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Studie av målrettet terapi vs. kjemoterapi hos pasienter med kreft i skjoldbruskkjertelen

21. september 2026 oppdatert av: ECOG-ACRIN Cancer Research Group

En randomisert fase III-studie av BRAF-målrettet terapi vs Cabozantinib i RAI-refraktær differensiert skjoldbruskkjertelkreft med BRAF V600Em

This phase III trial compares the effect of cabozantinib versus combination dabrafenib and trametinib for the treatment of patients with differentiated thyroid cancer that does not respond to treatment (refractory) and which expresses a BRAF V600E mutation. Cabozantinib is in a class of medications called receptor tyrosine kinase inhibitors. It binds to and blocks the action of several enzymes which are often over-expressed in a variety of tumor cell types. This may help stop or slow the growth of tumor cells and blood vessels the tumor needs to survive. Dabrafenib is an enzyme inhibitor that binds to and inhibits the activity of a protein called B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. Trametinib is also an enzyme inhibitor. It binds to and inhibits the activity of proteins called MEK 1 and 2, which play a key role in activating pathways that regulate cell growth. This may inhibit the growth of tumor cells mediated by these pathways. The usual approach for patients with thyroid cancer is targeted therapy with dabrafenib and trametinib. This trial may help researchers decide which treatment option (cabozantinib alone or dabrafenib in combination with trametinib) is safer and/or more effective in treating patients with refractory BRAF V600E-mutated differentiated thyroid cancer.

Studieoversikt

Status

Rekruttering

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

PRIMARY OBJECTIVE:

I. To compare progression-free survival (PFS) in patients with BRAF V600Em differentiated thyroid cancer who progressed on frontline multikinase inhibitor treated with dabrafenib/trametinib or cabozantinib.

SECONDARY OBJECTIVES:

I. To compare the objective response rate in patients with BRAF V600Em differentiated thyroid cancer that progressed on frontline multikinase inhibitor treated with dabrafenib/trametinib or cabozantinib.

II. To compare the duration of response in patients with BRAF V600Em differentiated thyroid cancer that progressed on frontline multikinase inhibitor treated with dabrafenib/trametinib or cabozantinib.

III. To compare the overall survival in patients with BRAF V600Em differentiated thyroid cancer that progressed on frontline multikinase inhibitor treated with dabrafenib/trametinib or cabozantinib.

IV. To compare the PFS2 in patients with BRAF V600Em differentiated thyroid cancer that progressed on frontline multikinase inhibitor treated with dabrafenib/trametinib or cabozantinib.

V. To compare the safety/tolerability in patients with BRAF V600Em differentiated thyroid cancer that progressed on frontline multikinase inhibitor treated with dabrafenib/trametinib or cabozantinib.

QUALITY OF LIFE OBJECTIVE:

I. To assess patient tolerability of treatment using the Functional Assessment Cancer Therapy General (FACT G) P5 and general quality of life using the FACT-G7.

OUTLINE: Patients are randomized to 1 of 2 arms. Patients may crossover to other treatment arm at the time of progression.

ARM A: Patients receive dabrafenib orally (PO) twice daily (BID) and trametinib PO once daily (QD) on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo computed tomography (CT) scan, blood sample collection and may undergo magnetic resonance imaging (MRI) throughout the study.

ARM B: Patients receive cabozantinib PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, blood sample collection and may undergo MRI throughout the study.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months thereafter up to 5 years.

Studietype

Intervensjonell

Registrering (Antatt)

