Paclitaxel en carboplatine met of zonder bevacizumab bij de behandeling van patiënten met stadium II, stadium III of stadium IV ovariumepitheelkanker, primaire peritoneale kanker of eileiderkanker
GOG-0262: een fase III-onderzoek van elke 3 weken paclitaxel versus dosis dichte wekelijkse paclitaxel in combinatie met carboplatine met of zonder gelijktijdige en consolidatie bevacizumab (NSC #704865) bij de behandeling van primair stadium II, III of IV epitheel ovarium, Peritoneale of eileiderkanker en ACRIN 6695: Perfusie CT-beeldvorming om de behandelingsrespons te evalueren bij patiënten die deelnemen aan GOG-0262
This phase III clinical trial studies two different dose schedules of paclitaxel to see how well they work in combination with carboplatin with or without bevacizumab in treating patients with stage II, III or IV ovarian epithelial cancer, primary peritoneal cancer, or fallopian tube cancer. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Bevacizumab is a type of drug called a monoclonal antibody and blocks tumor growth by stopping the growth of blood vessels that tumors need to grow. It is not yet known whether giving paclitaxel with combination chemotherapy once every three weeks is more effective than giving paclitaxel once a week in treating patients with ovarian, primary peritoneal, or fallopian tube cancer.
Studie Overzicht
Toestand
Conditie
- Ovarieel endometrioïde adenocarcinoom
- Ovarium seromucineus carcinoom
- Ovarium ongedifferentieerd carcinoom
- Eierstokslijmvlies adenocarcinoom
- Eileider overgangscelcarcinoom
- Ovariumovergangscelcarcinoom
- Endometrioïde adenocarcinoom van de eileider
- Eileiderslijmachtig adenocarcinoom
- Ovarieel sereus adenocarcinoom
- Primair peritoneaal sereus adenocarcinoom
- Stadium IIA Eileiderkanker AJCC v6 en v7
- Stadium IIA Eierstokkanker AJCC V6 en v7
- Stadium IIB eileiderkanker AJCC v6 en v7
- Stadium IIB eierstokkanker AJCC v6 en v7
- Stadium IIC eileiderkanker AJCC v6 en v7
- Stadium IIC eierstokkanker AJCC v6 en v7
- Stadium IIIA Eileiderkanker AJCC v7
- Stadium IIIA Eierstokkanker AJCC v6 en v7
- Stadium IIIA Primaire peritoneale kanker AJCC v7
- Stadium IIIB Eileiderkanker AJCC v7
- Stadium IIIB Eierstokkanker AJCC v6 en v7
- Stadium IIIB Primaire peritoneale kanker AJCC v7
- Stadium IIIC Eileiderkanker AJCC v7
- Stadium IIIC Eierstokkanker AJCC v6 en v7
- Stadium IIIC Primaire peritoneale kanker AJCC v7
- Stadium IV eileiderkanker AJCC v6 en v7
- Stadium IV Eierstokkanker AJCC v6 en v7
- Stadium IV primaire peritoneale kanker AJCC v7
- Ovariële Brenner-tumor
- Ovarieel heldercellig adenocarcinofibroom
Gedetailleerde beschrijving
PRIMARY OBJECTIVES:
I. To determine if the weekly paclitaxel regimen increases the time until first progression or death (progression-free survival [PFS]) compared to the every-3-week paclitaxel regimen in women with primary stage II, III or IV epithelial ovarian, peritoneal or fallopian tube cancer who are receiving carboplatin with or without bevacizumab.
SECONDARY OBJECTIVES:
I. To determine if the weekly paclitaxel increases the duration of overall survival compared to the every-3-week paclitaxel when combined with carboplatin with or without bevacizumab.
II. To compare the weekly paclitaxel to the every-3-week paclitaxel with respect to the incidence of severe or serious adverse events when it is combined with carboplatin with or without bevacizumab.
III. To compare the weekly paclitaxel to the every-3-week paclitaxel with respect to patients' self-reported quality of life (QOL) as measured by the Functional Assessment of Cancer Therapy-Ovarian (FACT-O)-Trial Outcome Index (TOI), when paclitaxel is combined with carboplatin with or without bevacizumab. (As of 02/08/2012, the QOL portion of this study is complete; patients enrolled after this date will not have QOL assessments)
TRANSLATIONAL RESEARCH OBJECTIVES:
I. To evaluate single nucleotide polymorphisms (SNPs) associated with progression-free survival and toxicity in advanced stage epithelial ovarian, peritoneal and fallopian tube cancer using genome wide association studies (GWAS).* II. To evaluate genomic signatures in tumor tissues which are predictive for patient survival in advanced stage epithelial ovarian, peritoneal and fallopian tube cancer.* III. To evaluate the association between serum and plasma biomarkers and response to anti-angiogenesis therapy in advanced stage epithelial ovarian, peritoneal, and fallopian tube cancer.*
NOTE: *As of 02/08/2012, the translational research (TR) portion of this study is complete; patients enrolled after this date will not have TR specimens collected.
IMAGING PRIMARY OBJECTIVES:
I. To determine whether larger changes in the tumor perfusion parameters from baseline timepoint (T0) to early-therapy T2 are prognostic of higher progression-free survival (PFS) rate at 6 months (PFS-6) from enrollment in patients treated with weekly or every-3-week paclitaxel regimens, who are receiving carboplatin with or without bevacizumab.***
IMAGING SECONDARY OBJECTIVES:
I. To determine whether larger changes in tumor perfusion parameters from baseline T0 to intermediate T1 and from T1 to T2 are prognostic of higher PFS-6 in patients treated with weekly or every-3-week paclitaxel regimens, who are receiving carboplatin with or without bevacizumab.*** II. To determine whether larger changes in tumor perfusion parameters values from T0 to T1, T0 to T2, and T1 to T2 are prognostic of better overall survival in all treatment arms.*** III. To assess the association between changes in tumor perfusion parameters before and after chemotherapy initiation (T0 to T1) and subsequent best tumor response according to standard anatomic Response Evaluation Criteria in Solid Tumors (RECIST).*** IV. To assess the association between tumor perfusion parameters before chemotherapy and subsequent best tumor response according to RECIST, PFS-6, and overall survival.*** V. To test the assumption that tumor perfusion parameters are reliable, user-independent, and reproducible parameters of tumor microvascular characteristics; a subgroup of 15 patients will have repeat computed tomography (CT) perfusion studies at the intermediate T1 time point.***
NOTE: ***Patients enrolled after February 8, 2012 must participate in the ACRIN 6695 component at ACRIN-qualified institutions.
OUTLINE: Patients are randomized to 1 of 2 treatment arms (beginning on 04-30-2012, the trial is no longer randomized and the chemotherapy regimen is selected and declared prior to enrolling in the study).
ARM I (adjuvant chemotherapy suboptimally debulked): Patients receive paclitaxel intravenously (IV) over 3 hours and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for 6 courses.
ARM II (neoadjuvant chemotherapy with interval cytoreductive surgery): Patients receive paclitaxel IV over 1 hour on days 1, 8, and 15 and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for 6 courses. Patients undergo interval cytoreductive surgery between courses 3 and 4.
Patients in both arms may receive optional** bevacizumab IV over 30-90 minutes on day 1 beginning in course 2. Courses of bevacizumab repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients in Arm II receive bevacizumab during courses 2, 5, and 6 only.
NOTE: **Before enrolling onto this study, each patient chooses whether the study treatment will include concurrent and maintenance bevacizumab.
After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.
