Effects of 12 Weeks of Omega 3 Supplementation on Resting Metabolic Rate
Fatty acids are the main components of the cell membranes. It has been demonstrated that diet can alter the characteristics and function of many membranes in the body, which has an effect on cardiovascular and metabolic health. Over the last two decades there has been a substantial rise in the research of the effects of Omega 3 polyunsaturated fatty acids on bodily function. There are two fatty acids that are of particular interest to researchers, eicosapentanoic acid (EPA) and docosahexanoic acid (DHA). These fatty acids have unique unsaturated structures, and their incorporation into biological membranes seems to generate important and positive physiological effects. The body is unable to synthesize these fatty acids in high concentrations to elicit significant effects, so they must be obtained through diet in food or via supplementation.
It has been suggested that EPA and DHA supplementation increases resting metabolic rate (RMR) in humans, in part by increasing the use of fat as a fuel during rest. There are a limited number of studies examining the effects of Omega 3 supplementation on RMR. Some have found an increase in RMR while others have found no change. These studies have some limitations, as that they have either used a small sample size, a low omega fatty acid dose and/or short supplementation periods. Due to the variable results, the investigators will improve the reliability of the RMR measurements by making measures on each subject during two consecutive days at each time point that it is measured (0, 6 and 12 weeks).
Therefore, the purpose of this study is to determine the effects of 12 weeks of omega 3 supplementation (3 g/d) on healthy young adults vs. the supplementation of a placebo. The researchers hypothesize that EPA and DHA supplementation will result in an increase in RMR and fat oxidation in some subjects and not in others. The duplicate RMR measures will determine the prevalence and magnitude of the omega 3 supplementation.
Studieoversikt
Status
Forhold
Intervensjon / Behandling
Studietype
Registrering (Faktiske)
Fase
- Ikke aktuelt
Kontakter og plasseringer
Studiesteder
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Ontario
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Guelph, Ontario, Canada, N1G 2W1
- University of Guelph
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Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- 18 - 30 years of age.
- Must currently practice a consistent diet and exercise regimen, and maintain this throughout the duration of the study.
Exclusion Criteria:
- Current or previous supplementation with omega-3's.
- Average fish intake greater than two times per week.
- Taken any medications, have any medical condition, and hospitalization or surgeries.
- Allergy to fish/fish oil, , (rosemary extract, ascorbyl palmitate, or natural tocopherols).
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Grunnvitenskap
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Enkelt
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
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Eksperimentell: Omega-3 komplett
Oralt inntak av 3000 mg (5 kapsler) Omega-3 Complete (Jamieson Laboratories Ltd., Windsor, Ontario, Canada) per dag i 12 uker.
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Placebo komparator: Placebo pille
Oralt inntak av 3 kapsler av en placebo-olivenoljepille (Swanson Health Products, PO Box 2803 - Fargo, ND 58108 USA) per dag i 12 uker.
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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Change in Resting Metabolic Rate From Baseline
Tidsramme: Baseline, 6 weeks, 12 weeks
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Percent change in resting metabolic rate
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Baseline, 6 weeks, 12 weeks
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Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
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Change in Maximum Oxygen Consumption From Baseline
Tidsramme: Baseline, 12 weeks
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Baseline, 12 weeks
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Change in Whole Body Resting Fat Oxidation From Baseline
Tidsramme: Baseline, 6 weeks, 12 weeks
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Baseline, 6 weeks, 12 weeks
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Change in Whole Body Resting Carbohydrate Oxidation From Baseline
Tidsramme: Baseline, 6 weeks, 12 weeks
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Baseline, 6 weeks, 12 weeks
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Variability of Resting Metabolic Rate Measurement on 2 Consecutive Days
Tidsramme: Baseline, 6 weeks, 12 weeks
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Baseline, 6 weeks, 12 weeks
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Change in Fasted Blood Triglyceride Concentration From Baseline
Tidsramme: Baseline, 12 weeks
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Baseline, 12 weeks
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Samarbeidspartnere og etterforskere
Sponsor
Publikasjoner og nyttige lenker
Studierekorddatoer
Studer hoveddatoer
Studiestart
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Anslag)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Andre studie-ID-numre
- 14JA044
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