264

Fase

  • Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

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    • Florida
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    • Idaho
      • Boise, Idaho, Forente stater, 83712
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      • Emmett, Idaho, Forente stater, 83617
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      • Nampa, Idaho, Forente stater, 83687
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        • Saint Luke's Cancer Institute - Nampa
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      • Nampa, Idaho, Forente stater, 83687
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        • Saint Alphonsus Cancer Care Center-Nampa
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      • Post Falls, Idaho, Forente stater, 83854
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        • Kootenai Clinic Cancer Services - Post Falls
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          • John M. Schallenkamp
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      • Sandpoint, Idaho, Forente stater, 83864
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        • Kootenai Clinic Cancer Services - Sandpoint
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          • John M. Schallenkamp
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      • Twin Falls, Idaho, Forente stater, 83301
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        • Saint Luke's Cancer Institute - Twin Falls
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    • Illinois
      • Alton, Illinois, Forente stater, 62002
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        • OSF Saint Anthony's Health Center
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      • Aurora, Illinois, Forente stater, 60506
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        • Advocate Outpatient Center - Aurora
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          • Thomas J. Saphner
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      • Barrington, Illinois, Forente stater, 60010
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        • Advocate Good Shepherd Hospital
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      • Centralia, Illinois, Forente stater, 62801
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        • Saint Mary's Hospital
      • Chicago, Illinois, Forente stater, 60637
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        • University of Chicago Comprehensive Cancer Center
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      • Chicago, Illinois, Forente stater, 60612
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        • University of Illinois
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      • Crystal Lake, Illinois, Forente stater, 60014
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        • AMG Crystal Lake - Oncology
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      • DeKalb, Illinois, Forente stater, 60115
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      • Downers Grove, Illinois, Forente stater, 60515
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      • Elgin, Illinois, Forente stater, 60123
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          • Telefonnummer: 847-429-2907
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      • Geneva, Illinois, Forente stater, 60134
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        • Northwestern Medicine Cancer Center Delnor
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      • Glenview, Illinois, Forente stater, 60026
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      • Grayslake, Illinois, Forente stater, 60030
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          • Jochen H. Lorch
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      • Hazel Crest, Illinois, Forente stater, 60429
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      • Lake Forest, Illinois, Forente stater, 60045
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      • Libertyville, Illinois, Forente stater, 60048
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        • AMG Libertyville - Oncology
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      • Libertyville, Illinois, Forente stater, 60048
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        • Condell Memorial Hospital
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      • Mount Vernon, Illinois, Forente stater, 62864
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        • SSM Health Good Samaritan
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      • New Lenox, Illinois, Forente stater, 60451
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        • UC Comprehensive Cancer Center at Silver Cross
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      • Oak Lawn, Illinois, Forente stater, 60453-2699
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        • Advocate Outpatient Center - Oak Lawn
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          • Thomas J. Saphner
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      • Palos Heights, Illinois, Forente stater, 60463
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        • Advocate High Tech Medical Park
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    • Indiana
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        • UChicago Medicine Northwest Indiana
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      • Ankeny, Iowa, Forente stater, 50023
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      • Bettendorf, Iowa, Forente stater, 52722
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        • University of Iowa Healthcare Cancer Services Quad Cities
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      • Carroll, Iowa, Forente stater, 51401
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        • Saint Anthony Regional Hospital
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      • Cedar Rapids, Iowa, Forente stater, 52403
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      • Clive, Iowa, Forente stater, 50325
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      • Clive, Iowa, Forente stater, 50325
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      • Council Bluffs, Iowa, Forente stater, 51503
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        • Heartland Oncology and Hematology LLP
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      • Council Bluffs, Iowa, Forente stater, 51503
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        • Methodist Jennie Edmundson Hospital
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      • Council Bluffs, Iowa, Forente stater, 51503
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        • Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ
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      • Creston, Iowa, Forente stater, 50801
        • Rekruttering
        • Greater Regional Medical Center
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          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Richard L. Deming
      • Des Moines, Iowa, Forente stater, 50314
        • Rekruttering
        • Broadlawns Medical Center
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          • Site Public Contact
          • Telefonnummer: 515-282-2200
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forente stater, 50314
        • Rekruttering
        • Mercy Medical Center - Des Moines
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          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Richard L. Deming
      • Des Moines, Iowa, Forente stater, 50309
        • Rekruttering
        • Iowa Methodist Medical Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-241-6727
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forente stater, 50309
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
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          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forente stater, 50314
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
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          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • Fort Dodge, Iowa, Forente stater, 50501
        • Rekruttering
        • UI Healthcare Mission Cancer and Blood - Fort Dodge
        • Hovedetterforsker:
          • Seema Harichand-Herdt
        • Ta kontakt med:
      • Iowa City, Iowa, Forente stater, 52242
