LASER: Real Life Antithrombotic Stent Evaluation Registry (LASER)

Patients with significant symptomatic coronary artery disease who for this reason undergo PCI with implantation of one or more drug eluting stent(s) (DES) or bare metal stent(s) and requiring Vitamin K Antagonist based full anticoagulation therapy (target INR 2-4,5) for any clinical indication.

The LASER Registry will collect the data of 1000 patients with the need for oral anticoagulation and 1000 matched control patients without the need for oral anticoagulation.

Inclusion Criteria:

• Patients with significant symptomatic coronary artery disease (stable angina class II or more (CCS) , unstable angina, NSTEMI, or STEMI) and who for this reason do undergo percutaneous coronary revascularization with one or more drug eluting stent(s) (DES) or bare metal stent(s)
• Patients requiring Vitamin K Antagonists based full anticoagulation therapy (target INR 2-4,5) for any clinical indication
• Age: >18 years; no upper age limit
• Informed consent has been obtained that the patient agrees to be fol-lowed up for up to one year

Exclusion Criteria:

• Patients who have been treated with a combined anticoagulant & antiplatelet therapy within the previous two months
• Overt or constant occult bleeding that cannot adequately be treated (proton pump inhibitors, H2-blockers e.g.)
• Any contraindication to the use of thienopyridines
• Any contraindication to the use of aspirin
• Severe liver or kidney disease
• Any reason that creates sufficient doubts that follow-up can be obtained with reasonable efforts
• Any other reason that in the eye of the investigator makes the patient unsuitable for the participation in the registry
• For female patients only: pregnant or not on oral contraceptives or child bearing potential