Ionized Calcium Changes for Predicting Postoperative Hypocalcemia After Total Thyroidectomy

July 8, 2026 updated by: Emrecan Deniz

Predictive Value of Preoperative, Intraoperative, and Postoperative Ionized Calcium Changes Measured by Blood Gas Analysis for Postoperative Hypocalcemia After Total Thyroidectomy

This prospective observational study aims to evaluate whether changes in ionized calcium levels measured by blood gas analysis during the preoperative, intraoperative, and postoperative periods can predict postoperative hypocalcemia in patients undergoing total thyroidectomy. Ionized calcium values obtained at predefined perioperative time points will be compared with postoperative biochemical and clinical hypocalcemia outcomes.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Postoperative hypocalcemia is a common complication after total thyroidectomy and may be associated with changes in calcium homeostasis and parathyroid function. Early identification of patients at risk for postoperative hypocalcemia may help guide postoperative monitoring and calcium replacement strategies.

This prospective observational study included patients who underwent total thyroidectomy. Ionized calcium levels were measured by blood gas analysis at predefined perioperative time points, including the preoperative, intraoperative, and postoperative periods. Serum parathyroid hormone levels were also recorded. The study evaluated the relationship between perioperative changes in ionized calcium levels, postoperative parathyroid hormone changes, and the development of postoperative hypocalcemia.

The primary objective was to determine whether perioperative ionized calcium changes can predict postoperative hypocalcemia after total thyroidectomy. Secondary objectives included evaluating the association between postoperative parathyroid hormone changes and postoperative hypocalcemia and assessing the diagnostic performance of ionized calcium measurements for predicting hypocalcemia.

Study Type

Observational

Enrollment (Actual)

327

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey (Türkiye)
      • Başakşehir, Turkey (Türkiye)
        • Başakşehir Çam and Sakura City Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

Patients admitted to Başakşehir Çam and Sakura City Hospital who are scheduled to undergo total thyroidectomy.

Description

Inclusion Criteria:

  • Patients aged 18 to 75 years
  • Present to the General Surgery Clinic of Başakşehir Çam and Sakura City Hospital
  • Diagnosis of thyroid disorders according to ICD code E07
  • Scheduled to undergo total thyroidectomy due to toxic multinodular goiter, multinodular goiter, or papillary carcinoma
  • Provide informed consent to participate in the study.

Exclusion Criteria:

  • Patients with preoperative parathyroid disorders associated hypocalcemia or hypercalcemia.
  • Patients with a history of previous thyroidectomy
  • Patients with a history of previous parathyroidectomy
  • Patients with a history of previous neck surgery.
  • Patients with chronic kidney disease.
  • Patients with a history of non-thyroid malignancy.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
total thyroidectomy patients
Diagnostic test: Calcium
Ionized calcium levels will be measured by blood gas analysis at predefined preoperative, intraoperative, and postoperative time points in patients undergoing total thyroidectomy.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
ionized calcium
Time Frame: Preoperative baseline; postoperative 10 minutes; postoperative 6 hours
Ionized calcium levels will be measured by blood gas analysis at predefined preoperative and postoperative time points in patients undergoing total thyroidectomy.
Preoperative baseline; postoperative 10 minutes; postoperative 6 hours
parathormone levels
Time Frame: Preoperative baseline; postoperative 10 minutes; postoperative 6 hours; and postoperative 6 months
Serum parathyroid hormone levels will be measured in patients undergoing total thyroidectomy to evaluate the association between postoperative parathyroid hormone changes and postoperative hypocalcemia.
Preoperative baseline; postoperative 10 minutes; postoperative 6 hours; and postoperative 6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Emrecan Deniz

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 12, 2025

Primary Completion (Actual)

April 25, 2026

Study Completion (Actual)

July 5, 2026

Study Registration Dates

First Submitted

June 26, 2026

First Submitted That Met QC Criteria

July 8, 2026

First Posted (Actual)

July 14, 2026

Study Record Updates

Last Update Posted (Actual)

July 14, 2026

Last Update Submitted That Met QC Criteria

July 8, 2026

Last Verified

July 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • KAEK-11/12.03.2025.87

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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