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Efficacy Of Gross Myofascial Release With Neural Mobilization Versus Neural Mobilization Alone On Pain, Functional Limitations, And Cervical Range Of Motion In Cervical Radiculopathy

7 settembre 2026 aggiornato da: Ibadat International University, Islamabad
This is a randomized control trial aims to evaluate the efficacy of gross myofascial release with neural mobilization versus neural mobilization alone on pain, functional limitations, and cervical range of motion in cervical radiculopathy. Cervical radiculopathy, is characterized by neck pain, pain radiating down the arm, numbness, tingling, weakness of muscles and functionality limitations with compression or irritation of the cervical nerve root due to cervical spondylosis, cervical disc herniations or degeneration of the cervical spine leading to cervical radiculopathy and the diminished quality of life from decreased day-to-day functional capacity and productivity at work. The study will evaluate pain, functional limitations, and cervical range of motion.

Panoramica dello studio

Stato

Reclutamento

Condizioni

Intervento / Trattamento

Tipo di studio

Interventistico

Iscrizione (Stimato)

44

Fase

  • Non applicabile

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Contatto studio

Backup dei contatti dello studio

Luoghi di studio

  • Pakistan
    • KPK
      • Peshawar, KPK, Pakistan
        • Reclutamento
        • My Health Wellness center, Peshawar
        • Contatto:

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

  • Adulto

Accetta volontari sani

No

Descrizione

Inclusion Criteria:

  • Male and female patients aged between 25-55 years
  • Presence of chronic neck pain radiating to one upper limb
  • Positive Upper Limb Tension Test-I (Median nerve)
  • Patients having pain, numbness, tingling, or paresthesia in the cervical nerve root distribution.
  • Symptom's duration of at least 4 weeks

Exclusion Criteria:

  • Patients with cervical myelopathy
  • History of cervical spine fracture, tumor, infection, or malignancy
  • Previous cervical spine surgery
  • Severe osteoporosis or inflammatory joint disease
  • Presence of systemic neurological disorders such as multiple sclerosis or stroke
  • Patients with severe cervical instability or vertebral artery insufficiency
  • Recent physiotherapy treatment for cervical radiculopathy within the last 3 months

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Trattamento
  • Assegnazione: Randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Separare

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Sperimentale: Gross Myofascial Release + Neural Mobilization
Participants in this group will receive Gross Myofascial Release followed by median nerve neural mobilization. The GMFR intervention will include a gross stretch of the posterior cervical musculature and an upper-quarter (arm pull) fascial stretch. The stretch will be maintained for 90 seconds or until a palpable release of fascial tension is appreciated. Neural mobilization will be performed using the median nerve slider technique. Neural mobilization will be performed by simultaneously moving the shoulder into greater abduction while the cervical spine is moved into contralateral side flexion to facilitate median nerve sliding(1 set of 10 repetitions with a 3-second hold per repetition). Each treatment session will also include a 10-minute hot pack before treatment and 10 minutes of TENS after treatment. The total session duration will be approximately 40 minutes, administered 3 sessions per week on alternate days for 4 weeks (12 sessions).
Altro: Gross Myofascial Release + Neural Mobilization
Participants allocated to the experimental group will receive Gross Myofascial Release (GMFR) followed by median nerve neural mobilization. The GMFR intervention will include a gross stretch of the posterior cervical musculature and an upper-quarter (arm pull) fascial stretch. The stretch will be maintained for 90 seconds or until a palpable release of fascial tension is appreciated. Neural mobilization will be performed using the median nerve slider technique.. Neural mobilization will be performed by simultaneously moving the shoulder into greater abduction while the cervical spine is moved into contralateral side flexion to facilitate median nerve sliding(1 set of 10 repetitions with a 3-second hold per repetition). Each treatment session will also include a 10-minute hot pack before treatment and 10 minutes of TENS after treatment. The total session duration will be approximately 40 minutes, administered 3 sessions per week on alternate days for 4 weeks (12 sessions).
Comparatore attivo: Neural Mobilization with conventional therapy
Participants allocated to the control group will receive neural mobilization technique. The intervention will be performed with the participant in the supine position, with the shoulder abducted and externally rotated, elbow extended, forearm supinated, and wrist, fingers, and thumb maintained in extension. Neural mobilization will be applied by simultaneously increasing shoulder abduction while moving the cervical spine into contralateral side flexion to facilitate median nerve sliding. Each treatment session will also include a 10-minute hot pack before treatment and 10 minutes of TENS after treatment. The treatment will be administered in 3 sets of 10 repetitions, with each repetition held for 3 seconds and a 60-second rest interval between sets, The total session duration will be approximately 40 minutes, administered 3 sessions per week on alternate days for 4 weeks (12 sessions).
Altro: Neural Mobilization
Participants allocated to the control group will receive neural mobilization technique. The intervention will be performed with the participant in the supine position, with the shoulder abducted and externally rotated, elbow extended, forearm supinated, and wrist, fingers, and thumb maintained in extension. Neural mobilization will be applied by simultaneously increasing shoulder abduction while moving the cervical spine into contralateral side flexion to facilitate median nerve sliding. Each treatment session will also include a 10-minute hot pack before treatment and 10 minutes of TENS after treatment. The treatment will be administered in 3 sets of 10 repetitions, with each repetition held for 3 seconds and a 60-second rest interval between sets, The total session duration will be approximately 40 minutes, administered 3 sessions per week on alternate days for 4 weeks (12 sessions).

