Investigation of the Prevalence of Sarcopenia and Dynapenia According to Disease Stage in Patients With Multiple Sclerosis and Evaluation of the Relationship Between Sarcopenia Severity and Clinical and Functional Parameters (MS-Sarcopenia)
This cross-sectional observational study aims to determine the prevalence of sarcopenia and dynapenia across disability stages in patients with multiple sclerosis (MS) and investigate their associations with clinical and functional parameters. Approximately 150 patients will be classified into two groups according to their Expanded Disability Status Scale (EDSS) scores: mild disability (EDSS < 4.0) and moderate disability (EDSS 4.0-6.5). Sarcopenia and dynapenia will be assessed using the ISarcoPRM algorithm. Physical activity, fatigue, and functional independence will also be evaluated.
調査の概要
詳細な説明
Participants will undergo assessments of handgrip strength, five-times sit-to-stand performance, and ultrasound-based muscle mass using the Sonographic Thigh Adjustment Ratio (STAR). Sarcopenia and dynapenia will be classified according to the ISarcoPRM algorithm. Additional assessments will include the SARC-F questionnaire, smartwatch-derived physical activity, Modified Fatigue Impact Scale (MFIS), Functional Independence Measure (FIM), and Barthel Index. The prevalence of sarcopenia and dynapenia will be compared between disability groups, and associations with clinical and functional parameters will be examined.
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：Süleyman Korkusuz, PhD
- 電話番号：+905388675480
- メール：suleyman.korkusuz@atilim.edu.tr
研究場所
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Ankara、トルコ（Türkiye）
- Baskent University Ankara Hospital
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コンタクト：
- Ali M Özcan, MSc
- 電話番号：0535 776 08 84
- メール：ozcanalimert1993@gmail.com
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
Approximately 150 adults diagnosed with multiple sclerosis (MS) receiving care at the Physiotherapy and Rehabilitation Unit of Başkent University Hospital. Participants will be classified into mild (EDSS <4.0) and moderate (EDSS 4.0-6.5) disability groups.
説明
Inclusion Criteria:
- Aged 18 years or older.
- Diagnosed with multiple sclerosis (MS) by a neurologist.
- Standardized Mini-Mental State Examination (SMMSE) score ≥24.
- Expanded Disability Status Scale (EDSS) score ≤6.5.
- Willing to participate and provide written informed consent.
Exclusion Criteria:
- Orthopedic surgery within the previous 3 months.
- Botulinum toxin injection within the previous 3 months.
- Severe cognitive impairment affecting the ability to complete assessments.
- Severe cardiopulmonary disease.
- Serious orthopedic or additional neurological conditions that may affect the assessments.
- Severe pain (Visual Analog Scale [VAS] score >7).
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 観測モデル：COHORT
- 時間の展望：CROSS_SECTIONAL
コホートと介入
グループ/コホート |
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Mild Disability MS
Patients with multiple sclerosis with an Expanded Disability Status Scale (EDSS) score below 4.0. |
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Moderate Disability MS
Patients with multiple sclerosis with an Expanded Disability Status Scale (EDSS) score between 4.0 and 6.5. |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Prevalence of Sarcopenia
時間枠：Baseline
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Sarcopenia will be classified using the ISarcoPRM algorithm based on low muscle mass (STAR) combined with reduced handgrip strength and/or physical performance. Prevalence will be calculated as the percentage of participants meeting the criteria in each EDSS group. |
Baseline
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Prevalence of Dynapenia
時間枠：Baseline
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Dynapenia will be defined as reduced muscle strength, independently of muscle mass, based on low handgrip strength (<32 kg for men; <19 kg for women) and/or prolonged five-times sit-to-stand time (≥12 seconds). Prevalence will be calculated as the percentage of participants meeting the criteria in each EDSS group. |
Baseline
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Handgrip Strength
時間枠：Baseline
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Handgrip strength will be measured using a calibrated hand dynamometer. The highest value from at least two trials will be recorded in kilograms (kg). |
Baseline
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Five-Times Sit-to-Stand Test
時間枠：Baseline
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Participants will be asked to stand up and sit down five times without using their arms. Completion time will be recorded in seconds. A duration of 12 seconds or longer will indicate reduced physical performance. |
Baseline
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Sonographic Thigh Adjustment Ratio (STAR)
時間枠：Baseline
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Anterior thigh muscle thickness will be assessed using ultrasonography and adjusted for body mass index to calculate STAR. Low muscle mass will be defined as STAR <1.0 in women and <1.4 in men. |
Baseline
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Sarcopenia Risk (SARC-F)
時間枠：Baseline
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Sarcopenia risk will be assessed using the five-item SARC-F questionnaire. Total scores range from 0 to 10, with higher scores indicating greater risk. A score of 4 or higher indicates sarcopenia risk. |
Baseline
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Modified Fatigue Impact Scale (MFIS)
時間枠：Baseline
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Fatigue will be assessed using the 21-item MFIS. Total scores range from 0 to 84, with higher scores indicating a greater impact of fatigue on daily functioning. |
Baseline
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Functional Independence Measure (FIM)
時間枠：Baseline
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Functional independence will be assessed using the 18-item FIM. Total scores range from 18 to 126, with higher scores indicating greater independence in daily activities. |
Baseline
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Barthel Index
時間枠：Baseline
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Independence in activities of daily living will be assessed using the Barthel Index. Total scores range from 0 to 100, with higher scores indicating greater functional independence. |
Baseline
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協力者と研究者
スポンサー
捜査官
- スタディチェア：Ayşenur Özcan、Çankırı Karatekin University
- 主任研究者：Büşra Seçkinoğulları Korkusuz, PhD、Ankara University
- スタディチェア：Süleyman Korkusuz、Atılım University
- スタディチェア：Ali M Özcan、Baskent University
出版物と役立つリンク
一般刊行物
- Kara M, Kaymak B, Frontera W, Ata AM, Ricci V, Ekiz T, Chang KV, Han DS, Michail X, Quittan M, Lim JY, Bean JF, Franchignoni F, Ozcakar L. Diagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM. J Rehabil Med. 2021 Jun 21;53(6):jrm00209. doi: 10.2340/16501977-2851.
- Severijns D, Lamers I, Kerkhofs L, Feys P. Hand grip fatigability in persons with multiple sclerosis according to hand dominance and disease progression. J Rehabil Med. 2015 Feb;47(2):154-60. doi: 10.2340/16501977-1897.
- Ozkeskin M, Ozden F, Ar E, Yuceyar N. The reliability and validity of the 30-second chair stand test and modified four square step test in persons with multiple sclerosis. Physiother Theory Pract. 2023 Oct 3;39(10):2189-2195. doi: 10.1080/09593985.2022.2070811. Epub 2022 Apr 26.
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- E-59394181-100-137243
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
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