        • Rekruttering
        • University of Iowa/Holden Comprehensive Cancer Center
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          • Site Public Contact
          • Telefonnummer: 800-237-1225
        • Hovedetterforsker:
          • Douglas E. Laux
      • Pella, Iowa, Forente stater, 50219
        • Rekruttering
        • UI Healthcare Mission Cancer and Blood - Pella
        • Hovedetterforsker:
          • Seema Harichand-Herdt
        • Ta kontakt med:
      • Waukee, Iowa, Forente stater, 50263
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Waukee Clinic
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          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Seema Harichand-Herdt
      • West Des Moines, Iowa, Forente stater, 50266
        • Rekruttering
        • Mercy Medical Center-West Lakes
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Hovedetterforsker:
          • Richard L. Deming
      • West Des Moines, Iowa, Forente stater, 50266
        • Rekruttering
        • The Iowa Clinic PC
        • Hovedetterforsker:
          • Seema Harichand-Herdt
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 515-875-9815
    • Kansas
      • Garden City, Kansas, Forente stater, 67846
        • Rekruttering
        • Central Care Cancer Center - Garden City
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
      • Great Bend, Kansas, Forente stater, 67530
        • Rekruttering
        • Central Care Cancer Center - Great Bend
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
      • Pittsburg, Kansas, Forente stater, 66762
        • Rekruttering
        • Mercy Hospital Pittsburg
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 888-446-3729
    • Kentucky
      • Lexington, Kentucky, Forente stater, 40536
        • Rekruttering
        • University of Kentucky/Markey Cancer Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 859-257-3379
        • Hovedetterforsker:
          • Omar M. El Kawkgi
    • Maryland
      • Baltimore, Maryland, Forente stater, 21201
        • Rekruttering
        • University of Maryland/Greenebaum Cancer Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 800-888-8823
        • Hovedetterforsker:
          • Ranee Mehra
    • Michigan
      • Alma, Michigan, Forente stater, 48801
        • Rekruttering
        • MyMichigan Medical Center Gratiot
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Alpena, Michigan, Forente stater, 49707
        • Rekruttering
        • MyMichigan Medical Center Alpena
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Ann Arbor, Michigan, Forente stater, 48109
        • Rekruttering
        • University of Michigan Rogel Cancer Center
        • Hovedetterforsker:
          • Francis P. Worden
        • Ta kontakt med:
      • Ann Arbor, Michigan, Forente stater, 48106
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Ann Arbor, Michigan, Forente stater, 48103
      • Brighton, Michigan, Forente stater, 48114
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Brighton, Michigan, Forente stater, 48116
        • Rekruttering
        • University of Michigan - Brighton Center for Specialty Care
        • Hovedetterforsker:
          • Francis P. Worden
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 800-865-1125
      • Brighton, Michigan, Forente stater, 48114
        • Rekruttering
        • Trinity Health Medical Center - Brighton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Canton, Michigan, Forente stater, 48188
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Canton, Michigan, Forente stater, 48188
        • Rekruttering
        • Trinity Health Medical Center - Canton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Caro, Michigan, Forente stater, 48723
        • Suspendert
        • Caro Cancer Center
      • Chelsea, Michigan, Forente stater, 48118
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Chelsea, Michigan, Forente stater, 48118
      • Clarkston, Michigan, Forente stater, 48346
        • Rekruttering
        • Hematology Oncology Consultants-Clarkston
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Clarkston, Michigan, Forente stater, 48346
        • Suspendert
        • Newland Medical Associates-Clarkston
      • Clarkston, Michigan, Forente stater, 48346
        • Rekruttering
        • Trinity Health IHA Medical Group - Primary Care - Clarkston
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Detroit, Michigan, Forente stater, 48236
        • Rekruttering
        • Henry Ford Health Saint John Hospital
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • East China, Michigan, Forente stater, 48054
        • Rekruttering
        • Henry Ford River District Hospital
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Flint, Michigan, Forente stater, 48503
        • Rekruttering
        • Genesee Hematology Oncology PC
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Flint, Michigan, Forente stater, 48503
        • Rekruttering
        • Genesys Hurley Cancer Institute
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Flint, Michigan, Forente stater, 48503
        • Rekruttering
        • Hurley Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Flint, Michigan, Forente stater, 48503
        • Rekruttering
        • Cancer Hematology Centers - Flint
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Gladwin, Michigan, Forente stater, 48624
        • Rekruttering
        • MyMichigan Medical Center Gladwin
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Grand Rapids, Michigan, Forente stater, 49503
        • Rekruttering
        • Trinity Health Grand Rapids Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Grosse Pointe Woods, Michigan, Forente stater, 48236
        • Rekruttering
        • Henry Ford Saint John Hospital - Breast
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Grosse Pointe Woods, Michigan, Forente stater, 48236
        • Rekruttering
        • Henry Ford Saint John Hospital - Academic
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Grosse Pointe Woods, Michigan, Forente stater, 48236
        • Rekruttering
        • Henry Ford Saint John Hospital - Van Elslander
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Lansing, Michigan, Forente stater, 48912
        • Rekruttering
        • University of Michigan Health - Sparrow Lansing
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Livonia, Michigan, Forente stater, 48154
        • Rekruttering
        • Trinity Health Saint Mary Mercy Livonia Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Macomb, Michigan, Forente stater, 48044
        • Rekruttering
        • Henry Ford Warren Hospital - Breast Macomb
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Macomb, Michigan, Forente stater, 48044
        • Rekruttering
        • Henry Ford Saint John Hospital - Macomb Medical
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Marlette, Michigan, Forente stater, 48453
        • Suspendert
        • Saint Mary's Oncology/Hematology Associates of Marlette
      • Midland, Michigan, Forente stater, 48670
        • Rekruttering
        • MyMichigan Medical Center Midland
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Mount Pleasant, Michigan, Forente stater, 48858
        • Rekruttering
        • MyMichigan Medical Center Mount Pleasant
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Muskegon, Michigan, Forente stater, 49444
        • Rekruttering
        • Trinity Health Muskegon Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Norton Shores, Michigan, Forente stater, 49444
        • Rekruttering
        • Cancer and Hematology Centers of Western Michigan - Norton Shores
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Pontiac, Michigan, Forente stater, 48341
        • Rekruttering
        • Newland Medical Associates-Pontiac
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Pontiac, Michigan, Forente stater, 48341
        • Suspendert
        • Hope Cancer Center
      • Pontiac, Michigan, Forente stater, 48341
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Oakland Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Pontiac, Michigan, Forente stater, 48341
        • Rekruttering
        • Michigan Healthcare Professionals Pontiac
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Saginaw, Michigan, Forente stater, 48604
        • Suspendert
        • Oncology Hematology Associates of Saginaw Valley PC
      • Saginaw, Michigan, Forente stater, 48601
        • Rekruttering
        • MyMichigan Medical Center Saginaw
