Study of XL147 (SAR245408) in Combination With Trastuzumab or Paclitaxel and Trastuzumab in Subjects With Metastatic Breast Cancer Who Have Progressed on a Previous Trastuzumab-based Regimen
9 maj 2016 uppdaterad av: Sanofi
A Phase 1/2 Study of XL147 (SAR245408) Administered in Combination With Trastuzumab or Paclitaxel and Trastuzumab in Subjects With Metastatic Breast Cancer Who Have Progressed on a Previous Trastuzumab-Based Regimen
Phase 1 of this study will evaluate the maximum tolerated dose (MTD) of XL147 when given in combination with trastuzumab (Herceptin) and in combination with trastuzumab and paclitaxel. After the MTD is established for each combination (Phase 2), subjects will be enrolled to evaluate the preliminary efficacy and safety of these combinations in metastatic HER2 positive breast cancer. Both trastuzumab and paclitaxel are used in the treatment of metastatic breast cancer (MBC), but patients can develop resistance.
The link between PI3K mutations and trastuzumab resistance has been seen in breast cancer patients. This suggests that inhibitors of the PI3K/PTEN pathway may have the potential to restore sensitivity to trastuzumab. Similarly, introduction of activated mutant forms of PI3K has been shown to transform and confer paclitaxel resistance to immortalized breast epithelial cells. XL147 is a potent and selective inhibitor of PI3K and inhibits phosphorylation of multiple downstream components of PI3K/PTEN signaling. Therefore, XL147 may have utility in the treatment of trastuzumab resistant/refractory and HER2-positive MBC when administered in combination with trastuzumab alone or with trastuzumab and paclitaxel.
Studieöversikt
Status
Avslutad
Betingelser
Intervention / Behandling
Studietyp
Interventionell
Inskrivning (Faktisk)
42
Fas
- Fas 2
- Fas 1
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
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California
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Los Angeles, California, Förenta staterna, 90033
- Investigational Site Number 1537
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Florida
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Fort Meyers, Florida, Förenta staterna, 33901
- Investigational Site Number 1238
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Massachusetts
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Boston, Massachusetts, Förenta staterna, 02115
- Investigational Site Number 1138
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Michigan
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Detroit, Michigan, Förenta staterna, 48201
- Investigational Site Number 1330
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New York
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Bronx, New York, Förenta staterna, 10467
- Investigational Site Number 1151
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New York, New York, Förenta staterna, 10032
- Investigational Site Number 1150
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Tennessee
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Nashville, Tennessee, Förenta staterna, 37203
- Investigational Site Number 1214
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Nashville, Tennessee, Förenta staterna, 37232
- Investigational Site Number 1246
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Madrid, Spanien, 28041
- Investigational Site Number 3413
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
18 år och äldre (Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Kvinna
Beskrivning
Inclusion Criteria:
- The subject has pathologically and radiologically confirmed metastatic HER2 positive breast cancer (Stage IV disease). Subjects must have received and progressed on at least one prior trastuzumab-containing regimen for metastatic disease. For subjects in Arm 2, they must also have received at least one prior taxane-containing regimen.
- The subject has at least one lesion that is not within a previously radiated field and measurable on computerized tomography (CT) or magnetic resonance imaging scan (MRI)
- The subjects enrolled in Phase 2 must be willing to undergo a biopsy of the primary tumor or a tumor metastasis at baseline, if tumor tissue is amenable to biopsy
- The subject's primary tumor and/or metastatic lesion must overexpress HER2
- For subjects enrolled in Phase 2: samples from archival or fresh tissue, or a tissue block of the subject's tumor.
- The subject has an Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2
- The subject has adequate organ and marrow function
- The subject is capable of understanding the informed consent and complying with the protocol and has signed the informed consent document prior to any study-specific screening procedures or evaluations being performed.
- Sexually active subjects must agree to use a medically-accepted barrier method of contraception during the course of the study and for 3 months following discontinuation of study treatments. For subjects using oral contraceptives, a barrier method must be used in addition to the oral contraceptive
- Subjects of childbearing potential must have a negative pregnancy test at screening and enrollment
Exclusion Criteria:
- The subject has previously been treated with a selective inhibitor of PI3K and / or AKT
- Certain restrictions on prior therapies apply
- The subject has not recovered from toxicity due to prior therapy to Grade ≤ 1 or to pre-therapy baseline
- The subject has untreated, symptomatic, or progressive brain metastases. Any corticosteroid use for brain metastases must have been discontinued without the subsequent appearance of symptoms for ≥4 weeks prior to first study treatment
- The subject has prothrombin time/International Normalized Ratio (PT/INR) or partial thromboplastin time (PTT) test results at screening that are ≥ 1.3 times above the laboratory upper limit of normal
- The subject has a diagnosis of uncontrolled diabetes mellitus
- The subject has uncontrolled significant intercurrent illness
- The subject has uncontrolled hypertension or other clinically significant cardiovascular disease
- The subject has left ventricular ejection fraction (LVEF) ≤ 50%
- The subject has a baseline corrected QT interval ≥ 460 ms
- The subject is currently receiving anticoagulation with therapeutic doses of warfarin (low-dose warfarin ≤ 1mg/day is permitted)
- The subject is pregnant or breastfeeding
- The subject is known to be positive for the human immunodeficiency virus (HIV) (a test for HIV at screening is not required)
- The subject has any other diagnosis of malignancy or evidence of malignancy (except non-melanoma skin cancer, in situ carcinoma of the cervix) within 2 years prior to screening for this study
- The subject has a previously identified allergy or hypersensitivity or is intolerant to components of any of the study treatment formulations
- The subject is unable or unwilling to abide by the study protocol or cooperate fully with the investigator or designee
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Icke-randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
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Experimentell: Arm 1
XL147 in combination with trastuzumab
|
administered orally once daily as tablet(s)
administered by IV once every 3 weeks
Andra namn:
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Experimentell: Arm 2
XL147 in combination with trastuzumab and paclitaxel
|
administered orally once daily as tablet(s)
administered by IV once every 3 weeks
Andra namn:
administered by IV once every week
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Tidsram |
|---|---|
|
Safety and tolerability of XL147 in combination with trastuzumab and in combination with trastuzumab and paclitaxel
Tidsram: safety assessments at weekly study visits
|
safety assessments at weekly study visits
|
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In Phase 1, the maximum tolerated dose (MTD) of XL147 when administered in combination with trastuzumab and in combination with trastuzumab and paclitaxel
Tidsram: assessed by weekly study visits
|
assessed by weekly study visits
|
|
In Phase 2, objective tumor response
Tidsram: every 6 weeks
|
every 6 weeks
|
Sekundära resultatmått
Resultatmått |
Tidsram |
|---|---|
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Duration of response and progression-free survival (Phase 2)
Tidsram: every 6 weeks
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every 6 weeks
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Pharmacokinetics and pharmacodynamics of XL147 and trastuzumab when given in combination, and of XL147, trastuzumab, and paclitaxel when given in combination
Tidsram: assessed weekly, then every 3 weeks
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assessed weekly, then every 3 weeks
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart
1 februari 2010
Primärt slutförande (Faktisk)
1 december 2012
Avslutad studie (Faktisk)
1 december 2012
Studieregistreringsdatum
Först inskickad
4 januari 2010
Först inskickad som uppfyllde QC-kriterierna
5 januari 2010
Första postat (Uppskatta)
6 januari 2010
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
3 juni 2016
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
9 maj 2016
Senast verifierad
1 maj 2016
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- ARD11439
- XL147-203 (Annan identifierare: (other study code))
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .