Vitamin D, Insulin Sensitivity, and Vascular Associations in Adolescents (DIVA)
Serum 25-hydroxyvitamin D, Vascular Functioning, and Insulin Sensitivity in Adolescent Girls [The DIVA Study (Vitamin D, Insulin, and Vascular Associations)] (Pediatric Physician Training in Translational Research)
The overall objectives of this study are to examine the relationships between circulating vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine whether vitamin D deficiency in AA is responsible for ethnic differences in insulin sensitivity and hypertension in AA and EA, as well as mechanisms underlying the association between insulin resistance and blood pressure. We hypothesize that 1) serum 25(OH)D is associated with insulin sensitivity and vascular functioning, independent of adiposity, 2) lower insulin sensitivity and vascular functioning in AA relative to EA is due to lower circulating 25(OH)D in AA, and 3) the relationship between insulin resistance and vascular dysfunction is mediated by 25(OH)D.
Acronyms: African American (AA), European American (EA), Serum 25-hydroxy vitamin D (25()H)D, Body mass index (BMI), Alabama (AL).
研究概览
研究类型
注册 (实际的)
联系人和位置
学习地点
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Alabama
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Birmingham、Alabama、美国、35243
- University of Alabama
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- African American or Caucasian ethnicity
- Ages 14-18 yrs
- Healthy
Exclusion Criteria:
- BMI-for age and -sex higher than 95th centile on the Centers for Disease Control and Prevention Growth Charts
- Use of medication(s) known to influence body composition, vascular function, or glucose metabolism
- Pregnancy
- Diabetes or any chronic diseases
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Healthy adolescents
Healthy adolescent African American and Caucasian females, ages 14-18
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
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Insulin Sensitivity
大体时间:Cross sectional study: at the first study visit
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Cross sectional study: at the first study visit
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次要结果测量
结果测量 |
大体时间 |
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Vascular Function
大体时间:Cross sectional study: at the second study visit, within 2 weeks of first study visit
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Cross sectional study: at the second study visit, within 2 weeks of first study visit
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合作者和调查者
调查人员
- 首席研究员:Ambika Ashraf, MD、University of Alabama at Birmingham
出版物和有用的链接
一般刊物
- Alvarez JA, Gower BA, Calhoun DA, Judd SE, Dong Y, Dudenbostel T, Scholl J, Ashraf AP. Serum 25-hydroxyvitamin D and Ethnic Differences in Arterial Stiffness and Endothelial Function. J Clin Med Res. 2012 Jun;4(3):197-205. doi: 10.4021/jocmr965w. Epub 2012 May 15.
- Ashraf AP, Huisingh C, Alvarez JA, Wang X, Gower BA. Insulin resistance indices are inversely associated with vitamin D binding protein concentrations. J Clin Endocrinol Metab. 2014 Jan;99(1):178-83. doi: 10.1210/jc.2013-2452. Epub 2013 Dec 20.
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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