Investigation of the Prevalence of Sarcopenia and Dynapenia According to Disease Stage in Patients With Multiple Sclerosis and Evaluation of the Relationship Between Sarcopenia Severity and Clinical and Functional Parameters (MS-Sarcopenia)
This cross-sectional observational study aims to determine the prevalence of sarcopenia and dynapenia across disability stages in patients with multiple sclerosis (MS) and investigate their associations with clinical and functional parameters. Approximately 150 patients will be classified into two groups according to their Expanded Disability Status Scale (EDSS) scores: mild disability (EDSS < 4.0) and moderate disability (EDSS 4.0-6.5). Sarcopenia and dynapenia will be assessed using the ISarcoPRM algorithm. Physical activity, fatigue, and functional independence will also be evaluated.
研究概览
详细说明
Participants will undergo assessments of handgrip strength, five-times sit-to-stand performance, and ultrasound-based muscle mass using the Sonographic Thigh Adjustment Ratio (STAR). Sarcopenia and dynapenia will be classified according to the ISarcoPRM algorithm. Additional assessments will include the SARC-F questionnaire, smartwatch-derived physical activity, Modified Fatigue Impact Scale (MFIS), Functional Independence Measure (FIM), and Barthel Index. The prevalence of sarcopenia and dynapenia will be compared between disability groups, and associations with clinical and functional parameters will be examined.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Süleyman Korkusuz, PhD
- 电话号码：+905388675480
- 邮箱：suleyman.korkusuz@atilim.edu.tr
学习地点
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Ankara、土耳其（türkiye）
- Baskent University Ankara Hospital
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接触：
- Ali M Özcan, MSc
- 电话号码：0535 776 08 84
- 邮箱：ozcanalimert1993@gmail.com
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Approximately 150 adults diagnosed with multiple sclerosis (MS) receiving care at the Physiotherapy and Rehabilitation Unit of Başkent University Hospital. Participants will be classified into mild (EDSS <4.0) and moderate (EDSS 4.0-6.5) disability groups.
描述
Inclusion Criteria:
- Aged 18 years or older.
- Diagnosed with multiple sclerosis (MS) by a neurologist.
- Standardized Mini-Mental State Examination (SMMSE) score ≥24.
- Expanded Disability Status Scale (EDSS) score ≤6.5.
- Willing to participate and provide written informed consent.
Exclusion Criteria:
- Orthopedic surgery within the previous 3 months.
- Botulinum toxin injection within the previous 3 months.
- Severe cognitive impairment affecting the ability to complete assessments.
- Severe cardiopulmonary disease.
- Serious orthopedic or additional neurological conditions that may affect the assessments.
- Severe pain (Visual Analog Scale [VAS] score >7).
学习计划
研究是如何设计的？
设计细节
- 观测模型：COHORT
- 时间观点：CROSS_SECTIONAL
队列和干预
团体/队列 |
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Mild Disability MS
Patients with multiple sclerosis with an Expanded Disability Status Scale (EDSS) score below 4.0. |
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Moderate Disability MS
Patients with multiple sclerosis with an Expanded Disability Status Scale (EDSS) score between 4.0 and 6.5. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Prevalence of Sarcopenia
大体时间：Baseline
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Sarcopenia will be classified using the ISarcoPRM algorithm based on low muscle mass (STAR) combined with reduced handgrip strength and/or physical performance. Prevalence will be calculated as the percentage of participants meeting the criteria in each EDSS group. |
Baseline
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Prevalence of Dynapenia
大体时间：Baseline
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Dynapenia will be defined as reduced muscle strength, independently of muscle mass, based on low handgrip strength (<32 kg for men; <19 kg for women) and/or prolonged five-times sit-to-stand time (≥12 seconds). Prevalence will be calculated as the percentage of participants meeting the criteria in each EDSS group. |
Baseline
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Handgrip Strength
大体时间：Baseline
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Handgrip strength will be measured using a calibrated hand dynamometer. The highest value from at least two trials will be recorded in kilograms (kg). |
Baseline
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Five-Times Sit-to-Stand Test
大体时间：Baseline
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Participants will be asked to stand up and sit down five times without using their arms. Completion time will be recorded in seconds. A duration of 12 seconds or longer will indicate reduced physical performance. |
Baseline
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Sonographic Thigh Adjustment Ratio (STAR)
大体时间：Baseline
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Anterior thigh muscle thickness will be assessed using ultrasonography and adjusted for body mass index to calculate STAR. Low muscle mass will be defined as STAR <1.0 in women and <1.4 in men. |
Baseline
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Sarcopenia Risk (SARC-F)
大体时间：Baseline
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Sarcopenia risk will be assessed using the five-item SARC-F questionnaire. Total scores range from 0 to 10, with higher scores indicating greater risk. A score of 4 or higher indicates sarcopenia risk. |
Baseline
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Modified Fatigue Impact Scale (MFIS)
大体时间：Baseline
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Fatigue will be assessed using the 21-item MFIS. Total scores range from 0 to 84, with higher scores indicating a greater impact of fatigue on daily functioning. |
Baseline
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Functional Independence Measure (FIM)
大体时间：Baseline
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Functional independence will be assessed using the 18-item FIM. Total scores range from 18 to 126, with higher scores indicating greater independence in daily activities. |
Baseline
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Barthel Index
大体时间：Baseline
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Independence in activities of daily living will be assessed using the Barthel Index. Total scores range from 0 to 100, with higher scores indicating greater functional independence. |
Baseline
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合作者和调查者
调查人员
- 学习椅：Ayşenur Özcan、Çankırı Karatekin University
- 首席研究员：Büşra Seçkinoğulları Korkusuz, PhD、Ankara University
- 学习椅：Süleyman Korkusuz、Atılım University
- 学习椅：Ali M Özcan、Baskent University
出版物和有用的链接
一般刊物
- Kara M, Kaymak B, Frontera W, Ata AM, Ricci V, Ekiz T, Chang KV, Han DS, Michail X, Quittan M, Lim JY, Bean JF, Franchignoni F, Ozcakar L. Diagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM. J Rehabil Med. 2021 Jun 21;53(6):jrm00209. doi: 10.2340/16501977-2851.
- Severijns D, Lamers I, Kerkhofs L, Feys P. Hand grip fatigability in persons with multiple sclerosis according to hand dominance and disease progression. J Rehabil Med. 2015 Feb;47(2):154-60. doi: 10.2340/16501977-1897.
- Ozkeskin M, Ozden F, Ar E, Yuceyar N. The reliability and validity of the 30-second chair stand test and modified four square step test in persons with multiple sclerosis. Physiother Theory Pract. 2023 Oct 3;39(10):2189-2195. doi: 10.1080/09593985.2022.2070811. Epub 2022 Apr 26.
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- E-59394181-100-137243
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
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