Ionized Calcium Changes for Predicting Postoperative Hypocalcemia After Total Thyroidectomy
Predictive Value of Preoperative, Intraoperative, and Postoperative Ionized Calcium Changes Measured by Blood Gas Analysis for Postoperative Hypocalcemia After Total Thyroidectomy
調査の概要
詳細な説明
Postoperative hypocalcemia is a common complication after total thyroidectomy and may be associated with changes in calcium homeostasis and parathyroid function. Early identification of patients at risk for postoperative hypocalcemia may help guide postoperative monitoring and calcium replacement strategies.
This prospective observational study included patients who underwent total thyroidectomy. Ionized calcium levels were measured by blood gas analysis at predefined perioperative time points, including the preoperative, intraoperative, and postoperative periods. Serum parathyroid hormone levels were also recorded. The study evaluated the relationship between perioperative changes in ionized calcium levels, postoperative parathyroid hormone changes, and the development of postoperative hypocalcemia.
The primary objective was to determine whether perioperative ionized calcium changes can predict postoperative hypocalcemia after total thyroidectomy. Secondary objectives included evaluating the association between postoperative parathyroid hormone changes and postoperative hypocalcemia and assessing the diagnostic performance of ionized calcium measurements for predicting hypocalcemia.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Başakşehir、トルコ（Türkiye）
- Başakşehir Çam and Sakura City Hospital
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参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Patients aged 18 to 75 years
- Present to the General Surgery Clinic of Başakşehir Çam and Sakura City Hospital
- Diagnosis of thyroid disorders according to ICD code E07
- Scheduled to undergo total thyroidectomy due to toxic multinodular goiter, multinodular goiter, or papillary carcinoma
- Provide informed consent to participate in the study.
Exclusion Criteria:
- Patients with preoperative parathyroid disorders associated hypocalcemia or hypercalcemia.
- Patients with a history of previous thyroidectomy
- Patients with a history of previous parathyroidectomy
- Patients with a history of previous neck surgery.
- Patients with chronic kidney disease.
- Patients with a history of non-thyroid malignancy.
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
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total thyroidectomy patients
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Ionized calcium levels will be measured by blood gas analysis at predefined preoperative, intraoperative, and postoperative time points in patients undergoing total thyroidectomy.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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ionized calcium
時間枠：Preoperative baseline; postoperative 10 minutes; postoperative 6 hours
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Ionized calcium levels will be measured by blood gas analysis at predefined preoperative and postoperative time points in patients undergoing total thyroidectomy.
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Preoperative baseline; postoperative 10 minutes; postoperative 6 hours
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parathormone levels
時間枠：Preoperative baseline; postoperative 10 minutes; postoperative 6 hours; and postoperative 6 months
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Serum parathyroid hormone levels will be measured in patients undergoing total thyroidectomy to evaluate the association between postoperative parathyroid hormone changes and postoperative hypocalcemia.
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Preoperative baseline; postoperative 10 minutes; postoperative 6 hours; and postoperative 6 months
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協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- KAEK-11/12.03.2025.87
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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