Studietype
Inschrijving (Werkelijk)
Fase
- Fase 3
Contacten en locaties
Studie Locaties
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Ontario
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Toronto, Ontario, Canada, M4N 3M5
- Odette Cancer Centre- Sunnybrook Health Sciences Centre
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Alabama
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Birmingham, Alabama, Verenigde Staten, 35233
- University of Alabama at Birmingham Cancer Center
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Mobile, Alabama, Verenigde Staten, 36688
- University of South Alabama Mitchell Cancer Institute
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Alaska
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Anchorage, Alaska, Verenigde Staten, 99508
- Providence Alaska Medical Center
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Arizona
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Phoenix, Arizona, Verenigde Staten, 85013
- Saint Joseph's Hospital and Medical Center
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Scottsdale, Arizona, Verenigde Staten, 85259
- Mayo Clinic in Arizona
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Tucson, Arizona, Verenigde Staten, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, Verenigde Staten, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Verenigde Staten, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Hot Springs, Arkansas, Verenigde Staten, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Little Rock, Arkansas, Verenigde Staten, 72205
- University of Arkansas for Medical Sciences
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California
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Antioch, California, Verenigde Staten, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Burbank, California, Verenigde Staten, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Castro Valley, California, Verenigde Staten, 94546
- East Bay Radiation Oncology Center
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Castro Valley, California, Verenigde Staten, 94546
- Valley Medical Oncology Consultants-Castro Valley
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Concord, California, Verenigde Staten, 94520
- John Muir Medical Center-Concord
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Emeryville, California, Verenigde Staten, 94608
- Bay Area Breast Surgeons Inc
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Fremont, California, Verenigde Staten, 94538
- Kaiser Permanente-Fremont
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Fremont, California, Verenigde Staten, 94538
- Valley Medical Oncology Consultants-Fremont
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Fresno, California, Verenigde Staten, 93720
- Kaiser Permanente-Fresno
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Greenbrae, California, Verenigde Staten, 94904
- Marin Cancer Care Inc
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La Jolla, California, Verenigde Staten, 92093
- UC San Diego Moores Cancer Center
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Long Beach, California, Verenigde Staten, 90806
- Long Beach Memorial Medical Center-Todd Cancer Institute
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Los Angeles, California, Verenigde Staten, 90048
- Cedars-Sinai Medical Center
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Los Angeles, California, Verenigde Staten, 90095
- UCLA / Jonsson Comprehensive Cancer Center
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Los Angeles, California, Verenigde Staten, 90027
- Kaiser Permanente Los Angeles Medical Center
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Martinez, California, Verenigde Staten, 94553-3156
- Contra Costa Regional Medical Center
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Mountain View, California, Verenigde Staten, 94040
- El Camino Hospital
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Mountain View, California, Verenigde Staten, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Oakland, California, Verenigde Staten, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Verenigde Staten, 94611
- Kaiser Permanente Oakland-Broadway
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Oakland, California, Verenigde Staten, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Verenigde Staten, 94609
- Hematology and Oncology Associates-Oakland
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Oakland, California, Verenigde Staten, 94609
- Tom K Lee Inc
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Oakland, California, Verenigde Staten, 94609
- Bay Area Tumor Institute
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Oakland, California, Verenigde Staten, 94602
- Wilma Chan Highland Hospital
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Palo Alto, California, Verenigde Staten, 94304
- Stanford Cancer Institute Palo Alto
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Rancho Cordova, California, Verenigde Staten, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Redwood City, California, Verenigde Staten, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Verenigde Staten, 94801
- Kaiser Permanente-Richmond
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Rohnert Park, California, Verenigde Staten, 94928
- Rohnert Park Cancer Center
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Roseville, California, Verenigde Staten, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
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Roseville, California, Verenigde Staten, 95661
- Kaiser Permanente-Roseville
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Roseville, California, Verenigde Staten, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Verenigde Staten, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Verenigde Staten, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Verenigde Staten, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Verenigde Staten, 95823
- South Sacramento Cancer Center
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Sacramento, California, Verenigde Staten, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, Verenigde Staten, 92123
- Sharp Memorial Hospital
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San Francisco, California, Verenigde Staten, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Verenigde Staten, 94115
- UCSF Medical Center-Mount Zion
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San Jose, California, Verenigde Staten, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Verenigde Staten, 94577
- Kaiser Permanente San Leandro
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San Pablo, California, Verenigde Staten, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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San Rafael, California, Verenigde Staten, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Verenigde Staten, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Rosa, California, Verenigde Staten, 95403
- Kaiser Permanente-Santa Rosa
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South San Francisco, California, Verenigde Staten, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, Verenigde Staten, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Verenigde Staten, 95210
- Kaiser Permanente-Stockton
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Sylmar, California, Verenigde Staten, 91342
- Olive View-University of California Los Angeles Medical Center
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Vacaville, California, Verenigde Staten, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Verenigde Staten, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, Verenigde Staten, 94596
- Kaiser Permanente-Walnut Creek
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Walnut Creek, California, Verenigde Staten, 94598
- John Muir Medical Center-Walnut Creek
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Colorado
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Aurora, Colorado, Verenigde Staten, 80045
- UCHealth University of Colorado Hospital
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Denver, Colorado, Verenigde Staten, 80205
- Kaiser Permanente-Franklin
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Englewood, Colorado, Verenigde Staten, 80110
- Rocky Mountain Gynecologic Oncology PC
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Fort Collins, Colorado, Verenigde Staten, 80524
- Poudre Valley Hospital
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Lafayette, Colorado, Verenigde Staten, 80026
- Kaiser Permanente-Rock Creek
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Connecticut
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Bridgeport, Connecticut, Verenigde Staten, 06606
- Hartford HealthCare - Saint Vincent's Medical Center
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Danbury, Connecticut, Verenigde Staten, 06810
- Danbury Hospital
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Hartford, Connecticut, Verenigde Staten, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, Verenigde Staten, 06102
- Hartford Hospital
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New Britain, Connecticut, Verenigde Staten, 06050
- The Hospital of Central Connecticut
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New Haven, Connecticut, Verenigde Staten, 06520
- Yale University
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Norwich, Connecticut, Verenigde Staten, 06360
- Eastern Connecticut Hematology and Oncology Associates
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Stamford, Connecticut, Verenigde Staten, 06904
- Stamford Hospital/Bennett Cancer Center
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Delaware
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Lewes, Delaware, Verenigde Staten, 19958
- Beebe Medical Center
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Newark, Delaware, Verenigde Staten, 19718
- Christiana Care Health System-Christiana Hospital
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District of Columbia
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Washington D.C., District of Columbia, Verenigde Staten, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, Verenigde Staten, 20016
- Sibley Memorial Hospital
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Florida
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Clearwater, Florida, Verenigde Staten, 33756
- Morton Plant Hospital
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Fort Lauderdale, Florida, Verenigde Staten, 33316
- Broward Health Medical Center
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Fort Myers, Florida, Verenigde Staten, 33905
- GenesisCare USA - FGO
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Jacksonville, Florida, Verenigde Staten, 32224-9980
- Mayo Clinic in Florida
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Jacksonville, Florida, Verenigde Staten, 32204
