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Inotuzumab Ozogamicin og frontlinjekjemoterapi ved behandling av unge voksne med nylig diagnostisert B akutt lymfatisk leukemi

2. november 2026 oppdatert av: Alliance for Clinical Trials in Oncology

En fase III-studie for å evaluere effekten av tilsetning av Inotuzumab Ozogamicin (et konjugert anti-CD22 monoklonalt antistoff) til frontlinjeterapi hos unge voksne (alder 18-39 år) med nydiagnostisert forløper B-celle ALL

This phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a chemotherapy drug called ozogamicin. Inotuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as CD22 receptors, and delivers ozogamicin to kill them. Chemotherapy drugs, such as [intervention], work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving inotuzumab ozogamicin with chemotherapy may work better in treating young adults with B acute lymphoblastic leukemia.

Studieoversikt

Status

Rekruttering

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

PRIMARY OBJECTIVES:

I. To confirm tolerability of the combination regimen with the addition of inotuzumab ozogamicin to the pediatric-inspired regimen of cancer and leukemia group B (CALGB) 10403.

II. To determine whether the addition of inotuzumab ozogamicin significantly improves the event-free survival (EFS) in patients who achieve an induction response achieved with the pediatric-inspired regimen of CALGB 10403, without censoring for transplant. (Phase III) III. To determine the safety and tolerability of a reduced dose of inotuzumab ozogamicin and two cycles of blinatumomab added to the pediatric-inspired regimen of CALGB 10403 (Pilor cohort).

SECONDARY OBJECTIVES:

I. To determine the impact of inotuzumab ozogamicin on disease-free (DFS) and overall survival (OS) in patients who achieve an induction response.

II. To determine whether the addition of inotuzumab ozogamicin significantly improves the event-free survival (EFS) in patients who achieve an induction response achieved with the pediatric-inspired regimen of CALGB 10403, with censoring for transplant.

III. To determine the impact of inotuzumab ozogamicin on minimal residual disease (MRD) and correlate this with the EFS, DFS and OS.

IV. To determine the prognosis based on patients' low-density array (LDA) gene signature in terms of EFS, DFS, and OS after treatment with or without inotuzumab ozogamicin when added to the C10403 backbone regimen.

V. To evaluate the toxicity and tolerability of the addition of inotuzumab ozogamicin to the pediatric-inspired regimen of CALGB 10403.

CORRELATIVE SCIENCE OBJECTIVES:

I. To assess both the correlation of MRD post-induction and at sequential timepoints with LDA signature.

II. To evaluate the influence of MRD status (detectable vs. not and as a continuous measure) in relation to EFS both in the univariate setting as well as adjusting for other clinical features including initial white blood cell (WBC), ethnicity, sex and age at diagnosis.

III. To evaluate the impact of inotuzumab ozogamicin (inotuzumab) on the kinetics of MRD during treatment with inotuzumab in patients randomized to the experimental treatment arm.

IV. To perform genomic analyses to identify and evaluate the incidence and clinical significance of recurring novel fusion genes including those associated with the BCR-ABL1-like signature and to correlate with MRD status, CR rate, EFS and OS.

V. To assess whether rs4958351 is correlated with L-asp allergic reaction in the adolescent and young adult (AYA) population.

VI. To assess the incidence of inherited genetic variants in the GR1A1, CEP72, CPA2, TPMT, NUDT15, GRIN3A, GRIK1, and other genes (which can be found using a whole genome association study [GWAS]), are correlated with increased rates of target toxicities including peripheral neuropathy, hepatotoxicity, pancreatitis, myelosuppression, neurotoxicity, thrombosis, and osteonecrosis, and correlate with treatment discontinuation and other clinical response parameters including complete response (CR) rate, EFS, and OS.

VII. To evaluate asparaginase pharmacokinetics in adolescents and young adults, and investigate its correlation with toxicities and treatment outcomes.

VIII. To investigate the effect of anti-polyethylene glycol (PEG) and anti-agouti signaling protein (ASP) antibodies (PEG-ASP) on ASP enzyme activity.

IX. To measure adherence to oral 6 mercaptopurine (MP) and methotrexate in AYAs with acute lymphoblastic leukemia (ALL) and to examine sociodemographic and behavioral determinants of adherence.

X. To determine the impact of adherence on risk of relapse among AYAs with ALL. XI. To correlate specific karyotype groups (normal or various primary and secondary chromosomal abnormalities) with clinical and laboratory parameters.

XII. To correlate specific karyotype groups with response rates, response duration, survival, and cure in patients treated on this protocol.

XIII. To correlate specific karyotype groups with MRD. XIV. To determine karyotype changes at relapse and the influence of the type of change (or no change) in karyotype at relapse.

XV. To define the rate, analytical performance, and diagnostic yield of ChromoSeq vs. conventional G-banded karyotyping and fluorescence in situ hybridization (FISH) for B ALL patients in a multicenter setting.

OUTLINE:

COURSE I (REMISSION INDUCTION THERAPY): All patients receive allopurinol orally (PO) once daily until peripheral blasts and extramedullary disease are reduced and cytarabine intrathecally (IT) over 1 minute on day 1. Patients also receive daunorubicin hydrochloride intravenously, over 1 to 30 minutes (IV) and vincristine sulfate IV on days 1, 8, 15 and 22, dexamethasone PO or IV twice daily (BID) on days 1-7 and 15-21, pegaspargase for patients >21.5 years IV, over 1 to 2 hours on day 4, 5, or 6, or calaspargase pegol IV, over 1 hour, on days 4, 5 or 6 and methotrexate IT over 1 minute on days 8 and 29. Patients with central nervous system (CNS) 3 disease receive methotrexate IT over 1 minute also on days 15 and 22. All patients then undergo bone marrow aspirate and biopsy on day 29.

Patients enrolled prior to Update 8 with response to remission induction therapy are randomized to 1 of 2 arms. Patients enrolled after amendment 8 are assigned to the pilot cohort. Patients with no response are omitted from the study.

ARM I (CLOSED 7/23/2025):

COURSE II (REMISSION CONSOLIDATION CHEMOTHERAPY): Patients receive cyclophosphamide IV on days 1 and 29, cytarabine IV or SC on days 1-4, 8-11, 29-32, and 36-39, mercaptopurine PO on days 1-14 and 29-42, and vincristine sulfate IV, over 1 to 10 minutes on days 15, 22, 43, and 50. Patients >21.5 years also receive pegaspargase IV, over 1 to 2 hours, on days 15 and 43 and patients <21.5 years old receive calaspargase pegol IV, over 1 hour, on days 2 and 22, and methotrexate IT on days 1, 8, 15, and 22. Patients with CNS3 receive methotrexate IT only on days 1 and 8. CD20 positive (+) patients receive rituximab IV on days 1, 8, 29, and 36. Patients with evidence of testicular disease at diagnosis also receive radiation therapy (RT). Patients who are MRD+ and CD19+ after completion of this course receive dexamethasone IV or PO on day 1 and blinatumomab IV via continuous infusion on days 1-28, followed by a 14 day break. Cycles repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. Patients then undergo bone marrow aspirate and biopsy on day 56.

COURSE III (INTERIM MAINTENANCE CHEMOTHERAPY): Patients receive vincristine sulfate IV, over 1 to 10 minutes, on days 1, 11, 21, 31, and 41, methotrexate IV, over 24 hours, and IT on days 1, 11, 21, 31, and 41, patients >21.5 years old receive pegaspargase IV, over 1 to 2 hours, and patients < 21.5 years old receive calaspargase pegol IV, over 1 hour on days 2 and 22. CD20+ patients receive rituximab IV on days 1 and 11.

COURSE IV (DELAYED INTENSIFICATION): Patients receive vincristine sulfate IV, over 1 to 10 minutes, on days 1, 8, 15, 43, and 50, dexamethasone PO or IV BID on days 1-7 and 15-21, doxorubicin IV, over 3 to 60 minutes, on days 1, 8, and 15, patients >21.5 years old receive pegaspargase IV, over 1 to 2 hours, on day 4, 5, or 6 and day 43, patients <21.5 years old receive calaspargase pegol IV, over 1 hour, on days 2 and 22. Patients also receive cyclophosphamide IV on day 29, cytarabine IV or SC on days 29-32 and 36-39, thioguanine PO on days 29-42 and methotrexate IT on days 1, 29, and 36. CD20+ patients receive rituximab IV on days 1 and 8. Patients then undergo bone marrow aspirate and biopsy one week after completion of course IV.

COURSE V (MAINTENANCE THERAPY): Patients receive vincristine sulfate IV, over 1 to 10 minutes, on days 1, 29, and 57, dexamethasone PO or IV BID on days 1-5, 29-33, and 57-61, and mercaptopurine PO on days 1-84. Patients also receive methotrexate IT or PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78. Treatment repeats every 12 weeks for up to 3 years in the absence of disease progression or unacceptable toxicity.

Patients undergo multigated acquisition scan (MUGA) or echocardiography and x ray imaging during screening, bone marrow aspiration and biopsy and lumbar puncture and blood sample collection throughout the study.

ARM II (CLOSED 7/23/2025): Patients receive inotuzumab ozogamicin IV, over 1 hour, on days 1, 8, and 15 and undergo bone marrow aspirate and biopsy on day 28. Treatment repeats every 28 days for up to 2 cycles in the absence of disease progression or unacceptable toxicity. Patients who are MRD+ and CD19+ after completion of 2 cycles of inotuzumab ozogamicin receive dexamethasone IV or PO on day 1 and blinatumomab IV via continuous infusion on days 1-28, followed by a 14 day break. Cycles repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. Patients also receive remission consolidated chemotherapy, interim maintenance chemotherapy, delayed intensification, and maintenance therapy as in Arm I.

Patients undergo MUGA or echocardiography and x ray imaging during screening, bone marrow aspiration and biopsy and lumbar puncture and blood sample collection throughout the study.

PILOT COHORT: Patients receive inotuzumab ozogamicin IV, over 1 hour, on days 1, 8, and 15 and undergo bone marrow aspirate and biopsy on day 28.

COURSE II (REMISSION CONSOLIDATION CHEMOTHERAPY): Patients receive cyclophosphamide IV on days 1 and 29, cytarabine IV or SC on days 1-4, 8-11, 29-32, and 36-39, mercaptopurine PO on days 1-14 and 29-42, and vincristine sulfate IV, over 1 to 10 minutes, on days 15, 22, 43, and 50. Patients > 21.5 years old also receive pegaspargase IV, over 1 to 2 hours, on days 15 and 43 and patients < 21.5 years old receive calaspargase pegol IV, over 1 hour, on days 15 and 43, and methotrexate IT on days 1, 8, 15, and 22. Patients with CNS3 receive methotrexate IT only on days 1 and 8. CD20+ patients receive rituximab IV on days 1, 8, 29, and 36. Patients with evidence of testicular disease at diagnosis also receive RT. Patients then undergo bone marrow aspirate and biopsy on day 56.

