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Effect of Plyometric Training Cross Education on Strength, Selective Motor Control and Balance in Children With Hemiplegic Cerebral Palsy (PLYO-HCP)

21 giugno 2026 aggiornato da: Mayada Ghalwash Abdelkarem, Cairo University

The goal of this clinical trial is to evaluate the effect of plyometric training with cross-education on lower limb muscle strength, selective motor control, and balance in children with hemiplegic cerebral palsy (HCP). It will also assess the safety and feasibility of applying this training program in pediatric rehabilitation.

The main questions it aims to answer are:

Does plyometric training with cross-education improve lower limb muscle strength in children with HCP? Does it improve selective motor control in the affected lower limb? Does it improve balance in children with HCP? Researchers will compare a study group receiving conventional physiotherapy plus plyometric training applied to the less affected limb to a control group receiving conventional physiotherapy only.

Participants will:

Receive treatment for 12 weeks (2 sessions per week) Attend regular physiotherapy sessions including stretching, strengthening, balance, and gait training Participate in plyometric exercises (study group only) Be assessed before and after the intervention using standardized tests for muscle strength, selective motor control, and balance

Panoramica dello studio

Stato

Non ancora reclutamento

Condizioni

Intervento / Trattamento

Descrizione dettagliata

This study will be conducted as a randomized controlled clinical trial to investigate the effect of unilateral plyometric training with cross-education on lower limb muscle strength, selective motor control, and balance in children with hemiplegic cerebral palsy (HCP).

Hemiplegic cerebral palsy is a non-progressive neurological disorder caused by early brain injury, resulting in unilateral motor impairment, muscle weakness, and balance dysfunction. The cross-education effect refers to the transfer of strength and motor improvements from a trained limb to the contralateral untrained limb, primarily mediated by central neural mechanisms.

A total of forty children diagnosed with HCP will be recruited from outpatient pediatric clinics affiliated with the Faculty of Physical Therapy, Cairo University. Eligible participants will be randomly allocated into two equal groups.

The study group will receive a conventional pediatric physiotherapy program combined with a structured progressive plyometric training program applied exclusively to the less affected lower limb. The control group will receive only the conventional physiotherapy program, which includes stretching exercises, active and resistive range of motion exercises, balance training, and gait training.

The intervention will be carried out over a period of twelve weeks, with two sessions per week, each lasting approximately one hour. The plyometric training will be designed to progressively challenge neuromuscular performance through exercises involving the stretch-shortening cycle, while the conventional program will focus on functional motor rehabilitation.

Allocation will be performed using a computer-generated block randomization method, and concealment will be ensured using sealed opaque envelopes. The study will adhere to CONSORT guidelines for randomized controlled trials to ensure methodological rigor and transparency.

Outcome measures will be assessed at baseline and post-intervention using standardized and validated tools to evaluate changes in muscle strength, selective motor control, and balance. Data analysis will be performed to determine the effectiveness of the intervention.

Tipo di studio

Interventistico

Iscrizione (Stimato)

40

Fase

  • Non applicabile

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Contatto studio

Luoghi di studio

  • Egitto
      • Cairo, Egitto
        • Faculty of physical therapy cairo university
        • Contatto:
      • Giza, Egitto
        • Physical Therapy Cairo University
        • Contatto:
    • Giza Governorate
      • Giza, Giza Governorate, Egitto, 11562
        • Cairo University
        • Contatto:
        • Contatto:
          • Mayada Ghalwash Abdelkarem

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

  • Bambino

Accetta volontari sani

No

Descrizione

Inclusion Criteria:Children eligible for participation in this study must meet all the following criteria:

  1. Diagnosed with HCP by a pediatric neurologist.
  2. Age range 6 and 10 years old.
  3. Their grade of spasticity level 1 or 1+ according to MAS.
  4. Their gross motor function level is I, II on GMFCS.
  5. Able to follow verbal instructions and cooperate during assessment and training.