- Southeast Gynecologic Oncology Associates
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Lakeland, Florida, Verenigde Staten, 33805
- The Watson Clinic
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Orlando, Florida, Verenigde Staten, 32806
- Orlando Health Cancer Institute
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Orlando, Florida, Verenigde Staten, 32803
- AdventHealth Orlando
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St. Petersburg, Florida, Verenigde Staten, 33713
- Women's Cancer Associates
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Georgia
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Atlanta, Georgia, Verenigde Staten, 30342
- Northside Hospital
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Gainesville, Georgia, Verenigde Staten, 30501
- Northeast Georgia Medical Center-Gainesville
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Macon, Georgia, Verenigde Staten, 31201
- Central Georgia Gynecologic Oncology
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Savannah, Georgia, Verenigde Staten, 31404
- Memorial Health University Medical Center
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Hawaii
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Honolulu, Hawaii, Verenigde Staten, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Verenigde Staten, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Verenigde Staten, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Verenigde Staten, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Verenigde Staten, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Verenigde Staten, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Verenigde Staten, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Verenigde Staten, 96819
- Kaiser Permanente Moanalua Medical Center
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Lihue, Hawaii, Verenigde Staten, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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Wailuku, Hawaii, Verenigde Staten, 96793
- Maui Memorial Medical Center
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Wailuku, Hawaii, Verenigde Staten, 96793
- Pacific Cancer Institute of Maui
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‘Aiea, Hawaii, Verenigde Staten, 96701
- Pali Momi Medical Center
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Idaho
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Boise, Idaho, Verenigde Staten, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Post Falls, Idaho, Verenigde Staten, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Illinois
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Aurora, Illinois, Verenigde Staten, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, Verenigde Staten, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, Verenigde Staten, 61701
- OSF Saint Joseph Medical Center
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Canton, Illinois, Verenigde Staten, 61520
- Illinois CancerCare-Canton
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Canton, Illinois, Verenigde Staten, 61520
- Graham Hospital Association
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Carthage, Illinois, Verenigde Staten, 62321
- Illinois CancerCare-Carthage
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Carthage, Illinois, Verenigde Staten, 62321
- Memorial Hospital
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Chicago, Illinois, Verenigde Staten, 60611
- Northwestern University
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Chicago, Illinois, Verenigde Staten, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, Verenigde Staten, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Verenigde Staten, 60631
- Presence Resurrection Medical Center
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Chicago, Illinois, Verenigde Staten, 60612
- Rush MD Anderson Cancer Center
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Decatur, Illinois, Verenigde Staten, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Verenigde Staten, 62526
- Heartland Cancer Research NCORP
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Elmhurst, Illinois, Verenigde Staten, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, Verenigde Staten, 61530
- Illinois CancerCare-Eureka
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Eureka, Illinois, Verenigde Staten, 61530
- Eureka Hospital
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Galesburg, Illinois, Verenigde Staten, 61401
- Illinois CancerCare-Galesburg
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Havana, Illinois, Verenigde Staten, 62644
- Mason District Hospital
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Havana, Illinois, Verenigde Staten, 62644
- Illinois CancerCare-Havana
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Hinsdale, Illinois, Verenigde Staten, 60521
- Sudarshan K Sharma MD Limited-Gynecologic Oncology
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Kankakee, Illinois, Verenigde Staten, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, Verenigde Staten, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, Verenigde Staten, 61455
- Illinois CancerCare-Macomb
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Macomb, Illinois, Verenigde Staten, 61455
- Mcdonough District Hospital
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Maywood, Illinois, Verenigde Staten, 60153
- Loyola University Medical Center
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Moline, Illinois, Verenigde Staten, 61265
- Garneau, Stewart C MD (UIA Investigator)
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Moline, Illinois, Verenigde Staten, 61265
- Porubcin, Michael MD (UIA Investigator)
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Moline, Illinois, Verenigde Staten, 61265
- Spector, David MD (UIA Investigator)
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Moline, Illinois, Verenigde Staten, 61265
- Trinity Medical Center
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Monmouth, Illinois, Verenigde Staten, 61462
- Illinois CancerCare-Monmouth
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Monmouth, Illinois, Verenigde Staten, 61462
- Holy Family Medical Center
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Normal, Illinois, Verenigde Staten, 61761
- Carle Cancer Institute Normal
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Normal, Illinois, Verenigde Staten, 61761
- Illinois CancerCare-Community Cancer Center
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Normal, Illinois, Verenigde Staten, 61761
- Carle BroMenn Medical Center
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Oak Lawn, Illinois, Verenigde Staten, 60453-2699
- Advocate Christ Medical Center
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Ottawa, Illinois, Verenigde Staten, 61350
- Illinois CancerCare-Ottawa Clinic
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Ottawa, Illinois, Verenigde Staten, 61350
- Ottawa Regional Hospital and Healthcare Center
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Park Ridge, Illinois, Verenigde Staten, 60068
- Advocate Lutheran General Hospital
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Pekin, Illinois, Verenigde Staten, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, Verenigde Staten, 61554
- OSF Saint Francis Radiation Oncology at Pekin
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Peoria, Illinois, Verenigde Staten, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Verenigde Staten, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Verenigde Staten, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, Verenigde Staten, 61614
- Proctor Hospital
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Peru, Illinois, Verenigde Staten, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Verenigde Staten, 61354
- Illinois Valley Hospital
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Princeton, Illinois, Verenigde Staten, 61356
- Illinois CancerCare-Princeton
-
Princeton, Illinois, Verenigde Staten, 61356
- Perry Memorial Hospital
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Spring Valley, Illinois, Verenigde Staten, 61362
- Illinois CancerCare-Spring Valley
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Springfield, Illinois, Verenigde Staten, 62781
- Springfield Memorial Hospital
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Urbana, Illinois, Verenigde Staten, 61801
- Carle Cancer Center
-
Warrenville, Illinois, Verenigde Staten, 60555
- Northwestern Medicine Cancer Center Warrenville
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Winfield, Illinois, Verenigde Staten, 60190
- Northwestern Medicine Central DuPage Hospital
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Indiana
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Beech Grove, Indiana, Verenigde Staten, 46107
- Franciscan Saint Francis Health-Beech Grove
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Elkhart, Indiana, Verenigde Staten, 46515
- Elkhart General Hospital
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Elkhart, Indiana, Verenigde Staten, 46514
- Michiana Hematology Oncology PC-Elkhart
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Elkhart, Indiana, Verenigde Staten, 46514-2098
- Elkhart Clinic
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Fort Wayne, Indiana, Verenigde Staten, 46845
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
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Indianapolis, Indiana, Verenigde Staten, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, Verenigde Staten, 46260
- Ascension Saint Vincent Indianapolis Hospital
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Kokomo, Indiana, Verenigde Staten, 46904
- Community Howard Regional Health
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La Porte, Indiana, Verenigde Staten, 46350
- IU Health La Porte Hospital
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Michigan City, Indiana, Verenigde Staten, 46360
- Franciscan Saint Anthony Health-Michigan City
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Mishawaka, Indiana, Verenigde Staten, 46545
- Michiana Hematology Oncology PC-Mishawaka
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Mishawaka, Indiana, Verenigde Staten, 46545
- Saint Joseph Regional Medical Center-Mishawaka
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Munster, Indiana, Verenigde Staten, 46321
- The Community Hospital
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Plymouth, Indiana, Verenigde Staten, 46563
- Michiana Hematology Oncology PC-Plymouth
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Richmond, Indiana, Verenigde Staten, 47374
- Reid Health
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South Bend, Indiana, Verenigde Staten, 46601
- Memorial Hospital of South Bend
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South Bend, Indiana, Verenigde Staten, 46628
