Emotional Prosody Recognition and Decision Making Inf fMRI and Vulnerability to Suicide (EMODES)
Suicide is known to be frequent in depression, and in most of the psychiatric diseases. But as it can occur in patients with no psychiatric illness and doesn't occur in every patients with psychiatric illness, it has to be considered henceforth as a specific vulnerability.
This trial will study two fMRI paradigms, emotional prosody recognition and decision making, in order to characterize emotional and cognitive trait factors in a population of patients vulnerable to suicide. Four different groups will be constituted : depressed suicide attempters, depressed patients with past history of suicidal acts, depressed patients with no history of suicidal acts and healthy controls.
The main goal will be to correlate fMRI activation during the two paradigms in subjects vulnerable to suicide. The secondary goals will be to characterize emotional and cognitive trait factors in these subjects, to demonstrate that those characteristics are independent from depression and to correlate these trait factors with socio-demographic and clinical features with fMRI activations.
調査の概要
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Rennes、フランス、35000
- Rennes University Hospital
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
説明
Inclusion Criteria:
- Right-handed,
- Depressed suicide attempters for the first group,
- Depressed patients with past history of suicidal acts for the second group,
- Depressed patients with no history of suicidal acts for the third group,
- Healthy controls for the fourth group.
Exclusion Criteria:
- Another psychiatric trouble than depression,
- Another psychotrope treatment than SSRI/SNRI and/or benzodiazepine at inclusion and/or one month before,
- For the first and secand groups : more than fous suicidals acts within the past 3 years,
- Deficits that do not allow test realisation (visual audition troubles, cognitif deficits,
- Prosopagnosia,
- Pregnancy,
- Severe central nervous system disease or somatic disease,
- MRI contra-indication,
- Major benefiting from a legal protective measure,
- No coverage care.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：他の
- 割り当て：非ランダム化
- 介入モデル：単一グループの割り当て
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：Depressed suicide attempters
20 subjects
|
two fMRI paradigms, emotional prosody recognition and decision making
|
|
実験的：Depressed patients with past history of
20 subjects
|
two fMRI paradigms, emotional prosody recognition and decision making
|
|
実験的：Depressed patients with no history of
20 subjects
|
two fMRI paradigms, emotional prosody recognition and decision making
|
|
プラセボコンパレーター：Healthy controls
20 subjects
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two fMRI paradigms, emotional prosody recognition and decision making
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
|
fMRI activation area
時間枠：1 day
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1 day
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協力者と研究者
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (推定)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。