Interest of Narrow Band Imaging in Detection of Upper Aerodigestive Cancers
Usefulness of Narrow-band Imaging to Estimate the Superficial Spread of Squamous Cell Carcinomas in Oropharynx, Hypopharynx and Larynx
調査の概要
詳細な説明
Several studies have already showed the interest of the use of NBI for the early diagnosis of malignancies of the upper aerodigestive tract. For all tumors, the most accurate evaluation of its limits is very important to perform the best strategy of treatment. If surgery seems to be the best option, surgical margins must be widely healthy. Despite the systematic transnasal flexible endoscopy with white lamp followed by laryngoscopy under general anesthesia (LGA) and tomodensitometric evaluation, surgical margins can be unhealthy (in situ carcinoma or dysplasia). We propose to evaluate if the use of the NBI could be useful to determine the superficial spread of squamous cell carcinomas in these locations.
To April 2013 to Mars 2015, all patients with a suspicion of squamous cell carcinoma of the oropharynx, hypopharynx or larynx and whom a LGA are expected, are included. The day before the LGA, two endoscopies by two different physicians were performed for each patients and recorded: the first one with white light and the second one with NBI. All results are noted on a schema. Superficial extension or synchronous lesions showed by NBI are analysed and compared with with lamp technic.
After surgery, surgical margins were evaluated and healthy margins were measured.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Toulouse、フランス、31059
- University of Toulouse
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Patients who can benefit a laryngoscopic exam under general anesthesia
Exclusion Criteria:
- General anesthesia contra-indications
- Local anesthesia allergy
- Breast-feeding period or pregnancy
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：診断
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Videoendoscopy with WL and NBI
The day before the laryngoscopy under general anesthesia (LGA), two endoscopies by two different physicians were performed for each patients and recorded: the first one with white light (WL) and the second one with NBI (NBI).
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For each patient with a suspicion of squamous cell carcinoma of the oropharynx, hypopharynx or larynx for whom a laryngoscopy under general anesthesia (LGA) is expected benefit the day before a transnasal endoscopy with white lamp (WL) and NBI by two different operators.
Suspected mucosal abnormalities showed by one or the two technics are reported in a table wich describes the different areas of the pharynx and the larynx.
During the LGA, several biopsies are performed and identified (WL and/or NBI).
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
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Number of patients for whom superficial extension of the tumors has been increased by NBI.
時間枠：4 minutes
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4 minutes
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二次結果の測定
結果測定 |
時間枠 |
|---|---|
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Number of tumors upstaged.
時間枠：4 minutes
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4 minutes
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Contribution of the NBI in the diagnosis of other synchronous locations.
時間枠：4 minutes
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4 minutes
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Contribution of the NBI in the diagnosis of pre-neoplastic lesions.
時間枠：4 minutes
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4 minutes
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Contribution of the NBI in the evaluation of surgical margins.
時間枠：4 minutes
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4 minutes
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協力者と研究者
捜査官
- 主任研究者：Sébastien VERGEZ, MD, PhD、University Hospital of Toulouse
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- 13 203 02
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