Exploring the Genetics of Schizophrenia in Manitoba (GENES-MB)
12 giugno 2026 aggiornato da: Kaarina Kowalec, University of Manitoba
Uncovering Schizophrenia Genetics Through Whole Genome Sequencing Across Manitoba
Schizophrenia is a serious mental illness that affects about 1 in 100 Canadians, shortens life expectancy, and places a large burden on individuals, families, and the healthcare system.
Genetics are known to play a major role, but current research explains only part of the inherited risk because most studies have looked at only a small portion of the genome and have mainly focused on people outside Canada.
This project will create the first large-scale Manitoba-based schizophrenia whole-genome sequencing database by studying 1,500 Manitobans with and without schizophrenia using both short-read and advanced long-read genome sequencing technologies.
Researchers will combine genetic data with lifelong provincial health records to better understand rare genetic variants linked to schizophrenia and how genetic differences influence medication response, side effects, hospitalizations, and treatment outcomes.
The study aims to fill important gaps in schizophrenia research in Canada, improve understanding of the disorder's biology, and support the development of more personalized and effective treatments for people living with schizophrenia.
Panoramica dello studio
Stato
Non ancora reclutamento
Condizioni
Descrizione dettagliata
This study aims to better understand the genetic factors involved in schizophrenia by collecting saliva samples from people with schizophrenia and individuals without psychiatric disorders across Manitoba.
Researchers will use advanced genome sequencing to examine differences in genetic variation and identify genes that may contribute to schizophrenia.
By combining genetic information with health and clinical data, this research will help improve our understanding of schizophrenia and support the development of more personalized approaches to treatment and care.
People with schizophrenia (cases) will be recruited through participating psychosis clinics in Manitoba, review and sign a consent form, provide a saliva sample for genetic testing, allow researchers to use information already collected through the Manitoba Psychosis Registry and link it with health records.
People without schizophrenia or other major psychiatric disorders (screened controls) will be screened to ensure they meet eligibility requirements, review and sign a consent form, complete questionnaires about their health, quality of life, and life experiences, provide a saliva sample for genetic testing, allow researchers to link their genetic information with health records.
Objective: To understand how genes contribute to schizophrenia and psychosis by analyzing DNA samples from people with and without these conditions.
Endpoints: Collection of DNA samples, identification of genetic differences associated with schizophrenia and psychosis, and understanding how these genetic factors relate to symptoms, health outcomes, and disease risk.
Tipo di studio
Osservativo
Iscrizione (Stimato)
1500
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Contatto studio
- Nome: Kaarina Kowalec, PhD
- Numero di telefono: 204-619-5711
- Email: kaarina.kowalec@umanitoba.ca
Luoghi di studio
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Manitoba
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Winnipeg, Manitoba, Canada, R3E0T5
- University of Manitoba
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Contatto:
- Danielle Perera, MSc
- Numero di telefono: 204-789-3380
- Email: mb.pr@umanitoba.ca
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Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
- Adulto
- Adulto più anziano
Accetta volontari sani
Sì
Metodo di campionamento
Campione non probabilistico
Popolazione di studio
The schizophrenia study population will consist of Manitoba residents aged 18 years and older with a clinical diagnosis of schizophrenia according to DSM-5 criteria.
Participants will be recruited from the MPR, including individuals receiving care through the Early Psychosis Prevention and Intervention Service (EPPIS), Schizophrenia Treatment and Education Program (STEP), Program of Assertive Community Treatment (PACT), and Assertive Community Treatment/Flexible Assertive Community Treatment (ACT/FACT) teams.
Eligible participants must be enrolled in the MPR and provide informed consent to participate in the genetic sub-study.
Participants will provide saliva samples for DNA extraction and whole genome sequencing, and their genetic data will be linked with clinical, questionnaire, and provincial administrative health data to support research on the genetic basis of schizophrenia and related health outcomes.