Exclusion Criteria:Children will be excluded from this study if they have any of the following:

  1. Presence of corrective neurological/musculoskeletal surgery of the lower limb in the previous year or botulinum toxin injections of the lower limb within the previous 6 months.
  2. Presence of visual or auditory impairments that would affect balance performance.
  3. Uncontrolled epileptic seizures or recent medication changes

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Trattamento
  • Assegnazione: Randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Separare

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Comparatore attivo: Gruppo di controllo
Altro: Conventional Physiotherapy
Stretching, strengthening, balance, and gait training program.
Sperimentale: Gruppo di studio
Altro: Conventional Physiotherapy
Stretching, strengthening, balance, and gait training program.
Altro: Plyometric training

The plyometric training program will be applied to the less affected lower limb and is designed to enhance neuromuscular performance, explosive strength, proprioception, and motor coordination through rapid eccentric-concentric muscle actions.

Each training session will begin with a 5-minute warm-up to prepare the child physically and psychologically for exercise. The main training phase will include progressive plyometric exercises targeting lower limb function. A 5-minute cool-down period will be performed at the end of each session to promote muscle relaxation and reduce fatigue

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Lower Limb Muscle Strength
Lasso di tempo: 12 weeks

Lower limb muscle strength will be assessed in the more affected limb using a hand-held dynamometer (HHD). Quadriceps and hamstring muscle groups will be tested.

The "make test" will be used to measure maximal isometric muscle strength. Each child will be instructed to gradually generate maximal force over approximately 5 seconds while maintaining a fixed joint position to avoid compensatory movements. The dynamometer will be stabilized and resistance applied via an ankle cuff positioned above the malleoli.

Each muscle group will be tested three times, with 30 seconds rest between trials. The average of the three maximal voluntary contractions will be recorded as the final value. Standardized positioning and verbal encouragement will be used to ensure maximal effort
12 weeks
Selective Motor Control (SMC)
Lasso di tempo: 12 weeks

Selective motor control of the lower limb will be assessed using the Selective Control Assessment of the Lower Extremity (SCALE), which is a simple clinical tool that can be completed in less than 15 minutes and does not require special equipment (Fowler et al., 2009).

The SCALE will be used to evaluate selective voluntary motor control at five joints of the lower limb including the hip, knee, ankle, subtalar joint, and toes on both sides. For each joint, a representative movement that is independent of typical synergistic flexor or extensor patterns will be selected.

Most assessments will be performed in sitting position, while hip movements will be assessed in side-lying position to allow optimal observation of movement control. These standardized positions also facilitate visual feedback and accommodate potential proprioceptive deficits.

The examiner will demonstrate each movement before testing. Children will then be asked to perform the movement independently, and performance wil
12 weeks
Balance
Lasso di tempo: 12 weeks
Postural stability will be assessed using the Biodex Balance System (BBS), a computerized dynamic platform used to evaluate neuromuscular control and balance performance. The system allows controlled platform movement in anterior-posterior and medial-lateral directions and provides stability indices including the Overall Stability Index (OSI), Anteroposterior Stability Index (APSI), and Mediolateral Stability Index (MLSI), which reflect postural control abilities Prior to testing, each child will undergo a familiarization session to ensure understanding of the procedure and reduce anxiety. During assessment, the child will stand barefoot on the platform in a two-leg stance with arms at the sides. Safety handrails will be adjusted according to height, but children will be instructed not to hold them during testing.
12 weeks

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

Cairo University

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Stimato)

25 giugno 2026

Completamento primario (Stimato)

25 settembre 2026

Completamento dello studio (Stimato)

30 settembre 2026

Date di iscrizione allo studio

Primo inviato

21 giugno 2026

Primo inviato che soddisfa i criteri di controllo qualità

21 giugno 2026

Primo Inserito (Effettivo)

25 giugno 2026

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

25 giugno 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

21 giugno 2026

Ultimo verificato

1 giugno 2026

Maggiori informazioni

Termini relativi a questo studio

Parole chiave

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

  • P.T.REC/012/006103

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

NO

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

No

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

No

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

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