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Tawas City, Michigan, Forente stater, 48764
        • Rekruttering
        • MyMichigan Medical Center Tawas
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Warren, Michigan, Forente stater, 48093
        • Rekruttering
        • Henry Ford Madison Heights Hospital - Breast
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Warren, Michigan, Forente stater, 48093
        • Rekruttering
        • Henry Ford Health Warren Hospital
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • Warren, Michigan, Forente stater, 48093
        • Rekruttering
        • Henry Ford Warren Hospital - GLCMS
        • Hovedetterforsker:
          • Tareq Al baghdadi
        • Ta kontakt med:
      • West Branch, Michigan, Forente stater, 48661
        • Suspendert
        • Saint Mary's Oncology/Hematology Associates of West Branch
      • Ypsilanti, Michigan, Forente stater, 48106
      • Ypsilanti, Michigan, Forente stater, 48197
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
    • Minnesota
      • Bemidji, Minnesota, Forente stater, 56601
      • Burnsville, Minnesota, Forente stater, 55337
        • Rekruttering
        • Minnesota Oncology - Burnsville
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Cambridge, Minnesota, Forente stater, 55008
        • Rekruttering
        • Cambridge Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Chaska, Minnesota, Forente stater, 55318
        • Rekruttering
        • Minnesota Oncology Hematology PA-Chaska
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Coon Rapids, Minnesota, Forente stater, 55433
        • Rekruttering
        • Mercy Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Coon Rapids, Minnesota, Forente stater, 55433
        • Rekruttering
        • Minnesota Oncology - Coon Rapids
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Edina, Minnesota, Forente stater, 55435
        • Rekruttering
        • Fairview Southdale Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Edina, Minnesota, Forente stater, 55435
        • Rekruttering
        • Minnesota Oncology - Edina
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Maple Grove, Minnesota, Forente stater, 55369
        • Rekruttering
        • Fairview Clinics and Surgery Center Maple Grove
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Maple Grove, Minnesota, Forente stater, 55369
        • Rekruttering
        • Minnesota Oncology - Maple Grove
        • Hovedetterforsker:
          • David M. King
        • Ta kontakt med:
      • Maplewood, Minnesota, Forente stater, 55109
        • Rekruttering
        • Minnesota Oncology Hematology PA-Maplewood
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Maplewood, Minnesota, Forente stater, 55109
        • Rekruttering
        • Saint John's Hospital - Healtheast
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Minneapolis, Minnesota, Forente stater, 55407
        • Rekruttering
        • Abbott-Northwestern Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Minneapolis, Minnesota, Forente stater, 55415
        • Rekruttering
        • Hennepin County Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Minneapolis, Minnesota, Forente stater, 55454
        • Rekruttering
        • Health Partners Inc
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Monticello, Minnesota, Forente stater, 55362
        • Rekruttering
        • Monticello Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • New Ulm, Minnesota, Forente stater, 56073
        • Rekruttering
        • New Ulm Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Princeton, Minnesota, Forente stater, 55371
        • Rekruttering
        • Fairview Northland Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Robbinsdale, Minnesota, Forente stater, 55422
        • Rekruttering
        • North Memorial Medical Health Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Rochester, Minnesota, Forente stater, 55905
        • Aktiv, ikke rekrutterende
        • Mayo Clinic in Rochester
      • Saint Louis Park, Minnesota, Forente stater, 55416
        • Rekruttering
        • Park Nicollet Clinic - Saint Louis Park
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Saint Paul, Minnesota, Forente stater, 55101
        • Rekruttering
        • Regions Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Saint Paul, Minnesota, Forente stater, 55102
        • Rekruttering
        • United Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Shakopee, Minnesota, Forente stater, 55379
        • Rekruttering
        • Saint Francis Regional Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Stillwater, Minnesota, Forente stater, 55082
        • Rekruttering
        • Lakeview Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Thief River Falls, Minnesota, Forente stater, 56701
        • Rekruttering
        • Sanford Thief River Falls Medical Center
        • Hovedetterforsker:
          • Daniel Almquist
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 605-312-3320
      • Waconia, Minnesota, Forente stater, 55387
        • Rekruttering
        • Ridgeview Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Willmar, Minnesota, Forente stater, 56201
        • Rekruttering
        • Rice Memorial Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Woodbury, Minnesota, Forente stater, 55125
        • Rekruttering
        • Minnesota Oncology Hematology PA-Woodbury
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Worthington, Minnesota, Forente stater, 56187
        • Rekruttering
        • Sanford Cancer Center Worthington
        • Hovedetterforsker:
          • Daniel Almquist
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 605-312-3320
      • Wyoming, Minnesota, Forente stater, 55092
        • Rekruttering
        • Fairview Lakes Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
    • Missouri
      • Ballwin, Missouri, Forente stater, 63011
        • Rekruttering
        • Mercy Oncology and Hematology - Clayton-Clarkson
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 888-446-3729
      • Bolivar, Missouri, Forente stater, 65613
        • Rekruttering
        • Central Care Cancer Center - Bolivar
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
      • Branson, Missouri, Forente stater, 65616
        • Rekruttering
        • Cox Cancer Center Branson
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 417-269-4520
      • Cape Girardeau, Missouri, Forente stater, 63703
        • Rekruttering
        • Mercy Cancer Center - Cape Girardeau
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 888-446-3729
      • City of Saint Peters, Missouri, Forente stater, 63376
        • Rekruttering
        • Siteman Cancer Center at Saint Peters Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Brendan J. Knapp
      • Creve Coeur, Missouri, Forente stater, 63141
        • Rekruttering
        • Siteman Cancer Center at West County Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Brendan J. Knapp
      • Joplin, Missouri, Forente stater, 64804
        • Rekruttering
        • Freeman Health System
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
      • Joplin, Missouri, Forente stater, 64804
        • Rekruttering
        • Mercy Hospital Joplin
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
      • Osage Beach, Missouri, Forente stater, 65065
        • Rekruttering
        • Lake Regional Hospital
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
      • Rolla, Missouri, Forente stater, 65401
        • Rekruttering
        • Mercy Clinic-Rolla-Cancer and Hematology
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 573-458-6379
      • Rolla, Missouri, Forente stater, 65401
        • Rekruttering
        • Phelps Health Delbert Day Cancer Institute
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
      • Saint Joseph, Missouri, Forente stater, 64506
        • Rekruttering
        • Heartland Regional Medical Center
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
      • Springfield, Missouri, Forente stater, 65804
        • Rekruttering
        • Mercy Hospital Springfield
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 417-269-4520
      • Springfield, Missouri, Forente stater, 65807
        • Rekruttering
        • CoxHealth South Hospital
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 417-269-4520
      • St Louis, Missouri, Forente stater, 63110
        • Rekruttering
        • Washington University School of Medicine
        • Ta kontakt med:
        • Hovedetterforsker:
          • Brendan J. Knapp
      • St Louis, Missouri, Forente stater, 63128