BLINATUMOMAB: Patients receive blinatumomab IV, continuously, on days 1-28 of one 42-day cycle in the absence of disease progression or unacceptable toxicity. Patients also receive dexamethasone PO or IV prior to starting the blinatumomab cycle, and a single dose of methotrexate IT between cycle days 29 and 42.

COURSE III (INTERIM MAINTENANCE CHEMOTHERAPY): Patients receive vincristine sulfate IV, over 1 to 10 minutes, on days 1, 11, 21, 31, and 41, methotrexate IV, over 24 hours, and IT on days 1, 11, 21, 31, and 41, patients >21.5 years old receive pegaspargase IV, over 1 to 2 hours, and patients < 21.5 years old receive calaspargase pegol IV, over 1 hour on days 2 and 22. CD20+ patients receive rituximab IV on days 1 and 11.

BLINATUMOMAB: Patients receive blinatumomab IV, continuously, on days 1-28 of one 42-day cycle in the absence of disease progression or unacceptable toxicity. Patients also receive dexamethasone PO or IV prior to starting the blinatumomab cycle, and a single dose of methotrexate IT between cycle days 29 and 42. Patients who are MRD positive and CD19+ after Course II may continue to receive blinatumomab IV, continuously on days 1-28 of each cycle. Cycles repeat every 42 days for an additional 2 cycles in the absence of disease progression or unacceptable toxicity, per investigator discretion.

COURSE IV (DELAYED INTENSIFICATION): Patients receive vincristine sulfate IV, over 1 to 10 minutes on days 1, 8, 15, 43, and 50, dexamethasone PO or IV BID on days 1-7 and 15-21, doxorubicin IV, over 3 to 60 minutes, on days 1, 8, and 15, patients > 21.5 years old receive pegaspargase IV, over 1 to 2 hours, on day 4, 5, or 6 and day 43, patients < 21.5 years old receive calaspargase pegol IV, over 1 hour, on day 4, 5, or 6 and 43. Patients also receive cyclophosphamide IV on day 29, cytarabine IV or SC on days 29-32 and 36-39, thioguanine PO on days 29-42 and methotrexate IT on days 1, 29, and 36. CD20+ patients receive rituximab IV on days 1 and 8. Patients then undergo bone marrow aspirate and biopsy one week after completion of course IV.

COURSE V (MAINTENANCE THERAPY): Patients receive vincristine sulfate IV, over 1 to 10 minutes on days 1, 29, and 57, dexamethasone PO or IV BID on days 1-5, 29-33, and 57-61, and mercaptopurine PO on days 1-84. Patients also receive methotrexate IT on day 1 of cycles 1-4 and PO once weekly (QW) of each cycle. Treatment repeats every 12 weeks for up to 3 years in the absence of disease progression or unacceptable toxicity.

Patients undergo MUGA or echocardiography and x ray imaging during screening, bone marrow aspiration and biopsy and lumbar puncture and blood sample collection throughout the study.

After completion of study treatment, patients are followed up every 2 months for 2 years, every 3 months 2 years, and then every 6 months for up to 10 years.

Studietype

Intervensjonell

Registrering (Antatt)

