Coronary Artery Disease in Elderly People Referred for TAVI (CEPTAVI)

Patients will be prospectively included in the study when aged of 80 years old or over and referred for TAVI at the university hospital of Montpellier.

Two groups of patients will be considered after coronary angiography which is systematic before TAVI Group 1: patients with significant > 50 % narrowing coronary stenosis ( revascularization by PCI / no revascularization) Group 2: No coronary lesion

Considering an end point at 1 year and a precision wished to i ± 6 percent with an alpha risk of 5 %, it's proposed , by the formula p= [(1.96)2 x [p(1-p)] / i2 ], a number of 170 subjects needed to highlight a incidence of major cardio-vascular event of 20 percent in the studied population.

Data collection by informatic files will include :

• Cardio vascular risk factor and medical history with evaluation of Charlston score
• Previous drug therapy
• Lifestyle : living alone or not, nursing home, ; home help
• Symptoms (angina (CSS classification) ; dyspnea (NHYA classification))
• Renal function (DFG) at admission
• Results of coronary angiography (number of lesions, proximal or non proximal, location of coronary stenosis)
• Geriatric assessment : autonomy, disability in daily living, weigh, BMI, falls, cognitive functions tests, assessment of the mood state by GDS
• Results of TAVI (success and complications of the procedure according to VARC2 criteria)
• Results of coronary revascularization if performed
• Length of hospitalisation for TAVI (days), length of stay in ICU (Intensive Care Unit) if necessary
• Events during the hospitalisation for TAVI (VARC and BARC criterias)

Follow up at 6 month (middle analysis) and at one year (primary end point) by phone conversation with the patient for assessment of :

• Major cardio-vascular events
• Hospitalisation occurred

• Short geriatric evaluation including :

  • cognition by Ottawa3DY
  • autonomy by ADL
  • polypharmacy
  • number of fall in the past 6 month
  • last weight
  • quality of life (Fried criterias)
  • mood state by GDS If neurocognitive disorders are known or discovers, data patient's validity will be check by calling his caregiver and/or his general practitioner (if caregiver not available).

Analysis associated of the computerized patient record.