Early Neurological Outcome in Pediatric Encephalitis
Predictors of Early Neurological Outcome in Children With Encephalitis: A Prospective Study From Assiut University Children Hospital
This prospective cohort study aims to identify baseline clinical, laboratory, and radiological factors at admission that are associated with early neurological outcomes in children with encephalitis admitted to Assiut University Children Hospital.
調査の概要
詳細な説明
Encephalitis in children carries a high risk of neurological sequelae. This observational study will include children aged 1 month to 12 years with possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition.
Baseline clinical, laboratory, neuroimaging, and EEG findings will be recorded. Early neurological outcome will be assessed at hospital discharge using the pediatric modified Rankin Scale (mRS).
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：Rania A Hussein
- 電話番号：01280633697
- メール：Rania.18313530@med.aun.edu.eg
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
Children aged 1 month to 12 years admitted to Assiut University Children Hospital with possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition.
説明
Inclusion Criteria:
- Age from 1 month to 12 years
- Possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition
- Written informed consent from parents or legal guardians
Exclusion Criteria:
-
Pre-existing severe neurodisability pediatric modified Rankin Scale greater than or equal to 3 before the index illness
- Primary diagnosis of traumatic brain injury or cerebral malaria
- Known inborn error of metabolism or neurodegenerative disorder prior to the encephalitis episode
- Absence of documented neurologic outcome assessment
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 観測モデル：COHORT
- 時間の展望：PROSPECTIVE
コホートと介入
グループ/コホート |
|---|
|
Single cohort: Children with encephalitis
Children aged 1 month to 12 years with possible or probable encephalitis who will be assessed for early neurological outcome at hospital discharge using the pediatric modified Rankin Scale. |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Functional neurological outcome at discharge
時間枠：Up to 30 days
|
Score on the pediatric modified Rankin Scale at hospital discharge. The scale ranges from 0 (no symptoms) to 6 (death), with higher scores indicating worse functional outcome |
Up to 30 days
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Duration of hospital stay
時間枠：Up to 30 days
|
Length of hospital stay in days. |
Up to 30 days
|
|
Need for intensive care unit admission
時間枠：Up to 30 days
|
Number of children who require intensive care unit admission |
Up to 30 days
|
|
Need for nasogastric tube feeding at discharge
時間枠：Up to 30 days
|
Number of children who require nasogastric tube feeding at the time of hospital discharge |
Up to 30 days
|
|
Nosocomial infections
時間枠：Up to 30 days
|
Number of children who develop nosocomial infections during hospitalization |
Up to 30 days
|
協力者と研究者
スポンサー
捜査官
- スタディチェア：Faisel A Ahmed, prof、Pediatrics Department, Assiut University Hospitals
出版物と役立つリンク
一般刊行物
- Granerod J, Ambrose HE, Davies NW, Clewley JP, Walsh AL, Morgan D, Cunningham R, Zuckerman M, Mutton KJ, Solomon T, Ward KN, Lunn MP, Irani SR, Vincent A, Brown DW, Crowcroft NS; UK Health Protection Agency (HPA) Aetiology of Encephalitis Study Group. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010 Dec;10(12):835-44. doi: 10.1016/S1473-3099(10)70222-X. Epub 2010 Oct 15.
- Venkatesan A, Tunkel AR, Bloch KC, Lauring AS, Sejvar J, Bitnun A, Stahl JP, Mailles A, Drebot M, Rupprecht CE, Yoder J, Cope JR, Wilson MR, Whitley RJ, Sullivan J, Granerod J, Jones C, Eastwood K, Ward KN, Durrheim DN, Solbrig MV, Guo-Dong L, Glaser CA; International Encephalitis Consortium. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis. 2013 Oct;57(8):1114-28. doi: 10.1093/cid/cit458. Epub 2013 Jul 15.
- Pillai SC, Hacohen Y, Tantsis E, Prelog K, Merheb V, Kesson A, Barnes E, Gill D, Webster R, Menezes M, Ardern-Holmes S, Gupta S, Procopis P, Troedson C, Antony J, Ouvrier RA, Polfrit Y, Davies NW, Waters P, Lang B, Lim MJ, Brilot F, Vincent A, Dale RC. Infectious and autoantibody-associated encephalitis: clinical features and long-term outcome. Pediatrics. 2015 Apr;135(4):e974-84. doi: 10.1542/peds.2014-2702.
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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