303

Fase

  • Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Studiesteder

  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 5G2
        • Suspendert
        • Arthur J E Child Comprehensive Cancer Centre
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3E 0V9
        • Suspendert
        • CancerCare Manitoba
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 2Y9
        • Rekruttering
        • QEII Health Sciences Centre/Nova Scotia Health Authority
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 902-473-6000
        • Hovedetterforsker:
          • Nicholas A. Forward
    • Ontario
      • Ottawa, Ontario, Canada, K1H 8L6
        • Rekruttering
        • Ottawa Hospital and Cancer Center-General Campus
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 613-761-4395
        • Hovedetterforsker:
          • Jill Fulcher
    • Quebec
      • Montreal, Quebec, Canada, H3T 1E2
        • Suspendert
        • Jewish General Hospital
  • Forente stater
    • Alabama
      • Birmingham, Alabama, Forente stater, 35233
        • Aktiv, ikke rekrutterende
        • University of Alabama at Birmingham Cancer Center
    • Alaska
      • Anchorage, Alaska, Forente stater, 98508
        • Suspendert
        • Anchorage Associates in Radiation Medicine
      • Anchorage, Alaska, Forente stater, 99504
        • Suspendert
        • Anchorage Radiation Therapy Center
      • Anchorage, Alaska, Forente stater, 99508
        • Suspendert
        • Alaska Breast Care and Surgery LLC
      • Anchorage, Alaska, Forente stater, 99508
        • Suspendert
        • Alaska Oncology and Hematology LLC
      • Anchorage, Alaska, Forente stater, 99508
        • Suspendert
        • Alaska Women's Cancer Care
      • Anchorage, Alaska, Forente stater, 99508
        • Suspendert
        • Anchorage Oncology Centre
      • Anchorage, Alaska, Forente stater, 99508
        • Suspendert
        • Katmai Oncology Group
      • Anchorage, Alaska, Forente stater, 99508
        • Suspendert
        • Providence Alaska Medical Center
      • Fairbanks, Alaska, Forente stater, 99701
        • Suspendert
        • Fairbanks Memorial Hospital
    • Arizona
      • Kingman, Arizona, Forente stater, 86401
        • Suspendert
        • Kingman Regional Medical Center
      • Phoenix, Arizona, Forente stater, 85054
        • Suspendert
        • Mayo Clinic Hospital in Arizona
      • Scottsdale, Arizona, Forente stater, 85259
        • Tilbaketrukket
        • Mayo Clinic in Arizona
    • Arkansas
      • Fort Smith, Arkansas, Forente stater, 72903
        • Suspendert
        • Mercy Hospital Fort Smith
    • California
      • Antioch, California, Forente stater, 94531
        • Rekruttering
        • Kaiser Permanente-Deer Valley Medical Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Arroyo Grande, California, Forente stater, 93420
        • Suspendert
        • PCR Oncology
      • Burbank, California, Forente stater, 91505
        • Suspendert
        • Providence Saint Joseph Medical Center/Disney Family Cancer Center
      • Clovis, California, Forente stater, 93611
        • Rekruttering
        • Community Cancer Institute
        • Hovedetterforsker:
          • Mohammed S. Bukari
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 559-387-1827
      • Clovis, California, Forente stater, 93611
        • Suspendert
        • University Oncology Associates
      • Costa Mesa, California, Forente stater, 92627
        • Rekruttering
        • UC Irvine Health Cancer Center-Newport
        • Hovedetterforsker:
          • Deepa Jeyakumar
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-827-8839
      • Dublin, California, Forente stater, 94568
        • Rekruttering
        • Kaiser Permanente Dublin
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Fremont, California, Forente stater, 94538
        • Rekruttering
        • Kaiser Permanente-Fremont
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Fresno, California, Forente stater, 93720
        • Rekruttering
        • Kaiser Permanente-Fresno
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Fresno, California, Forente stater, 93720
        • Suspendert
        • Fresno Cancer Center
      • Fresno, California, Forente stater, 93720
        • Rekruttering
        • Kaiser Permanente Fresno Orchard Plaza
        • Hovedetterforsker:
          • Jennifer M. Suga
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 833-574-2273
      • Irvine, California, Forente stater, 92612
        • Rekruttering
        • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
        • Hovedetterforsker:
          • Deepa Jeyakumar
        • Ta kontakt med:
      • Modesto, California, Forente stater, 95356
        • Rekruttering
        • Kaiser Permanente-Modesto
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Modesto, California, Forente stater, 95356
        • Rekruttering
        • Kaiser Permanente- Modesto MOB II
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Oakland, California, Forente stater, 94611
        • Rekruttering
        • Kaiser Permanente-Oakland
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Oakland, California, Forente stater, 94611
        • Suspendert
        • Kaiser Permanente Oakland-Broadway
      • Orange, California, Forente stater, 92868
        • Rekruttering
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
        • Hovedetterforsker:
          • Deepa Jeyakumar
        • Ta kontakt med:
      • Palo Alto, California, Forente stater, 94304
        • Rekruttering
        • Stanford Cancer Institute Palo Alto
        • Hovedetterforsker:
          • Michaela Liedtke
        • Ta kontakt med:
      • Rancho Cordova, California, Forente stater, 95670
        • Suspendert
        • Kaiser Permanente-Rancho Cordova Cancer Center
      • Redwood City, California, Forente stater, 94063
        • Suspendert
        • Kaiser Permanente-Redwood City
      • Redwood City, California, Forente stater, 94063
        • Suspendert
        • Kaiser Permanente- Marshall Medical Offices
      • Richmond, California, Forente stater, 94801
        • Rekruttering
        • Kaiser Permanente-Richmond
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Rohnert Park, California, Forente stater, 94928
        • Suspendert
        • Rohnert Park Cancer Center
      • Roseville, California, Forente stater, 95661
        • Rekruttering
        • Kaiser Permanente-Roseville
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Roseville, California, Forente stater, 95678
        • Suspendert
        • The Permanente Medical Group-Roseville Radiation Oncology
      • Sacramento, California, Forente stater, 95817
        • Rekruttering
        • University of California Davis Comprehensive Cancer Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 916-734-3089
        • Hovedetterforsker:
          • Brian A. Jonas
      • Sacramento, California, Forente stater, 95814
        • Rekruttering
        • Kaiser Permanente Downtown Commons
        • Hovedetterforsker:
          • Jennifer M. Suga
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: kpoct@kp.org
      • Sacramento, California, Forente stater, 95823
        • Rekruttering
        • Kaiser Permanente-South Sacramento
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Sacramento, California, Forente stater, 95823
        • Suspendert
        • South Sacramento Cancer Center
      • Sacramento, California, Forente stater, 95825
        • Suspendert
        • Kaiser Permanente Sacramento Medical Center
      • San Francisco, California, Forente stater, 94115
        • Rekruttering
        • Kaiser Permanente-San Francisco
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • San Jose, California, Forente stater, 95119
        • Rekruttering
        • Kaiser Permanente-Santa Teresa-San Jose
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • San Leandro, California, Forente stater, 94577
        • Rekruttering
        • Kaiser Permanente San Leandro
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • San Rafael, California, Forente stater, 94903
        • Rekruttering
        • Kaiser San Rafael-Gallinas
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • San Rafael, California, Forente stater, 94903
        • Suspendert
        • Kaiser Permanente-San Rafael
      • Santa Clara, California, Forente stater, 95051
        • Rekruttering
        • Kaiser Permanente Medical Center - Santa Clara
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Santa Rosa, California, Forente stater, 95403
        • Rekruttering
        • Kaiser Permanente-Santa Rosa
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • South San Francisco, California, Forente stater, 94080
        • Suspendert
        • Kaiser Permanente Cancer Treatment Center
      • South San Francisco, California, Forente stater, 94080
        • Rekruttering
        • Kaiser Permanente-South San Francisco
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Stockton, California, Forente stater, 95210
        • Rekruttering
        • Kaiser Permanente-Stockton
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Vacaville, California, Forente stater, 95688
        • Rekruttering
        • Kaiser Permanente Medical Center-Vacaville
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Vallejo, California, Forente stater, 94589
        • Rekruttering
        • Kaiser Permanente-Vallejo
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
      • Walnut Creek, California, Forente stater, 94596
        • Rekruttering
        • Kaiser Permanente-Walnut Creek
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-post: Kpoct@kp.org
        • Hovedetterforsker:
          • Jennifer M. Suga
    • Colorado
      • Aurora, Colorado, Forente stater, 80012
        • Suspendert
        • The Medical Center of Aurora
      • Aurora, Colorado, Forente stater, 80012
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Aurora
      • Boulder, Colorado, Forente stater, 80303
        • Aktiv, ikke rekrutterende
        • Boulder Community Foothills Hospital
      • Boulder, Colorado, Forente stater, 80304
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Boulder
      • Centennial, Colorado, Forente stater, 80112
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers - Centennial
      • Denver, Colorado, Forente stater, 80220
        • Suspendert
        • Rose Medical Center
      • Denver, Colorado, Forente stater, 80204
        • Suspendert
        • Cancer Center of Colorado at Sloan's Lake
      • Denver, Colorado, Forente stater, 80206
        • Suspendert
        • National Jewish Health-Main Campus
      • Denver, Colorado, Forente stater, 80218
        • Aktiv, ikke rekrutterende
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forente stater, 80209
        • Aktiv, ikke rekrutterende
        • The Women's Imaging Center
      • Denver, Colorado, Forente stater, 80218
        • Aktiv, ikke rekrutterende
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Forente stater, 80218
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Forente stater, 80220
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Forente stater, 80220
        • Aktiv, ikke rekrutterende
        • Western Surgical Care
      • Denver, Colorado, Forente stater, 80218
        • Suspendert
        • Saint Joseph Hospital - Cancer Centers of Colorado
      • Englewood, Colorado, Forente stater, 80113
        • Suspendert
        • Swedish Medical Center
      • Englewood, Colorado, Forente stater, 80113
        • Aktiv, ikke rekrutterende
        • Mountain Blue Cancer Care Center - Swedish
      • Englewood, Colorado, Forente stater, 80113
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers - Swedish
      • Englewood, Colorado, Forente stater, 80113
        • Aktiv, ikke rekrutterende
        • The Melanoma and Skin Cancer Institute
      • Golden, Colorado, Forente stater, 80401
        • Suspendert
        • National Jewish Health-Western Hematology Oncology
      • Grand Junction, Colorado, Forente stater, 81501
        • Suspendert
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, Forente stater, 80631
        • Suspendert
        • Banner North Colorado Medical Center
      • Lafayette, Colorado, Forente stater, 80026
        • Suspendert
        • Good Samaritan Hospital - Cancer Centers of Colorado
      • Lakewood, Colorado, Forente stater, 80228
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Lakewood
      • Littleton, Colorado, Forente stater, 80120
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Littleton
      • Lone Tree, Colorado, Forente stater, 80124
        • Suspendert
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Forente stater, 80124
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Loveland, Colorado, Forente stater, 80539
        • Suspendert
        • Banner North Colorado Medical Center - Loveland Campus
      • Thornton, Colorado, Forente stater, 80260
        • Suspendert
        • National Jewish Health-Northern Hematology Oncology
      • Thornton, Colorado, Forente stater, 80260
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Thornton
      • Wheat Ridge, Colorado, Forente stater, 80401
        • Suspendert
        • Intermountain Health Lutheran Hospital
    • Connecticut
      • Hartford, Connecticut, Forente stater, 06105
        • Suspendert
        • Smilow Cancer Hospital Care Center at Saint Francis
      • New Haven, Connecticut, Forente stater, 06520
        • Rekruttering
        • Yale University
        • Ta kontakt med:
        • Hovedetterforsker:
          • Lourdes M. Mendez
      • New Haven, Connecticut, Forente stater, 06510
        • Suspendert
        • Smilow Cancer Center/Yale-New Haven Hospital
    • Florida
      • Fort Lauderdale, Florida, Forente stater, 33308
        • Suspendert
        • Holy Cross Hospital
      • Hollywood, Florida, Forente stater, 33021
        • Rekruttering
        • Memorial Regional Hospital/Joe DiMaggio Children's Hospital
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 954-265-1847
          • E-post: OHR@mhs.net
        • Hovedetterforsker:
          • Fernando M. Vargas Madueno
      • Miami, Florida, Forente stater, 33176
        • Aktiv, ikke rekrutterende
        • Miami Cancer Institute
      • Orlando, Florida, Forente stater, 32806
        • Rekruttering
        • Orlando Health Cancer Institute
        • Ta kontakt med:
        • Hovedetterforsker:
          • Jose E. Sarriera
      • Pembroke Pines, Florida, Forente stater, 33028
        • Suspendert
        • Memorial Hospital West
    • Georgia
      • Atlanta, Georgia, Forente stater, 30322
        • Rekruttering
        • Emory University Hospital/Winship Cancer Institute
        • Hovedetterforsker:
          • William G. Blum
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 404-778-1868
      • Augusta, Georgia, Forente stater, 30912
        • Rekruttering
        • Augusta University Medical Center
        • Hovedetterforsker:
          • Vamsi Kota
        • Ta kontakt med:
    • Hawaii
      • Hilo, Hawaii, Forente stater, 96720
        • Suspendert
        • Island Urology-Hilo
      • Honolulu, Hawaii, Forente stater, 96826
        • Rekruttering
        • Kapiolani Medical Center for Women and Children
        • Hovedetterforsker:
          • Craig S. Boddy
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 808-983-6090
      • Honolulu, Hawaii, Forente stater, 96813
        • Suspendert
        • Island Urology
      • Honolulu, Hawaii, Forente stater, 96813
        • Rekruttering
        • Straub Clinic and Hospital
        • Hovedetterforsker:
          • Craig S. Boddy
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 808-522-4333
      • Honolulu, Hawaii, Forente stater, 96813
        • Suspendert
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, Forente stater, 96813
        • Suspendert
        • Queen's Cancer Cenrer - POB I
      • Honolulu, Hawaii, Forente stater, 96813
        • Suspendert
        • Queen's Medical Center
      • Honolulu, Hawaii, Forente stater, 96813
        • Suspendert
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forente stater, 96817
        • Suspendert
        • Hawaii Cancer Care Inc-Liliha
      • Honolulu, Hawaii, Forente stater, 96817
        • Suspendert
        • Kuakini Medical Center
      • Honolulu, Hawaii, Forente stater, 96817
        • Suspendert
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, Forente stater, 96817
        • Suspendert
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, Forente stater, 96819
        • Suspendert
        • Kaiser Permanente Moanalua Medical Center
      • Lihue, Hawaii, Forente stater, 96766
        • Suspendert
        • Wilcox Memorial Hospital and Kauai Medical Clinic
      • ‘Aiea, Hawaii, Forente stater, 96701
        • Rekruttering
        • Pali Momi Medical Center
        • Hovedetterforsker:
          • Craig S. Boddy
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 808-486-6000
      • ‘Aiea, Hawaii, Forente stater, 96701
        • Suspendert
        • Queen's Cancer Center - Pearlridge
      • ‘Aiea, Hawaii, Forente stater, 96701
        • Suspendert
        • The Cancer Center of Hawaii-Pali Momi
      • ‘Aiea, Hawaii, Forente stater, 96701
        • Suspendert
        • Hawaii Cancer Care - Westridge
    • Idaho
      • Boise, Idaho, Forente stater, 83712
        • Rekruttering
        • Saint Luke's Cancer Institute - Boise
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Boise, Idaho, Forente stater, 83706
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Boise
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Caldwell, Idaho, Forente stater, 83605
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Caldwell
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Coeur d'Alene, Idaho, Forente stater, 83814
        • Rekruttering
        • Kootenai Health - Coeur d'Alene
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Emmett, Idaho, Forente stater, 83617
        • Suspendert
        • Walter Knox Memorial Hospital
      • Fruitland, Idaho, Forente stater, 83619
        • Rekruttering
        • Saint Luke's Cancer Institute - Fruitland
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Meridian, Idaho, Forente stater, 83642
        • Suspendert
        • Idaho Urologic Institute-Meridian
      • Meridian, Idaho, Forente stater, 83642
        • Rekruttering
        • Saint Luke's Cancer Institute - Meridian
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Nampa, Idaho, Forente stater, 83687
        • Rekruttering
        • Saint Luke's Cancer Institute - Nampa
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Nampa, Idaho, Forente stater, 83687
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Nampa
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Post Falls, Idaho, Forente stater, 83854
        • Rekruttering
        • Kootenai Clinic Cancer Services - Post Falls
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Sandpoint, Idaho, Forente stater, 83864
        • Rekruttering
        • Kootenai Clinic Cancer Services - Sandpoint
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Twin Falls, Idaho, Forente stater, 83301
        • Rekruttering
        • Saint Luke's Cancer Institute - Twin Falls
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
    • Illinois
      • Alton, Illinois, Forente stater, 62002
        • Suspendert
        • OSF Saint Anthony's Health Center
      • Burr Ridge, Illinois, Forente stater, 60527
        • Suspendert
        • Loyola Center for Health at Burr Ridge
      • Chicago, Illinois, Forente stater, 60637
        • Rekruttering
        • University of Chicago Comprehensive Cancer Center
        • Hovedetterforsker:
          • Wendy Stock
        • Ta kontakt med:
      • Chicago, Illinois, Forente stater, 60611
        • Rekruttering
        • Northwestern University
        • Hovedetterforsker:
          • Shira N. Dinner
        • Ta kontakt med:
      • Chicago, Illinois, Forente stater, 60612
        • Rekruttering
        • University of Illinois
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 312-355-3046
        • Hovedetterforsker:
          • John G. Quigley
      • Chicago, Illinois, Forente stater, 60612
        • Rekruttering
        • Rush MD Anderson Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Melissa L. Larson
      • Evanston, Illinois, Forente stater, 60201
        • Rekruttering
        • NorthShore University HealthSystem-Evanston Hospital
        • Hovedetterforsker:
          • Amy Y. Wang
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 847-570-2109
      • Glenview, Illinois, Forente stater, 60026
        • Rekruttering
        • NorthShore University HealthSystem-Glenbrook Hospital
        • Hovedetterforsker:
          • Amy Y. Wang
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 847-570-2109
      • Highland Park, Illinois, Forente stater, 60035
        • Rekruttering
        • NorthShore University HealthSystem-Highland Park Hospital
        • Hovedetterforsker:
          • Amy Y. Wang
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 847-570-2109
      • Homer Glen, Illinois, Forente stater, 60491
        • Suspendert
        • Loyola Medicine Homer Glen
      • Lake Forest, Illinois, Forente stater, 60045
        • Aktiv, ikke rekrutterende
        • Northwestern Medicine Lake Forest Hospital
      • Lisle, Illinois, Forente stater, 60532
        • Suspendert
        • Rush MD Anderson Cancer Center at Rush Lisle
      • Maywood, Illinois, Forente stater, 60153
        • Rekruttering
        • Loyola University Medical Center
        • Hovedetterforsker:
          • Patrick A. Hagen
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 708-226-4357
      • Melrose Park, Illinois, Forente stater, 60160
        • Suspendert
        • Marjorie Weinberg Cancer Center at Loyola-Gottlieb
      • Mount Vernon, Illinois, Forente stater, 62864
        • Suspendert
        • SSM Health Good Samaritan
      • New Lenox, Illinois, Forente stater, 60451
        • Rekruttering
        • UC Comprehensive Cancer Center at Silver Cross
        • Hovedetterforsker:
          • Wendy Stock
        • Ta kontakt med:
      • Orland Park, Illinois, Forente stater, 60462
        • Rekruttering
        • University of Chicago Medicine-Orland Park
        • Hovedetterforsker:
          • Wendy Stock
        • Ta kontakt med:
    • Iowa
      • Carroll, Iowa, Forente stater, 51401
        • Aktiv, ikke rekrutterende
        • Saint Anthony Regional Hospital
      • Des Moines, Iowa, Forente stater, 50314
        • Aktiv, ikke rekrutterende
        • Broadlawns Medical Center
      • Des Moines, Iowa, Forente stater, 50309
        • Aktiv, ikke rekrutterende
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forente stater, 50316
        • Aktiv, ikke rekrutterende
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forente stater, 50309
        • Aktiv, ikke rekrutterende
        • Blank Children's Hospital
      • Des Moines, Iowa, Forente stater, 50309
        • Aktiv, ikke rekrutterende
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
      • Fort Dodge, Iowa, Forente stater, 50501
        • Aktiv, ikke rekrutterende
        • UI Healthcare Mission Cancer and Blood - Fort Dodge
      • Iowa City, Iowa, Forente stater, 52242
        • Rekruttering
        • University of Iowa/Holden Comprehensive Cancer Center
        • Hovedetterforsker:
          • Grerk Sutamtewagul
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 800-237-1225
      • West Des Moines, Iowa, Forente stater, 50266-7700
        • Aktiv, ikke rekrutterende
        • Methodist West Hospital
    • Kansas
      • Garden City, Kansas, Forente stater, 67846
        • Suspendert
        • Central Care Cancer Center - Garden City
      • Great Bend, Kansas, Forente stater, 67530
        • Suspendert
        • Central Care Cancer Center - Great Bend
      • Kansas City, Kansas, Forente stater, 66160
        • Rekruttering
        • University of Kansas Cancer Center
        • Hovedetterforsker:
          • Kenneth Byrd
        • Ta kontakt med:
      • Lawrence, Kansas, Forente stater, 66044
        • Suspendert
        • Lawrence Memorial Hospital
      • Westwood, Kansas, Forente stater, 66205
        • Rekruttering
        • University of Kansas Hospital-Westwood Cancer Center
        • Hovedetterforsker:
          • Kenneth Byrd
        • Ta kontakt med:
      • Wichita, Kansas, Forente stater, 67214
        • Rekruttering
        • Cancer Center of Kansas - Wichita
        • Ta kontakt med:
        • Hovedetterforsker:
          • Dennis F. Moore
      • Wichita, Kansas, Forente stater, 67208
        • Suspendert
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forente stater, 67214
        • Suspendert
        • Ascension Via Christi Hospitals Wichita
      • Wichita, Kansas, Forente stater, 67214
        • Suspendert
        • Wesley Medical Center
    • Kentucky
      • Lexington, Kentucky, Forente stater, 40536
        • Rekruttering
        • University of Kentucky/Markey Cancer Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 859-257-3379
        • Hovedetterforsker:
          • Ayman Qasrawi
    • Louisiana
      • Baton Rouge, Louisiana, Forente stater, 70809
        • Aktiv, ikke rekrutterende
        • Ochsner Health Center-Summa
      • Baton Rouge, Louisiana, Forente stater, 70816
        • Aktiv, ikke rekrutterende
        • Medical Center of Baton Rouge
      • Baton Rouge, Louisiana, Forente stater, 70836
        • Aktiv, ikke rekrutterende
        • Ochsner High Grove
      • New Orleans, Louisiana, Forente stater, 70121
        • Aktiv, ikke rekrutterende
        • Ochsner Medical Center Jefferson
    • Maryland
      • Baltimore, Maryland, Forente stater, 21201
        • Rekruttering
        • University of Maryland/Greenebaum Cancer Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 800-888-8823
        • Hovedetterforsker:
          • Shella Saint Fleur-Lominy
    • Massachusetts
      • Boston, Massachusetts, Forente stater, 02215
        • Suspendert
        • Beth Israel Deaconess Medical Center
      • Boston, Massachusetts, Forente stater, 02114
        • Suspendert
        • Massachusetts General Hospital Cancer Center
      • Boston, Massachusetts, Forente stater, 02215
        • Suspendert
        • Dana-Farber Cancer Institute
    • Michigan
      • Ann Arbor, Michigan, Forente stater, 48106
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Battle Creek, Michigan, Forente stater, 49017
        • Suspendert
        • Bronson Battle Creek
      • Brighton, Michigan, Forente stater, 48114
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Brighton, Michigan, Forente stater, 48114
        • Rekruttering
        • Trinity Health Medical Center - Brighton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Canton, Michigan, Forente stater, 48188
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Canton, Michigan, Forente stater, 48188
        • Rekruttering
        • Trinity Health Medical Center - Canton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Caro, Michigan, Forente stater, 48723
        • Suspendert
        • Caro Cancer Center
      • Chelsea, Michigan, Forente stater, 48118
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Chelsea, Michigan, Forente stater, 48118
      • Clarkston, Michigan, Forente stater, 48346
        • Suspendert
        • Hematology Oncology Consultants-Clarkston
      • Clarkston, Michigan, Forente stater, 48346
        • Suspendert
        • Newland Medical Associates-Clarkston
      • Detroit, Michigan, Forente stater, 48201
        • Rekruttering
        • Wayne State University/Karmanos Cancer Institute
        • Hovedetterforsker:
          • Jay Yang
        • Ta kontakt med:
      • Detroit, Michigan, Forente stater, 48236
        • Suspendert
        • Henry Ford Health Saint John Hospital
      • East China Township, Michigan, Forente stater, 48054
        • Suspendert
        • Henry Ford River District Hospital
      • Farmington Hills, Michigan, Forente stater, 48334
        • Rekruttering
        • Weisberg Cancer Treatment Center
        • Hovedetterforsker:
          • Jay Yang
        • Ta kontakt med:
      • Flint, Michigan, Forente stater, 48503
        • Rekruttering
        • Genesys Hurley Cancer Institute
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Flint, Michigan, Forente stater, 48503
        • Rekruttering
        • Hurley Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Flint, Michigan, Forente stater, 48503
        • Suspendert
        • Genesee Hematology Oncology PC
      • Flint, Michigan, Forente stater, 48503
        • Rekruttering
        • Cancer Hematology Centers - Flint
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Grand Rapids, Michigan, Forente stater, 49503
        • Rekruttering
        • Trinity Health Grand Rapids Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Grand Rapids, Michigan, Forente stater, 49503
        • Rekruttering
        • Corewell Health Grand Rapids Hospitals - Butterworth Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Kathleen Y. Butler
      • Grand Rapids, Michigan, Forente stater, 49503
        • Suspendert
        • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
      • Grosse Pointe Woods, Michigan, Forente stater, 48236
        • Suspendert
        • Henry Ford Saint John Hospital - Academic
      • Grosse Pointe Woods, Michigan, Forente stater, 48236
        • Suspendert
        • Henry Ford Saint John Hospital - Breast
      • Grosse Pointe Woods, Michigan, Forente stater, 48236
        • Suspendert
        • Henry Ford Saint John Hospital - Van Elslander
      • Kalamazoo, Michigan, Forente stater, 49007
        • Rekruttering
        • Bronson Methodist Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Kathleen Y. Butler
      • Kalamazoo, Michigan, Forente stater, 49007
        • Rekruttering
        • West Michigan Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Kathleen Y. Butler
      • Kalamazoo, Michigan, Forente stater, 49009
        • Rekruttering
        • Beacon Kalamazoo Cancer Center
        • Hovedetterforsker:
          • Kathleen Y. Butler
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 574-647-7370
      • Kalamazoo, Michigan, Forente stater, 49048
        • Suspendert
        • Beacon Kalamazoo
      • Lansing, Michigan, Forente stater, 48912
        • Suspendert
        • University of Michigan Health - Sparrow Lansing
      • Livonia, Michigan, Forente stater, 48154
        • Suspendert
        • Hope Cancer Clinic
      • Livonia, Michigan, Forente stater, 48154
        • Rekruttering
        • Trinity Health Saint Mary Mercy Livonia Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Macomb, Michigan, Forente stater, 48044
        • Suspendert
        • Henry Ford Warren Hospital - Breast Macomb
      • Macomb, Michigan, Forente stater, 48044
        • Rekruttering
        • Henry Ford Saint John Hospital - Macomb Medical
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Marlette, Michigan, Forente stater, 48453
        • Suspendert
        • Saint Mary's Oncology/Hematology Associates of Marlette
      • Muskegon, Michigan, Forente stater, 49444
        • Suspendert
        • Trinity Health Muskegon Hospital
      • Niles, Michigan, Forente stater, 49120
        • Rekruttering
        • Corewell Health Lakeland Hospitals - Niles Hospital
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 616-391-1230
        • Hovedetterforsker:
          • Kathleen Y. Butler
      • Norton Shores, Michigan, Forente stater, 49444
        • Suspendert
        • Cancer and Hematology Centers of Western Michigan - Norton Shores
      • Pontiac, Michigan, Forente stater, 48341
        • Suspendert
        • Hope Cancer Center
      • Pontiac, Michigan, Forente stater, 48341
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Oakland Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Pontiac, Michigan, Forente stater, 48341
        • Suspendert
        • Michigan Healthcare Professionals Pontiac
      • Pontiac, Michigan, Forente stater, 48341
        • Suspendert
        • Trinity Health IHA Medical Group-Alice Gustafson Center
      • Reed City, Michigan, Forente stater, 49677
        • Rekruttering
        • Corewell Health Reed City Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Kathleen Y. Butler
      • Rochester Hills, Michigan, Forente stater, 48309
        • Suspendert
        • Henry Ford Rochester Hospital
      • Saginaw, Michigan, Forente stater, 48604
        • Suspendert
        • Oncology Hematology Associates of Saginaw Valley PC
      • Saginaw, Michigan, Forente stater, 48601
        • Suspendert
        • MyMichigan Medical Center Saginaw
      • Saint Joseph, Michigan, Forente stater, 49085
        • Rekruttering
        • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Kathleen Y. Butler
      • Saint Joseph, Michigan, Forente stater, 49085
        • Suspendert
        • Corewell Health Lakeland Hospitals - Saint Joseph Hospital
      • Sterling Heights, Michigan, Forente stater, 48312
        • Suspendert
        • Bhadresh Nayak MD PC-Sterling Heights
      • Tawas City, Michigan, Forente stater, 48764
        • Suspendert
        • MyMichigan Medical Center Tawas
      • Traverse City, Michigan, Forente stater, 49684
        • Rekruttering
        • Munson Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Kathleen Y. Butler
      • Warren, Michigan, Forente stater, 48088
        • Suspendert
        • Advanced Breast Care Center PLLC
      • Warren, Michigan, Forente stater, 48093
        • Suspendert
        • Macomb Hematology Oncology PC
      • Warren, Michigan, Forente stater, 48093
        • Suspendert
        • Henry Ford Madison Heights Hospital - Breast
      • Warren, Michigan, Forente stater, 48093
        • Suspendert
        • Henry Ford Health Warren Hospital
      • Warren, Michigan, Forente stater, 48093
        • Suspendert
        • Henry Ford Warren Hospital - GLCMS
      • West Branch, Michigan, Forente stater, 48661
        • Suspendert
        • Saint Mary's Oncology/Hematology Associates of West Branch
      • Wyoming, Michigan, Forente stater, 49519
        • Rekruttering
        • University of Michigan Health - West
        • Ta kontakt med:
        • Hovedetterforsker:
          • Kathleen Y. Butler
      • Ypsilanti, Michigan, Forente stater, 48106
      • Ypsilanti, Michigan, Forente stater, 48197
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
    • Minnesota
      • Aitkin, Minnesota, Forente stater, 56431
        • Suspendert
        • Riverwood Healthcare Center
      • Brainerd, Minnesota, Forente stater, 56401
        • Suspendert
        • Essentia Health Saint Joseph's Medical Center
      • Burnsville, Minnesota, Forente stater, 55337
        • Suspendert
        • Fairview Ridges Hospital
      • Burnsville, Minnesota, Forente stater, 55337
        • Suspendert
        • Minnesota Oncology - Burnsville
      • Cambridge, Minnesota, Forente stater, 55008
        • Suspendert
        • Cambridge Medical Center
      • Coon Rapids, Minnesota, Forente stater, 55433
        • Suspendert
        • Mercy Hospital
      • Deer River, Minnesota, Forente stater, 56636
        • Suspendert
        • Essentia Health - Deer River Clinic
      • Detroit Lakes, Minnesota, Forente stater, 56501
        • Suspendert
        • Essentia Health Saint Mary's - Detroit Lakes Clinic
      • Duluth, Minnesota, Forente stater, 55805
        • Rekruttering
        • Essentia Health Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Bret E. Friday
      • Duluth, Minnesota, Forente stater, 55805
        • Suspendert
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Forente stater, 55805
        • Suspendert
        • Miller-Dwan Hospital
      • Edina, Minnesota, Forente stater, 55435
        • Suspendert
        • Fairview Southdale Hospital
      • Fergus Falls, Minnesota, Forente stater, 56537
        • Suspendert
        • Lake Region Healthcare Corporation-Cancer Care
      • Fosston, Minnesota, Forente stater, 56542
        • Suspendert
        • Essentia Health - Fosston
      • Fridley, Minnesota, Forente stater, 55432
        • Aktiv, ikke rekrutterende
        • Unity Hospital
      • Hibbing, Minnesota, Forente stater, 55746
        • Suspendert
        • Essentia Health Hibbing Clinic
      • Maple Grove, Minnesota, Forente stater, 55369
        • Suspendert
        • Fairview Clinics and Surgery Center Maple Grove
      • Maplewood, Minnesota, Forente stater, 55109
        • Suspendert
        • Minnesota Oncology Hematology PA-Maplewood
      • Maplewood, Minnesota, Forente stater, 55109
        • Suspendert
        • Saint John's Hospital - Healtheast
      • Minneapolis, Minnesota, Forente stater, 55407
        • Rekruttering
        • Abbott-Northwestern Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Yan Ji
      • Minneapolis, Minnesota, Forente stater, 55415
        • Suspendert
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forente stater, 55454
        • Suspendert
        • Health Partners Inc
      • Monticello, Minnesota, Forente stater, 55362
        • Suspendert
        • Monticello Cancer Center
      • New Ulm, Minnesota, Forente stater, 56073
        • Suspendert
        • New Ulm Medical Center
      • Park Rapids, Minnesota, Forente stater, 56470
        • Suspendert
        • Essentia Health - Park Rapids
      • Princeton, Minnesota, Forente stater, 55371
        • Suspendert
        • Fairview Northland Medical Center
      • Robbinsdale, Minnesota, Forente stater, 55422
        • Suspendert
        • North Memorial Medical Health Center
      • Rochester, Minnesota, Forente stater, 55905
        • Rekruttering
        • Mayo Clinic in Rochester
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 855-776-0015
        • Hovedetterforsker:
          • Aasiya Matin
      • Saint Louis Park, Minnesota, Forente stater, 55416
        • Suspendert
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Forente stater, 55102
        • Suspendert
        • United Hospital
      • Saint Paul, Minnesota, Forente stater, 55101
        • Suspendert
        • Regions Hospital
      • Sandstone, Minnesota, Forente stater, 55072
        • Suspendert
        • Essentia Health Sandstone
      • Shakopee, Minnesota, Forente stater, 55379
        • Suspendert
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forente stater, 55082
        • Suspendert
        • Lakeview Hospital
      • Virginia, Minnesota, Forente stater, 55792
        • Suspendert
        • Essentia Health Virginia Clinic
      • Waconia, Minnesota, Forente stater, 55387
        • Suspendert
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forente stater, 56201
        • Suspendert
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forente stater, 55125
        • Suspendert
        • Minnesota Oncology Hematology PA-Woodbury
      • Wyoming, Minnesota, Forente stater, 55092
        • Suspendert
        • Fairview Lakes Medical Center
    • Missouri
      • Ballwin, Missouri, Forente stater, 63011
        • Suspendert
        • Mercy Oncology and Hematology - Clayton-Clarkson
