Effects of Elastic Resistance Training on Performance and Biochemical Parameters
Effects of Elastic Resistance Training on Physical Performance, Inflammatory Marker and Myokines in Elderly Women
Studie Overzicht
Toestand
Conditie
Interventie / Behandeling
Gedetailleerde beschrijving
Evidence regarding the relationship between RT and systemic myokine responses, as well as inflammation and physical performance in elderly is limited. Thus, this study aimed to evaluate the effect of short-term progressive elastic resistance training on muscular strength and physical performance, as well as the acute and chronic response of myokines and inflammatory markers after resistance exercise in elderly women living in a nursing home. From January to February 2016, we invited 95 older women (≥ 65 years) living in nursing home in the south of Slovenia to participate in our study.
The experimental design consisted of 1) baseline testing; 2) acute elastic resistance exercises with post-exercise and 2h post-exercise biochemical analysis; 3) a 3 months of supervised, progressive elastic resistance training program of moderate intensity; and 4) post-training testing.
The quantification of biomarkers was done using the MAGPIX® system, magnetic bead-based multi-analyte panels and MILLIPLEX® Analyst 5.1 software (MAGPIX®, Merck Millipore) and a human premixed 4-plex kit (R&D System Inc., Minneapolis, MN, USA), strictly following the manufacturer's instructions.
Two-way mixed ANOVA model was used to test group × time interaction. Tukey's post hoc test was applied for statistically significant interaction. To test for significant differences between groups relating anthropometric and biochemical variables, we used a Student's t-test. All values are expressed as mean and standard deviation (SD). P values of <0.05 is considered statistically significant. Bonferroni's correction for multiple testing will be performed by multiplying the P value with the number of tests where appropriate. Statistical analyses will be carried out using the SPSS program, version 21 (Chicago, IL).
Studietype
Inschrijving (Werkelijk)
Fase
- Niet toepasbaar
Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
Accepteert gezonde vrijwilligers
Geslachten die in aanmerking komen voor studie
Beschrijving
Inclusion Criteria:
- nursing home residents
- participants did not perform any regular resistance training
Exclusion Criteria:
- immobility
- implantable cardiac peacemaker
- severe dementia
- terminal illness
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Behandeling
- Toewijzing: Gerandomiseerd
- Interventioneel model: Parallelle opdracht
- Masker: Geen (open label)
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
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Experimenteel: Exercise
Participant in this group performed an acute resistance exercise protocol.
The exercise protocol consisted of general warm-up of 10 min, followed by 8 exercises with 2 sets of 8 repetition and 1 min between sets.
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Exercise session consisted of general warm-up of 10 min, followed by 35-40 min of resistance exercises (chair squats, band seated: biceps curl, seated row, knee extension, leg press and hip abduction; standing behind the chair: knee flexion, and calf rise), and general cool down of 10 min.
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Experimenteel: Training
Participants allocated to intervention group initiated the progressive resistance training program of moderate intensity, with three weekly sessions throughout the 12-week treatment period.
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Each training session consisted of general warm-up of 10 min, followed by 35-40 min of resistance exercises (chair squats, band seated: biceps curl, seated row, knee extension, leg press and hip abduction; standing behind the chair: knee flexion, and calf rise), and general cool down of 10 min.
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Actieve vergelijker: Control group
Participants allocated to control group did not receive any placebo or treatment.
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The control group did not receive any treatment.
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Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
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Functional performance
Tijdsspanne: 1 week
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A short battery of physical performance tests (SPPB) was used to assess baseline and post-training lower extremity function (0-12 point scale).
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1 week
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Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
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Acute effect of resistance exercise
Tijdsspanne: 4 hours
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The acute effect of resistance exercise on plasma concentrations of myokines and inflammatory markers measured pre-, post- and 2h post-exercise.
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4 hours
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Biochemical analysis of chronic effect of resistance training
Tijdsspanne: 2 weeks
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The chronic effect of resistance training on plasma concentrations of myokines and inflammatory markers measured at baseline and post-training.
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2 weeks
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Medewerkers en onderzoekers
Sponsor
Onderzoekers
- Hoofdonderzoeker: Felicita Urzi, MSc, University of Primorska Faculty of Mathematics, Natural Sciences and Information Technologies
Publicaties en nuttige links
Algemene publicaties
- Argiles JM, Lopez-Soriano FJ, Busquets S. Therapeutic potential of interleukin-15: a myokine involved in muscle wasting and adiposity. Drug Discov Today. 2009 Feb;14(3-4):208-13. doi: 10.1016/j.drudis.2008.10.010. Epub 2008 Dec 16.
- Busquets S, Figueras M, Almendro V, Lopez-Soriano FJ, Argiles JM. Interleukin-15 increases glucose uptake in skeletal muscle. An antidiabetogenic effect of the cytokine. Biochim Biophys Acta. 2006 Nov;1760(11):1613-7. doi: 10.1016/j.bbagen.2006.09.001. Epub 2006 Sep 12.
- Geroldi D, Minoretti P, Emanuele E. Brain-derived neurotrophic factor and the metabolic syndrome: more than just a hypothesis. Med Hypotheses. 2006;67(1):195-6. doi: 10.1016/j.mehy.2006.02.001. Epub 2006 Mar 20. No abstract available.
- Martins WR, Safons MP, Bottaro M, Blasczyk JC, Diniz LR, Fonseca RM, Bonini-Rocha AC, de Oliveira RJ. Effects of short term elastic resistance training on muscle mass and strength in untrained older adults: a randomized clinical trial. BMC Geriatr. 2015 Aug 12;15:99. doi: 10.1186/s12877-015-0101-5.
- Oesen S, Halper B, Hofmann M, Jandrasits W, Franzke B, Strasser EM, Graf A, Tschan H, Bachl N, Quittan M, Wagner KH, Wessner B. Effects of elastic band resistance training and nutritional supplementation on physical performance of institutionalised elderly--A randomized controlled trial. Exp Gerontol. 2015 Dec;72:99-108. doi: 10.1016/j.exger.2015.08.013. Epub 2015 Sep 2.
- Prestes J, Shiguemoto G, Botero JP, Frollini A, Dias R, Leite R, Pereira G, Magosso R, Baldissera V, Cavaglieri C, Perez S. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. J Sports Sci. 2009 Dec;27(14):1607-15. doi: 10.1080/02640410903352923.
- Pereira DS, de Queiroz BZ, Miranda AS, Rocha NP, Felicio DC, Mateo EC, Favero M, Coelho FM, Jesus-Moraleida F, Gomes Pereira DA, Teixeira AL, Maximo Pereira LS. Effects of physical exercise on plasma levels of brain-derived neurotrophic factor and depressive symptoms in elderly women--a randomized clinical trial. Arch Phys Med Rehabil. 2013 Aug;94(8):1443-50. doi: 10.1016/j.apmr.2013.03.029. Epub 2013 Apr 18.
- Troseid M, Lappegard KT, Claudi T, Damas JK, Morkrid L, Brendberg R, Mollnes TE. Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome. Eur Heart J. 2004 Feb;25(4):349-55. doi: 10.1016/j.ehj.2003.12.006.
- Yeo NH, Woo J, Shin KO, Park JY, Kang S. The effects of different exercise intensity on myokine and angiogenesis factors. J Sports Med Phys Fitness. 2012 Aug;52(4):448-54.
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Studieregistratiedata
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Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Andere studie-ID-nummers
- UP-FVZ-ERT-Myokine
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
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