- Northern Indiana Cancer Research Consortium
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South Bend, Indiana, Verenigde Staten, 46617
- South Bend Clinic
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Westville, Indiana, Verenigde Staten, 46391
- Michiana Hematology Oncology PC-Westville
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Iowa
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Ames, Iowa, Verenigde Staten, 50010
- McFarland Clinic - Ames
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Bettendorf, Iowa, Verenigde Staten, 52722
- Constantinou, Costas L MD (UIA Investigator)
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Cedar Rapids, Iowa, Verenigde Staten, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Verenigde Staten, 52403
- Oncology Associates at Mercy Medical Center
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Clive, Iowa, Verenigde Staten, 50325
- Mercy Cancer Center-West Lakes
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Clive, Iowa, Verenigde Staten, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
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Des Moines, Iowa, Verenigde Staten, 50309
- Iowa Methodist Medical Center
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Des Moines, Iowa, Verenigde Staten, 50314
- Mercy Medical Center - Des Moines
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Des Moines, Iowa, Verenigde Staten, 50316
- Iowa Lutheran Hospital
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Des Moines, Iowa, Verenigde Staten, 50309
- Iowa-Wide Oncology Research Coalition NCORP
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Des Moines, Iowa, Verenigde Staten, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Verenigde Staten, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
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Iowa City, Iowa, Verenigde Staten, 52242
- University of Iowa/Holden Comprehensive Cancer Center
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Mason City, Iowa, Verenigde Staten, 50401
- Mercy Medical Center - North Iowa
-
Sioux City, Iowa, Verenigde Staten, 51101
- Siouxland Regional Cancer Center
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Sioux City, Iowa, Verenigde Staten, 51102
- Mercy Medical Center-Sioux City
-
Sioux City, Iowa, Verenigde Staten, 51104
- Saint Luke's Regional Medical Center
-
West Des Moines, Iowa, Verenigde Staten, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Verenigde Staten, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Kansas City, Kansas, Verenigde Staten, 66160
- University of Kansas Cancer Center
-
Overland Park, Kansas, Verenigde Staten, 66209
- Menorah Medical Center
-
Overland Park, Kansas, Verenigde Staten, 66213
- Saint Luke's South Hospital
-
Prairie Village, Kansas, Verenigde Staten, 66208
- Kansas City NCI Community Oncology Research Program
-
-
Kentucky
-
Edgewood, Kentucky, Verenigde Staten, 41017
- Saint Elizabeth Healthcare Edgewood
-
Lexington, Kentucky, Verenigde Staten, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Verenigde Staten, 40503
- Baptist Health Lexington
-
Louisville, Kentucky, Verenigde Staten, 40202
- Norton Hospital Pavilion and Medical Campus
-
Louisville, Kentucky, Verenigde Staten, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Pikeville, Kentucky, Verenigde Staten, 41501
- Pikeville Medical Center
-
-
Louisiana
-
Baton Rouge, Louisiana, Verenigde Staten, 70817
- Woman's Hospital
-
New Orleans, Louisiana, Verenigde Staten, 70112
- Tulane University School of Medicine
-
New Orleans, Louisiana, Verenigde Staten, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Verenigde Staten, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, Verenigde Staten, 70112
- Louisiana State University Health Science Center
-
Shreveport, Louisiana, Verenigde Staten, 71103
- LSU Health Sciences Center at Shreveport
-
Shreveport, Louisiana, Verenigde Staten, 71105
- Highland Clinic
-
-
Maine
-
Bangor, Maine, Verenigde Staten, 04401
- Eastern Maine Medical Center
-
Portland, Maine, Verenigde Staten, 04102
- MaineHealth Maine Medical Center - Portland
-
-
Maryland
-
Baltimore, Maryland, Verenigde Staten, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Verenigde Staten, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, Verenigde Staten, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, Verenigde Staten, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Verenigde Staten, 21201
- University of Maryland/Greenebaum Cancer Center
-
Easton, Maryland, Verenigde Staten, 21601
- University of Maryland Shore Medical Center at Easton
-
Elkton, Maryland, Verenigde Staten, 21921
- Christiana Care - Union Hospital
-
Silver Spring, Maryland, Verenigde Staten, 20910
- Holy Cross Hospital
-
-
Massachusetts
-
Attleboro, Massachusetts, Verenigde Staten, 02703
- Sturdy Memorial Hospital
-
Boston, Massachusetts, Verenigde Staten, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, Verenigde Staten, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Verenigde Staten, 02111
- Tufts Medical Center
-
Boston, Massachusetts, Verenigde Staten, 02114
- Massachusetts General Hospital Cancer Center
-
Burlington, Massachusetts, Verenigde Staten, 01805
- Lahey Clinic
-
Methuen, Massachusetts, Verenigde Staten, 01844
- Holy Family Hospital
-
Springfield, Massachusetts, Verenigde Staten, 01199
- Baystate Medical Center
-
Worcester, Massachusetts, Verenigde Staten, 01605
- UMass Memorial Medical Center - Memorial Division
-
-
Michigan
-
Ann Arbor, Michigan, Verenigde Staten, 48106
- Michigan Cancer Research Consortium NCORP
-
Ann Arbor, Michigan, Verenigde Staten, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Verenigde Staten, 49017
- Bronson Battle Creek
-
Big Rapids, Michigan, Verenigde Staten, 49307
- Spectrum Health Big Rapids Hospital
-
Dearborn, Michigan, Verenigde Staten, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Verenigde Staten, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Verenigde Staten, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Verenigde Staten, 48236
- Henry Ford Health Saint John Hospital
-
Escanaba, Michigan, Verenigde Staten, 49829
- OSF Saint Francis Hospital and Medical Group
-
Flint, Michigan, Verenigde Staten, 48532
- Genesys Regional Medical Center-West Flint Campus
-
Flint, Michigan, Verenigde Staten, 48503
- Hurley Medical Center
-
Grand Blanc, Michigan, Verenigde Staten, 48439
- Genesys Regional Medical Center
-
Grand Rapids, Michigan, Verenigde Staten, 49503
- Cancer Research Consortium of West Michigan NCORP
-
Grand Rapids, Michigan, Verenigde Staten, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Verenigde Staten, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Jackson, Michigan, Verenigde Staten, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Verenigde Staten, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Verenigde Staten, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Verenigde Staten, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, Verenigde Staten, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Verenigde Staten, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Muskegon, Michigan, Verenigde Staten, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Verenigde Staten, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Pontiac, Michigan, Verenigde Staten, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Port Huron, Michigan, Verenigde Staten, 48060
- Lake Huron Medical Center
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Verenigde Staten, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Verenigde Staten, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Verenigde Staten, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Southfield, Michigan, Verenigde Staten, 48075
- Henry Ford Health Providence Southfield Hospital
-
Traverse City, Michigan, Verenigde Staten, 49684
- Munson Medical Center
-
Warren, Michigan, Verenigde Staten, 48093
- Henry Ford Health Warren Hospital
-
Wyoming, Michigan, Verenigde Staten, 49519
- University of Michigan Health - West
-
-
Minnesota
-
Bemidji, Minnesota, Verenigde Staten, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Verenigde Staten, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Verenigde Staten, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Verenigde Staten, 55433
- Mercy Hospital
-
Duluth, Minnesota, Verenigde Staten, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, Verenigde Staten, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Verenigde Staten, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Verenigde Staten, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Verenigde Staten, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Verenigde Staten, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Verenigde Staten, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Verenigde Staten, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, Verenigde Staten, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Verenigde Staten, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Verenigde Staten, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Verenigde Staten, 55407
- Abbott-Northwestern Hospital
-
New Ulm, Minnesota, Verenigde Staten, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Verenigde Staten, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Verenigde Staten, 55905
- Mayo Clinic in Rochester
-
Saint Louis Park, Minnesota, Verenigde Staten, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Verenigde Staten, 55426
- Park Nicollet Frauenshuh Cancer Center
-
Saint Louis Park, Minnesota, Verenigde Staten, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, Verenigde Staten, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Verenigde Staten, 55102
- United Hospital
-
Shakopee, Minnesota, Verenigde Staten, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Verenigde Staten, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Verenigde Staten, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Verenigde Staten, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Verenigde Staten, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Jackson, Mississippi, Verenigde Staten, 39216
- University of Mississippi Medical Center
-
Jackson, Mississippi, Verenigde Staten, 39216
- Saint Dominic-Jackson Memorial Hospital
-
-
Missouri
-
Joplin, Missouri, Verenigde Staten, 64804
- Freeman Health System
-
Kansas City, Missouri, Verenigde Staten, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, Verenigde Staten, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Verenigde Staten, 64132
- Research Medical Center
-
Kansas City, Missouri, Verenigde Staten, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, Verenigde Staten, 64114
- Saint Joseph Health Center
-
Lee's Summit, Missouri, Verenigde Staten, 64086
- Saint Luke's East - Lee's Summit
-
Liberty, Missouri, Verenigde Staten, 64068
- Liberty Hospital
-
Saint Joseph, Missouri, Verenigde Staten, 64506
