Effect of Injectable Platelet-rich Fibrin (i-PRF) on Wound Healing After Gingivectomy (i-PRF-GIN)

Inclusion Criteria:Achieving an optimal level of oral hygiene following Phase I periodontal therapy

• Presence of bilateral, symmetric chronic inflammatory gingival overgrowth in the anterior mandibular or maxillary region
• Absence of attachment loss and bone loss at the surgical site
• Absence of systemic conditions that could affect wound healing and periodontal surgical outcomes, such as uncontrolled diabetes, cancer, HIV, or metabolic bone diseases
• No use of systemic corticosteroids, immunosuppressive agents, radiotherapy, and/or chemotherapy prescribed or taken within 2 months prior to the study intervention, which could affect study outcomes, wound healing, and the coagulation mechanism
• Normal physiological hormonal balance

Exclusion Criteria:

Patients unable to achieve optimal oral hygiene or with poor compliance/communication

• Presence of any systemic disease adversely affecting periodontal health and post-procedural wound healing (e.g., diabetes, rheumatoid arthritis, neurological disorders, pulmonary and renal diseases)
• Use of medications known to cause gingival overgrowth, including immunosuppressants, anticonvulsants, and calcium channel blockers
• Pregnancy or lactation in female participants
• Presence of moderate to advanced gingivitis or periodontitis
• Current smoking