CLCNKA (Ka Renal Chloride Channel[ClC-Ka]) Polymorphism Effects on Hypertrophy Regression
2015年6月1日 更新者:Washington University School of Medicine
A Randomized, Double Blind Pilot Study Evaluating CLCNKA (Ka Renal Chloride Channel[ClC-Ka]) Polymorphism Effects on Hypertrophy Regression in Caucasian Hypertensive Patients Treated With Eplerenone
This study will consist of middle-aged Caucasian non-failing subjects with high blood pressure who are homozygous for a gene that confers increased risk of developing heart failure, the Glycine 83 variant of the Ka renal chloride channel (ClC-Ka Gly/Gly 83), or middle-aged Caucasian non-failing hypertensive subjects who lack the heart failure risk gene, the wild-type Arginine 83 Ka renal chloride channel (ClC-Ka Arg/Arg 83).
Subjects on standard therapy for high blood pressure with an angiotensin converting inhibitor (ACEI) or angiotensin receptor blocker (ARB) will be randomized to additional treatment with eplerenone (an aldosterone antagonist) or placebo, and assessed for changes in echocardiographic left ventricular hypertrophy (LVMI).
Secondary endpoints will assess left ventricular remodeling and other echocardiographic variables.
The investigators hypothesize that subjects homozygous for the CLCNKA risk allele will have a greater response to eplerenone in terms of reductions in LVMI than those lacking the risk allele.
研究概览
详细说明
The screening phase will involve identifying Caucasian hypertensive patients who are homozygous for the ClC-Ka Gly/Gly83 and the ClC-Ka Arg/Arg 83 allele.
All patients will be on background therapy with an angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) at least mid range dosing.
If patient is not at recommended dose of ACE or ARB they must be titrated up and be stable on a midrange dose of ACEI or ARB for at least 4 weeks before they can be entered into the study.
There will be 2 treatment phases.
Phase 1 will be up to 4 weeks in duration and will consist of randomization to one table of eplerenone (25 mg) or matching placebo.
On week 2 the patient will be up titrated to two tablets of eplerenone (50 mg) or matching placebo, to achieve a target dose of 50 mg of eplerenone.
If the patient cannot tolerate two tablets of eplerenone or matching placebo they can be down titrated to one tablet of eplerenone or matching placebo.
The target BP on study medication is < 130/80 mmHg.
After the patients have been up titrated to the maximally tolerated dose of study medication, the background hypertension therapy can be adjusted to reach the target BP of < 130/80 mmHg by the end of week 4. Phase 2 will be 52 weeks in duration to assess the effects of placebo or eplerenone on LV hypertrophy.
Serum potassium will be monitored throughout the study, and if necessary, doses of eplerenone will be titrated down as necessary.
研究类型
介入性
阶段
- 第四阶段
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
-
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Missouri
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St. Louis、Missouri、美国、63108
- Barnes Jewish Hospital
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Pennsylvania
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Philadelphia、Pennsylvania、美国、19104
- Hospital of the University of Pennsylvania
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-
参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
40年 至 80年 (成人、年长者)
接受健康志愿者
不
有资格学习的性别
全部
描述
Inclusion Criteria:
- Caucasians with hypertension who are homozygous for the ClC-Ka Gly/Gly83 and the ClC-Ka Arg/Arg 83 allele.
- Male or non-pregnant female aged 40 to 80 years.
- Hypertension, defined as currently taking high blood pressure medications or not on medications but having SDP >140 or DBP >90.
- Ejection fraction > 50% by any method within 6 months of the screening visit.
- The Investigator must obtain written informed consent before the subject is screened for the study.
- Subject should be on stable dose of ACE or ARB at moderate dosing for at least 4 weeks before randomization.
Exclusion Criteria:
- History of heart failure with preserved or depressed ejection fraction.
- Creatinine clearance of < 45 mL/min based on the Cockcroft-Gault formula (Appendix C).
- Pregnancy
- Life expectancy less than 12 months.
- Planned cardiac surgery or percutaneous cardiac intervention within 3 months.
- Serum potassium >5.5 mEq/L.
- History of hyperkalemia (K>6.0 mEq/L) with eplerenone or spironolactone.
- Myocardial infarction or stroke within 3 months of screening.
- Evidence of clinical instability (hypotension, arrhythmias, unstable angina etc.).
- Subjects on or requiring K-sparing diuretics or spironolactone.
- Concomitant use of potent inhibitors of CYP3A4 including ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir or any drug noted in the Contraindications, Warnings or Precautions sections of their labeling to be potent CYP3A4 inhibitors
- Known hypersensitivity to eplerenone or spironolactone.
- Evidence of current alcohol or drug abuse Severe organic disorders or surgery or disease of the gastrointestinal tract that in the opinion of the Investigator may interfere in the absorption and elimination of the study drug.
- Psychoses or behavioral conditions that in the opinion of the Investigator would limit study compliance.
- Subjects who have received any investigational medication or used any investigational device within 30 days prior to first dose of study drug or subjects actively participating in any investigational drug or device study.
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:随机化
- 介入模型:阶乘赋值
- 屏蔽:四人间
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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有源比较器:Arm 1
Caucasian hypertensive patients who are homozygous for the ClC-Ka Gly/Gly83 allele
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Eplerenone 50 mg/day
其他名称:
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有源比较器:Arm 2
Caucasian hypertensive patients who are homozygous for ClC-Ka Arg/Arg 83 allele
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Eplerenone 50 mg/day
其他名称:
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安慰剂比较:Arm 3
Caucasian hypertensive patients who are homozygous for ClC-Ka Arg/Arg 83 allele
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安慰剂
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安慰剂比较:Arm 4
Caucasian hypertensive patients who are homozygous for the ClC-Ka Gly/Gly83 allele
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安慰剂
|
研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Change in LV mass index (g/m2) in ClC-Ka Gly/Gly83 patients and ClC-Ka Gly/Gly83 patients
大体时间:12 months
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12 months
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次要结果测量
结果测量 |
大体时间 |
|---|---|
|
Change in LV relative wall thickness
大体时间:6 and 12 months
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6 and 12 months
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Change in N-terminal pro-brain natriuretic peptide (NT-proBNP)
大体时间:6 and 12 months
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6 and 12 months
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Change in LV mass index (g/m2)
大体时间:6 months
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6 months
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员:Thomas Cappola, MD、University of Pennsylvania
- 首席研究员:Gerald Dorn, MD、Washington University School of Medicine
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2011年12月1日
初级完成 (预期的)
2014年12月1日
研究完成 (实际的)
2015年6月1日
研究注册日期
首次提交
2011年1月10日
首先提交符合 QC 标准的
2011年1月11日
首次发布 (估计)
2011年1月12日
研究记录更新
最后更新发布 (估计)
2015年6月3日
上次提交的符合 QC 标准的更新
2015年6月1日
最后验证
2015年6月1日
更多信息
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