- Heartland Regional Medical Center
-
Springfield, Missouri, Verenigde Staten, 65804
- Cancer Research for the Ozarks NCORP
-
Springfield, Missouri, Verenigde Staten, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Verenigde Staten, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Verenigde Staten, 63110
- Washington University School of Medicine
-
-
Montana
-
Billings, Montana, Verenigde Staten, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Verenigde Staten, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Verenigde Staten, 59102
- Montana Cancer Consortium NCORP
-
Billings, Montana, Verenigde Staten, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Verenigde Staten, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Verenigde Staten, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Verenigde Staten, 59405
- Great Falls Clinic
-
Great Falls, Montana, Verenigde Staten, 59405
- Benefis Sletten Cancer Institute
-
Havre, Montana, Verenigde Staten, 59501
- Northern Montana Hospital
-
Helena, Montana, Verenigde Staten, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Verenigde Staten, 59901
- Glacier Oncology PLLC
-
Kalispell, Montana, Verenigde Staten, 59901
- Kalispell Medical Oncology
-
Kalispell, Montana, Verenigde Staten, 59901
- Logan Health Medical Center
-
Missoula, Montana, Verenigde Staten, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Verenigde Staten, 59802
- Montana Cancer Specialists
-
-
Nebraska
-
Kearney, Nebraska, Verenigde Staten, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Verenigde Staten, 68510
- Nebraska Cancer Research Center
-
Omaha, Nebraska, Verenigde Staten, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Verenigde Staten, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Verenigde Staten, 68106
- Missouri Valley Cancer Consortium
-
-
Nevada
-
Las Vegas, Nevada, Verenigde Staten, 89106
- Women's Cancer Center of Nevada
-
Reno, Nevada, Verenigde Staten, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Verenigde Staten, 89502
- Center of Hope at Renown Medical Center
-
-
New Jersey
-
Camden, New Jersey, Verenigde Staten, 08103
- Cooper Hospital University Medical Center
-
Hackensack, New Jersey, Verenigde Staten, 07601
- Hackensack University Medical Center
-
Morristown, New Jersey, Verenigde Staten, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, Verenigde Staten, 08060
- Virtua Memorial
-
Neptune City, New Jersey, Verenigde Staten, 07753
- Jersey Shore Medical Center
-
Phillipsburg, New Jersey, Verenigde Staten, 08865
- Saint Luke's Hospital-Warren Campus
-
Ridgewood, New Jersey, Verenigde Staten, 07450
- Valley Health System Ridgewood Campus
-
Summit, New Jersey, Verenigde Staten, 07902
- Overlook Hospital
-
Vineland, New Jersey, Verenigde Staten, 08360
- Inspira Medical Center Vineland
-
Voorhees Township, New Jersey, Verenigde Staten, 08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, Verenigde Staten, 87106
- Southwest Gynecologic Oncology Associates Inc
-
Albuquerque, New Mexico, Verenigde Staten, 87106
- University of New Mexico Cancer Center
-
Las Cruces, New Mexico, Verenigde Staten, 88011
- Memorial Medical Center-Las Cruces
-
-
New York
-
Albany, New York, Verenigde Staten, 12208
- Women's Cancer Care Associates LLC
-
Brightwaters, New York, Verenigde Staten, 11718
- Island Gynecologic Oncology
-
Brooklyn, New York, Verenigde Staten, 11203
- State University of New York Downstate Medical Center
-
Buffalo, New York, Verenigde Staten, 14263
- Roswell Park Cancer Institute
-
Jamaica, New York, Verenigde Staten, 11432
- Queens Hospital Center
-
Lake Success, New York, Verenigde Staten, 11042
- Northwell Health/Center for Advanced Medicine
-
Manhasset, New York, Verenigde Staten, 11030
- North Shore University Hospital
-
Middletown, New York, Verenigde Staten, 10940
- Garnet Health Medical Center
-
Mineola, New York, Verenigde Staten, 11501
- NYU Langone Hospital - Long Island
-
New Hyde Park, New York, Verenigde Staten, 11040
- Long Island Jewish Medical Center
-
New York, New York, Verenigde Staten, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, Verenigde Staten, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, Verenigde Staten, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Staten Island, New York, Verenigde Staten, 10305
- Staten Island University Hospital
-
Stony Brook, New York, Verenigde Staten, 11794
- Stony Brook University Medical Center
-
Syracuse, New York, Verenigde Staten, 13210
- State University of New York Upstate Medical University
-
The Bronx, New York, Verenigde Staten, 10461
- Montefiore Medical Center-Einstein Campus
-
-
North Carolina
-
Asheville, North Carolina, Verenigde Staten, 28816
- Hope Women's Cancer Centers-Asheville
-
Burlington, North Carolina, Verenigde Staten, 27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, Verenigde Staten, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, Verenigde Staten, 28203
- Carolinas Medical Center/Levine Cancer Institute
-
Charlotte, North Carolina, Verenigde Staten, 28204
- Novant Health Presbyterian Medical Center
-
Durham, North Carolina, Verenigde Staten, 27710
- Duke University Medical Center
-
Goldsboro, North Carolina, Verenigde Staten, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, Verenigde Staten, 28791
- Margaret R Pardee Memorial Hospital
-
Pinehurst, North Carolina, Verenigde Staten, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Rutherfordton, North Carolina, Verenigde Staten, 28139
- Rutherford Hospital
-
Wilmington, North Carolina, Verenigde Staten, 28401
- Novant Health New Hanover Regional Medical Center
-
Winston-Salem, North Carolina, Verenigde Staten, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, Verenigde Staten, 58501
- Sanford Bismarck Medical Center
-
Bismarck, North Dakota, Verenigde Staten, 58501
- Mid Dakota Clinic
-
Bismarck, North Dakota, Verenigde Staten, 58501
- Saint Alexius Medical Center
-
Fargo, North Dakota, Verenigde Staten, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Verenigde Staten, 58122
- Sanford Broadway Medical Center
-
-
Ohio
-
Akron, Ohio, Verenigde Staten, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, Verenigde Staten, 44304
- Summa Health System - Akron Campus
-
Bellefontaine, Ohio, Verenigde Staten, 43311
- Mary Rutan Hospital
-
Canton, Ohio, Verenigde Staten, 44710
- Aultman Health Foundation
-
Chillicothe, Ohio, Verenigde Staten, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Verenigde Staten, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Verenigde Staten, 45220
- Good Samaritan Hospital - Cincinnati
-
Cleveland, Ohio, Verenigde Staten, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Verenigde Staten, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Verenigde Staten, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Verenigde Staten, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Verenigde Staten, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Verenigde Staten, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Verenigde Staten, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Verenigde Staten, 43228
- Doctors Hospital
-
Columbus, Ohio, Verenigde Staten, 43215
- Grant Medical Center
-
Columbus, Ohio, Verenigde Staten, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Verenigde Staten, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, Verenigde Staten, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Verenigde Staten, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Verenigde Staten, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Verenigde Staten, 45405
- Grandview Hospital
-
Dayton, Ohio, Verenigde Staten, 45459
- Dayton NCI Community Oncology Research Program
-
Delaware, Ohio, Verenigde Staten, 43015
- Grady Memorial Hospital
-
Findlay, Ohio, Verenigde Staten, 45840
- Blanchard Valley Hospital
-
Franklin, Ohio, Verenigde Staten, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, Verenigde Staten, 45331
- Wayne Hospital
-
Kettering, Ohio, Verenigde Staten, 45429
- Kettering Medical Center
-
Lancaster, Ohio, Verenigde Staten, 43130
- Fairfield Medical Center
-
Lima, Ohio, Verenigde Staten, 45801
- Saint Rita's Medical Center
-
Marietta, Ohio, Verenigde Staten, 45750
- Marietta Memorial Hospital
-
Mayfield Heights, Ohio, Verenigde Staten, 44124
- Hillcrest Hospital Cancer Center
-
Mentor, Ohio, Verenigde Staten, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Mount Vernon, Ohio, Verenigde Staten, 43050
- Knox Community Hospital
-
Newark, Ohio, Verenigde Staten, 43055
- Licking Memorial Hospital
-
Portsmouth, Ohio, Verenigde Staten, 45662
- Southern Ohio Medical Center
-
Springfield, Ohio, Verenigde Staten, 45504
- Springfield Regional Medical Center
-
Troy, Ohio, Verenigde Staten, 45373
- Upper Valley Medical Center
-
Westerville, Ohio, Verenigde Staten, 43081
- Saint Ann's Hospital
-
Wilmington, Ohio, Verenigde Staten, 45177
- Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center
-
Xenia, Ohio, Verenigde Staten, 45385
- Greene Memorial Hospital
-
Zanesville, Ohio, Verenigde Staten, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Verenigde Staten, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, Verenigde Staten, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Bend, Oregon, Verenigde Staten, 97701
- Saint Charles Health System
-
Portland, Oregon, Verenigde Staten, 97239
- Oregon Health and Science University
-
Portland, Oregon, Verenigde Staten, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Verenigde Staten, 97227
- Compass Oncology Rose Quarter
-
-
Pennsylvania
-
Abington, Pennsylvania, Verenigde Staten, 19001
- Jefferson Abington Hospital
-
Allentown, Pennsylvania, Verenigde Staten, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Verenigde Staten, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr, Pennsylvania, Verenigde Staten, 19010
- Bryn Mawr Hospital
-
Drexel Hill, Pennsylvania, Verenigde Staten, 19026
- Delaware County Memorial Hospital
-
Hershey, Pennsylvania, Verenigde Staten, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lancaster, Pennsylvania, Verenigde Staten, 17602
- Lancaster General Hospital
-
Paoli, Pennsylvania, Verenigde Staten, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Verenigde Staten, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Verenigde Staten, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, Verenigde Staten, 19140
- Temple University Hospital
-
Philadelphia, Pennsylvania, Verenigde Staten, 19107
- Pennsylvania Hospital
-
Phoenixville, Pennsylvania, Verenigde Staten, 19460
- Reading Hospital McGlinn Cancer Institute at Phoenixville
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15224
- West Penn Hospital
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15232
- UPMC Hillman Cancer Center
-
Pittsburgh, Pennsylvania, Verenigde Staten, 15213
- UPMC-Magee Womens Hospital
-
Scranton, Pennsylvania, Verenigde Staten, 18510
- Scranton Hematology Oncology
-
Scranton, Pennsylvania, Verenigde Staten, 18501
- Mercy Hospital
-