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Universal Goniometer
Lasso di tempo: Baseline to 4th week
The Universal Goniometer (UG) will used in this study to measure active cervical range of motion (ROM), is a simple, inexpensive, and portable clinical instrument that provides objective measurements of joint movement in degrees. Cervical range of motion is recorded in degrees (°) for each movement direction. Lower ROM values indicate greater movement restriction and functional impairment, whereas higher values reflect improved cervical mobility.
Baseline to 4th week
Neck Disability Index (NDI)
Lasso di tempo: Baseline to 4th week
The Neck Disability Index (NDI) will used in this study to evaluate the level of functional disability associated with cervical radiculopathy. The NDI is one of the most widely accepted patient-reported outcome measures for assessing the impact of neck pain on daily functioning. The questionnaire consists of 10 items, including pain intensity, personal care, lifting, reading, headaches, concentration, work, driving, sleeping, and recreational activities. Each item is scored from 0 to 5, The total NDI score ranges from 0 to 50, with higher scores representing greater functional disability. For clinical interpretation, scores are commonly classified as follows: 0-4 (no disability), 5-14 (mild disability), 15-24 (moderate disability), 25-34 (severe disability), and 35-50 (complete disability). A reduction in the total score following treatment indicates an improvement in functional status and a decreased impact of neck pain on daily activities.
Baseline to 4th week
Visual Analogue Scale
Lasso di tempo: Baseline to 4th week
The intensity of the pain will be measured with the help of the Visual Analogue Scale (VAS). The VAS is a 10-cm horizontal line with two opposite endpoints marked with the following words: "no pain" at one end and "worst imaginable pain" at the other. The patient will then mark a point on the line that they feel most accurately reflects their current pain. The distance in centimeters or millimeters between the "no pain" point and the patient's mark will be taken as the measure of the patient's pain.
Baseline to 4th week
Magnetic Resonance Imaging (MRI)
Lasso di tempo: Baseline to 4th week
Magnetic Resonance Imaging (MRI) of the cervical spine was used in this study to confirm the diagnosis cervical radiculopathy before participant enrollment. It enables accurate identification of disc herniation, foraminal stenosis, nerve root compression, and other degenerative changes associated with cervical radiculopathy.
Baseline to 4th week

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

Ibadat International University, Islamabad

Investigatori

  • Cattedra di studio: salma bibi, Ibadat International University, Islamabad

Pubblicazioni e link utili

La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.

Pubblicazioni generali

  • Agarwal, V., Goel, A., Srivastava, A., Rawat, P., & Singh, R. (2024). Optimizing Pain Relief and Range of Motion in Unilateral Cervical Radiculopathy: A Study on Neural Tissue Mobilization and Cervical Stabilization Exercises. Cureus, 16(7), e65646. doi:10.7759/cureus.65646 Borrella-Andrés, S., Marqués-García, I., Lucha-López, M. O., Fanlo-Mazas, P., Hernández-Secorún, M., Pérez-Bellmunt, A., . . . Hidalgo-García, C. (2021). Manual Therapy as a Management of Cervical Radiculopathy: A Systematic Review. Biomed Res Int, 2021, 9936981. doi:10.1155/2021/9936981 Butler, D. S. (2005). The neurodynamic techniques: a definitive guide from the Noigroup team: Noigroup publications. Gauns, S. V., & Gurudut, P. V. (2018). A randomized controlled trial to study the effect of gross myofascial release on mechanical neck pain referred to upper limb. International journal of health sciences, 12(5), 51. Kuligowski, T., Skrzek, A., & Cieślik, B. (2021). Manual Therapy in Cervical and Lumbar Radiculopathy: A Systematic Review of the Literature. Int J Environ Res Public Health, 18(11). doi:10.3390/ijerph18116176 Lopez-Pardo, M. J., Calvache-Mateo, A., Martin-Nunez, J., Heredia-Ciuro, A., Lopez-Lopez, L., Valenza, M. C., & Cabrera-Martos, I. (2024). Routine physical therapy with and without neural mobilization in chronic musculoskeletal neck disorders with nerve-related symptoms: Systematic review and meta-analysis. Paper presented at the Healthcare. Lutke Schipholt, I. J., Scholten-Peeters, G. G. M., Logghe, S., Koop, M., Donders, S., Stenneberg, M. S., & Coppieters, M. W. (2024). The CROM-VAS Test: A novel and reliable clinical test to assess immediate pain relief following treatment for movement-evoked neck pain. Musculoskeletal Science and Practice, 74, 103191. doi:https://doi.org/10.1016/j.msksp.2024.103191 Mahmoud, L., Aly, S., & Abd Alhamid, H. M. M. (2025). Gross myofascial release on pain and function in cervical radiculopathy: a randomised controlled study. Human Movement, 26,

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

10 luglio 2026

Completamento primario (Stimato)

15 novembre 2026

Completamento dello studio (Stimato)

30 novembre 2026

Date di iscrizione allo studio

Primo inviato

28 agosto 2026

Primo inviato che soddisfa i criteri di controllo qualità

7 settembre 2026

Primo Inserito (Effettivo)

8 settembre 2026

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

8 settembre 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

7 settembre 2026

Ultimo verificato

1 settembre 2026

Maggiori informazioni

Termini relativi a questo studio

Parole chiave

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

  • IIUI/RERC/ADT/2026/07/371

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

NO

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

No

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

No

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

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