Descrizione
Inclusion Criteria:
- Individuals aged 18 years and older,
- Reside in Manitoba,
- Involved in the EPPIS, STEP, PACT, ACT/FACTT clinics,
- Clinical diagnosis of schizophrenia using standard DSM-5 criteria,
- Previously consented and enrolled in the MPR.
Exclusion Criteria:
- There are no specific exclusion criteria beyond meeting the inclusion criteria or not providing informed consent.
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
Coorti e interventi
Gruppo / Coorte |
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Schizophrenia (cases)
The schizophrenia case group will consist of Manitoba residents aged 18 years and older who have a clinical diagnosis of schizophrenia based on standard DSM-5 criteria and who are already enrolled in the Manitoba Psychosis Registry (MPR).
Participants will be recruited through psychosis-focused clinical programs in Manitoba, including the Early Psychosis Prevention and Intervention Service (EPPIS), Schizophrenia Treatment and Education Program (STEP), Program of Assertive Community Treatment (PACT), and Assertive Community Treatment/Flexible Assertive Community Treatment (ACT/FACT) teams.
Cases will provide saliva samples for DNA extraction and whole genome sequencing, and genetic data will be linked with clinical information, questionnaire data, and provincial health administrative data to investigate the genetic basis of schizophrenia and related health outcomes.
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Control (screened)
The screened control group will consist of Manitoba residents aged 40 years and older who have no known history of psychiatric disorders.
Potential controls will be identified through the Manitoba Population Research Data Repository and recruited by invitation.
Individuals will be excluded if they have had contact with a psychiatric specialist or have a history of antidepressant, lithium, mood stabilizer, or antipsychotic medication use.
Participants will provide saliva samples for DNA extraction and whole genome sequencing, and their genetic data will be linked with provincial health administrative data.
This group will serve as a comparison population for investigating genetic differences associated with schizophrenia.
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Control (unscreened)
An unscreened control group of approximately 2,500 individuals from Manitoba and Saskatchewan will be included through the PrairieGen project.
These participants were sequenced using the same whole genome sequencing technologies as the study participants and represent the general Prairie population.
While no psychiatric screening or health administrative data linkage will be available for this group, they will provide a population-based genetic reference to improve statistical power and enhance the generalizability of genetic findings.
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Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
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Genetic variation associated with schizophrenia
Lasso di tempo: through study completion, an average of 1 year
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Identification of rare and common genetic variants through short-read and long-read whole genome sequencing.
Comparison of genetic variant burden between schizophrenia cases and controls.
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through study completion, an average of 1 year
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Rare variant burden in schizophrenia
Lasso di tempo: through study completion, an average of 1 year
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Evaluation of the frequency and distribution of rare genetic variants in individuals with schizophrenia compared with controls.
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through study completion, an average of 1 year
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Pharmacogenetic associations
Lasso di tempo: through study completion, an average of 1 year
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Identification of genetic variants associated with antipsychotic treatment response and adverse drug reactions.
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through study completion, an average of 1 year
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Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Collaboratori
Studiare le date dei record
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Studia le date principali
Inizio studio (Stimato)
1 agosto 2026
Completamento primario (Stimato)
1 aprile 2031
Completamento dello studio (Stimato)
1 aprile 2031
Date di iscrizione allo studio
Primo inviato
5 giugno 2026
Primo inviato che soddisfa i criteri di controllo qualità
12 giugno 2026
Primo Inserito (Effettivo)
18 giugno 2026
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
18 giugno 2026
Ultimo aggiornamento inviato che soddisfa i criteri QC
12 giugno 2026
Ultimo verificato
1 giugno 2026
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- RITHIM #4915
- PJT-206077 (Altro numero di sovvenzione/finanziamento: Canadian Institutes of Health Research)
Piano per i dati dei singoli partecipanti (IPD)
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INDECISO
Descrizione del piano IPD
IPD may or may not be shared depending on whether the participant consents to allowing sharing.
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
No
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
No
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