invasive blood pressure (NIBP) monitors will be attached. Baseline vitals will be noted. Intravenous access will be secured and crystalloids at 100ml/hr will be given. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be neither elevated or wrapped. Vitals will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Muscle relaxation will be achieved by inj. vecuronium 0.1mg/kg body weight. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube.
Altro: control
no intervention has been done
Sperimentale: Group E Leg elevation
Patient will be shifted to operation theatre. Crystalloids at 100ml/hr will be given. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs are elevated and supported on a stand making an angle of 30 degree to the horizontal. Vitals will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Muscle relaxation will be achieved by inj. vecuronium 0.1mg/kg body weight. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Stand will be removed and legs will be brought to horizontal position 10 minutes after intubation.
Altro: leg elevation
A stand making an angle of 30 degree to the horizontal is used to elevate both the legs
Sperimentale: Group W Leg wrapping
Patient will be shifted to operation theatre. Crystalloids at 100ml/hr will be given. Analgesia will be given by inj fentanyl. Each lower limb will be elevated alternately and wrapped from toe to mid-thigh with Esmarch bandage. Care will be taken to avoid compressing the legs to greater than arterial pressure by confirming the presence of pulse using a saturation probe. Following wrapping, the lower limbs will be brought to horizontal position. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol injected over 30 seconds. Muscle relaxation by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Esmarch bandage will be removed 10 minutes after intubation.
Altro: leg wrapping
Esmarch bandage is used to wrap each lower limb

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
incidence of hypotension at baseline
Lasso di tempo: baseline
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
baseline
incidence of hypotension at 0 minutes after leg elevation or wrapping
Lasso di tempo: 0 minutes after leg elevation or wrapping
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
0 minutes after leg elevation or wrapping
incidence of hypotension at 0 minutes after induction with propofol
Lasso di tempo: 0 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
0 minutes after induction with propofol
incidence of hypotension at 1 minute after induction
Lasso di tempo: 1 minute after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
1 minute after induction
incidence of hypotension at 2 minutes after induction
Lasso di tempo: 2 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
2 minutes after induction
incidence of hypotension at 3 minutes after induction
Lasso di tempo: 3 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
3 minutes after induction
incidence of hypotension at 4 minutes after induction
Lasso di tempo: 4 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
4 minutes after induction
incidence of hypotension at 5 minutes after induction
Lasso di tempo: 5 minutes after induction
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
5 minutes after induction
incidence of hypotension at 0 minutes after intubation
Lasso di tempo: 0 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
0 minutes after intubation
incidence of hypotension at 1 minute after intubation
Lasso di tempo: 1 minute after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
1 minute after intubation
incidence of hypotension at 2 minutes after intubation
Lasso di tempo: 2 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
2 minutes after intubation
incidence of hypotension at 3 minutes after intubation
Lasso di tempo: 3 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
3 minutes after intubation
incidence of hypotension at 4 minutes after intubation
Lasso di tempo: 4 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
4 minutes after intubation
incidence of hypotension at 5 minutes after intubation
Lasso di tempo: 5 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
5 minutes after intubation
incidence of hypotension at 6 minutes after intubation
Lasso di tempo: 6 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
6 minutes after intubation
incidence of hypotension at 7 minutes after intubation
Lasso di tempo: 7 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
7 minutes after intubation
incidence of hypotension at 8 minutes after intubation
Lasso di tempo: 8 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
8 minutes after intubation
incidence of hypotension at 9 minutes after intubation
Lasso di tempo: 9 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
9 minutes after intubation
incidence of hypotension at 10 minutes after intubation
Lasso di tempo: 10 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline blood pressure including systolic, diastolic and mean arterial blood pressures will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Blood pressures will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Blood pressures will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Hypotension will be defined as a drop in systolic blood pressure to less than 30% of baseline values or to MAP <60mm Hg. Incidence of hypotension will be noted.
10 minutes after intubation