Scranton, Pennsylvania, Verenigde Staten, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Upland, Pennsylvania, Verenigde Staten, 19013
- Associates In Hematology Oncology PC-Upland
-
West Chester, Pennsylvania, Verenigde Staten, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, Verenigde Staten, 19611
- Reading Hospital
-
Wynnewood, Pennsylvania, Verenigde Staten, 19096
- Lankenau Medical Center
-
Wynnewood, Pennsylvania, Verenigde Staten, 19096
- Main Line Health NCORP
-
-
Rhode Island
-
Providence, Rhode Island, Verenigde Staten, 02905
- Women and Infants Hospital
-
-
South Carolina
-
Anderson, South Carolina, Verenigde Staten, 29621
- AnMed Health Cancer Center
-
Anderson, South Carolina, Verenigde Staten, 29621
- AnMed Health Hospital
-
Boiling Springs, South Carolina, Verenigde Staten, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Verenigde Staten, 29425
- Medical University of South Carolina
-
Greenville, South Carolina, Verenigde Staten, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Verenigde Staten, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Verenigde Staten, 29601
- Saint Francis Hospital
-
Spartanburg, South Carolina, Verenigde Staten, 29303
- Spartanburg Medical Center
-
-
South Dakota
-
Rapid City, South Dakota, Verenigde Staten, 57701
- Black Hills Obstetrics and Gynecology
-
Sioux Falls, South Dakota, Verenigde Staten, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Verenigde Staten, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Verenigde Staten, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Kingsport, Tennessee, Verenigde Staten, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Knoxville, Tennessee, Verenigde Staten, 37920
- University of Tennessee - Knoxville
-
-
Texas
-
Dallas, Texas, Verenigde Staten, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Verenigde Staten, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Sam Houston, Texas, Verenigde Staten, 78234
- Brooke Army Medical Center
-
Galveston, Texas, Verenigde Staten, 77555-0565
- University of Texas Medical Branch
-
Houston, Texas, Verenigde Staten, 77026-1967
- Lyndon Baines Johnson General Hospital
-
Houston, Texas, Verenigde Staten, 77030
- UT MD Anderson Cancer Center
-
Houston, Texas, Verenigde Staten, 77030
- Houston Methodist Hospital
-
Temple, Texas, Verenigde Staten, 76508
- Scott and White Memorial Hospital
-
-
Utah
-
American Fork, Utah, Verenigde Staten, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Verenigde Staten, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Verenigde Staten, 84321
- Logan Regional Hospital
-
Murray, Utah, Verenigde Staten, 84107
- Intermountain Medical Center
-
Ogden, Utah, Verenigde Staten, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Verenigde Staten, 84604
- Utah Valley Regional Medical Center
-
Salt Lake City, Utah, Verenigde Staten, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Verenigde Staten, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Verenigde Staten, 84143
- LDS Hospital
-
Salt Lake City, Utah, Verenigde Staten, 84103
- Intermountain Health Care
-
St. George, Utah, Verenigde Staten, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Burlington, Vermont, Verenigde Staten, 05401
- University of Vermont Medical Center
-
-
Virginia
-
Annandale, Virginia, Verenigde Staten, 22003
- Northern Virginia Pelvic Surgery Associates
-
Charlottesville, Virginia, Verenigde Staten, 22908
- University of Virginia Cancer Center
-
Danville, Virginia, Verenigde Staten, 24541
- Danville Regional Medical Center
-
Fredericksburg, Virginia, Verenigde Staten, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Hampton, Virginia, Verenigde Staten, 23666
- Virginia Oncology Associates-Hampton
-
Lynchburg, Virginia, Verenigde Staten, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Norfolk, Virginia, Verenigde Staten, 23502
- Virginia Oncology Associates - Norfolk
-
Norton, Virginia, Verenigde Staten, 24273
- Ballad Health Cancer Care - Norton
-
Richmond, Virginia, Verenigde Staten, 23298
- VCU Massey Comprehensive Cancer Center
-
Roanoke, Virginia, Verenigde Staten, 24033
- Carilion Roanoke Memorial Hospital
-
-
Washington
-
Bellingham, Washington, Verenigde Staten, 98226
- PeaceHealth Medical Group PC
-
Everett, Washington, Verenigde Staten, 98201
- Providence Regional Cancer Partnership
-
Mount Vernon, Washington, Verenigde Staten, 98274
- Skagit Regional Health Cancer Care Center
-
Poulsbo, Washington, Verenigde Staten, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Seattle, Washington, Verenigde Staten, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, Verenigde Staten, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Verenigde Staten, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, Verenigde Staten, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Verenigde Staten, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Verenigde Staten, 98109
- Fred Hutchinson Cancer Center
-
Seattle, Washington, Verenigde Staten, 98133
- University of Washington Medical Center - Northwest
-
Sequim, Washington, Verenigde Staten, 98384
- Olympic Medical Cancer Care Center
-
Silverdale, Washington, Verenigde Staten, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Verenigde Staten, 99202
- Cancer Care Northwest - Spokane South
-
Spokane, Washington, Verenigde Staten, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Tacoma, Washington, Verenigde Staten, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Verenigde Staten, 98405
- Saint Joseph Medical Center
-
Walla Walla, Washington, Verenigde Staten, 99362
- Providence Saint Mary Regional Cancer Center
-
Wenatchee, Washington, Verenigde Staten, 98801
- Wenatchee Valley Hospital and Clinics
-
Yakima, Washington, Verenigde Staten, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
Wisconsin
-
Antigo, Wisconsin, Verenigde Staten, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, Verenigde Staten, 54911
- ThedaCare Regional Cancer Center
-
Chippewa Falls, Wisconsin, Verenigde Staten, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Verenigde Staten, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Green Bay, Wisconsin, Verenigde Staten, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Verenigde Staten, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Verenigde Staten, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Verenigde Staten, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
La Crosse, Wisconsin, Verenigde Staten, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Verenigde Staten, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Manitowoc, Wisconsin, Verenigde Staten, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Verenigde Staten, 54143
- Bay Area Medical Center
-
Marshfield, Wisconsin, Verenigde Staten, 54449
- Marshfield Medical Center-Marshfield
-
Milwaukee, Wisconsin, Verenigde Staten, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Verenigde Staten, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Verenigde Staten, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Verenigde Staten, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Verenigde Staten, 53149
- ProHealth D N Greenwald Center
-
Oconomowoc, Wisconsin, Verenigde Staten, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Verenigde Staten, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Verenigde Staten, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Rhinelander, Wisconsin, Verenigde Staten, 54501
- Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
-
Rice Lake, Wisconsin, Verenigde Staten, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Verenigde Staten, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Verenigde Staten, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, Verenigde Staten, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Verenigde Staten, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Verenigde Staten, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Verenigde Staten, 54401
- Aspirus Cancer Care-Wausau
-
West Allis, Wisconsin, Verenigde Staten, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Verenigde Staten, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Verenigde Staten, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Casper, Wyoming, Verenigde Staten, 82609
- Rocky Mountain Oncology
-
Sheridan, Wyoming, Verenigde Staten, 82801
- Welch Cancer Center
-
-
-
-
-
Seoul, Zuid -Korea, 05505
- Asan Medical Center
-
Seoul, Zuid -Korea, 06273
- Gangnam Severance Hospital
-
Seoul, Zuid -Korea, 110-744
- Seoul National University Hospital
-
Seoul, Zuid -Korea, 135-720
- Yongdong Severence Hospital
-
-
Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
Accepteert gezonde vrijwilligers
Geslachten die in aanmerking komen voor studie
Beschrijving
Inclusion Criteria:
-
Primary Surgery and Neoadjuvant Chemotherapy with Interval Cytoreductive Surgery Patients:
-
Patients must have measurable disease; at least one target lesion must have a minimum length of 1 cm in both the long and short axis (determined at the local site); for primary surgery patients, if no radiographic evidence of measurable disease is obtained prior to registration this can be based on surgical findings; imaging then would need to be completed in the 14 days between Gynecology Oncology Group (GOG) registration and chemotherapy initiation
- After GOG registration, the American College of Radiology [ACR] Imaging Core Laboratory will confirm target lesion as required per protocol; the GOG-eligibility (RECIST) scan and baseline T0 perfusion CT scans will be reviewed prior to the intermediate T1 perfusion CT time point
-
Primary Surgery Patients:
-
Patients with a histologic diagnosis of epithelial ovarian cancer, peritoneal primary carcinoma or fallopian tube cancer, stage II -IV suboptimally debulked (any residual disease > 1 cm); International Federation of Gynecology and Obstetrics (FIGO) stage is assessed following the completion of initial abdominal surgery, appropriate imaging studies and with appropriate tissue available for histologic evaluation; the minimum surgery required is an abdominal surgery providing tissue for histologic evaluation and establishing and documenting the primary site and stage; if additional surgery was performed, it should have been in accordance with appropriate surgery for ovarian or peritoneal carcinoma described in the GOG Surgical Procedures Manual
-
Neoadjuvant Chemotherapy (NAC) with Interval Cytoreductive Surgery (ICS) Patients:
-
For patients undergoing NAC-ICS, a core tissue (not fine needle aspiration) biopsy is required; the tissue must be consistent with a Müllerian origin; patients will require documentation of at least stage II or extraovarian sites of disease acquired via imaging or surgery (without attempt at cytoreduction)
-