      • Bolivar, Missouri, Forente stater, 65613
        • Suspendert
        • Central Care Cancer Center - Bolivar
      • Branson, Missouri, Forente stater, 65616
        • Suspendert
        • Cox Cancer Center Branson
      • City of Saint Peters, Missouri, Forente stater, 63376
        • Rekruttering
        • Siteman Cancer Center at Saint Peters Hospital
        • Hovedetterforsker:
          • Geoffrey L. Uy
        • Ta kontakt med:
      • Creve Coeur, Missouri, Forente stater, 63141
        • Rekruttering
        • Siteman Cancer Center at West County Hospital
        • Hovedetterforsker:
          • Geoffrey L. Uy
        • Ta kontakt med:
      • Joplin, Missouri, Forente stater, 64804
        • Suspendert
        • Freeman Health System
      • Joplin, Missouri, Forente stater, 64804
        • Suspendert
        • Mercy Hospital Joplin
      • Rolla, Missouri, Forente stater, 65401
        • Suspendert
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Rolla, Missouri, Forente stater, 65401
        • Suspendert
        • Phelps Health Delbert Day Cancer Institute
      • Saint Joseph, Missouri, Forente stater, 64506
        • Suspendert
        • Heartland Regional Medical Center
      • Springfield, Missouri, Forente stater, 65804
        • Suspendert
        • Mercy Hospital Springfield
      • Springfield, Missouri, Forente stater, 65807
        • Suspendert
        • CoxHealth South Hospital
      • St Louis, Missouri, Forente stater, 63110
        • Rekruttering
        • Washington University School of Medicine
        • Hovedetterforsker:
          • Geoffrey L. Uy
        • Ta kontakt med:
      • St Louis, Missouri, Forente stater, 63128
        • Rekruttering
        • Mercy Hospital South
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
      • St Louis, Missouri, Forente stater, 63141
        • Rekruttering
        • Mercy Hospital Saint Louis
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 314-251-7066
      • St Louis, Missouri, Forente stater, 63129
        • Rekruttering
        • Siteman Cancer Center-South County
        • Hovedetterforsker:
          • Geoffrey L. Uy
        • Ta kontakt med:
      • St Louis, Missouri, Forente stater, 63109
        • Suspendert
        • Mercy Infusion Center - Chippewa
      • Washington, Missouri, Forente stater, 63090
        • Suspendert
        • Mercy Hospital Washington
    • Montana
      • Anaconda, Montana, Forente stater, 59711
        • Rekruttering
        • Community Hospital of Anaconda
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Billings, Montana, Forente stater, 59101
        • Rekruttering
        • Billings Clinic Cancer Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Billings, Montana, Forente stater, 59101
        • Suspendert
        • Saint Vincent Healthcare
      • Billings, Montana, Forente stater, 59102
        • Suspendert
        • Saint Vincent Frontier Cancer Center
      • Bozeman, Montana, Forente stater, 59715
        • Rekruttering
        • Bozeman Health Deaconess Hospital
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Butte, Montana, Forente stater, 59701
        • Suspendert
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Forente stater, 59405
        • Suspendert
        • Great Falls Clinic
      • Great Falls, Montana, Forente stater, 59405
        • Rekruttering
        • Benefis Sletten Cancer Institute
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Kalispell, Montana, Forente stater, 59901
        • Rekruttering
        • Logan Health Medical Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Missoula, Montana, Forente stater, 59802
        • Suspendert
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Forente stater, 59804
        • Rekruttering
        • Community Medical Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
    • Nebraska
      • Bellevue, Nebraska, Forente stater, 68123
        • Rekruttering
        • Nebraska Medicine-Bellevue
        • Hovedetterforsker:
          • Krishna Gundabolu
        • Ta kontakt med:
      • Omaha, Nebraska, Forente stater, 68198
        • Rekruttering
        • University of Nebraska Medical Center
        • Hovedetterforsker:
          • Krishna Gundabolu
        • Ta kontakt med:
      • Omaha, Nebraska, Forente stater, 68118
        • Rekruttering
        • Nebraska Medicine-Village Pointe
        • Hovedetterforsker:
          • Krishna Gundabolu
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 402-559-5600
    • Nevada
      • Carson City, Nevada, Forente stater, 89703
        • Suspendert
        • Carson Tahoe Regional Medical Center
      • Henderson, Nevada, Forente stater, 89052
        • Suspendert
        • Cancer and Blood Specialists-Henderson
      • Henderson, Nevada, Forente stater, 89052
        • Suspendert
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, Forente stater, 89052
        • Suspendert
        • Comprehensive Cancer Centers of Nevada-Horizon Ridge
      • Henderson, Nevada, Forente stater, 89052
        • Suspendert
        • Las Vegas Cancer Center-Henderson
      • Henderson, Nevada, Forente stater, 89074
        • Suspendert
        • Comprehensive Cancer Centers of Nevada-Southeast Henderson
      • Henderson, Nevada, Forente stater, 89074
        • Suspendert
        • Las Vegas Urology - Green Valley
      • Henderson, Nevada, Forente stater, 89074
        • Suspendert
        • Las Vegas Urology - Pebble
      • Henderson, Nevada, Forente stater, 89074
        • Suspendert
        • Urology Specialists of Nevada - Green Valley
      • Henderson, Nevada, Forente stater, 89074
        • Suspendert
        • Oncology Las Vegas - Henderson
      • Las Vegas, Nevada, Forente stater, 89102
        • Suspendert
        • Desert West Surgery
      • Las Vegas, Nevada, Forente stater, 89074
        • Suspendert
        • Las Vegas Urology - Pecos
      • Las Vegas, Nevada, Forente stater, 89102
        • Suspendert
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forente stater, 89103
        • Suspendert
        • Hope Cancer Care of Nevada
      • Las Vegas, Nevada, Forente stater, 89106
        • Suspendert
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, Forente stater, 89106
        • Suspendert
        • Urology Specialists of Nevada - Central
      • Las Vegas, Nevada, Forente stater, 89109
        • Suspendert
        • Sunrise Hospital and Medical Center
      • Las Vegas, Nevada, Forente stater, 89113
        • Suspendert
        • Las Vegas Prostate Cancer Center
      • Las Vegas, Nevada, Forente stater, 89113
        • Suspendert
        • Las Vegas Urology - Sunset
      • Las Vegas, Nevada, Forente stater, 89113
        • Suspendert
        • Urology Specialists of Nevada - Southwest
      • Las Vegas, Nevada, Forente stater, 89119
        • Suspendert
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, Forente stater, 89128
        • Suspendert
        • Ann M Wierman MD LTD
      • Las Vegas, Nevada, Forente stater, 89128
        • Suspendert
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, Forente stater, 89128
        • Suspendert
        • Las Vegas Urology - Cathedral Rock
      • Las Vegas, Nevada, Forente stater, 89128
        • Suspendert
        • Las Vegas Urology - Smoke Ranch
      • Las Vegas, Nevada, Forente stater, 89128
        • Suspendert
        • OptumCare Cancer Care at MountainView
      • Las Vegas, Nevada, Forente stater, 89128
        • Suspendert
        • Urology Specialists of Nevada - Northwest
      • Las Vegas, Nevada, Forente stater, 89135
        • Suspendert
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
      • Las Vegas, Nevada, Forente stater, 89144
        • Suspendert
        • Comprehensive Cancer Centers of Nevada - Town Center
      • Las Vegas, Nevada, Forente stater, 89144
        • Suspendert
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, Forente stater, 89144
        • Suspendert
        • Summerlin Hospital Medical Center
      • Las Vegas, Nevada, Forente stater, 89148-2405
        • Suspendert
        • Las Vegas Cancer Center-Medical Center
      • Las Vegas, Nevada, Forente stater, 89148
        • Suspendert
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Forente stater, 89169
        • Suspendert
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Forente stater, 89169
        • Suspendert
        • University Cancer Center
      • Las Vegas, Nevada, Forente stater, 89102
        • Suspendert
        • OptumCare Cancer Care at Charleston
      • Las Vegas, Nevada, Forente stater, 89128
        • Suspendert
        • Oncology Las Vegas - Tenaya
      • Las Vegas, Nevada, Forente stater, 89183
        • Suspendert
        • OptumCare Cancer Care at Fort Apache
      • Pahrump, Nevada, Forente stater, 89048
        • Suspendert
        • Hope Cancer Care of Nevada-Pahrump
      • Reno, Nevada, Forente stater, 89502
        • Suspendert
        • Renown Regional Medical Center
      • Reno, Nevada, Forente stater, 89503
        • Suspendert
        • Saint Mary's Regional Medical Center
      • Reno, Nevada, Forente stater, 89509
        • Suspendert
        • Radiation Oncology Associates
    • New Mexico
      • Albuquerque, New Mexico, Forente stater, 87106
        • Aktiv, ikke rekrutterende
        • University of New Mexico Cancer Center
    • New York
      • Buffalo, New York, Forente stater, 14263
        • Rekruttering
        • Roswell Park Cancer Institute
        • Hovedetterforsker:
          • Eunice S. Wang
        • Ta kontakt med:
      • Lake Success, New York, Forente stater, 11042
        • Rekruttering
        • Northwell Health/Center for Advanced Medicine
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 516-734-8896
        • Hovedetterforsker:
          • Bradley H. Goldberg
      • Manhasset, New York, Forente stater, 11030
        • Rekruttering
        • North Shore University Hospital
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 516-734-8896
        • Hovedetterforsker:
          • Bradley H. Goldberg
      • New Hyde Park, New York, Forente stater, 11040
        • Rekruttering
        • Long Island Jewish Medical Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 516-734-8896
        • Hovedetterforsker:
          • Bradley H. Goldberg
      • New York, New York, Forente stater, 10029
        • Rekruttering
        • Mount Sinai Hospital
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 212-824-7309
          • E-post: CCTO@mssm.edu
        • Hovedetterforsker:
          • Hannah Levavi
      • New York, New York, Forente stater, 10065
        • Rekruttering
        • NYP/Weill Cornell Medical Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 212-746-1848
        • Hovedetterforsker:
          • Gail J. Roboz
      • Rochester, New York, Forente stater, 14642
        • Rekruttering
        • University of Rochester
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 585-275-5830
        • Hovedetterforsker:
          • Kristen M. O'Dwyer
      • Stony Brook, New York, Forente stater, 11794
        • Aktiv, ikke rekrutterende
        • Stony Brook University Medical Center
      • Syracuse, New York, Forente stater, 13210
        • Aktiv, ikke rekrutterende
        • State University of New York Upstate Medical University
      • Verona, New York, Forente stater, 13478
        • Aktiv, ikke rekrutterende
        • Upstate Cancer Center at Verona
    • North Carolina
      • Chapel Hill, North Carolina, Forente stater, 27599
        • Rekruttering
        • UNC Lineberger Comprehensive Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Daniel R. Richardson
      • Durham, North Carolina, Forente stater, 27710
        • Aktiv, ikke rekrutterende
        • Duke University Medical Center
      • Greenville, North Carolina, Forente stater, 27834
        • Rekruttering
        • East Carolina University
        • Hovedetterforsker:
          • Darla K. Liles
        • Ta kontakt med:
      • Winston-Salem, North Carolina, Forente stater, 27157
        • Rekruttering
        • Wake Forest University Health Sciences
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 336-713-6771
        • Hovedetterforsker:
          • Bayard L. Powell
    • North Dakota
      • Fargo, North Dakota, Forente stater, 58103
        • Suspendert
        • Essentia Health Cancer Center-South University Clinic
      • Jamestown, North Dakota, Forente stater, 58401
        • Suspendert
        • Essentia Health - Jamestown Clinic
    • Ohio
      • Cincinnati, Ohio, Forente stater, 45219
        • Rekruttering
        • University of Cincinnati Cancer Center-UC Medical Center
        • Hovedetterforsker:
          • Emily K. Curran
        • Ta kontakt med:
      • Cleveland, Ohio, Forente stater, 44195
        • Rekruttering
        • Cleveland Clinic Foundation
        • Ta kontakt med:
        • Hovedetterforsker:
          • Anjali S. Advani
      • Cleveland, Ohio, Forente stater, 44106
        • Rekruttering
        • Case Western Reserve University
        • Hovedetterforsker:
          • Brenda W. Cooper
        • Ta kontakt med:
      • Columbus, Ohio, Forente stater, 43210
        • Rekruttering
        • Ohio State University Comprehensive Cancer Center
        • Hovedetterforsker:
          • Meixiao Long
        • Ta kontakt med:
      • West Chester, Ohio, Forente stater, 45069
        • Rekruttering
        • University of Cincinnati Cancer Center-West Chester
        • Hovedetterforsker:
          • Emily K. Curran
        • Ta kontakt med:
    • Oklahoma
      • Oklahoma City, Oklahoma, Forente stater, 73104
        • Rekruttering
        • University of Oklahoma Health Sciences Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Mohamad Khawandanah
      • Oklahoma City, Oklahoma, Forente stater, 73120
        • Suspendert
        • Mercy Hospital Oklahoma City
    • Oregon
      • Baker City, Oregon, Forente stater, 97814
        • Suspendert
        • Saint Alphonsus Cancer Care Center-Baker City
      • Bend, Oregon, Forente stater, 97701
        • Suspendert
        • Saint Charles Health System
      • Clackamas, Oregon, Forente stater, 97015
        • Suspendert
        • Clackamas Radiation Oncology Center
      • Clackamas, Oregon, Forente stater, 97015
        • Suspendert
        • Providence Cancer Institute Clackamas Clinic
      • Coos Bay, Oregon, Forente stater, 97420
        • Suspendert
        • Bay Area Hospital
      • Newberg, Oregon, Forente stater, 97132
        • Rekruttering
        • Providence Newberg Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Ontario, Oregon, Forente stater, 97914
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Ontario
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Portland, Oregon, Forente stater, 97239
        • Rekruttering
        • Oregon Health and Science University
        • Ta kontakt med:
        • Hovedetterforsker:
          • Brandon M. Hayes-Lattin
      • Portland, Oregon, Forente stater, 97213
        • Rekruttering
        • Providence Portland Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Portland, Oregon, Forente stater, 97225
        • Rekruttering
        • Providence Saint Vincent Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Redmond, Oregon, Forente stater, 97756
        • Suspendert
        • Saint Charles Health System-Redmond
    • Pennsylvania
      • Allentown, Pennsylvania, Forente stater, 18103
        • Rekruttering
        • Lehigh Valley Hospital-Cedar Crest
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Bethlehem, Pennsylvania, Forente stater, 18017
        • Rekruttering
        • Lehigh Valley Hospital - Muhlenberg
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • East Stroudsburg, Pennsylvania, Forente stater, 18301
        • Suspendert
        • Pocono Medical Center
      • Hazleton, Pennsylvania, Forente stater, 18201
        • Suspendert
        • Lehigh Valley Hospital-Hazleton
      • Philadelphia, Pennsylvania, Forente stater, 19107
        • Rekruttering
        • Thomas Jefferson University Hospital
        • Hovedetterforsker:
          • Lindsay Wilde
        • Ta kontakt med:
      • Philadelphia, Pennsylvania, Forente stater, 19104
        • Rekruttering
        • University of Pennsylvania/Abramson Cancer Center
        • Hovedetterforsker:
          • Keith W. Pratz
        • Ta kontakt med:
      • Pittsburgh, Pennsylvania, Forente stater, 15232
        • Aktiv, ikke rekrutterende
        • UPMC Hillman Cancer Center
    • Rhode Island
      • Providence, Rhode Island, Forente stater, 02903
        • Rekruttering
        • Rhode Island Hospital
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 401-444-1488
        • Hovedetterforsker:
          • Rabin Niroula
      • Providence, Rhode Island, Forente stater, 02906
        • Suspendert
        • Miriam Hospital
    • South Carolina
      • Boiling Springs, South Carolina, Forente stater, 29316
        • Rekruttering
        • Prisma Health Cancer Institute - Spartanburg
        • Hovedetterforsker:
          • Ki Y. Chung
        • Ta kontakt med:
      • Clinton, South Carolina, Forente stater, 29325
        • Suspendert
        • Prisma Health Cancer Institute - Laurens
      • Columbia, South Carolina, Forente stater, 29203
        • Rekruttering
        • Prisma Health Richland Hospital
        • Hovedetterforsker:
          • Ki Y. Chung
        • Ta kontakt med:
      • Easley, South Carolina, Forente stater, 29640
        • Rekruttering
        • Prisma Health Cancer Institute - Easley
        • Hovedetterforsker:
          • Ki Y. Chung
        • Ta kontakt med:
      • Greenville, South Carolina, Forente stater, 29601
        • Rekruttering
        • Saint Francis Hospital
        • Hovedetterforsker:
          • Stephen H. Dyar
        • Ta kontakt med:
      • Greenville, South Carolina, Forente stater, 29605
        • Rekruttering
        • Prisma Health Cancer Institute - Faris
        • Hovedetterforsker:
          • Ki Y. Chung
        • Ta kontakt med:
      • Greenville, South Carolina, Forente stater, 29607
        • Rekruttering
        • Saint Francis Cancer Center
        • Hovedetterforsker:
          • Stephen H. Dyar
        • Ta kontakt med:
      • Greenville, South Carolina, Forente stater, 29605
        • Rekruttering
        • Prisma Health Cancer Institute - Butternut
        • Hovedetterforsker:
          • Ki Y. Chung
        • Ta kontakt med:
      • Greenville, South Carolina, Forente stater, 29615
        • Rekruttering
        • Prisma Health Cancer Institute - Eastside
        • Hovedetterforsker:
          • Ki Y. Chung
        • Ta kontakt med:
      • Greenville, South Carolina, Forente stater, 29605
        • Rekruttering
        • Prisma Health Greenville Memorial Hospital
        • Hovedetterforsker:
          • Ki Y. Chung
        • Ta kontakt med:
      • Greenville, South Carolina, Forente stater, 29605
        • Suspendert
        • BI-LO Charities Children's Cancer Center
      • Greer, South Carolina, Forente stater, 29650
        • Rekruttering
        • Prisma Health Cancer Institute - Greer
        • Hovedetterforsker:
          • Ki Y. Chung
        • Ta kontakt med:
      • Seneca, South Carolina, Forente stater, 29672
        • Rekruttering
        • Prisma Health Cancer Institute - Seneca
        • Hovedetterforsker:
          • Ki Y. Chung
        • Ta kontakt med:
    • Texas
      • Houston, Texas, Forente stater, 77030
        • Rekruttering
        • Houston Methodist Hospital
        • Hovedetterforsker:
          • Siddhartha Ganguly
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 713-790-2700
      • Lubbock, Texas, Forente stater, 79410
        • Aktiv, ikke rekrutterende
        • Covenant Medical Center-Lakeside
    • Utah
      • American Fork, Utah, Forente stater, 84003
        • Suspendert
        • American Fork Hospital / Huntsman Intermountain Cancer Center
      • Cedar City, Utah, Forente stater, 84720
        • Suspendert
        • Sandra L Maxwell Cancer Center
      • Logan, Utah, Forente stater, 84321
        • Suspendert
        • Logan Regional Hospital
      • Murray, Utah, Forente stater, 84107
        • Suspendert
        • Intermountain Medical Center
      • Ogden, Utah, Forente stater, 84403
        • Suspendert
        • McKay-Dee Hospital Center
      • Provo, Utah, Forente stater, 84604
        • Suspendert
        • Utah Valley Regional Medical Center
      • Riverton, Utah, Forente stater, 84065
        • Suspendert
        • Riverton Hospital
      • Salt Lake City, Utah, Forente stater, 84112
        • Rekruttering
        • Huntsman Cancer Institute/University of Utah
        • Ta kontakt med:
        • Hovedetterforsker:
          • Paul J. Shami
      • Salt Lake City, Utah, Forente stater, 84106
        • Suspendert
        • Utah Cancer Specialists-Salt Lake City
      • Salt Lake City, Utah, Forente stater, 84143
        • Suspendert
        • LDS Hospital
      • St. George, Utah, Forente stater, 84770
        • Suspendert
        • Saint George Regional Medical Center
    • Virginia
      • Fairfax, Virginia, Forente stater, 22031
        • Aktiv, ikke rekrutterende
        • Inova Schar Cancer Institute
      • Falls Church, Virginia, Forente stater, 22042
        • Aktiv, ikke rekrutterende
        • Inova Fairfax Hospital
      • Richmond, Virginia, Forente stater, 23298
        • Rekruttering
        • VCU Massey Comprehensive Cancer Center
        • Hovedetterforsker:
          • Keri R. Maher
        • Ta kontakt med:
    • Washington
      • Aberdeen, Washington, Forente stater, 98520
        • Suspendert
        • Providence Regional Cancer System-Aberdeen
      • Bellevue, Washington, Forente stater, 98004
        • Suspendert
        • Overlake Medical Center
      • Bellingham, Washington, Forente stater, 98225
        • Suspendert
        • PeaceHealth Saint Joseph Medical Center
      • Centralia, Washington, Forente stater, 98531
        • Suspendert
        • Providence Regional Cancer System-Centralia
      • Edmonds, Washington, Forente stater, 98026
        • Rekruttering
        • Swedish Cancer Institute-Edmonds
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Everett, Washington, Forente stater, 98201
        • Suspendert
        • Providence Regional Cancer Partnership
      • Issaquah, Washington, Forente stater, 98029
        • Suspendert
        • Swedish Cancer Institute-Issaquah
      • Kennewick, Washington, Forente stater, 99336
        • Suspendert
        • Kadlec Clinic Hematology and Oncology
      • Lacey, Washington, Forente stater, 98503
        • Suspendert
        • Providence Regional Cancer System-Lacey
      • Longview, Washington, Forente stater, 98632
        • Suspendert
        • PeaceHealth Saint John Medical Center
      • Port Townsend, Washington, Forente stater, 98368
        • Aktiv, ikke rekrutterende
        • Jefferson Healthcare
      • Renton, Washington, Forente stater, 98055
        • Suspendert
        • Valley Medical Center
      • Seattle, Washington, Forente stater, 98104
        • Suspendert
        • Pacific Gynecology Specialists
      • Seattle, Washington, Forente stater, 98107
        • Suspendert
        • Swedish Medical Center-Ballard Campus
      • Seattle, Washington, Forente stater, 98122-5711
        • Suspendert
        • Swedish Medical Center-Cherry Hill
      • Seattle, Washington, Forente stater, 98122
        • Rekruttering
        • Swedish Medical Center-First Hill
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Seattle, Washington, Forente stater, 98112
        • Aktiv, ikke rekrutterende
        • Kaiser Permanente Washington
      • Sedro-Woolley, Washington, Forente stater, 98284
        • Suspendert
        • PeaceHealth United General Medical Center
      • Shelton, Washington, Forente stater, 98584
        • Suspendert
        • Providence Regional Cancer System-Shelton
      • Vancouver, Washington, Forente stater, 98664
        • Suspendert
        • PeaceHealth Southwest Medical Center
      • Walla Walla, Washington, Forente stater, 99362
        • Suspendert
        • Providence Saint Mary Regional Cancer Center
      • Yakima, Washington, Forente stater, 98902
        • Suspendert
        • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
      • Yelm, Washington, Forente stater, 98597
        • Suspendert
        • Providence Regional Cancer System-Yelm
    • Wisconsin
      • Ashland, Wisconsin, Forente stater, 54806
        • Suspendert
        • Northwest Wisconsin Cancer Center
      • Ashland, Wisconsin, Forente stater, 54806
        • Suspendert
        • Duluth Clinic Ashland
      • Hayward, Wisconsin, Forente stater, 54843
        • Suspendert
        • Essentia Health-Hayward Clinic
      • Madison, Wisconsin, Forente stater, 53792
        • Rekruttering
        • University of Wisconsin Carbone Cancer Center - University Hospital
        • Hovedetterforsker:
          • Ryan J. Mattison
        • Ta kontakt med:
      • Madison, Wisconsin, Forente stater, 53718
        • Rekruttering
        • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
        • Hovedetterforsker:
          • Ryan J. Mattison
        • Ta kontakt med:
      • Marshfield, Wisconsin, Forente stater, 54449
      • Milwaukee, Wisconsin, Forente stater, 53226
        • Rekruttering
        • Medical College of Wisconsin
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 414-805-3666
        • Hovedetterforsker:
          • Guru Subramanian Guru Murthy
      • New Richmond, Wisconsin, Forente stater, 54017
        • Suspendert
        • Cancer Center of Western Wisconsin
      • Spooner, Wisconsin, Forente stater, 54801
        • Suspendert
        • Essentia Health-Spooner Clinic
      • Superior, Wisconsin, Forente stater, 54880
        • Suspendert
        • Essentia Health Saint Mary's Hospital - Superior
    • Wyoming
      • Cheyenne, Wyoming, Forente stater, 82001
        • Aktiv, ikke rekrutterende
        • Cheyenne Regional Medical Center-West
      • Cody, Wyoming, Forente stater, 82414
        • Suspendert
        • Billings Clinic-Cody
      • Sheridan, Wyoming, Forente stater, 82801
        • Suspendert
        • Welch Cancer Center