        • Rekruttering
        • Mercy Hospital South
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
      • St Louis, Missouri, Forente stater, 63141
        • Rekruttering
        • Mercy Hospital Saint Louis
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 314-251-7066
      • St Louis, Missouri, Forente stater, 63129
        • Rekruttering
        • Siteman Cancer Center-South County
        • Ta kontakt med:
        • Hovedetterforsker:
          • Brendan J. Knapp
      • St Louis, Missouri, Forente stater, 63136
        • Rekruttering
        • Siteman Cancer Center at Christian Hospital
        • Ta kontakt med:
        • Hovedetterforsker:
          • Brendan J. Knapp
      • St Louis, Missouri, Forente stater, 63109
        • Rekruttering
        • Mercy Infusion Center - Chippewa
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 888-446-3729
      • Washington, Missouri, Forente stater, 63090
        • Rekruttering
        • Mercy Hospital Washington
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 636-390-1600
    • Montana
      • Anaconda, Montana, Forente stater, 59711
        • Rekruttering
        • Community Hospital of Anaconda
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Billings, Montana, Forente stater, 59101
        • Rekruttering
        • Billings Clinic Cancer Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Bozeman, Montana, Forente stater, 59715
        • Rekruttering
        • Bozeman Health Deaconess Hospital
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Great Falls, Montana, Forente stater, 59405
        • Rekruttering
        • Great Falls Clinic
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Great Falls, Montana, Forente stater, 59405
        • Rekruttering
        • Benefis Sletten Cancer Institute
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Havre, Montana, Forente stater, 59501
        • Rekruttering
        • Hi-Line Sletten Cancer Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Helena, Montana, Forente stater, 59601
        • Rekruttering
        • Benefis Helena Specialty Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Kalispell, Montana, Forente stater, 59901
        • Rekruttering
        • Logan Health Medical Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Missoula, Montana, Forente stater, 59802
        • Rekruttering
        • Saint Patrick Hospital - Community Hospital
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Missoula, Montana, Forente stater, 59804
        • Rekruttering
        • Community Medical Center
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
    • Nebraska
      • Omaha, Nebraska, Forente stater, 68114
        • Rekruttering
        • Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 402-334-4773
        • Hovedetterforsker:
          • Yungpo B. Su
      • Omaha, Nebraska, Forente stater, 68114
        • Rekruttering
        • Nebraska Methodist Hospital
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 402-354-5144
        • Hovedetterforsker:
          • Yungpo B. Su
      • Omaha, Nebraska, Forente stater, 68114
        • Suspendert
        • Oncology Associates PC
    • North Carolina
      • Cary, North Carolina, Forente stater, 27518
        • Suspendert
        • Duke Cancer Center Cary
      • Chapel Hill, North Carolina, Forente stater, 27599
        • Rekruttering
        • UNC Lineberger Comprehensive Cancer Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Siddharth Sheth
      • Durham, North Carolina, Forente stater, 27710
        • Rekruttering
        • Duke University Medical Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 888-275-3853
        • Hovedetterforsker:
          • Neal E. Ready
      • Raleigh, North Carolina, Forente stater, 27609
        • Suspendert
        • Duke Cancer Center Raleigh
    • North Dakota
      • Bismarck, North Dakota, Forente stater, 58501
      • Fargo, North Dakota, Forente stater, 58122
      • Fargo, North Dakota, Forente stater, 58103
        • Rekruttering
        • Sanford South University Medical Center
        • Hovedetterforsker:
          • Daniel Almquist
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 701-234-6161
      • Fargo, North Dakota, Forente stater, 58122
      • Fargo, North Dakota, Forente stater, 58103
        • Rekruttering
        • Southpointe-Sanford Medical Center Fargo
        • Hovedetterforsker:
          • Daniel Almquist
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 605-312-3320
      • Fargo, North Dakota, Forente stater, 58104
        • Rekruttering
        • Sanford Medical Center Fargo
        • Hovedetterforsker:
          • Daniel Almquist
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 800-437-4010
    • Oklahoma
      • Lawton, Oklahoma, Forente stater, 73505
        • Rekruttering
        • Cancer Centers of Southwest Oklahoma Research
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 877-231-4440
        • Hovedetterforsker:
          • Minh Phan
      • Oklahoma City, Oklahoma, Forente stater, 73104
        • Rekruttering
        • University of Oklahoma Health Sciences Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Minh Phan
      • Oklahoma City, Oklahoma, Forente stater, 73120
        • Rekruttering
        • Mercy Hospital Oklahoma City
        • Hovedetterforsker:
          • Jay W. Carlson
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 405-752-3402
    • Oregon
      • Baker City, Oregon, Forente stater, 97814
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Baker City
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Bend, Oregon, Forente stater, 97701
        • Rekruttering
        • Saint Charles Health System
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Clackamas, Oregon, Forente stater, 97015
        • Rekruttering
        • Clackamas Radiation Oncology Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Clackamas, Oregon, Forente stater, 97015
        • Suspendert
        • Providence Cancer Institute Clackamas Clinic
      • Coos Bay, Oregon, Forente stater, 97420
        • Rekruttering
        • Bay Area Hospital
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Hood River, Oregon, Forente stater, 97031
        • Rekruttering
        • Providence Hood River Memorial Hospital
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Newberg, Oregon, Forente stater, 97132
        • Rekruttering
        • Providence Newberg Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Ontario, Oregon, Forente stater, 97914
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Ontario
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Oregon City, Oregon, Forente stater, 97045
        • Rekruttering
        • Providence Willamette Falls Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Portland, Oregon, Forente stater, 97213
        • Rekruttering
        • Providence Portland Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Portland, Oregon, Forente stater, 97225
        • Rekruttering
        • Providence Saint Vincent Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Portland, Oregon, Forente stater, 97239
        • Aktiv, ikke rekrutterende
        • Oregon Health and Science University
      • Redmond, Oregon, Forente stater, 97756
        • Rekruttering
        • Saint Charles Health System-Redmond
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 541-706-2909
    • Pennsylvania
      • Allentown, Pennsylvania, Forente stater, 18103
        • Rekruttering
        • Lehigh Valley Hospital-Cedar Crest
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Bethlehem, Pennsylvania, Forente stater, 18017
        • Rekruttering
        • Lehigh Valley Hospital - Muhlenberg
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • East Stroudsburg, Pennsylvania, Forente stater, 18301
        • Rekruttering
        • Pocono Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Erie, Pennsylvania, Forente stater, 16505
        • Rekruttering
        • UPMC Hillman Cancer Center Erie
        • Hovedetterforsker:
          • Dan P. Zandberg
        • Ta kontakt med:
      • Hazleton, Pennsylvania, Forente stater, 18201
        • Rekruttering
        • Lehigh Valley Hospital-Hazleton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Tareq Al baghdadi
      • Philadelphia, Pennsylvania, Forente stater, 19104
        • Rekruttering
        • University of Pennsylvania/Abramson Cancer Center
        • Hovedetterforsker:
          • Lova Sun
        • Ta kontakt med:
      • Pittsburgh, Pennsylvania, Forente stater, 15232
        • Rekruttering