Misure di risultato secondarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Magnitude of change in systolic blood pressure from baseline at 0 minutes after leg leg elevation or wrapping
Lasso di tempo: baseline, after leg elevation or wrapping
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, after leg elevation or wrapping
Magnitude of change in systolic blood pressure from baseline at 0 minutes after induction
Lasso di tempo: baseline, at 0 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 0 minutes after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 1 minute after induction
Lasso di tempo: baseline, at 1 minute after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 1 minute after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 2 minutes after induction
Lasso di tempo: baseline, at 2 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 2 minutes after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 3 minutes after induction
Lasso di tempo: baseline, at 3 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 3 minutes after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 4 minutes after induction
Lasso di tempo: baseline, at 4 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 4 minutes after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 5 minutes after induction
Lasso di tempo: baseline, at 5 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 5 minutes after induction with propofol
Magnitude of change in systolic blood pressure from baseline at 0 minutes after intubation
Lasso di tempo: baseline, at 0 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 0 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 1 minute after intubation
Lasso di tempo: baseline, at 1 minute after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 1 minute after intubation
Magnitude of change in systolic blood pressure from baseline at 2 minutes after intubation
Lasso di tempo: baseline, at 2 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 2 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 3 minutes after intubation
Lasso di tempo: baseline, at 3 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 3 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 4 minutes after intubation
Lasso di tempo: baseline, at 4 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 4 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 5 minutes after intubation
Lasso di tempo: baseline, at 5 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 5 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 6 minutes after intubation
Lasso di tempo: baseline, at 6 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 6 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 7 minutes after intubation
Lasso di tempo: baseline, at 7 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 7 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 8 minutes after intubation
Lasso di tempo: baseline, at 8 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 8 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 9 minutes after intubation
Lasso di tempo: baseline, at 9 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 9 minutes after intubation
Magnitude of change in systolic blood pressure from baseline at 10 minutes after intubation
Lasso di tempo: baseline, at 10 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline systolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Systolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Systolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Systolic blood pressure will be recorded every minute till 10 min post intubation. Magnitude of change in systolic blood pressure from baseline will be noted
baseline, at 10 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 0 minutes after leg elevation or wrapping
Lasso di tempo: baseline, at 0 minutes after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 0 minutes after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Magnitude of change in diastolic blood pressure from baseline at 0 minutes after induction with propofol
Lasso di tempo: baseline, at 0 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 0 minutes after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 1 minute after induction with propofol
Lasso di tempo: baseline, at 1 minute after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 1 minute after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 2 minutes after induction with propofol
Lasso di tempo: baseline, at 2 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 2 minutes after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 3 minutes after induction with propofol
Lasso di tempo: baseline, at 3 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 3 minutes after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 4 minutes after induction with propofol
Lasso di tempo: baseline, at 4 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 4 minutes after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 5 minutes after induction with propofol
Lasso di tempo: baseline, at 5 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 5 minutes after induction with propofol
Magnitude of change in diastolic blood pressure from baseline at 0 minutes after intubation
Lasso di tempo: baseline, at 0 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 0 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 1 minute after intubation
Lasso di tempo: baseline, at 1 minute after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 1 minute after intubation
Magnitude of change in diastolic blood pressure from baseline at 2 minutes after intubation
Lasso di tempo: baseline, at 2 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 2 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 3 minutes after intubation
Lasso di tempo: baseline, at 3 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 3 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 4 minutes after intubation
Lasso di tempo: baseline, at 4 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 4 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 5 minutes after intubation
Lasso di tempo: baseline, at 5 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 5 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 6 minutes after intubation
Lasso di tempo: baseline, at 6 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 6 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 7 minutes after intubation
Lasso di tempo: baseline, at 7 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 7 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 8 minutes after intubation
Lasso di tempo: baseline, at 8 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 8 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 9 minutes after intubation
Lasso di tempo: baseline, at 9 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 9 minutes after intubation
Magnitude of change in diastolic blood pressure from baseline at 10 minutes after intubation
Lasso di tempo: baseline, at 10 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline diastolic blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Diastolic blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Diastolic blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in diastolic blood pressure from baseline will be noted.
baseline, at 10 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 0 minutes after leg elevation or wrapping
Lasso di tempo: baseline, 0 minutes after leg elevation or wrapping