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år til 39 år (Voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion Criteria:

REGISTRATION ELIGIBILITY CRITERIA (STEP 1)

  • Newly diagnosed patients with CD-22 positive B-cell acute lymphoblastic leukemia (WHO criteria) are eligible. Patients with Burkitt type ALL are NOT eligible

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Single-dose intrathecal cytarabine is allowed prior to registration or prior to initiation of systematic therapy for patient convenience; this is usually done at the time of the diagnostic bone marrow or venous line placement to avoid a second lumbar puncture; systemic chemotherapy must begin within 72 hours of this intrathecal therapy

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Age >= 18 years and < 40 years

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Eastern Cooperative Oncology Group (ECOG) performance status 0-2

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liver

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Direct bilirubin =< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liver

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Calculated (calc.) creatinine clearance >= 50 mL/min by Cockcroft-Gault

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Completion of remission induction therapy

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) CONFIRMATION OF TOLERABILITY AND PHASE III ONLY):Patients with M2 marrow or better are eligible; patients with M3 or M4 marrow (greater than 25% lymphoblasts) will not be eligible to be randomized

    • Rating: M0, M1; Blast Cells (%): 0-5.0
    • Rating: M2; Blast Cells (%): 5.1-25.0
    • Rating: M3; Blast Cells (%): > 25-50
    • Rating: M4; Blast Cells (%): > 50.0
    • The term "blast cell" includes any cell that cannot be classified as a more mature normal element, and includes "leukemic cells," pathologic lymphocytes, and stem cells

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Absolute neutrophil count (ANC) >= 750/mm^3

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Platelet count >= 75,000/mm^3

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Total bilirubin =< 1.5 x upper limit of normal (ULN), except for patients with known Gilbert's syndrome

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Aspartate aminotransferase (AST) =< 8 x upper limit of normal (ULN)

EXCLUSION CRITERIA

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients who have BCR-ABL fusion transcript determined by fluorescence in situ hybridization (FISH) or real time-polymerase chain reaction (RT-PCR) or t(9;22)(q34;q11) by cytogenetics are not eligible and should be considered for enrollment on studies that incorporate imatinib during induction; please note: patients must also be assessed for CD20 positivity and other markers; positivity for CD22 and CD20 is defined as baseline expression of the CD22 or CD20 antigen in more than 20% of leukemic cells using local multiparameter flow-cytometric immunophenotyping with the use of CD45 expression as a marker to gate the ALL blast population, according to recommendations from the European LeukemiaNet
  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): No prior therapy for ALL except for limited treatment (=< 7 days) with corticosteroids or hydroxyurea and a single dose of intrathecal cytarabine; however, patients who are being treated with chronic steroids for other reasons (for example, to treat asthma, autoimmune disorders, lupus, etc.) are eligible
  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): No prior therapy for acute leukemia except emergency therapy (corticosteroids or hydroxyurea) for blast cell crisis, superior vena cava syndrome, or renal failure due to leukemic infiltration of the kidneys; when indicated, leukapheresis or exchange transfusion is recommended to reduce the WBC
  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Not pregnant and not nursing, because this study involves agents that have known genotoxic, mutagenic and teratogenic effects; therefore, for women of childbearing potential only, a negative urine or serum pregnancy test done =< 8 days prior to registration is required
  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients with down syndrome are excluded from this study due to the likelihood of excessive toxicity resulting; these patients should be treated in consultation with a pediatric oncologist

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Ingen (Open Label)

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Aktiv komparator: Arm I (frontline chemotherapy)

See detailed description.
Annen: Laboratory Biomarker Analysis

Correlative studies

Legemiddel: Cyclophosphamide

Given IV

Biologisk: Rituximab

Given IV

Legemiddel: Vincristine Sulfate

Given IV

Legemiddel: Daunorubicin Hydrochloride

Given IV

Legemiddel: Mercaptopurine

Given PO

Legemiddel: Dexamethasone

Given PO or IV

Legemiddel: Thioguanine

Given PO

Legemiddel: Allopurinol

Given PO

Legemiddel: Cytarabine

Given IT, IV, SC

Legemiddel: Pegylated L-Asparaginase

Given IV

Legemiddel: Methotrexate

Given IT, IV, PO

Fremgangsmåte: Bone Marrow Aspiration and Biopsy

Undergo bone marrow aspiration and biopsy
Eksperimentell: Arm II (frontline chemotherapy, inotuzumab ozogamicin)

Patients receive inotuzumab ozogamicin IV on days 1, 8, and 15 and undergo bone marrow aspirate and biopsy on day 28. Treatment repeats every 28 days for up to 2 cycles in the absence of disease progression or unacceptable toxicity. Patients who are MRD+ and CD19+ after completion of 2 cycles of inotuzumab ozogamicin receive dexamethasone IV or PO on day 1 and blinatumomab IV via continuous infusion on days 1-28, followed by a 14 day break. Cycles repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. Patients also receive remission consolidated chemotherapy, interim maintenance chemotherapy, delayed intensification, and maintenance therapy as in Arm I. Patients undergo MUGA or echocardiography and x ray imaging during screening, bone marrow aspiration and biopsy and lumbar puncture and blood sample collection throughout the study.
Annen: Laboratory Biomarker Analysis

Correlative studies

Legemiddel: Cyclophosphamide

Given IV

Legemiddel: Doxorubicin

Given IV

Biologisk: Rituximab

Given IV

Legemiddel: Vincristine Sulfate

Given IV

Legemiddel: Daunorubicin Hydrochloride

Given IV

Legemiddel: Mercaptopurine

Given PO

Biologisk: Inotuzumab Ozogamicin

Given IV

Legemiddel: Dexamethasone

Given PO or IV

Legemiddel: Thioguanine

Given PO

Legemiddel: Allopurinol

Given PO

Legemiddel: Cytarabine

Given IT, IV, SC

Legemiddel: Pegylated L-Asparaginase

Given IV

Legemiddel: Methotrexate

Given IT, IV, PO

Fremgangsmåte: Bone Marrow Aspiration and Biopsy

Undergo bone marrow aspiration and biopsy

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Event-free survival (EFS)
Tidsramme: Time from induction response to the time of progressive-disease, secondary malignancy, or death, assessed up to 3 years

The EFS distributions between the two arms will be compared using non-stratified log-rank tests. EFS curves will be constructed using the Kaplan-Meier product limit method, and additional analyses will be done using the Cox proportional hazards model. with diagnostics test on proportional hazard assumptions first. The corresponding hazard ratio, 2- and 3-year EFS estimates will be assessed, and EFS medians along with their 95% confidence intervals for the two treatment arms.
Time from induction response to the time of progressive-disease, secondary malignancy, or death, assessed up to 3 years

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Disease-free survival (DFS)
Tidsramme: Time from achievement of complete response (CR) to the time of relapse and/or death, assessed up to 10 years
Time from achievement of complete response (CR) to the time of relapse and/or death, assessed up to 10 years
Overall Survival (OS)
Tidsramme: Time from randomization to the time of death due to any cause, assessed up to 10 years

Will be evaluated using Kaplan-Meier as well as Cox regression models.
Time from randomization to the time of death due to any cause, assessed up to 10 years
Proportion of patients who achieve CR or any response to induction therapy
Tidsramme: Up to 10 years

Will be summarized as the proportion of patients who achieve any type of response to induction therapy divided by the number of all evaluable patients registered to this trial and who received at least one dose of induction therapy. Corresponding 95% binomial confidence intervals will also be calculated.
Up to 10 years
Overall induction response rates
Tidsramme: Up to 10 years

Will be summarized as the proportion of patients who achieve any type of response to induction therapy divided by the number of all evaluable patients registered to this trial and who received at least one dose of induction therapy. Corresponding 95% binomial confidence intervals will also be calculated.
Up to 10 years
Incidence of adverse events as assessed by Common Terminology Criteria for Adverse Events version 5.0
Tidsramme: Up to 10 years

The maximum grade for each type of toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns. In addition, all adverse event data that is graded as 3, 4, or 5 will be reviewed and classified as either "unrelated" or "unlikely to be related" to study treatment in the event of an actual relationship developing. The incidence of severe (grade 3+) adverse events or toxicities will be described for each treatment arm, but will also be compared between the arms. Fisher's exact tests will be used to quantitatively compare the incidence of severe as well as specific toxicities of interest between the treatment arms and we will graphically assess differences in maximum grades observed for toxicities between the arms. Tolerability of the treatment arms will be assessed through assessing the number of patients who required dose modifications and/or dose delays.
Up to 10 years
Proportion of patients who go off treatment due to adverse reactions
Tidsramme: Up to 10 years

Will be assessed within each of the treatment arms and differences explores in these measures between the arms.
Up to 10 years
Proportion of patients who refuse further treatment for lesser toxicities that inhibit their willingness to continue participation on the trial
Tidsramme: Up to 10 years

Will be assessed within each of the treatment arms and differences explores in these measures between the arms.
Up to 10 years

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbeidspartnere

National Cancer Institute (NCI)

Etterforskere

  • Studiestol: daniel_deangelo@dfci.harvard.edu J. DeAngelo, MD, PhD, Dana-Farber Cancer Institute

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

20. september 2017

Primær fullføring (Antatt)

1. november 2027

Studiet fullført (Antatt)

1. april 2028

Datoer for studieregistrering

Først innsendt

9. mai 2017

Først innsendt som oppfylte QC-kriteriene

10. mai 2017

Først lagt ut (Faktiske)

12. mai 2017

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

3. november 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

2. november 2026

Sist bekreftet

1. november 2026

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • A041501
  • U10CA180821 (U.S. NIH-stipend/kontrakt)
  • NCI-2016-01981 (Registeridentifikator: Clinical Trial Reporting Program)

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Ja

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Abonnere