Patients with the following histologic epithelial cell types are eligible: serous, endometrioid, clear cell, mucinous adenocarcinoma, undifferentiated carcinoma, mixed epithelial carcinoma, transitional cell carcinoma, malignant Brenner's Tumor, or adenocarcinoma not otherwise specified (N.O.S.); however, the histologic features of the tumor must be compatible with a primary Müllerian epithelial adenocarcinoma; patients may have co-existing fallopian tube carcinoma in-situ so long as the primary origin of invasive tumor is ovarian, peritoneal or fallopian tube; of note, patients with clear cell and mucinous tumors will be eligible unless there is a higher priority protocol
-
Absolute neutrophil count (ANC) greater than or equal to 1,500/mcl; this ANC cannot have been induced or supported by granulocyte colony stimulating factors
-
Platelets greater than or equal to 100,000/mcl
-
Creatinine =< 1.5 x institutional upper limit normal (ULN)
-
Bilirubin less than or equal to 1.5 x ULN
-
Serum glutamic oxaloacetic transaminase (SGOT) less than or equal to 3 x ULN
-
Alkaline phosphatase less than or equal to 2.5 x ULN
-
Neuropathy (sensory or motor) less than or equal to Common Terminology Criteria for Adverse Events (CTCAE) grade 1
-
Patients must have a GOG performance status of 0, 1, or 2
-
Patients must be entered within 12 weeks of diagnostic/staging surgery
-
Patients who have met the pre-entry requirements
-
An approved informed consent and authorization permitting release of personal health information and must be signed by the patient or guardian
-
Only applies for patients who elect to receive bevacizumab:
- Patients in this trial may receive ovarian estrogen +/- progestin replacement therapy as indicated at the lowest effective dose(s) for control of menopausal symptoms at any time, but not high-dose progestins for management of anorexia while on protocol-directed therapy or prior to disease progression due to thrombophlebitis risk
- Prothrombin time (PT) such that international normalized ratio (INR) is =< 1.5 (or an in-range INR, usually between 2 and 3, if a patient is on a stable dose of therapeutic warfarin for management of venous thrombosis including pulmonary thromboembolus) and a partial prothrombin time (PTT) < 1.2 times the upper limit of normal; (heparin, lovenox or alternative anticoagulants are acceptable)
- All patients enrolled into GOG-0262 at sites where ACRIN 6695 is open will be enrolled in the advanced imaging protocol; patients receiving adjuvant or neoadjuvant chemotherapy are eligible for ACRIN 6695; the following sentence does not apply to those patients entered after 02/08/2012: if a patient declines to participate in the perfusion imaging portion of the protocol, a clinical rationale for declination of imaging form will be completed as part of the data submission for ACRIN 6695
-
ACRIN 6695 Eligible Patients:
- Confirmation of ACRIN 6695 eligibility after the baseline T0 perfusion computed tomography (CT) will be assessed by the ACR Imaging Core Lab: At least one target lesion must have a minimum length of 1 cm in both the long and short axis (as determined by the local site), at least half of the target lesion must have attenuation greater than or equal to 10 Hounsfield Units (HU) on the unenhanced CT, and at least half of the lesion must have maximum enhancement greater than or equal to 5 HU in the perfusion CT scan (as determined by the ACR Imaging Core Lab)
Exclusion Criteria:
-
Patients with a current diagnosis of borderline epithelial ovarian tumor (formerly "tumors of low malignant potential") or recurrent invasive epithelial ovarian, primary peritoneal or fallopian tube cancer treated with surgery only (such as patients with stage I-A or I-B low grade epithelial ovarian or fallopian tube cancers) are not eligible; patients with a prior diagnosis of a borderline tumor that was surgically resected and who subsequently develop an unrelated, new invasive epithelial ovarian, peritoneal primary or fallopian tube cancer are eligible, provided that they have not received prior chemotherapy for any ovarian tumor
-
Patients who have received prior radiotherapy to any portion of the abdominal cavity or pelvis; prior radiation for localized cancer of the breast, head and neck, or skin is permitted, provided that it was completed more than three years prior to registration, and the patient remains free of recurrent or metastatic disease
-
Patients who have received prior chemotherapy for any abdominal or pelvic tumor including neo-adjuvant chemotherapy for their ovarian, primary peritoneal or fallopian tube cancer; patients may have received prior adjuvant chemotherapy for localized breast cancer, provided that it was completed more than three years prior to registration, and that the patient remains free of recurrent or metastatic disease
-
Patients who have received any targeted therapy (including but not limited to vaccines, antibodies, tyrosine kinase inhibitors) or hormonal therapy for management of their epithelial ovarian, fallopian tube or peritoneal primary cancer
-
Patients with synchronous primary endometrial cancer, or a past history of primary endometrial cancer, unless all of the following conditions are met: stage not greater than I-A, grade 1 or 2, no more than superficial myometrial invasion, without vascular or lymphatic invasion; no poorly differentiated subtypes, including papillary serous, clear cell or other FIGO grade 3 lesions
-
With the exception of non-melanoma skin cancer, patients with other invasive malignancies who had (or have) any evidence of the other cancer present within the last five years or whose previous cancer treatment contraindicates this protocol therapy
-
Patients with acute hepatitis or active infection that requires parenteral antibiotics
-
Patients with clinically significant cardiovascular disease; this includes:
- Myocardial infarction or unstable angina < 6 months prior to registration
- New York Heart Association (NYHA) grade II or greater congestive heart failure
- Serious cardiac arrhythmia requiring medication; this does not include asymptomatic, atrial fibrillation with controlled ventricular rate
-
Patients who are pregnant or nursing; patients of childbearing potential must agree to use contraceptive measures during study therapy and for at least six months after completion of bevacizumab therapy
-
Patients who have received prior therapy with any anti-vascular endothelial growth factor (VEGF) drug, including bevacizumab
-
Patients with medical history or conditions not otherwise previously specified which in the opinion of the investigator should exclude participation in this study; the investigator should feel free to consult the Statistical and Data Center (SDC) randomization desk for uncertainty in this regard
-
Patients with known allergy to cremophor or polysorbate 80
-
Only applies to patients who elect to receive bevacizumab:
-
Patients with serious non-healing wound, ulcer, or bone fracture; this includes history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 28 days; patients with granulating incisions healing by secondary intention with no evidence of fascial dehiscence or infection are eligible but require weekly wound examinations
-
Patients with active bleeding or pathologic conditions that carry high risk of bleeding, such as known bleeding disorder, coagulopathy, or tumor involving major vessels
-
Patients with history or evidence upon physical examination of central nervous system (CNS) disease, including primary brain tumor, seizures not controlled with standard medical therapy, any brain metastases, or history of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) or subarachnoid hemorrhage within six months of the first date of treatment on this study
- Patients with CTCAE grade 2 or greater peripheral vascular disease (at least brief [< 24 hours] episodes of ischemia managed non-surgically and without permanent deficit)
- Patients with a history of CVA within six months
-
Patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human or humanized antibodies
-
Patients with clinically significant proteinuria; urine protein should be screened by urine protein-creatinine ratio (UPCR); the UPCR has been found to correlate directly with the amount of protein excreted in a 24 hour urine collection; specifically, a UPCR of 1.0 is equivalent to 1.0 gram of protein in a 24-hour urine collection; obtain at least 4 ml of a random urine sample in a sterile container (does not have to be a 24-hour urine); send sample to lab with request for urine protein and creatinine levels (separate requests); the lab will measure protein concentration (mg/dL) and creatinine concentration (mg/dL); the UPCR is derived as follows: protein concentration (mg/dL)/creatinine (mg/dL); patients must have a UPCR < 1.0 to allow participation in the study
-
Patients with or with anticipation of invasive procedures as defined below:
- Major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to the first date of bevacizumab therapy (cycle 2)
- Major surgical procedure anticipated during the course of the study; this includes, but is not limited to abdominal surgery (laparotomy or laparoscopy) prior to disease progression such as colostomy or enterostomy reversal, secondary cytoreductive surgery, or second look surgery; please consult with the SDC Randomization Desk prior to patient entry for any questions related to the classification of surgical procedures
- Any tissue biopsy, such as a core biopsy, within 7 days prior to the first date of bevacizumab therapy (cycle 2)
-
Patients with clinical symptoms or signs of gastrointestinal obstruction and who require parenteral hydration and/or nutrition
-
Patients with metastasis tumor in the parenchyma of the liver or lungs with proximity to large vessels which could make the patients at high risk of lethal hemorrhage during treatment with bevacizumab (ie. hemoptysis, liver rupture)
-
ACRIN 6695 Ineligible Patients:
- Patients with contraindication to iodinated contrast for perfusion CT imaging
- Patients who receive Metformin within 48 hours before perfusion CT imaging
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Behandeling
- Toewijzing: Niet-gerandomiseerd
- Interventioneel model: Parallelle opdracht
- Masker: Geen (open label)
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
|---|---|
|
Experimenteel: Arm I (adjuvant chemotherapy suboptimally debulked)
Patients receive paclitaxel IV over 3 hours and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for 6 courses. |
Given IV
Andere namen:
Given IV
Andere namen:
Given IV
Andere namen:
Undergo surgery Correlative studies
Andere namen:
|
|
Experimenteel: Arm II (neoadjuvant chemotherapy)
Patients receive paclitaxel IV over 1 hour on days 1, 8, and 15 and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for 6 courses. Patients undergo interval cytoreductive surgery between courses 3 and 4. |
Given IV
Andere namen:
Given IV
Andere namen:
Given IV
Andere namen:
Undergo surgery Correlative studies
Andere namen:
|
Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Progression-Free Survival
Tijdsspanne: The timeframe is from enrollment onto the study up to 3 years following enrollment.
