Human Sinonasal Mucosa Heterogeneity Study
Heterogeneity of Mucosa Across Different Human Sinonasal Sites: An Observational Study
This observational study aims to better understand how the lining of the nose and sinuses differs across different sinonasal sites in humans, including participants with and without sinonasal inflammatory disease. Mucosal tissue samples will be collected from participants who are undergoing clinically indicated sinonasal surgery. The study will compare tissue structure, gene expression, protein expression, and immune cell composition among different regions of the sinonasal mucosa.
By studying these differences, researchers hope to identify site-specific features of human sinonasal mucosa and improve understanding of normal and disease-related changes in the nose and sinuses. This study does not assign participants to any treatment or intervention. The findings may provide a foundation for future research on chronic rhinosinusitis, nasal polyps, and other sinonasal diseases.
調査の概要
詳細な説明
The human sinonasal mucosa lines different regions of the nasal cavity and paranasal sinuses and plays an important role in mucosal defense, inflammation, and tissue homeostasis. However, the biological characteristics of mucosa from different sinonasal sites are not fully understood.
This observational study will collect sinonasal mucosal tissue samples from participants undergoing clinically indicated sinonasal surgery. Samples may be obtained from different anatomical sites of the sinonasal tract when available as part of the surgical procedure. No treatment or intervention will be assigned by the study.
Collected samples will be analyzed to compare site-specific features of human sinonasal mucosa, including tissue structure, gene expression patterns, protein expression profiles, and immune cell composition. Relevant clinical information may also be collected to support interpretation of the biological findings.
The purpose of this study is to characterize the heterogeneity of human sinonasal mucosa across different anatomical sites. The results may help improve understanding of normal sinonasal mucosal biology and provide a reference for future studies of chronic rhinosinusitis, nasal polyps, and other sinonasal inflammatory diseases.
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：YAN YAN, Master's Degree
- 電話番号：+8613016018473
- メール：yany38@mail2.sysu.edu.cn
研究連絡先のバックアップ
- 名前：yanran huang, Doctor of Medicine
- 電話番号：13016018473
- メール：yany38@mail2.sysu.edu.cn
研究場所
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Guangdong
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Guangzhou、Guangdong、中国、510030
- 募集
- The First Affiliated Hospital of Sun Yat-sen University
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コンタクト：
- 電話番号：13016018473
- メール：yany38@mail2.sysu.edu.cn
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コンタクト：
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参加基準
適格基準
就学可能な年齢
- 子
- 大人
- 高齢者
健康ボランティアの受け入れ
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Adults aged 18 years or older.
- Scheduled for clinically indicated sinonasal surgery.
- Sinonasal mucosal tissue can be collected during surgery without significant additional risk.
- Able and willing to provide written informed consent.
- Relevant clinical information is available.
Exclusion Criteria:
- Unable or unwilling to provide informed consent.
- Younger than 18 years of age.
- Tissue collection may interfere with standard care or increase surgical risk.
- History of sinonasal malignancy, sinonasal radiotherapy, or chemotherapy affecting sinonasal mucosa.
- Active systemic infection or severe systemic disease affecting study participation or interpretation.
- Use of systemic corticosteroids, immunosuppressants, or biologics within 4 weeks before surgery.
- Insufficient or poor-quality tissue for planned analyses.
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
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健康的なコントロール
健康な人
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CRSwNP
CRSwNP patient
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Site-Specific Heterogeneity of Human Sinonasal Mucosa
時間枠：Baseline
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Differences in histological features, gene expression patterns, protein expression profiles, and immune cell composition will be compared among mucosal tissue samples collected from different anatomical sites of the human sinonasal tract.
These analyses will be used to characterize site-specific biological features and support construction of a human sinonasal mucosal spatial atlas.
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Baseline
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協力者と研究者
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- Human Sinonasal Mucosa Heterog
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。