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Effects of Supplementation on Performance in Football Players (FOOTBALL-TCP)

21 mei 2026 bijgewerkt door: Krzysztof Mizera

Effects of Combined Taurine, Caffeine, and Phosphatidylserine Supplementation on Physical and Cognitive Performance in Professional Male Football Players

This study investigated the effects of short-term supplementation with taurine, caffeine, and phosphatidylserine on physical and cognitive performance in professional male football players. Eighty-one players were randomly assigned to one of three groups: placebo, taurine plus caffeine, or taurine plus caffeine combined with phosphatidylserine. Supplementation was administered for 10 days, with a final dose taken 60 minutes before a standardized 105-minute football training session.

Primary and secondary outcomes included sprint performance, reaction time, GPS-derived locomotor variables, and technical and tactical performance indicators. The aim of the study was to evaluate whether combined multi-ingredient supplementation could improve performance and attenuate fatigue-related declines under match-like conditions.

Studie Overzicht

Toestand

Voltooid

Conditie

Interventie / Behandeling

Gedetailleerde beschrijving

This randomized, placebo-controlled, single-blind study evaluated the effects of combined supplementation with taurine, caffeine, and phosphatidylserine on physical and cognitive performance in professional male football players.

Eighty-one participants aged 19-32 years were randomly assigned to one of three groups: placebo (lactose), taurine plus caffeine (1500 mg taurine + 200 mg caffeine), or taurine plus caffeine plus phosphatidylserine (1500 mg taurine + 150 mg caffeine + 300 mg phosphatidylserine daily for 10 days). All participants completed a 10-day supplementation period, followed by a standardized 105-minute football training session.

Outcome measures included sprint performance (30 m sprint time), reaction time (visual and auditory), GPS-derived variables (total distance, sprint activity, speed, accelerations, and decelerations), and technical and tactical performance indicators assessed by coaching staff and video analysis.

The study was conducted under controlled environmental conditions and in accordance with standardized training procedures. Data were analyzed using analysis of variance (ANOVA) with post hoc testing. The aim was to determine whether multi-ingredient supplementation could enhance performance and reduce fatigue-related declines in a football-specific setting.

Studietype

Ingrijpend

Inschrijving (Werkelijk)

81

Fase

  • Niet toepasbaar

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studie Locaties

  • Polen
    • Łódżkie
      • Lodz, Łódżkie, Polen, 94-020
        • ŁKS Łódź

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

  • Volwassen

Accepteert gezonde vrijwilligers

Ja

Beschrijving

Inclusion Criteria:

  • Male professional football (soccer) players
  • Age 19-32 years
  • Currently participating in regular team training (4-5 sessions per week)
  • Medically cleared for participation in high-intensity physical activity
  • Provided written informed consent

Exclusion Criteria:

  • Current injury or musculoskeletal condition affecting performance
  • Chronic disease or medical condition
  • Use of medications that may affect physical or cognitive performance
  • Regular use of dietary supplements or caffeine prior to the study period
  • Smoking or alcohol consumption
  • Failure to comply with study procedures

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

  • Primair doel: Fundamentele wetenschap
  • Toewijzing: Gerandomiseerd
  • Interventioneel model: Parallelle opdracht
  • Masker: Dubbele

Wapens en interventies

Deelnemersgroep / Arm
Interventie / Behandeling
Placebo-vergelijker: Placebo
Participants received a placebo (lactose) daily for 10 days.
Ander: Placebo
Placebo (lactose) administered daily for 10 days
Experimenteel: Taurine + Caffeine
Participants received taurine (1500 mg) and caffeine (200 mg) daily for 10 days.
Voedingssupplement: Taurine and Caffeine
Taurine 1500 mg and caffeine 200 mg administered daily for 10 days
Experimenteel: Taurine + Caffeine + PS
Participants received taurine (1500 mg), caffeine (150 mg), and phosphatidylserine (300 mg) daily for 10 days.
Voedingssupplement: Taurine, Caffeine, and Phosphatidylserine
Taurine 1500 mg, caffeine 150 mg, and phosphatidylserine 300 mg administered daily for 10 days

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
30 m sprint time (seconds)
Tijdsspanne: Day 10 (final training session following supplementation)
Time to complete a 30 meter sprint under standardized conditions, expressed in seconds; calculated as the mean of valid trials.
Day 10 (final training session following supplementation)

Secundaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Reaction time (visual and auditory)
Tijdsspanne: Day 10 (post-supplementation)
Visual and auditory reaction time measured using standardized computerized reaction time tests (e.g., validated software-based assessment tools), expressed as mean response time in seconds across valid trials.
Day 10 (post-supplementation)
Total distance (meters)
Tijdsspanne: Day 10 (during standardized training session)
Total distance covered during the standardized training session, measured using GPS tracking devices (e.g., 10 Hz GPS units), expressed in meters.
Day 10 (during standardized training session)
Running speed (m/s)
Tijdsspanne: Day 10 (during standardized training session)
Mean running speed during the standardized training session, measured using GPS tracking devices (e.g., 10 Hz GPS units), expressed in meters per second.
Day 10 (during standardized training session)
Sprint count (number)
Tijdsspanne: Day 10 (during standardized training session)
Total number of sprint efforts recorded during the standardized training session using GPS tracking devices.
Day 10 (during standardized training session)
High-speed running distance (meters)
Tijdsspanne: Day 10 (during standardized training session)
Distance covered at high-speed running thresholds during the standardized training session, measured using GPS tracking and expressed in meters.
Day 10 (during standardized training session)

Andere uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Sprint time decline (%)
Tijdsspanne: Day 10 (during final training session; comparison between first and second halves)
Percentage decline in 30 m sprint time between the first and second halves of the standardized training session, measured using electronic timing gates and expressed as percentage change.
Day 10 (during final training session; comparison between first and second halves)
Running speed decline (%)
Tijdsspanne: Day 10 (during final training session; comparison between first and second halves)
Percentage decline in running speed between the first and second halves of the standardized training session, measured using GPS tracking devices and expressed as percentage change.
Day 10 (during final training session; comparison between first and second halves)
Passing accuracy (%)
Tijdsspanne: Day 10 (during standardized training session)
Percentage of successful passes during the standardized training session, assessed using video-based performance analysis and expressed as a percentage.
Day 10 (during standardized training session)
Dribbling success (%)
Tijdsspanne: Day 10 (during standardized training session)
Percentage of successful dribbling attempts during the standardized training session, assessed using video-based performance analysis and expressed as a percentage.
Day 10 (during standardized training session)
Ball recoveries (number)
Tijdsspanne: Day 10 (during standardized training session)
Total number of ball recoveries performed during the standardized training session, assessed using video-based performance analysis and expressed as a count.
Day 10 (during standardized training session)
Tactical performance score (units)
Tijdsspanne: Day 10 (during standardized training session)
Coach-rated tactical performance during the standardized training session, including positioning, decision-making, and support play, assessed using a standardized rating scale and expressed in standardized score units.
Day 10 (during standardized training session)

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

Krzysztof Mizera

Onderzoekers

  • Hoofdonderzoeker: Krzysztof Maciej MIZERA, PhD, 1. Vizja University in Warsaw, Faculty of Medical Sciences and Health Sciences, 01-143 Warsaw, Poland

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Werkelijk)

25 maart 2025

Primaire voltooiing (Werkelijk)

5 april 2025

Studie voltooiing (Werkelijk)

5 april 2025

Studieregistratiedata

Eerst ingediend

28 april 2026

Eerst ingediend dat voldeed aan de QC-criteria

5 mei 2026

Eerst geplaatst (Werkelijk)

12 mei 2026

Updates van studierecords

Laatste update geplaatst (Werkelijk)

26 mei 2026

Laatste update ingediend die voldeed aan QC-criteria

21 mei 2026

Laatst geverifieerd

1 mei 2026

Meer informatie

Termen gerelateerd aan deze studie

Trefwoorden

Aanvullende relevante MeSH-voorwaarden

Andere studie-ID-nummers

  • MIZERA-2025-FOOTBALL-RCT

Plan Individuele Deelnemersgegevens (IPD)

Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?

NEE

Beschrijving IPD-plan

Individual participant data will not be publicly available due to confidentiality restrictions related to professional athletes. Data may be available from the corresponding author upon reasonable request.

Informatie over medicijnen en apparaten, studiedocumenten

Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel

Nee

Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct

Nee

Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .

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