Effect of Continuous Positive Airway Pressure Treatment on Inflammation in Patients With Obstructive Sleep Apnea
A Longitudinal Study of Short-Term Effects of CPAP Treatment on Airway and Systemic Inflammation in Patients With Obstructive Sleep Apnea
研究概览
详细说明
Obstructive sleep apnea (OSA) is characterised by repetitive episodes of upper airway obstruction during sleep. Systemic and airway inflammation has been recently shown to be associated with OSA and is hypothesized to contribute to the clinical manifestation and the complications of OSA patients.
Continuous positive airway pressure (CPAP) is a first-line treatment for OSA and improves diurnal and nocturnal symptoms. However, the effectiveness of CPAP in reversing airway inflammation is less compelling in comparison to systemic inflammation.
This study will assess NO in exhaled breath, inflammatory biomarkers in induced sputum and blood of OSA patients and other clinical measurements before and after 3 months of CPAP treatment.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Kyoto、日本、6068507
- Kyoto University Graduate School of Medicine
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Subjects on admission for sleep study under the Respiratory Care and Sleep Control Medicine, Kyoto University Hospital.
- Subjects diagnosed with OSA (apnea hypopnea index >=20/hour) by overnight polysomnography.
Exclusion Criteria:
- Known history of respiratory diseases that will affect airway inflammatory markers like asthma, chronic obstructive pulmonary disease and bronchiectasis.
- Treatments with corticosteroids or other immunosuppressive drugs.
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：非随机化
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：呼吸机
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保持上呼吸道通畅并最大限度地减少阻塞事件
其他名称：
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Inflammatory biomarkers in induced sputum and blood. Cell counts in induced sputum.
大体时间：3 months
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3 months
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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生活质量
大体时间：3个月
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3个月
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睡眠质量
大体时间：3个月
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3个月
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NO in exhaled breath
大体时间：3 months
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3 months
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Airway resistance
大体时间：3 months
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3 months
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PSG measurement(AHI,etc.)
大体时间：3 months
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3 months
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Psychological status
大体时间：3 months
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3 months
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合作者和调查者
调查人员
- 首席研究员：Kazuo Chin, MD,PhD、Kyoto University, Graduate School of Medicine
- 首席研究员：Toru Oga, MD,PhD、Kyoto University, Graduate School of Medicine
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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