Doxercalciferol in Treating Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

DISEASE CHARACTERISTICS:

• Morphologically and cytogenetically confirmed myelodysplastic syndromes or chronic myelomonocytic leukemia

  • No more than 20% blasts by bone marrow biopsy

• Must meet at least 1 of the following criteria:

  • Anemia

    • Hemoglobin less than 11 g/dL over a 2-month period
  • Thrombocytopenia
  • Neutropenia

PATIENT CHARACTERISTICS:

Age

• 18 and over

Performance status

• ECOG 0-2

Life expectancy

• Not specified

Hematopoietic

• See Disease Characteristics

Hepatic

• ALT and AST less than 1.5 times upper limit of normal
• Bilirubin less than 3 mg/dL
• Albumin greater than 3.0 g/dL

Renal

• Creatinine clearance greater than 50 mL/min
• No history of hypercalcemia
• No renal stones within the past 5 years

Cardiovascular

• No clinically significant heart failure
• No uncontrolled hypertension

Pulmonary

• No clinically significant pulmonary failure

Other

• Not pregnant
• Fertile patients must use effective contraception during and for 6 months after study

PRIOR CONCURRENT THERAPY:

Biologic therapy

• At least 4 weeks since prior growth factor or cytokine therapy

Chemotherapy

• At least 8 weeks since prior cytotoxic chemotherapy

Endocrine therapy

• Not specified

Radiotherapy

• Not specified

Surgery

• Not specified

Other

• Concurrent transfusion support allowed