        • UPMC Hillman Cancer Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 412-647-8073
        • Hovedetterforsker:
          • Dan P. Zandberg
    • Rhode Island
      • Westerly, Rhode Island, Forente stater, 02891
        • Rekruttering
        • Smilow Cancer Hospital Care Center - Westerly
        • Ta kontakt med:
        • Hovedetterforsker:
          • Aarti Bhatia
    • South Carolina
      • Charleston, South Carolina, Forente stater, 29425
        • Rekruttering
        • Medical University of South Carolina
        • Ta kontakt med:
        • Hovedetterforsker:
          • John M. Kaczmar
    • South Dakota
      • Sioux Falls, South Dakota, Forente stater, 57104
        • Rekruttering
        • Sanford Cancer Center Oncology Clinic
        • Hovedetterforsker:
          • Daniel Almquist
        • Ta kontakt med:
      • Sioux Falls, South Dakota, Forente stater, 57117-5134
    • Tennessee
      • Franklin, Tennessee, Forente stater, 37067
        • Suspendert
        • Vanderbilt-Ingram Cancer Center Cool Springs
      • Nashville, Tennessee, Forente stater, 37232
        • Rekruttering
        • Vanderbilt University/Ingram Cancer Center
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 800-811-8480
        • Hovedetterforsker:
          • Jennifer H. Choe
      • Nashville, Tennessee, Forente stater, 37204
        • Rekruttering
        • Vanderbilt Breast Center at One Hundred Oaks
        • Ta kontakt med:
          • Site Public Contact
          • Telefonnummer: 800-811-8480
        • Hovedetterforsker:
          • Jennifer H. Choe
    • Utah
      • Salt Lake City, Utah, Forente stater, 84112
        • Rekruttering
        • Huntsman Cancer Institute/University of Utah
        • Hovedetterforsker:
          • Kathleen C. Kerrigan
        • Ta kontakt med:
    • Washington
      • Aberdeen, Washington, Forente stater, 98520
        • Rekruttering
        • Providence Regional Cancer System-Aberdeen
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Bellingham, Washington, Forente stater, 98225
        • Rekruttering
        • PeaceHealth Saint Joseph Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Centralia, Washington, Forente stater, 98531
        • Rekruttering
        • Providence Regional Cancer System-Centralia
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Edmonds, Washington, Forente stater, 98026
        • Rekruttering
        • Swedish Cancer Institute-Edmonds
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Everett, Washington, Forente stater, 98201
        • Rekruttering
        • Providence Regional Cancer Partnership
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Issaquah, Washington, Forente stater, 98029
        • Rekruttering
        • Swedish Cancer Institute-Issaquah
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Kennewick, Washington, Forente stater, 99336
        • Rekruttering
        • Kadlec Clinic Hematology and Oncology
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Lacey, Washington, Forente stater, 98503
        • Rekruttering
        • Providence Regional Cancer System-Lacey
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Longview, Washington, Forente stater, 98632
        • Rekruttering
        • PeaceHealth Saint John Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Mount Vernon, Washington, Forente stater, 98274
      • Seattle, Washington, Forente stater, 98122
        • Rekruttering
        • Swedish Medical Center-First Hill
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Seattle, Washington, Forente stater, 98107
        • Rekruttering
        • Swedish Medical Center-Ballard Campus
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Seattle, Washington, Forente stater, 98122-5711
        • Rekruttering
        • Swedish Medical Center-Cherry Hill
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Sedro-Woolley, Washington, Forente stater, 98284
        • Rekruttering
        • PeaceHealth United General Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Spokane, Washington, Forente stater, 99202
        • Rekruttering
        • Cancer Care Northwest - Spokane South
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Spokane, Washington, Forente stater, 99216
        • Rekruttering
        • Cancer Care Northwest-Valley
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Spokane, Washington, Forente stater, 99218
        • Rekruttering
        • Cancer Care Northwest-North Spokane
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Vancouver, Washington, Forente stater, 98664
        • Rekruttering
        • PeaceHealth Southwest Medical Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
      • Walla Walla, Washington, Forente stater, 99362
        • Rekruttering
        • Providence Saint Mary Regional Cancer Center
        • Hovedetterforsker:
          • Alison K. Conlin
        • Ta kontakt med:
    • Wisconsin
      • Burlington, Wisconsin, Forente stater, 53105
        • Rekruttering
        • Aurora Cancer Care-Southern Lakes VLCC
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Cudahy, Wisconsin, Forente stater, 53110
        • Rekruttering
        • Aurora Saint Luke's South Shore
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Eau Claire, Wisconsin, Forente stater, 54701
      • Germantown, Wisconsin, Forente stater, 53022
        • Rekruttering
        • Aurora Health Care Germantown Health Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Grafton, Wisconsin, Forente stater, 53024
        • Rekruttering
        • Aurora Cancer Care-Grafton
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Green Bay, Wisconsin, Forente stater, 54311
        • Rekruttering
        • Aurora BayCare Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Kenosha, Wisconsin, Forente stater, 53142
        • Rekruttering
        • Aurora Cancer Care-Kenosha South
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Marinette, Wisconsin, Forente stater, 54143
        • Rekruttering
        • Aurora Bay Area Medical Group-Marinette
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Marshfield, Wisconsin, Forente stater, 54449
      • Milwaukee, Wisconsin, Forente stater, 53209
        • Rekruttering
        • Aurora Cancer Care-Milwaukee
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Milwaukee, Wisconsin, Forente stater, 53215
        • Rekruttering
        • Aurora Saint Luke's Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Milwaukee, Wisconsin, Forente stater, 53233
        • Rekruttering
        • Aurora Sinai Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Minocqua, Wisconsin, Forente stater, 54548
      • New Richmond, Wisconsin, Forente stater, 54017
        • Rekruttering
        • Cancer Center of Western Wisconsin
        • Ta kontakt med:
        • Hovedetterforsker:
          • David M. King
      • Oshkosh, Wisconsin, Forente stater, 54904
        • Rekruttering
        • Vince Lombardi Cancer Clinic - Oshkosh
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Racine, Wisconsin, Forente stater, 53406
        • Rekruttering
        • Aurora Cancer Care-Racine
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Rice Lake, Wisconsin, Forente stater, 54868
      • Sheboygan, Wisconsin, Forente stater, 53081
        • Rekruttering
        • Vince Lombardi Cancer Clinic-Sheboygan
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Stevens Point, Wisconsin, Forente stater, 54482
      • Summit, Wisconsin, Forente stater, 53066
        • Rekruttering
        • Aurora Medical Center in Summit
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Two Rivers, Wisconsin, Forente stater, 54241
        • Rekruttering
        • Vince Lombardi Cancer Clinic-Two Rivers
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Wauwatosa, Wisconsin, Forente stater, 53226
        • Rekruttering
        • Aurora Cancer Care-Milwaukee West
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • West Allis, Wisconsin, Forente stater, 53227
        • Rekruttering
        • Aurora West Allis Medical Center
        • Ta kontakt med:
        • Hovedetterforsker:
          • Thomas J. Saphner
      • Weston, Wisconsin, Forente stater, 54476
    • Wyoming
      • Cheyenne, Wyoming, Forente stater, 82001
        • Rekruttering
        • Memorial Hospital of Laramie County
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Cody, Wyoming, Forente stater, 82414
        • Rekruttering
        • Billings Clinic-Cody
        • Hovedetterforsker:
          • John M. Schallenkamp
        • Ta kontakt med:
      • Sheridan, Wyoming, Forente stater, 82801
        • Suspendert
        • Welch Cancer Center

