A Comparison of p53-induced Genes Activation in Patients With and Without Acute Myocardial Infarction
A Comparison of p53-induced Genes Activation as Possible Markers Differentiating Between Patients Presenting With Acute Myocardial Infarction and Controls
研究概览
详细说明
The diagnosis of acute myocardial infarction is based on the rise of bio-markers for cardiac necrosis such as troponin. While troponin measurement is highly sensitive for myocardial necrosis it has several limitations that influence its clinical use. First, since the troponin test is reliable only after 4-6 hours from symptoms onset, it has only limited value in the assessment of patients presenting earlier. Second, several clinical situations, most commonly renal dysfunction, are associated with increased troponin level and therefore may decrease the specificity of the test. Third, since troponin rise indicates myocardial infarction it is not useful in the common situations where there is myocardial ischemia without necrosis.
The P53 is a tumor suppressing gene activated in different stressful situations including hypoxia. This activation is associated with accelerated transcription (up to 30-50 folds from baseline) of different genes that are involved in apoptosis, DNA repair and in stopping the cell cycle. A study on pregnant women demonstrated high levels of fetal mRNA of these genes in maternal circulation. This gene expression correlated with other signs of fetal stress associated with hypoxia. Myocardial ischemia is another stressful event associated with tissue hypoxia. Nevertheless, the association of this gene expression with myocardial ischemia has not been investigated yet.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Kfar Saba、以色列
- Meir Medical Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Aacute MI group- Patients with acute ST elevation MI planned for emergency primary PCI
Controls: Patients undergoing non-invasive evaluation of possible myocardial ischemia
描述
Inclusion Criteria:
Acute MI group:
Patient presenting with chest pain lasting for at leasY 1 hour and no more than 6 hours accompanied by 1 of the following ECG criteria:
- ST segment elevation of anterior or inferior wall (at least 2 consecutive leads)
- New LBBB
Controls:
- Patients undergoing non-invasive evaluation of possible myocardial ischemia
Exclusion Criteria:
- Chronic lung disease requiring chronic treatment
- Any malignancy in the 5 year prior to enrollment
学习计划
研究是如何设计的?
设计细节
- 观测模型:病例对照
- 时间观点:预期
队列和干预
团体/队列 |
干预/治疗 |
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acute MI group
Patients presenting with acute ST elevation myocardial infarction, admitted to the intensive cardiac care unit and that are planned for emergency primary PCI
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验血
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Controls
Patients undergoing a non-invasive evaluation of possible myocardial ischemia.
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验血
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
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Expression of P53 induced genes in patients with and without acute myocardial infarction
大体时间:Up to 4 hours following recruitment
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Up to 4 hours following recruitment
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次要结果测量
结果测量 |
大体时间 |
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Correlation between P53 associated gene expression with troponin level
大体时间:After 5 days from recruitment
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After 5 days from recruitment
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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验血的临床试验
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University of North Carolina, Chapel HillEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); National... 和其他合作者完全的
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National University of Ireland, Galway, IrelandHealth Research Board, Ireland完全的
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PATHUnited States Agency for International Development (USAID); Kintampo Health Research Centre,...完全的