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 0 minutes after leg elevation or wrapping
Magnitude of change in mean arterial blood pressure from baseline at 1 minute after induction with propofol
Lasso di tempo: baseline, 0 minute after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 0 minute after induction with propofol
Magnitude of change in mean arterial blood pressure from baseline at 2 minutes after induction with propofol
Lasso di tempo: baseline, 2 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 2 minutes after induction with propofol
Magnitude of change in mean arterial blood pressure from baseline at 3 minutes after induction with propofol
Lasso di tempo: baseline, 3 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 3 minutes after induction with propofol
Magnitude of change in mean arterial blood pressure from baseline at 4 minutes after induction with propofol
Lasso di tempo: baseline, 4 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 4 minutes after induction with propofol
Magnitude of change in mean arterial blood pressure from baseline at 5 minutes after induction with propofol
Lasso di tempo: baseline, 5 minutes after induction with propofol
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 5 minutes after induction with propofol
Magnitude of change in mean arterial blood pressure from baseline at 0 minute after intubation
Lasso di tempo: baseline, 0 minute after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 0 minute after intubation
Magnitude of change in mean arterial blood pressure from baseline at 1 minutes after intubation
Lasso di tempo: baseline, 1 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 1 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 2 minutes after intubation
Lasso di tempo: baseline, 2 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 2 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 3 minutes after intubation
Lasso di tempo: baseline, 3 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 3 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 4 minutes after intubation
Lasso di tempo: baseline, 4 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 4 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 5 minutes after intubation
Lasso di tempo: baseline, 5 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 5 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 6 minutes after intubation
Lasso di tempo: baseline, 6 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 6 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 7 minutes after intubation
Lasso di tempo: baseline, 7 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 7 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 8 minutes after intubation
Lasso di tempo: baseline, 8 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 8 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 9 minutes after intubation
Lasso di tempo: baseline, 9 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 9 minutes after intubation
Magnitude of change in mean arterial blood pressure from baseline at 10 minutes after intubation
Lasso di tempo: baseline, 10 minutes after intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. Mean arterial blood pressure will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Mean arterial blood pressure will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Magnitude of change in mean arterial blood pressure from baseline will be noted
baseline, 10 minutes after intubation
changes in heart rate from baseline at 0 minutes after leg elevation or wrapping
Lasso di tempo: baseline, 0 minutes after leg elevation or wrapping
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 0 minutes after leg elevation or wrapping
changes in heart rate from baseline at 0 minutes after induction with propofol
Lasso di tempo: baseline, 0 minute after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 0 minute after induction with propofol
changes in heart rate from baseline at 1 minutes after induction with propofol
Lasso di tempo: baseline, 1 minutes after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 1 minutes after induction with propofol
changes in heart rate from baseline at 2 minutes after induction with propofol
Lasso di tempo: baseline, 2 minutes after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 2 minutes after induction with propofol
changes in heart rate from baseline at 3 minutes after induction with propofol
Lasso di tempo: baseline, 3 minutes after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 3 minutes after induction with propofol
changes in heart rate from baseline at 4 minutes after induction with propofol
Lasso di tempo: baseline, 4 minutes after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 4 minutes after induction with propofol
changes in heart rate from baseline at 5 minutes after induction with propofol
Lasso di tempo: baseline, 5 minutes after induction with propofol
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 5 minutes after induction with propofol
changes in heart rate from baseline at 0 minutes after intubation
Lasso di tempo: baseline, 0 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 0 minutes after intubation
changes in heart rate from baseline at 1 minute after intubation
Lasso di tempo: baseline, 1 minute after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 1 minute after intubation
changes in heart rate from baseline at 2 minutes after intubation
Lasso di tempo: baseline, 2 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 2 minutes after intubation
changes in heart rate from baseline at 3 minutes after intubation
Lasso di tempo: baseline, 3 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 3 minutes after intubation
changes in heart rate from baseline at 4 minutes after intubation
Lasso di tempo: baseline, 4 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 4 minutes after intubation
changes in heart rate from baseline at 5 minutes after intubation
Lasso di tempo: baseline, 5 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 5 minutes after intubation
changes in heart rate from baseline at 6 minutes after intubation
Lasso di tempo: baseline, 6 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 6 minutes after intubation
changes in heart rate from baseline at 7 minutes after intubation
Lasso di tempo: baseline, 7 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 7 minutes after intubation
changes in heart rate from baseline at 8 minutes after intubation
Lasso di tempo: baseline, 8 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 8 minutes after intubation
changes in heart rate from baseline at 9 minutes after intubation
Lasso di tempo: baseline, 9 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 9 minutes after intubation
changes in heart rate from baseline at 10 minutes after intubation
Lasso di tempo: baseline, 10 minutes after intubation
Patient will be shifted to operation theatre. Baseline heart rate will be noted. Analgesia will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be elevated, wrapped or none according to group allocation. Heart rate will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Heart rate will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation will be achieved by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Heart rate will be recorded every minute till 10 min post intubation. Changes in heart rate from baseline will be noted
baseline, 10 minutes after intubation