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion Criteria:

  • Patient must be ≥ 18 years of age

  • Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-2

  • Patient must have differentiated thyroid cancer (DTC) with BRAF V600E mutation as determined by local testing, including the following subtypes (Note: results of a previous biopsy will be accepted):

    • Papillary thyroid carcinoma including histological variants of papillary thyroid carcinoma (PTC) such as follicular variant, tall cell, columnar cell, cribriform-morular, solid, oxyphil, Warthin-like, trabecular, tumor with nodular fasciitis-like stroma, Hürthle cell variant of papillary carcinoma, poorly differentiated.
    • Follicular thyroid carcinoma including histological variants of follicular thyroid carcinoma (FTC) such as Hürthle cell, clear cell, insular, and poorly differentiated

  • Patient must have been previously treated with or deemed ineligible for treatment with Iodine-131 for DTC, and must be receiving thyroxine suppression therapy

  • Patient must have had prior treatment with at least one of the following vascular endothelial growth factor receptors (VEGFR)-targeting tyrosine kinase inhibitor (TKI) agents for DTC: lenvatinib or sorafenib.

    • NOTE: Up to two prior VEGFR-targeting TKI agents are allowed including, but not limited to lenvatinib and sorafenib

  • Patient must have measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) 1·1 on chest CT (computed tomography)/abdominal/pelvis CT/MRI (magnetic resonance imaging) performed within 4 weeks prior to randomization

  • Patient must have radiographic progression by RECIST 1.1 over any time interval on or after most recent prior systemic treatment

  • Patient must not have any of the following cardiovascular and thromboembolic disorders or medical conditions:

    • Congestive heart failure class 3 or 4 as defined by the New York Heart Association, unstable angina pectoris, or serious cardiac arrhythmias.
    • Uncontrolled hypertension defined as sustained blood pressure > 150 mm Hg systolic or > 100 mm Hg diastolic despite optimal antihypertensive treatment.
    • Stroke, myocardial infarction, or thromboembolic event (e.g., deep venous thrombosis, pulmonary embolism) within 6 months prior to randomization. Patients with more recent diagnosis of deep venous thrombosis are allowed if stable and treated with therapeutic anticoagulation for at least 6 weeks prior to randomization

  • Patient must not have any clinically significant hematemesis or haemoptysis of > 0·5 teaspoon (> 2·5 mL) of red blood or history of other significant bleeding within 3 months prior to randomization

  • Patient must not have any cavitating pulmonary lesion(s) or lesions invading major pulmonary blood vessels

  • Patient must not be on any concomitant anticoagulation with oral anticoagulants or platelet inhibitors, except for the following allowed agents:

    • Low-dose aspirin for cardioprotection.
    • Therapeutic anticoagulation with any agent in patients (1) without known brain metastases, (2) on a stable dose for at least 6 weeks prior to randomization, and (3) with no clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor

  • Patient must not have any gastrointestinal (GI) disorders associated with a high risk of perforation or fistula formation:

    • Tumors invading the GI tract, active peptic ulcer disease, inflammatory bowel disease, ulcerative colitis, diverticulitis, cholecystitis, symptomatic cholangitis or appendicitis, acute pancreatitis, or acute obstruction of the pancreatic or biliary duct, or gastric outlet obstruction
    • Abdominal fistula, GI perforation, bowel obstruction, or intra-abdominal abscess within 6 months prior to randomization

  • Patient must have completed any prior local therapy (e.g., surgery, radiation, ablation) at least 4 weeks prior to randomization, with complete wound healing and resolution of clinically relevant complications from prior local therapy

  • Patient must not have had major surgery (e.g., GI surgery, removal or biopsy of brain metastasis) within 8 weeks prior to randomization. Complete wound healing from major surgery must have occurred 4 weeks prior to randomization and from minor surgery (e.g., simple excision, tooth extraction) at least 10 days prior to randomization

  • Patient must not have pathologically documented anaplastic histology or transformation on any recurrence specimen collected after initial thyroidectomy/neck dissection

  • Patient must not have had prior treatment with cabozantinib or any prior BRAF targeted therapy for thyroid cancer

    • NOTE: Prior treatment with checkpoint inhibitor (e.g., pembrolizumab) for thyroid cancer is allowed, but must be noted on the eCRF (electronic case report form)

  • Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used.

All patients of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy.

A patient of childbearing potential is defined as someone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

  • Patients must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for the duration of their participation in the study and for 2 weeks after the last dose of dabrafenib and 4 months after the last dose of trametinib or cabozantinib. Patients must also not breastfeed while on study treatment and for 2 weeks after the last dose of dabrafenib and for 4 months after the last dose of trametinib or cabozantinib.

    • NOTE: Patients of childbearing potential who are on hormonal contraceptives may be at risks because dabrafenib may decrease the efficacy of hormonal contraceptives. An effective non-hormonal contraception should be used during therapy and for 2 weeks following discontinuation of dabrafenib and at least 4 months following the last dose of trametinib and cabozantinib

  • Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible

  • Hemoglobin (Hgb) ≥ 8 g/dL obtained ≤ 28 days prior to protocol randomization

  • Leukocytes ≥ 3,000/mcL obtained ≤ 28 days prior to protocol randomization

  • Absolute neutrophil count (ANC) ≥ 1,500/mcL obtained ≤ 28 days prior to protocol randomization

  • Platelets ≥ 100,000/mcL obtained ≤ 28 days prior to protocol randomization

  • Total bilirubin ≤ 2.0 x institutional upper limit of normal (ULN) obtained ≤ 28 days prior to protocol randomization

  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) ≤ 3.0 × institutional ULN or < 5.0 x ULN with the presence of hepatic metastasis obtained ≤ 28 days prior to protocol randomization

  • Estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m² obtained ≤ 28 days prior to protocol randomization

  • Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial

  • For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated

  • Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

  • Patients with treated brain metastases are eligible if follow-up brain imaging obtained after central nervous system (CNS)-directed therapy (radiotherapy and/or surgery) shows no evidence of progression. CNS disease must be stable for at least 4 weeks prior to randomization; patients must be neurologically asymptomatic and without corticosteroid treatment at time of randomization

  • Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial

  • Patients must have corrected QT interval calculated by the Fridericia formula (QTcF) ≤ 500 ms obtained within 28 days prior to randomization.

    • NOTE: If a single electrocardiogram (ECG) shows a QTcF with an absolute value > 500 ms, two additional ECGs at intervals of approximately 3 minutes (min) must be performed within 30 min after the initial ECG, and the average of these 3 consecutive results for QTcF will be used to determine eligibility

  • Patient must be English or Spanish speaking to be eligible for the quality of life (QOL) component of the study.

