Study of Individual Neurocognitive Changes Associated With the Training of the Working Memory. (SAMPLEX)
Study of Individual Neurocognitive Changes Associated With the Training of the Working Memory(SAMPLEX)
8 participants including 2 pilots. The 2 pilot participants will each execute an MRI acquisition session in order to adjust the experimental paradigm
調査の概要
状態
条件
詳細な説明
The participants will benefit from a comprehensive training program in the Memory of the taught by the computerized CogMed method. This training showed a positive effect for improve the skills in Memory of the working in the healthy subject
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：CACHIA Arnaud
- 電話番号：0661519200
- メール：arnaud.cachia@u-paris.fr
研究場所
-
-
-
Paris、フランス、75014
- 募集
- CACHIA
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
healthy adult volunteers aged 18 to 30 who have no contraindications to an MRI scan.
説明
Inclusion Criteria:
The inclusion criteria include
- age between 18 and 30 years,
- right-handedness (assessed using the Edinburgh Handedness Inventory),
- native French speaker, affiliation with the French national health insurance system
- provision of written informed consent prior to participation.
Exclusion Criteria:
Exclusion criteria include:
- contraindications to MRI,
- neurological or psychiatric disorders
- history of traumatic brain injury
- any geographical or psychological condition preventing full compliance with the study protocol.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 観測モデル：CASE_ONLY
- 時間の展望：OTHER
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Working memory performance - Cogmed
時間枠：5 week.
|
Cognitive trajectories will be characterized using performance measures derived from the home-based training. |
5 week.
|
|
Working memory performance - CANTAB
時間枠：2 week
|
Cognitive trajectories will be characterized using performance measures derived from the Spatial Span (SSP) task from the CANTAB battery, administered under standardized conditions at GHU Paris Psychiatry and Neurosciences. |
2 week
|
|
Multimodal MRI data
時間枠：2 week
|
Multimodal MRI data - including anatomical, resting-state, working memory (WM) task-based functional, and diffusion-weighted sequences - will be acquired repeatedly over a six-week period during WM training, as well as before and after the training phase. |
2 week
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
executive functions performance
時間枠：1 week
|
To enable complementary analyses of non-trained executive functions (EF), the participant will complete three tasks from the NIH Toolbox Cognitive Battery. |
1 week
|
|
behavioral variables
時間枠：5 week for most variables
|
At baseline, we will collect demographic and cognitive information including age, sex, years of education, and baseline cognitive performance. In addition, we will record a set of covariates related to the participant's state during the scanning session and within the 24 hours preceding each training session. |
5 week for most variables
|
協力者と研究者
捜査官
- 主任研究者：CACHIA Arnaud、hospital saint anne of the GHU Paris
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。