- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT07603206
Replacing Gas Stoves With Portable Electric Appliances to Improve Indoor Air Quality and Asthma Control
연구 개요
상세 설명
Cooking on natural gas stoves is a major source of indoor air pollution and may contribute to asthma exacerbations. The investigators recently completed a single-arm trial in which gas stoves were replaced with electric induction stoves in the homes of 85 individuals with poorly controlled asthma. This led to 70% reductions in indoor NO2 levels and clinically important improvements in multiple measures of asthma control. Asthma Control Questionnaire scores improved by 1.1 points in this trial, which is twice as large as the average improvement seen with medical treatment such as inhaled corticosteroids and/or long-acting beta-agonists.
While these results are promising, the trial lacked a control group which limits the causal inferences that can be drawn. In addition, lung function was not directly measured. Moreover, the costs for stove installation and required electrical upgrades averaged nearly $10,000 per home. Most of this cost was related to the older housing stock of trial participants that often required upgrading the entire electrical panel in a house to install a new 240-volt kitchen outlet for the new electric stove. These costs can be a financial challenge for low-income households, limiting the scalability of a potentially effective solution for improving indoor air quality and asthma control.
To address these limitations, the investigators now propose a pilot randomized controlled trial using a delayed crossover design to evaluate the effectiveness of a low-cost intervention to improve indoor air quality, asthma control, and lung function. The investigators will leave gas stoves in place but will instruct participants to preferentially use two relatively inexpensive portable electric appliances that the investigators will provide. Cooking will be done with an electric induction hot plate and baking with an electric toaster oven. Induction hot plates use magnetic coils beneath a ceramic glass surface to send electromagnetic pulses directly to cookware. The investigators will provide induction stove compatible cookware because it is necessary to use cookware that has some steel or iron in order for the energy transfer to work.
The two portable electric appliances and induction cookware are estimated to cost approximately $600 in total and may provide a more affordable option for low-income households. If a household already has a microwave oven, they will be encouraged to use that as well. As the future scalability of the intervention will depend on its usage, the investigators will also evaluate usage and identify facilitators and barriers to consistent use of the portable devices.
연구 유형
등록 (추정된)
단계
- 해당 없음
연락처 및 위치
연구 연락처
- 이름: Ash Sehgal, MD
- 전화번호: 216-778-7728
- 이메일: axs81@cwru.edu
연구 연락처 백업
- 이름: Ther Aung, PhD
- 전화번호: 216-778-4061
- 이메일: taung@metrohealth.org
참여기준
자격 기준
공부할 수 있는 나이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
설명
Inclusion Criteria:
- Currently use gas stove for cooking or baking at least three times a week
- Poorly controlled asthma as defined by an Asthma Control Questionnaire score of 1.5 or larger
Exclusion Criteria:
- Impaired decision making capacity
- Pregnancy
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
|
실험적: Immediate Intervention
Participants will receive electric hotplate and electric toaster oven immediately after enrollment.
|
The investigators will leave gas stoves in place but will instruct participants to preferentially use two relatively inexpensive portable electric appliances that the investigators will provide.
Cooking will be done with an electric induction hot plate and baking with an electric toaster oven.
|
|
실험적: Delayed Intervention
Participants will receive electric hotplate and electric toaster oven six months after enrollment.
|
The investigators will leave gas stoves in place but will instruct participants to preferentially use two relatively inexpensive portable electric appliances that the investigators will provide.
Cooking will be done with an electric induction hot plate and baking with an electric toaster oven.
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Change in asthma control
기간: Baseline assessment 1-2 weeks before portable appliances given to participant. Final assessment 2-3 months after portable appliances given to participant.
|
Change in Asthma Control Questionnaire score from baseline to final assessment.
Asthma Control Questionnaire scores can range from 0 to 6 with higher scores indicating poor asthma control.
|
Baseline assessment 1-2 weeks before portable appliances given to participant. Final assessment 2-3 months after portable appliances given to participant.
|
|
Change in indoor nitrogen dioxide levels
기간: Baseline assessment 1-2 weeks before portable appliances given to participant. Final assessment 2-3 months after portable appliances given to participant.
|
Change in nitrogen dioxide level from baseline to final assessment
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Baseline assessment 1-2 weeks before portable appliances given to participant. Final assessment 2-3 months after portable appliances given to participant.
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Change in forced expiratory volume in 1 second (FEV1)
기간: Baseline assessment 1-2 weeks before portable appliances given to participant. Final assessment 2-3 months after portable appliances given to participant.
|
Changes in FEV1 from baseline to final assessment.
|
Baseline assessment 1-2 weeks before portable appliances given to participant. Final assessment 2-3 months after portable appliances given to participant.
|
공동 작업자 및 조사자
간행물 및 유용한 링크
일반 간행물
- Bime C, Nguyen J, Wise RA. Measures of asthma control. Curr Opin Pulm Med. 2012 Jan;18(1):48-56. doi: 10.1097/MCP.0b013e32834db0f2.
- Audignon-Durand S, Ramalho O, Mandin C, Roudil A, Le Bihan O, Delva F, Lacourt A. Indoor exposure to ultrafine particles related to domestic activities: A systematic review and meta-analysis. Sci Total Environ. 2023 Dec 15;904:166947. doi: 10.1016/j.scitotenv.2023.166947. Epub 2023 Sep 9.
- Lebel ED, Finnegan CJ, Ouyang Z, Jackson RB. Methane and NOx Emissions from Natural Gas Stoves, Cooktops, and Ovens in Residential Homes. Environ Sci Technol. 2022 Feb 15;56(4):2529-2539. doi: 10.1021/acs.est.1c04707. Epub 2022 Jan 27.
연구 기록 날짜
연구 주요 날짜
연구 시작 (추정된)
기본 완료 (추정된)
연구 완료 (추정된)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
천식 조절에 대한 임상 시험
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Near East University, TurkeyAl-Ahli Hospital, Hebron모집하지 않고 적극적으로DVT 예방 | DVT - 심부 정맥 혈전증 | 심장 온펌프 수술 | DVT 예방 | On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - Complications | 간호 관리 프로토콜키프로스
Portable cooking appliances에 대한 임상 시험
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University of New EnglandHarvard Medical School (HMS and HSDM); Harvard School of Public Health (HSPH)완전한
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IRCCS San Raffaele모병