    • NOTE: Sites cannot translate the associated QOL forms

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Ingen (Open Label)

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Aktiv komparator: Arm A (Dabrafenib and trametinib)

Patients receive dabrafenib PO BID and trametinib PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, blood sample collection and may undergo MRI throughout the study.
Fremgangsmåte: Biospecimen Collection

Undergo blood sample collection

Andre navn:
  • Biologisk prøvesamling
  • Bioprøve samlet
  • Prøvesamling
Fremgangsmåte: Magnetic Resonance Imaging

Undergo MRI

Andre navn:
  • MR
  • Magnetisk resonans
  • Magnetic Resonance Imaging Scan
  • Medisinsk bildebehandling, magnetisk resonans / kjernemagnetisk resonans
  • MR Imaging
  • MR-skanning
  • NMR-avbildning
  • NMRI
  • Kjernemagnetisk resonansavbildning
  • Magnetisk resonanstomografi (MR)
  • sMRI
  • Magnetisk resonansavbildning (prosedyre)
  • MR-er
  • Strukturell MR
Legemiddel: Trametinib

Given PO

Andre navn:
  • GSK1120212
  • JTP-74057
  • MEK-hemmer GSK1120212
  • GSK 1120212
  • GSK-1120212
  • GSK 212
  • GSK-212
  • GSK212
  • JTP 74057
  • JTP74057
Fremgangsmåte: Computed Tomography

Undergo CT scan

Andre navn:
  • CT
  • KATT
  • CAT-skanning
  • Beregnet aksial tomografi
  • Datastyrt aksialtomografi
  • Datastyrt tomografi
  • CT skann
  • tomografi
  • Datastyrt aksial tomografi (prosedyre)
  • Datastyrt tomografi (CT) skanning
  • Diagnostisk CAT -skanning
  • Diagnostisk CAT -skannertype
Legemiddel: Dabrafenib

Given PO

Andre navn:
  • GSK2118436
  • BRAF-hemmer GSK2118436
  • GSK-2118436
  • GSK-2118436A
  • GSK 2118436
  • GSK 2118436A
  • GSK2118436A
Annen: Questionnaire Administration

Ancillary study
Eksperimentell: Arm B (Cabozantinib)

Patients receive cabozantinib PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, blood sample collection and may undergo MRI throughout the study.
Fremgangsmåte: Biospecimen Collection

Undergo blood sample collection

Andre navn:
  • Biologisk prøvesamling
  • Bioprøve samlet
  • Prøvesamling
Fremgangsmåte: Magnetic Resonance Imaging

Undergo MRI

Andre navn:
  • MR
  • Magnetisk resonans
  • Magnetic Resonance Imaging Scan
  • Medisinsk bildebehandling, magnetisk resonans / kjernemagnetisk resonans
  • MR Imaging
  • MR-skanning
  • NMR-avbildning
  • NMRI
  • Kjernemagnetisk resonansavbildning
  • Magnetisk resonanstomografi (MR)
  • sMRI
  • Magnetisk resonansavbildning (prosedyre)
  • MR-er
  • Strukturell MR
Fremgangsmåte: Computed Tomography

Undergo CT scan

Andre navn:
  • CT
  • KATT
  • CAT-skanning
  • Beregnet aksial tomografi
  • Datastyrt aksialtomografi
  • Datastyrt tomografi
  • CT skann
  • tomografi
  • Datastyrt aksial tomografi (prosedyre)
  • Datastyrt tomografi (CT) skanning
  • Diagnostisk CAT -skanning
  • Diagnostisk CAT -skannertype
Legemiddel: Cabozantinib

Given PO

Annen: Questionnaire Administration

Ancillary study

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Progression free survival (PFS)
Tidsramme: From randomization to radiographic progression of disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or death from any cause, up to 5 years

PFS will be compared between the two groups using a stratified log-rank test with one-sided type I error of 0.05. Median PFS and 95% confidence interval (CI) for each treatment arm will be estimated using the Kaplan-Meier method. The stratified hazard ratio and 95% CI will be estimated using a Cox proportional hazard model with treatment group as the independent variable.
From randomization to radiographic progression of disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or death from any cause, up to 5 years

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Objective response
Tidsramme: Up to 5 years

Will be assessed based on international criteria proposed by the RECIST 1.1 guideline. Response (complete and partial responses) rate will be estimated. Will be compared using the Fisher's exact test.
Up to 5 years
Overall survival
Tidsramme: From randomization to death from any cause, up to 5 years

Median and 95% CI will be estimated in each arm using the Kaplan-Meier method.
From randomization to death from any cause, up to 5 years
Duration of response
Tidsramme: From confirmed response (complete response or partial response) to progression among patients who achieve a response, up to 5 years

Median and 95% CI will be estimated in each arm using the Kaplan-Meier method.
From confirmed response (complete response or partial response) to progression among patients who achieve a response, up to 5 years
PFS2
Tidsramme: From randomization to progression on subsequent therapy or death from any cause, up to 5 years

Median and 95% CI will be estimated in each arm using the Kaplan-Meier method.
From randomization to progression on subsequent therapy or death from any cause, up to 5 years
Incidence of adverse events
Tidsramme: Up to the end of treatment

Using the National Cancer Institute's Common Terminology Criteria for Adverse Events. Response rate and grade 3 or higher toxicity rates will be compared using the Fisher's exact test between the two arms.
Up to the end of treatment

Andre resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Patient tolerability
Tidsramme: At baseline, 4, 8, 16, and 28 weeks

Will assess patients tolerability of treatment using the Functional Assessment of Cancer Therapy-General (FACT G)7 and general quality of life using the FACT-GP.
At baseline, 4, 8, 16, and 28 weeks
Treatment effect
Tidsramme: Up to 5 years

The corresponding 95% CIs will be provided.
Up to 5 years
Treatment effect by sex
Tidsramme: Up to 5 years

The corresponding 95% CIs will be provided.
Up to 5 years
Treatment effect by race
Tidsramme: Up to 5 years

The corresponding 95% CIs will be provided.
Up to 5 years
Treatment effect by ethnicity
Tidsramme: Up to 5 years

The corresponding 95% CIs will be provided.
Up to 5 years

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

ECOG-ACRIN Cancer Research Group

Etterforskere

  • Hovedetterforsker: Lova Sun, ECOG-ACRIN Cancer Research Group

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

27. desember 2024

Primær fullføring (Antatt)

30. september 2030

Studiet fullført (Antatt)

30. september 2030

Datoer for studieregistrering

Først innsendt

17. mai 2024

Først innsendt som oppfylte QC-kriteriene

20. juni 2024

Først lagt ut (Faktiske)

26. juni 2024

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

24. september 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

21. september 2026

Sist bekreftet

1. september 2026

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • EA3231
  • U10CA180820 (U.S. NIH-stipend/kontrakt)
  • EA3231 (Annen identifikator: CTEP)
  • NCI-2024-03023 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
  • EA3231 (Annen identifikator: ECOG-ACRIN Cancer Research Group)

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Ja

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

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