|
First progression or death for weekly paclitaxel treatment relative to standard 3 week paclitaxel. Progression is defined using response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions. |
The timeframe is from enrollment onto the study up to 3 years following enrollment.
|
Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Median Duration of First Quartile Survival
Tijdsspanne: The timeframe is from enrollment onto the study up to 3 years after enrollment
|
First Quartile Overall Survival |
The timeframe is from enrollment onto the study up to 3 years after enrollment
|
|
Quality of Life Score as Measured by Functional Assessment of Cancer Therapy-Ovary-Total Outcome Index (Fact-O TOI)
Tijdsspanne: 18 weeks after enrolling on the study, which is the time it takes to complete 6 cycles of treatment plus 3 weeks
|
Mean quality of life score after 6 cycles of study treatment estimated from a mixed model. The FACT-O-TOI is composed of three subscales: Physical Well Being (PWB) (7 Items), Functional Well Being (FWB) (7 items), and Ovarian Cancer Subscale (OCS) (12 items). Each item in the FACT-O TOI are scored using a 5-point scale (0=not at all; 1=a little bit; 2=somewhat; 3=quite a bit; 4=very much). A subscale score is computed as long as more than 50% of subscale items have been answered. A Total score of the FACT-O TOI is the summation of the three subscale scores; if more than 80% of the FACT-O TOI items provide valid responses and all three subscales have valid scores. A score of the FACT-O TOI is ranged 0-104 with a larger score indicating a more preferred state of health-related quality of life (HRQOL) |
18 weeks after enrolling on the study, which is the time it takes to complete 6 cycles of treatment plus 3 weeks
|
Andere uitkomstmaten
Uitkomstmaat |
Tijdsspanne |
|---|---|
|
Veranderingen in de tumorperfusieparameters zoals gekwantificeerd door vasculariteit of bloedvolume; Perfusie of doorbloeding; gemiddelde transittijd; en Microvasculaire permeabiliteit of permeabiliteitsoppervlakteproduct
Tijdsspanne: Baseline (T0) tot 10 dagen na de start van kuur 2 (T2)
|
Baseline (T0) tot 10 dagen na de start van kuur 2 (T2)
|
Medewerkers en onderzoekers
Sponsor
Medewerkers
Onderzoekers
- Hoofdonderzoeker: John K Chan, NRG Oncology
Publicaties en nuttige links
Algemene publicaties
- Chan JK, Brady MF, Penson RT, Huang H, Birrer MJ, Walker JL, DiSilvestro PA, Rubin SC, Martin LP, Davidson SA, Huh WK, O'Malley DM, Boente MP, Michael H, Monk BJ. Weekly vs. Every-3-Week Paclitaxel and Carboplatin for Ovarian Cancer. N Engl J Med. 2016 Feb 25;374(8):738-48. doi: 10.1056/NEJMoa1505067.
- Gaitskell K, Rogozinska E, Platt S, Chen Y, Abd El Aziz M, Tattersall A, Morrison J. Angiogenesis inhibitors for the treatment of epithelial ovarian cancer. Cochrane Database Syst Rev. 2023 Apr 18;4(4):CD007930. doi: 10.1002/14651858.CD007930.pub3.
Studie record data
Bestudeer belangrijke data
Studie start (Werkelijk)
Primaire voltooiing (Werkelijk)
Studie voltooiing (Werkelijk)
Studieregistratiedata
Eerst ingediend
Eerst ingediend dat voldeed aan de QC-criteria
Eerst geplaatst (Geschat)
Updates van studierecords
Laatste update geplaatst (Werkelijk)
Laatste update ingediend die voldeed aan QC-criteria
Laatst geverifieerd
Meer informatie
Termen gerelateerd aan deze studie
Aanvullende relevante MeSH-voorwaarden
- Urogenitale ziekten
- Genitale ziekten
- Endocriene systeemziekten
- Urogenitale neoplasmata
- Neoplasmata per site
- Neoplasmata
- Vrouwelijke urogenitale ziekten
- Vrouwelijke urogenitale ziekten en zwangerschapscomplicaties
- Neoplasmata per histologisch type
- Genitale ziekten, vrouw
- Neoplasmata, glandulair en epitheel
- Ovariële ziekten
- Adnexale ziekten
- Genitale neoplasmata, vrouwelijk
- Gonadale aandoeningen
- Neoplasmata, bindweefsel en zacht weefsel
- Neoplasmata, bindweefsel
- Ziekten van de eileiders
- Ovariumneoplasmata
- Neoplasmata, vezelig weefsel
- Neoplasmata, fibro-epitheliaal
- Eileiderneoplasmata
- Brenner-tumor
- Aminozuren, peptiden en eiwitten
- Eiwitten
- Zwavelverbindingen
- Organische chemicaliën
- Koolwaterstoffen
- Cycloparaffins
- Koolwaterstoffen, alicyclisch
- Koolwaterstoffen, cyclisch
- Terpenen
- Antilichamen, monoklonaal, gehumaniseerd
- Antilichamen, monoklonaal
- Antilichamen
- Immunoglobulinen
- Immunoproteïnen
- Bloedeiwitten
- Serum -globulines
- Globulines
- Anorganische chemicaliën
- Coördinatiecomplexen
- Taxoids
- Cyclodecanes
- Diterpenen
- Gezondheidszorg economie en organisaties
- Immunoglobuline -isotypes
- Sulfiden
- Anionen
- Ionen
- Elektrolyten
- Waterstofsulfide
- Economie
- Bevacizumab
- Carboplatine
- Paclitaxel
- Immunoglobuline G
- Disulfides
- Belastingen
Andere studie-ID-nummers
- NCI-2011-03812
- U10CA180868 (Subsidie/contract van de Amerikaanse NIH)
- U10CA027469 (Subsidie/contract van de Amerikaanse NIH)
- NCI-2011-03812 (Register-ID: CTRP (Clinical Trial Reporting Program))
- GOG-0262/ACRIN 6695
- 11-00374
- CDR0000681448
- ACRIN 6695
- GOG-0262 (Andere identificatie: CTEP)
- GOG-0262 (Andere identificatie: NRG Oncology)
Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .