Blood Volume and Fluid Kinetics in Patients Undergoing Extracorporal Circulation
研究概览
地位
详细说明
In many clinical situations, such as extensive surgery, it is of value to determine blood volume and rate of fluid loss from the intravascular space, since hypo- and hypervolemia are combined with increased morbidity and mortality. In this study we which to use the large variations in hemoglobin during extracorporal to calculate both these variables.
Hemoglobin is measured every 5 minutes during one hour beginning shortly before start of the heart-lung machine. When the extracorporal circulation begins the hemoglobin decreases due to the quick mix and dilution of the priming fluid from the heart-lung machine with the patients blood.
From the amount of priming fluid and the fall of the hemoglobin, the blood volume can be calculated. If no further fluid is given the next 20 to 30 minutes, the hemoglobin concentration will in most cases increase as a result of the fluid loss from the vascular space. This increase in combination with the diureses can be used to calculate the intravascular fluid loss to the interstitium during surgery.
Sodium concentration will also be measured in parallel with the hemoglobin concentration.
The Sodium concentrations in combination with given and excreted (urine)Sodium can be used in a mass balance to calculate if intracellular edema is induced.
研究类型
注册 (实际的)
联系人和位置
学习地点
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-
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Linkoeping、瑞典、581 85
- University Hospital, Thoracic operation ward
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- open heart surgery, with extracorporal circulation
- consent to participation
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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Cardiac surgery
Patients subjected to open cardiac surgery with the help of extracorporal circulation.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Blood Volume
大体时间：30 minutes after start of CPB
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volume kinetic technique: During start of cardio pulmonary by-pass a known amount of fluid will expand the blood volume and dilute the hemoglobin.
To achieve the blood volume prior to anesthesia a hemoglobin value before anesthesia and the last hemoglobin value before CPB are used to correct the blood volume calculation. In this way blood volume prior to anaesthesia can be calculated. |
30 minutes after start of CPB
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Intracellular Edema
大体时间：30 minutes after CPB
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Mass balance based on repeated Sodium concentration, fluid volume given, given and excreted Sodium. A positive value indicating intracellular fluid accumulation and a negative value indicating cell dehydration. This is the change that will occur during the first 30 min after start of cardio pulmonary bypass. |
30 minutes after CPB
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其他结果措施
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Fluid Extravasation
大体时间：Two distribution half-times. Approximately 16 minutes.
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Rate of fluid transfer from the intravascular to the extravascular compartment during two distribution half-times.
Graph derived from the hemoglobin change during 20 to 30 minutes after start of cardio pulmonary by-pass.
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Two distribution half-times. Approximately 16 minutes.
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合作者和调查者
调查人员
- 首席研究员：Joachim Zdolsek, MD, PhD、University Hospital, Linköping, Sweden
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他研究编号
- BVECC
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