Human Sinonasal Mucosa Heterogeneity Study
Heterogeneity of Mucosa Across Different Human Sinonasal Sites: An Observational Study
This observational study aims to better understand how the lining of the nose and sinuses differs across different sinonasal sites in humans, including participants with and without sinonasal inflammatory disease. Mucosal tissue samples will be collected from participants who are undergoing clinically indicated sinonasal surgery. The study will compare tissue structure, gene expression, protein expression, and immune cell composition among different regions of the sinonasal mucosa.
By studying these differences, researchers hope to identify site-specific features of human sinonasal mucosa and improve understanding of normal and disease-related changes in the nose and sinuses. This study does not assign participants to any treatment or intervention. The findings may provide a foundation for future research on chronic rhinosinusitis, nasal polyps, and other sinonasal diseases.
Studie Overzicht
Toestand
Gedetailleerde beschrijving
The human sinonasal mucosa lines different regions of the nasal cavity and paranasal sinuses and plays an important role in mucosal defense, inflammation, and tissue homeostasis. However, the biological characteristics of mucosa from different sinonasal sites are not fully understood.
This observational study will collect sinonasal mucosal tissue samples from participants undergoing clinically indicated sinonasal surgery. Samples may be obtained from different anatomical sites of the sinonasal tract when available as part of the surgical procedure. No treatment or intervention will be assigned by the study.
Collected samples will be analyzed to compare site-specific features of human sinonasal mucosa, including tissue structure, gene expression patterns, protein expression profiles, and immune cell composition. Relevant clinical information may also be collected to support interpretation of the biological findings.
The purpose of this study is to characterize the heterogeneity of human sinonasal mucosa across different anatomical sites. The results may help improve understanding of normal sinonasal mucosal biology and provide a reference for future studies of chronic rhinosinusitis, nasal polyps, and other sinonasal inflammatory diseases.
Studietype
Inschrijving (Geschat)
Contacten en locaties
Studiecontact
- Naam: YAN YAN, Master's Degree
- Telefoonnummer: +8613016018473
- E-mail: yany38@mail2.sysu.edu.cn
Studie Contact Back-up
- Naam: yanran huang, Doctor of Medicine
- Telefoonnummer: 13016018473
- E-mail: yany38@mail2.sysu.edu.cn
Studie Locaties
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Guangdong
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Guangzhou, Guangdong, China, 510030
- Werving
- The First Affiliated Hospital of Sun Yat-sen University
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Contact:
- Telefoonnummer: 13016018473
- E-mail: yany38@mail2.sysu.edu.cn
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Contact:
- E-mail: yany38@mail2.sysu.edu.cn
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Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
- Kind
- Volwassen
- Oudere volwassene
Accepteert gezonde vrijwilligers
Bemonsteringsmethode
Studie Bevolking
Beschrijving
Inclusion Criteria:
- Adults aged 18 years or older.
- Scheduled for clinically indicated sinonasal surgery.
- Sinonasal mucosal tissue can be collected during surgery without significant additional risk.
- Able and willing to provide written informed consent.
- Relevant clinical information is available.
Exclusion Criteria:
- Unable or unwilling to provide informed consent.
- Younger than 18 years of age.
- Tissue collection may interfere with standard care or increase surgical risk.
- History of sinonasal malignancy, sinonasal radiotherapy, or chemotherapy affecting sinonasal mucosa.
- Active systemic infection or severe systemic disease affecting study participation or interpretation.
- Use of systemic corticosteroids, immunosuppressants, or biologics within 4 weeks before surgery.
- Insufficient or poor-quality tissue for planned analyses.
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
Cohorten en interventies
Groep / Cohort |
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gezonde controle
Gezonde mensen
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CRSwNP
CRSwNP patient
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Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
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Site-Specific Heterogeneity of Human Sinonasal Mucosa
Tijdsspanne: Baseline
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Differences in histological features, gene expression patterns, protein expression profiles, and immune cell composition will be compared among mucosal tissue samples collected from different anatomical sites of the human sinonasal tract.
These analyses will be used to characterize site-specific biological features and support construction of a human sinonasal mucosal spatial atlas.
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Baseline
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Medewerkers en onderzoekers
Studie record data
Bestudeer belangrijke data
Studie start (Werkelijk)
Primaire voltooiing (Geschat)
Studie voltooiing (Geschat)
Studieregistratiedata
Eerst ingediend
Eerst ingediend dat voldeed aan de QC-criteria
Eerst geplaatst (Werkelijk)
Updates van studierecords
Laatste update geplaatst (Werkelijk)
Laatste update ingediend die voldeed aan QC-criteria
Laatst geverifieerd
Meer informatie
Termen gerelateerd aan deze studie
Andere studie-ID-nummers
- Human Sinonasal Mucosa Heterog
Plan Individuele Deelnemersgegevens (IPD)
Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
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