Altre misure di risultato

Misura del risultato
Misura Descrizione
Lasso di tempo
Need for pharmacological measures to treat hypotension
Lasso di tempo: baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Patient will be shifted to operation theatre. Non-invasive blood pressure (NIBP) monitor will be attached. Baseline mean arterial blood pressure (MAP) will be noted. Analgesia will be given by inj fentanyl. Lower limbs will be elevated, wrapped or none according to group allocation. MAP will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol. MAP will be noted at induction with propofol and for every minute till 5 minutes after induction. Muscle relaxation by inj. vecuronium. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed. MAP<55mm Hg will be treated by rapid intravenous fluid administration and by intravenous mephentermine 6mg bolus increments every minute until the systolic pressure rises to greater than 70% of baseline or to above 90mm Hg. Total dose of mephentermine required will be noted.
baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Tachycardia
Lasso di tempo: baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Tachycardia will be defined as heart rate more than 100bpm or increase by more than 30% over baseline value. Any incidence of tachycardia during the procedure will be noted
baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Bradycardia
Lasso di tempo: baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Bradycardia will be defined as heart rate less than 50bpm or decrease by more than 30% below baseline value. Any incidence of bradycardia during the procedure will be noted
baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
Arrhythmia
Lasso di tempo: baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation
any incidence of arrhythmia during the procedure will be noted
baseline, after leg elevation or wrapping, at induction with propofol, every minute till 5 minutes after induction, at intubation and every minute thereafter upto 10 min post intubation

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

Nitte University

Investigatori

  • Direttore dello studio: Sripada G Mehandale, MBBS, MD, Associate Professor

Pubblicazioni e link utili

La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.

Pubblicazioni generali

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio

1 gennaio 2016

Completamento primario (Anticipato)

1 agosto 2017

Completamento dello studio (Anticipato)

1 dicembre 2017

Date di iscrizione allo studio

Primo inviato

30 giugno 2016

Primo inviato che soddisfa i criteri di controllo qualità

23 luglio 2016

Primo Inserito (Stima)

27 luglio 2016

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Stima)

27 luglio 2016

Ultimo aggiornamento inviato che soddisfa i criteri QC

23 luglio 2016

Ultimo verificato

1 luglio 2016

Maggiori informazioni

Termini relativi a questo studio

Parole chiave

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

  • INST.EC/EC/066/2015-16

Piano per i dati dei singoli partecipanti (IPD)

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Descrizione del piano IPD

Age, sex, weight, diagnosis, surgery, asa physical status, heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure

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